p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics
Antecedentes: El exón 2 de KRAS p. La mutación G12C en pacientes con adenocarcinoma de pulmón ha ido aumentando en relevancia debido al desarrollo y la eficacia de nuevos medicamentos de tratamiento. Estudios en diferentes poblaciones indican que la variabilidad regional entre etnias y ascendencias...
- Autores:
-
Ruíz-Patiño, Alejandro
Rodríguez, July
Ávila, Jenny
Archila, Pilar
Carranza, Hernán
Vargas, Carlos Alberto
Otero, Jorge Miguel
Arrieta, Oscar
Zatarain-Barrón, Lucia
Sotelo, Carolina
Ordoñez, Camila
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2022
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/6801
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/6801
https://doi.org/10.1016/j.tranon.2021.101276
- Palabra clave:
- Epidemiología molecular
Cáncer de pulmón de células no pequeñas
Marcadores de población
KRAS
Molecular epidemiology
Non small cell lung cancer
Population markers
- Rights
- openAccess
- License
- Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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| dc.title.spa.fl_str_mv |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| dc.title.translated.spa.fl_str_mv |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| title |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| spellingShingle |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics Epidemiología molecular Cáncer de pulmón de células no pequeñas Marcadores de población KRAS Molecular epidemiology Non small cell lung cancer Population markers |
| title_short |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| title_full |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| title_fullStr |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| title_full_unstemmed |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| title_sort |
p.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanics |
| dc.creator.fl_str_mv |
Ruíz-Patiño, Alejandro Rodríguez, July Ávila, Jenny Archila, Pilar Carranza, Hernán Vargas, Carlos Alberto Otero, Jorge Miguel Arrieta, Oscar Zatarain-Barrón, Lucia Sotelo, Carolina Ordoñez, Camila |
| dc.contributor.author.none.fl_str_mv |
Ruíz-Patiño, Alejandro Rodríguez, July Ávila, Jenny Archila, Pilar Carranza, Hernán Vargas, Carlos Alberto Otero, Jorge Miguel Arrieta, Oscar Zatarain-Barrón, Lucia Sotelo, Carolina Ordoñez, Camila |
| dc.contributor.orcid.none.fl_str_mv |
Cardona, Andrés Felipe [https://orcid.org/0000-0003-3525-4126] |
| dc.subject.spa.fl_str_mv |
Epidemiología molecular Cáncer de pulmón de células no pequeñas Marcadores de población |
| topic |
Epidemiología molecular Cáncer de pulmón de células no pequeñas Marcadores de población KRAS Molecular epidemiology Non small cell lung cancer Population markers |
| dc.subject.keywords.spa.fl_str_mv |
KRAS Molecular epidemiology Non small cell lung cancer Population markers |
| description |
Antecedentes: El exón 2 de KRAS p. La mutación G12C en pacientes con adenocarcinoma de pulmón ha ido aumentando en relevancia debido al desarrollo y la eficacia de nuevos medicamentos de tratamiento. Estudios en diferentes poblaciones indican que la variabilidad regional entre etnias y ascendencias podría desempeñar un papel fundamental en el desarrollo de esta alteración molecular dentro del cáncer de pulmón. Results: Included were 979 patients with a national mean frequency for the KRAS exon 2 p.G12C mutation of 7.97% (95%CI 6.27-9.66%). Variation between regions was also identified with Antioquia reaching a positivity value of 12.7% (95%CI 9.1-16.3%) in contrast to other regions such as Bogota DC (Capital region) with 5.4% (2.7-8.2%) and Bolivar with 2.4% (95%CI 0-7.2%) (p-value = 0.00262). Furthermore, Short tandem repeat population substructures were found for eight markers that strongly yielded association with KRAS exon 2 p.G12C frequency reaching an adjusted R2 of 0.945 and a p-value of < 0.0001. Conclusions: Widespread identification of KRAS exon 2 p.G12C mutations, especially in cases where NGS is not easily achieved is feasible at a population based level that can characterize regional and national patterns of mutation status. Furthermore, this type of mutation prevalence follows a population substructure pattern that can be easily determined by population and ancestral markers such as STR. |
| publishDate |
2022 |
| dc.date.accessioned.none.fl_str_mv |
2022-02-09T22:07:28Z |
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2022-02-09T22:07:28Z |
| dc.date.issued.none.fl_str_mv |
2022-01 |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Artículo de revista |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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1936-5233 |
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http://hdl.handle.net/20.500.12495/6801 |
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https://doi.org/10.1016/j.tranon.2021.101276 |
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instname:Universidad El Bosque |
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repourl:https://repositorio.unbosque.edu.co |
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1936-5233 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
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http://hdl.handle.net/20.500.12495/6801 https://doi.org/10.1016/j.tranon.2021.101276 |
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eng |
| language |
eng |
| dc.relation.ispartofseries.spa.fl_str_mv |
Translational Oncology, 1936-5233, Vol 15, Num 1, 2022 |
