Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome
The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2...
- Autores:
-
Lynch, Rebecca M.
Mantus, Grace
Encinales, Liliana
Pacheco, Nelly
Li, Guangzhao
Porras-Ramírez, Alexandra
Rico Mendoza, Alejandro
Peng, Jin
Rengifo Pardo, Monica
Montoya Cruz, Magelda
Harris, Eva
Bethony, Jeffrey Michael
Simon, Gary L.
Chang, Aileen
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/2069
- Palabra clave:
- Anticuerpos neutralizantes
Virus zika
Virus del dengue
Guillain-Barré syndrome
Neutralizing antibody
Flavivirus
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Repositorio U. El Bosque |
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| dc.title.spa.fl_str_mv |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome |
| title |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome |
| spellingShingle |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome Anticuerpos neutralizantes Virus zika Virus del dengue Guillain-Barré syndrome Neutralizing antibody Flavivirus |
| title_short |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome |
| title_full |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome |
| title_fullStr |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome |
| title_full_unstemmed |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome |
| title_sort |
Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndrome |
| dc.creator.fl_str_mv |
Lynch, Rebecca M. Mantus, Grace Encinales, Liliana Pacheco, Nelly Li, Guangzhao Porras-Ramírez, Alexandra Rico Mendoza, Alejandro Peng, Jin Rengifo Pardo, Monica Montoya Cruz, Magelda Harris, Eva Bethony, Jeffrey Michael Simon, Gary L. Chang, Aileen |
| dc.contributor.author.none.fl_str_mv |
Lynch, Rebecca M. Mantus, Grace Encinales, Liliana Pacheco, Nelly Li, Guangzhao Porras-Ramírez, Alexandra Rico Mendoza, Alejandro Peng, Jin Rengifo Pardo, Monica Montoya Cruz, Magelda Harris, Eva Bethony, Jeffrey Michael Simon, Gary L. Chang, Aileen |
| dc.contributor.orcid.none.fl_str_mv |
Porras-Ramírez, Alexandra [0000-0002-0800-1388] |
| dc.subject.decs.spa.fl_str_mv |
Anticuerpos neutralizantes Virus zika Virus del dengue |
| topic |
Anticuerpos neutralizantes Virus zika Virus del dengue Guillain-Barré syndrome Neutralizing antibody Flavivirus |
| dc.subject.keywords.spa.fl_str_mv |
Guillain-Barré syndrome Neutralizing antibody Flavivirus |
| description |
The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection. |
| publishDate |
2019 |
| dc.date.issued.none.fl_str_mv |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2020-03-16T20:49:58Z |
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2020-03-16T20:49:58Z |
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article |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://purl.org/coar/resource_type/c_6501 |
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artículo |
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1537-6613 |
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http://hdl.handle.net/20.500.12495/2069 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1093/infdis/jiy466 |
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instname:Universidad El Bosque |
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reponame:Repositorio Institucional Universidad El Bosque |
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1537-6613 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
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http://hdl.handle.net/20.500.12495/2069 https://doi.org/10.1093/infdis/jiy466 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofseries.spa.fl_str_mv |
Journal of infectious diseases, 1537-6613, Vol. 219, Nro. 1, 2019, p. 26-30 |
| dc.relation.uri.none.fl_str_mv |
https://academic.oup.com/jid/article/219/1/26/5064749 |
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Attribution-NonCommercial-NoDerivatives 4.0 International |
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http://purl.org/coar/access_right/c_abf2 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Acceso abierto |
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http://purl.org/coar/access_right/c_abf198 |
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2018 |
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application/pdf |
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Oxford University Press |
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Journal of infectious diseases |
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Lynch, Rebecca M.Mantus, GraceEncinales, LilianaPacheco, NellyLi, GuangzhaoPorras-Ramírez, AlexandraRico Mendoza, AlejandroPeng, JinRengifo Pardo, MonicaMontoya Cruz, MageldaHarris, EvaBethony, Jeffrey MichaelSimon, Gary L.Chang, AileenPorras-Ramírez, Alexandra [0000-0002-0800-1388]2020-03-16T20:49:58Z2020-03-16T20:49:58Z20191537-6613http://hdl.handle.net/20.500.12495/2069https://doi.org/10.1093/infdis/jiy466instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengOxford University PressJournal of infectious diseasesJournal of infectious diseases, 1537-6613, Vol. 219, Nro. 1, 2019, p. 26-30https://academic.oup.com/jid/article/219/1/26/5064749Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf1982018http://purl.org/coar/access_right/c_abf2Augmented zika and dengue neutralizing antibodies are associated with guillain-Barré syndromearticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anticuerpos neutralizantesVirus zikaVirus del dengueGuillain-Barré syndromeNeutralizing antibodyFlavivirusThe role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://18.204.144.38/bitstreams/ff05d238-ca4f-44d3-821d-683dd5a17115/download4460e5956bc1d1639be9ae6146a50347MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://18.204.144.38/bitstreams/6ac7e0ad-d504-49e4-bc24-98b21e404e92/download8a4605be74aa9ea9d79846c1fba20a33MD55THUMBNAILLynch R.M., Mantus G., Encinales L., Pacheco N., Li G., Porras A., Mendoza A.R., Peng J., Rengifo-Pardo M., Cruz M.M., Harris E., Bethony J.M., Simon G.L., Chang A.Y.,_2019.pdf.jpgLynch R.M., Mantus G., Encinales L., Pacheco N., Li G., Porras A., Mendoza A.R., Peng J., Rengifo-Pardo M., Cruz M.M., Harris E., Bethony J.M., Simon G.L., Chang A.Y.,_2019.pdf.jpgIM Thumbnailimage/jpeg14334http://18.204.144.38/bitstreams/53c8f42c-b659-453d-82c3-e9e2b74c0a8f/downloade04c6929634da4464680b64d431afadfMD56ORIGINALLynch R.M., Mantus G., Encinales L., Pacheco N., Li G., Porras A., Mendoza A.R., Peng J., Rengifo-Pardo M., Cruz M.M., Harris E., Bethony J.M., Simon G.L., Chang A.Y.,_2019.pdfLynch R.M., Mantus G., Encinales L., Pacheco N., Li G., Porras A., Mendoza A.R., Peng J., Rengifo-Pardo M., Cruz M.M., Harris E., Bethony J.M., Simon G.L., Chang A.Y.,_2019.pdfapplication/pdf822735http://18.204.144.38/bitstreams/5d5a58a1-974d-4c83-8a5a-c59c19fcaba0/download2c7b0826f55f51bb956802dbd345c4ecMD51TEXTLynch R.M., Mantus G., Encinales L., Pacheco N., Li G., Porras A., Mendoza A.R., Peng J., Rengifo-Pardo M., Cruz M.M., Harris E., Bethony J.M., Simon G.L., Chang A.Y.,_2019.pdf.txtLynch R.M., Mantus G., Encinales L., Pacheco N., Li G., Porras A., Mendoza A.R., Peng J., Rengifo-Pardo M., Cruz M.M., Harris E., Bethony J.M., Simon G.L., Chang A.Y.,_2019.pdf.txtExtracted texttext/plain26108http://18.204.144.38/bitstreams/ba3365be-e0de-408f-a91c-5a708af56f5a/download426a09fe6c83110377f86454cb571cbdMD5720.500.12495/2069oai:18.204.144.38:20.500.12495/20692024-02-06 22:25:26.81http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttp://18.204.144.38DSpace Pre-instalado Biteca S.A.Sbibliotecas@biteca.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 |