Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano
La ectasia y el aneurisma coronario son parte de la enfermedad coronaria aterosclerótica, caracterizada por el remodelado positivo del vaso. Aunque el tratamiento de la enfermedad aterosclerótica estenótica ha avanzado con la angioplastia y la terapia antitrombótica, no ha ocurrido lo mismo para la...
- Autores:
-
Cabrera Villamizar, Alfredo
Rodríguez Ariza, Carlos Daniel
- Tipo de recurso:
- https://purl.org/coar/resource_type/c_7a1f
- Fecha de publicación:
- 2017
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/12790
- Acceso en línea:
- https://hdl.handle.net/20.500.12495/12790
- Palabra clave:
- Ectasia coronaria
Aneurisma coronaria
Terapía antitrombótica
Eventos adversos cardiovasculares mayores
Sangrado
Coronary ectasia
Coronary aneurysm
Antithrombotic therapy
Major cardiovascular adverse events
Bleeding
WG 100
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 4.0 Internacional
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Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano |
| dc.title.translated.none.fl_str_mv |
Major cardiovascular outcomes at one year of follow-up in patients diagnosed with ectasia and coronary aneurysms in a Latin American center |
| title |
Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano |
| spellingShingle |
Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano Ectasia coronaria Aneurisma coronaria Terapía antitrombótica Eventos adversos cardiovasculares mayores Sangrado Coronary ectasia Coronary aneurysm Antithrombotic therapy Major cardiovascular adverse events Bleeding WG 100 |
| title_short |
Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano |
| title_full |
Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano |
| title_fullStr |
Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano |
| title_full_unstemmed |
Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano |
| title_sort |
Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericano |
| dc.creator.fl_str_mv |
Cabrera Villamizar, Alfredo Rodríguez Ariza, Carlos Daniel |
| dc.contributor.advisor.none.fl_str_mv |
Lineros Montañez, Alberto |
| dc.contributor.author.none.fl_str_mv |
Cabrera Villamizar, Alfredo Rodríguez Ariza, Carlos Daniel |
| dc.contributor.orcid.none.fl_str_mv |
Cabrera-Villamizar, Alfredo [0009-0003-5224-5309] Rodríguez-Ariza, Carlos Daniel [0000-0001-8025-1851] |
| dc.subject.none.fl_str_mv |
Ectasia coronaria Aneurisma coronaria Terapía antitrombótica Eventos adversos cardiovasculares mayores Sangrado |
| topic |
Ectasia coronaria Aneurisma coronaria Terapía antitrombótica Eventos adversos cardiovasculares mayores Sangrado Coronary ectasia Coronary aneurysm Antithrombotic therapy Major cardiovascular adverse events Bleeding WG 100 |
| dc.subject.keywords.none.fl_str_mv |
Coronary ectasia Coronary aneurysm Antithrombotic therapy Major cardiovascular adverse events Bleeding |
| dc.subject.nlm.none.fl_str_mv |
WG 100 |
| description |
La ectasia y el aneurisma coronario son parte de la enfermedad coronaria aterosclerótica, caracterizada por el remodelado positivo del vaso. Aunque el tratamiento de la enfermedad aterosclerótica estenótica ha avanzado con la angioplastia y la terapia antitrombótica, no ha ocurrido lo mismo para la ectasia y el aneurisma. No hay consenso sobre la mejor estrategia antitrombótica para estos pacientes, lo que resulta en tratamientos basados en estudios observacionales pequeños, sin claridad sobre su impacto en desenlaces clínicos. Hemos realizado un estudio observacional retrospectivo con 93 pacientes con ectasia y/o aneurisma coronario (98.9% con ectasia, 12.9% con aneurisma). Las características de los pacientes y la distribución de factores de riesgo fueron las esperadas para la enfermedad coronaria. La principal indicación para el cateterismo fue infarto agudo de miocardio sin elevación del segmento ST. Ninguna variable se asoció con un aumento de eventos cardíacos adversos mayores (MACE) en análisis univariado ni multivariado (p>0.05). Para el desenlace de sangrado, el análisis univariado mostró una asociación significativa con el número de arterias con ectasia (OR: 2.5355, 95% CI: 1.0146-6.3366, p=0.036) y el tratamiento antitrombótico (OR: 1.3449, 95% CI: 0.9714-1.8622, p=0.042). Sin embargo, en el análisis multivariado, solo el tratamiento antitrombótico alcanzó significancia estadística (OR: 1.6825, 95% CI: 1.003-2.822, p=0.049). La capacidad del modelo para predecir eventos de sangrado fue limitada (p = 0.2). |
