Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia

The pathogenesis of SpA is considered to be a complex and multi-factorial process and, similar to other autoimmune diseases, includes the activity of proinflammatory cytokines such as TNF alpha. Our study compared the -308 promoter polymorphism of TNF alpha with TNF alpha levels, HLA-B27 status, age...

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Autores:
Romero-Sánchez, Consuelo
Londoño, J.
Delgado, G.
Jaimes, D. A.
De Avila, J.
Mora, A.
Avila, M.
Castellanos, Jaime
Briceño, I.
Valle-Oñate, R.
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3877
Acceso en línea:
http://hdl.handle.net/20.500.12495/3877
https://doi.org/10.1007/s00296-011-1883-1
https://repositorio.unbosque.edu.co
Palabra clave:
Metaloendopeptidasas
Enfermedades de la columna vertebral
Polimorfismo genético
TNF Alpha
Polymorphism
Spondyloarthritides
Rights
openAccess
License
Acceso abierto
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repository_id_str
dc.title.spa.fl_str_mv Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
dc.title.translated.spa.fl_str_mv Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
spellingShingle Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
Metaloendopeptidasas
Enfermedades de la columna vertebral
Polimorfismo genético
TNF Alpha
Polymorphism
Spondyloarthritides
title_short Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_full Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_fullStr Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_full_unstemmed Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
title_sort Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia
dc.creator.fl_str_mv Romero-Sánchez, Consuelo
Londoño, J.
Delgado, G.
Jaimes, D. A.
De Avila, J.
Mora, A.
Avila, M.
Castellanos, Jaime
Briceño, I.
Valle-Oñate, R.
dc.contributor.author.none.fl_str_mv Romero-Sánchez, Consuelo
Londoño, J.
Delgado, G.
Jaimes, D. A.
De Avila, J.
Mora, A.
Avila, M.
Castellanos, Jaime
Briceño, I.
Valle-Oñate, R.
dc.contributor.orcid.none.fl_str_mv Castellanos, Jaime [0000-0003-1596-8383]
Romero-Sánchez, Consuelo [0000-0002-6973-7639]
dc.subject.decs.spa.fl_str_mv Metaloendopeptidasas
Enfermedades de la columna vertebral
Polimorfismo genético
topic Metaloendopeptidasas
Enfermedades de la columna vertebral
Polimorfismo genético
TNF Alpha
Polymorphism
Spondyloarthritides
dc.subject.keywords.spa.fl_str_mv TNF Alpha
Polymorphism
Spondyloarthritides
description The pathogenesis of SpA is considered to be a complex and multi-factorial process and, similar to other autoimmune diseases, includes the activity of proinflammatory cytokines such as TNF alpha. Our study compared the -308 promoter polymorphism of TNF alpha with TNF alpha levels, HLA-B27 status, age at the onset of symptoms, SpA subtype and the clinical degree of activity in Colombian SpA patients and healthy subjects (HS). Comparisons of the TNF alpha-308A genotype among HS and SpA patients (P = 0.004), uSpA patients (P = 0.040), ReA patients (P = 0.001), were significantly different and AS patients (P = 0.110), as were alleles for SpAs (P = 0.007) between patients with SpAs and controls. Initial exploratory analyses demonstrated that the TNF alpha-308 SNP genotype frequencies were different among SpA patients and HS in the Colombian population studied. Furthermore, there was no significant correlation with activity and functional clinical index, serum TNF alpha level or HLA B27 status. Allele frequencies, on the other hand, were correlated with the activity clinical index.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2020-08-31T08:35:27Z
dc.date.available.none.fl_str_mv 2020-08-31T08:35:27Z
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.none.fl_str_mv 1437-160X
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/3877
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/s00296-011-1883-1
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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identifier_str_mv 1437-160X
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
url http://hdl.handle.net/20.500.12495/3877
https://doi.org/10.1007/s00296-011-1883-1
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Rheumatology International, 1437-160X, Vol. 32, No. 7, 2012 p. 2195-2197
dc.relation.uri.none.fl_str_mv https://link.springer.com/article/10.1007/s00296-011-1883-1
dc.rights.local.spa.fl_str_mv Acceso abierto
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rights_invalid_str_mv Acceso abierto
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2012-07
eu_rights_str_mv openAccess
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dc.publisher.spa.fl_str_mv Springer Link
dc.publisher.journal.spa.fl_str_mv Rheumatology International
institution Universidad El Bosque
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spelling Romero-Sánchez, ConsueloLondoño, J.Delgado, G.Jaimes, D. A.De Avila, J.Mora, A.Avila, M.Castellanos, JaimeBriceño, I.Valle-Oñate, R.Castellanos, Jaime [0000-0003-1596-8383]Romero-Sánchez, Consuelo [0000-0002-6973-7639]2020-08-31T08:35:27Z2020-08-31T08:35:27Z20121437-160Xhttp://hdl.handle.net/20.500.12495/3877https://doi.org/10.1007/s00296-011-1883-1instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengSpringer LinkRheumatology InternationalRheumatology International, 1437-160X, Vol. 32, No. 7, 2012 p. 2195-2197https://link.springer.com/article/10.1007/s00296-011-1883-1Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in ColombiaAssociation of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85MetaloendopeptidasasEnfermedades de la columna vertebralPolimorfismo genéticoTNF AlphaPolymorphismSpondyloarthritidesThe pathogenesis of SpA is considered to be a complex and multi-factorial process and, similar to other autoimmune diseases, includes the activity of proinflammatory cytokines such as TNF alpha. Our study compared the -308 promoter polymorphism of TNF alpha with TNF alpha levels, HLA-B27 status, age at the onset of symptoms, SpA subtype and the clinical degree of activity in Colombian SpA patients and healthy subjects (HS). Comparisons of the TNF alpha-308A genotype among HS and SpA patients (P = 0.004), uSpA patients (P = 0.040), ReA patients (P = 0.001), were significantly different and AS patients (P = 0.110), as were alleles for SpAs (P = 0.007) between patients with SpAs and controls. Initial exploratory analyses demonstrated that the TNF alpha-308 SNP genotype frequencies were different among SpA patients and HS in the Colombian population studied. Furthermore, there was no significant correlation with activity and functional clinical index, serum TNF alpha level or HLA B27 status. Allele frequencies, on the other hand, were correlated with the activity clinical index.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2012-07THUMBNAILRomero_Sánchez_C_2012.pdf.jpgRomero_Sánchez_C_2012.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/162f5dd9-5bbb-45d2-b08d-23d839a3cf2b/download7210a811635d1799e7c05fee5d259be7MD53ORIGINALRomero_Sánchez_C_2012.pdfRomero_Sánchez_C_2012.pdfapplication/pdf151406https://repositorio.unbosque.edu.co/bitstreams/ea2b1426-20d5-4aaa-8dd5-54a98ce833ad/download10e88b07e8c9f3196c2274aa8c30be87MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/b8bd1b13-5306-4c6d-a0fa-c0aac7f990f3/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTRomero_Sánchez_C_2012.pdf.txtRomero_Sánchez_C_2012.pdf.txtExtracted texttext/plain10570https://repositorio.unbosque.edu.co/bitstreams/cabc65c2-e217-4cd9-b642-5b895ca81026/downloadc1c1ae079e75f985577251a872fdd93aMD5420.500.12495/3877oai:repositorio.unbosque.edu.co:20.500.12495/38772024-02-07 10:45:30.185restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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