The rabies virus phosphoprotein synthesis and subcellular localization are modified by nerve growth factor

Rabies virus P protein participates as a regulating factor in viral transcription and replication; recent studies found an antitranscriptional and antireplicative effect of nerve growth factor (NGF) and Neurotrophin-3 (NT-3) in infected neuron cultures. We investigated here the specific effect of the neurotrophins on P protein, evaluating its synthesis and subcellular distribution in adult mouse dorsal root ganglia neuron cultures infected and treated with NGF or NT-3. The results showed that NGF, but not NT-3, caused an increase in the quantity of P protein and an accumulation of protein in neuronal bodies, revealing changes in transport to the neuritic processes.

• Autores: Castañeda, Nadia Y.; Chaparro-Olaya, Jacqueline; Acosta, Orlando; Castellanos, Jaime
• Tipo de recurso: Article of journal
• Fecha de publicación: 2009
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/5114
• Acceso en línea: http://hdl.handle.net/20.500.12495/5114; https://doi.org/10.1080/00207450802324291; https://repositorio.unbosque.edu.co
• Palabra clave: Antiviral; Nerve Growth Factor (NGF); Neurotrophin-3; Rabies virus; Rabies virus phosphoprotein; Sensory neurons
• Rights: openAccess
• License: Acceso abierto