| publishDate |
2017 |
| dc.date.issued.none.fl_str_mv |
2017-07 |
| dc.date.accessioned.none.fl_str_mv |
2024-08-01T21:13:22Z |
| dc.date.available.none.fl_str_mv |
2024-08-01T21:13:22Z |
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http://purl.org/coar/resource_type/c_7a1f |
| dc.type.local.spa.fl_str_mv |
Tesis/Trabajo de grado - Monografía - Especialización |
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https://purl.org/coar/resource_type/c_7a1f |
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info:eu-repo/semantics/bachelorThesis |
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https://purl.org/coar/version/c_ab4af688f83e57aa |
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https://purl.org/coar/resource_type/c_7a1f |
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https://hdl.handle.net/20.500.12495/12790 |
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instname:Universidad El Bosque |
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reponame:Repositorio Institucional Universidad El Bosque |
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N Engl J Med. 2009 Sep 10;361(11):1045-57. doi: 10.1056/NEJMoa0904327. PMID: 19717846. 41. Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, et al.; TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007 Nov 15;357(20):2001-15. doi: 10.1056/NEJMoa0706482. PMID: 17982182. 42. Pranata R, Yonas E, Chintya V, Alkatiri AA. Is Anticoagulant Necessary in Patients with Coronary Artery Ectasia Presenting with Acute Coronary Syndrome? A Systematic Review of Case Reports. Int J Angiol. 2019 Dec;28(4):231-236. doi: 10.1055/s-0039-1692706. PMID: 31787821; PMCID: PMC6882670. 43. Núñez-Gil IJ, Terol B, Feltes G, Nombela-Franco L, Salinas P, Escaned J, et al. Coronary aneurysms in the acute patient: Incidence, characterization and long-term management results. Cardiovasc Revasc Med. 2018 Jul-Aug;19(5 Pt B):589-596. doi: 10.1016/j.carrev.2017.12.003. PMID: 29276176. 44. Ipek G, Gungor B, Karatas MB, Onuk T, Keskin M, Tanik O, et al. Risk factors and outcomes in patients with ectatic infarct-related artery who underwent primary percutaneous coronary intervention after ST elevated myocardial infarction. Catheter Cardiovasc Interv. 2016 Nov;88(5):748-753. doi: 10.1002/ccd.26553. PMID: 27143640. 45. Mello BH, Oliveira GB, Ramos RF, Lopes BB, Barros CB, Carvalho Ede O, et al. Validation of the Killip-Kimball classification and late mortality after acute myocardial infarction. Arq Bras Cardiol. 2014 Aug;103(2):107-17. doi: 10.5935/abc.20140091. PMID: 25014060; PMCID: PMC4150661. |
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Lineros Montañez, AlbertoCabrera Villamizar, AlfredoRodríguez Ariza, Carlos DanielCabrera-Villamizar, Alfredo [0009-0003-5224-5309]Rodríguez-Ariza, Carlos Daniel [0000-0001-8025-1851]2024-08-01T21:13:22Z2024-08-01T21:13:22Z2017-07https://hdl.handle.net/20.500.12495/12790instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coLa ectasia y el aneurisma coronario son parte de la enfermedad coronaria aterosclerótica, caracterizada por el remodelado positivo del vaso. Aunque el tratamiento de la enfermedad aterosclerótica estenótica ha avanzado con la angioplastia y la terapia antitrombótica, no ha ocurrido lo mismo para la ectasia y el aneurisma. No hay consenso sobre la mejor estrategia antitrombótica para estos pacientes, lo que resulta en tratamientos basados en estudios observacionales pequeños, sin claridad sobre su impacto en desenlaces clínicos. Hemos realizado un estudio