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https://linkinghub.elsevier.com/retrieve/pii/S1936-5233(21)00267-9 |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Acceso abierto |
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http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
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Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Neoplasia Press, Inc. |
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Translational Oncology |
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Ruíz-Patiño, AlejandroRodríguez, JulyÁvila, JennyArchila, PilarCarranza, HernánVargas, Carlos AlbertoOtero, Jorge MiguelArrieta, OscarZatarain-Barrón, LuciaSotelo, CarolinaOrdoñez, CamilaCardona, Andrés Felipe [https://orcid.org/0000-0003-3525-4126]2022-02-09T22:07:28Z2022-02-09T22:07:28Z2022-011936-5233http://hdl.handle.net/20.500.12495/6801https://doi.org/10.1016/j.tranon.2021.101276instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coAntecedentes: El exón 2 de KRAS p. La mutación G12C en pacientes con adenocarcinoma de pulmón ha ido aumentando en relevancia debido al desarrollo y la eficacia de nuevos medicamentos de tratamiento. Estudios en diferentes poblaciones indican que la variabilidad regional entre etnias y ascendencias podría desempeñar un papel fundamental en el desarrollo de esta alteración molecular dentro del cáncer de pulmón. Results: Included were 979 patients with a national mean frequency for the KRAS exon 2 p.G12C mutation of 7.97% (95%CI 6.27-9.66%). Variation between regions was also identified with Antioquia reaching a positivity value of 12.7% (95%CI 9.1-16.3%) in contrast to other regions such as Bogota DC (Capital region) with 5.4% (2.7-8.2%) and Bolivar with 2.4% (95%CI 0-7.2%) (p-value = 0.00262). Furthermore, Short tandem repeat population substructures were found for eight markers that strongly yielded association with KRAS exon 2 p.G12C frequency reaching an adjusted R2 of 0.945 and a p-value of < 0.0001. Conclusions: Widespread identification of KRAS exon 2 p.G12C mutations, especially in cases where NGS is not easily achieved is feasible at a population based level that can characterize regional and national patterns of mutation status. Furthermore, this type of mutation prevalence follows a population substructure pattern that can be easily determined by population and ancestral markers such as STR.Background: The KRAS exon 2 p. G12C mutation in patients with lung adenocarcinoma has been increasing in relevance due to the development and effectiveness of new treatment medications. Studies around different populations indicate that regional variability between ethnic groups and ancestries could play an essential role in developing this molecular alteration within lung cancer. Methods: In a prospective and retrospective cohort study on samples from lung adenocarcinoma from 1000 patients from different administrative regions in Colombia were tested for the KRAS p.G12C mutation. An analysis of STR populations markers was conducted to identify substructure contributions to mutation prevalence. Results: Included were 979 patients with a national mean frequency for the KRAS exon 2 p.G12C mutation of 7.97% (95%CI 6.27-9.66%). Variation between regions was also identified with Antioquia reaching a positivity value of 12.7% (95%CI 9.1-16.3%) in contrast to other regions such as Bogota DC (Capital region) with 5.4% (2.7-8.2%) and Bolivar with 2.4% (95%CI 0-7.2%) (p-value = 0.00262). Furthermore, Short tandem repeat population substructures were found for eight markers that strongly yielded association with KRAS exon 2 p.G12C frequency reaching an adjusted R2 of 0.945 and a p-value of < 0.0001. Conclusions: Widespread identification of KRAS exon 2 p.G12C mutations, especially in cases where NGS is not easily achieved is feasible at a population based level that can characterize regional and national patterns of mutation status. Furthermore, this type of mutation prevalence follows a population substructure pattern that can be easily determined by population and ancestral markers such as STR.application/pdfengNeoplasia Press, Inc.Translational OncologyTranslational Oncology, 1936-5233, Vol 15, Num 1, 2022https://linkinghub.elsevier.com/retrieve/pii/S1936-5233(21)00267-9Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abiertoEpidemiología molecularCáncer de pulmón de células no pequeñasMarcadores de poblaciónKRASMolecular epidemiologyNon small cell lung cancerPopulation markersp.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among Hispanicsp.G12C KRAS mutation prevalence in non-small cell lung cancer: Contribution from interregional variability and population substructures among HispanicsArtículo de revistainfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85ORIGINALp.G12C KRAS mutation prevalence in non-small cell lung cancer Contribution from interregional variability and population substructures among Hispanics.pdfp.G12C KRAS mutation prevalence in non-small cell lung cancer Contribution from interregional variability and population substructures among Hispanics.pdfp.G12C KRAS mutation prevalence in non-small cell lung cancer Contribution from interregional variability and population substructures among Hispanicsapplication/pdf1579206https://repositorio.unbosque.edu.co/bitstreams/a5a2f27a-3abf-48f3-af9a-d227e90f53e3/downloadb2385d3f129e9ba40af40fa97566b995MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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