observacional retrospectivo con 93 pacientes con ectasia y/o aneurisma coronario (98.9% con ectasia, 12.9% con aneurisma). Las características de los pacientes y la distribución de factores de riesgo fueron las esperadas para la enfermedad coronaria. La principal indicación para el cateterismo fue infarto agudo de miocardio sin elevación del segmento ST. Ninguna variable se asoció con un aumento de eventos cardíacos adversos mayores (MACE) en análisis univariado ni multivariado (p>0.05). Para el desenlace de sangrado, el análisis univariado mostró una asociación significativa con el número de arterias con ectasia (OR: 2.5355, 95% CI: 1.0146-6.3366, p=0.036) y el tratamiento antitrombótico (OR: 1.3449, 95% CI: 0.9714-1.8622, p=0.042). Sin embargo, en el análisis multivariado, solo el tratamiento antitrombótico alcanzó significancia estadística (OR: 1.6825, 95% CI: 1.003-2.822, p=0.049). La capacidad del modelo para predecir eventos de sangrado fue limitada (p = 0.2).Fundación Santa Fe de BogotáEspecialista en Cardiología de AdultosEspecializaciónCoronary ectasia and aneurysm are part of atherosclerotic coronary artery disease, characterized by positive remodeling of the vessel. Although the treatment of stenotic atherosclerotic disease has advanced with angioplasty and antithrombotic therapy, the same has not occurred for ectasia and aneurysm. There is no consensus on the best antithrombotic strategy for these patients, resulting in treatments based on small observational studies, without clarity about their impact on clinical outcomes. We have carried out a retrospective observational study with 93 patients with ectasia and/or coronary aneurysm (98.9% with ectasia, 12.9% with aneurysm). Patient characteristics and distribution of risk factors were as expected for coronary heart disease. The main indication for catheterization was acute non-ST segment elevation myocardial infarction. No variable was associated with an increase in major adverse cardiac events (MACE) in univariate or multivariate analysis (p>0.05). For the bleeding outcome, univariate analysis showed a significant association with the number of arteries with ectasia (OR: 2.5355, 95% CI: 1.0146-6.3366, p=0.036) and antithrombotic treatment (OR: 1.3449, 95% CI: 0.9714-1.8622, p=0.042). However, in the multivariate analysis, only antithrombotic treatment reached statistical significance (OR: 1.6825, 95% CI: 1.003-2.822, p=0.049). The ability of the model to predict bleeding events was limited (p = 0.2).application/pdfAtribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ectasia coronariaAneurisma coronariaTerapía antitrombóticaEventos adversos cardiovasculares mayoresSangradoCoronary ectasiaCoronary aneurysmAntithrombotic therapyMajor cardiovascular adverse eventsBleedingWG 100Desenlaces cardiovasculares mayores al año de seguimiento en pacientes con diagnóstico de ectasia y aneurismas coronarios en un centro latinoamericanoMajor cardiovascular outcomes at one year of follow-up in patients diagnosed with ectasia and coronary aneurysms in a Latin American centerEspecialización en Cardiología AdultosUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. 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PMID: 25014060; PMCID: PMC4150661.spaORIGINALTrabajo de grado.pdfTrabajo de grado.pdfapplication/pdf1061551https://repositorio.unbosque.edu.co/bitstreams/b420de9e-aff9-4da1-93a4-b457fd7826c3/downloadcd342dd4be4232ae7280b2a61c419f6eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82000https://repositorio.unbosque.edu.co/bitstreams/77e03187-0376-4782-840f-43233f528fa3/download17cc15b951e7cc6b3728a574117320f9MD53Carta de autorización.pdfapplication/pdf224681https://repositorio.unbosque.edu.co/bitstreams/6257b59b-5e53-48d8-9ead-3937678c75cd/download5ef470b5776f8eb36eb5f416811ef5e5MD54Acta de grado.pdfapplication/pdf878326https://repositorio.unbosque.edu.co/bitstreams/c4258b2d-9104-4868-b832-6c7bcf82d77a/download054f6299c14aaeae89de73835e733dfaMD55Anexo 2. 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