A low-cost electrochemical biosensor platform for C-reactive protein detection

Antibiotic resistance is a worldwide problem aggravated by the overuse of prophylactic antibiotic therapies and lack of real-time biosensing equipment to differentiate viral from bacterial infections at the Point of Care (POC), particularly in rural areas with limited access to clinical laboratory f...

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Autores:
Guillem, Pedro
Bustos, Rosa Helena
Garzon, Vivian
Munoz, Andres
Juez, Graciela
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/5568
Acceso en línea:
http://hdl.handle.net/20.500.12495/5568
https://doi.org/10.1016/j.sbsr.2021.100402
Palabra clave:
Electrochemical biosensor
Antibiotic resistance
CRP
Point-of-care diagnostics
Rights
openAccess
License
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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dc.title.spa.fl_str_mv A low-cost electrochemical biosensor platform for C-reactive protein detection
dc.title.translated.spa.fl_str_mv A low-cost electrochemical biosensor platform for C-reactive protein detection
title A low-cost electrochemical biosensor platform for C-reactive protein detection
spellingShingle A low-cost electrochemical biosensor platform for C-reactive protein detection
Electrochemical biosensor
Antibiotic resistance
CRP
Point-of-care diagnostics
title_short A low-cost electrochemical biosensor platform for C-reactive protein detection
title_full A low-cost electrochemical biosensor platform for C-reactive protein detection
title_fullStr A low-cost electrochemical biosensor platform for C-reactive protein detection
title_full_unstemmed A low-cost electrochemical biosensor platform for C-reactive protein detection
title_sort A low-cost electrochemical biosensor platform for C-reactive protein detection
dc.creator.fl_str_mv Guillem, Pedro
Bustos, Rosa Helena
Garzon, Vivian
Munoz, Andres
Juez, Graciela
dc.contributor.author.none.fl_str_mv Guillem, Pedro
Bustos, Rosa Helena
Garzon, Vivian
Munoz, Andres
Juez, Graciela
dc.subject.keywords.spa.fl_str_mv Electrochemical biosensor
Antibiotic resistance
CRP
Point-of-care diagnostics
topic Electrochemical biosensor
Antibiotic resistance
CRP
Point-of-care diagnostics
description Antibiotic resistance is a worldwide problem aggravated by the overuse of prophylactic antibiotic therapies and lack of real-time biosensing equipment to differentiate viral from bacterial infections at the Point of Care (POC), particularly in rural areas with limited access to clinical laboratory facilities. As recent studies reveal the potential of C-Reactive Protein (CRP) and other acute phase biomarkers to achieve early determination of etiology in acute febrile illness, novel biosensing equipment become a plausible approach in preventing the unnecessary prescription of antibiotics. A low-cost experimental platform was engineered to measure CRP concentrations in 50 μL samples of buffer and enriched plasma, using label-free antigenic probes, legacy electrochemical methods and open-source hardware. The prototype presents a portable, cost-effective device for use at the POC with a simplified user interface that can be used wirelessly by healthcare professionals using a mobile phone or laptop. Based on the measured CRP levels, the device suggests if the acute febrile episode is likely to be of bacterial etiology.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-03-08T16:35:20Z
dc.date.available.none.fl_str_mv 2021-03-08T16:35:20Z
dc.date.issued.none.fl_str_mv 2021
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dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 2214-1804
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/5568
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.sbsr.2021.100402
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/5568
https://doi.org/10.1016/j.sbsr.2021.100402
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Sensing and Bio-Sensing Research, 2214-1804, Vol. 31, 2021 p. 100402
dc.relation.uri.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S2214180421000076?via%3Dihub
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
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Acceso abierto
dc.rights.creativecommons.none.fl_str_mv 2021
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
Acceso abierto
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eu_rights_str_mv openAccess
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier B.V.
dc.publisher.journal.spa.fl_str_mv Sensing and Bio-Sensing Research
institution Universidad El Bosque
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spelling Guillem, PedroBustos, Rosa HelenaGarzon, VivianMunoz, AndresJuez, Graciela2021-03-08T16:35:20Z2021-03-08T16:35:20Z20212214-1804http://hdl.handle.net/20.500.12495/5568https://doi.org/10.1016/j.sbsr.2021.100402instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengElsevier B.V.Sensing and Bio-Sensing ResearchSensing and Bio-Sensing Research, 2214-1804, Vol. 31, 2021 p. 100402https://www.sciencedirect.com/science/article/pii/S2214180421000076?via%3DihubAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2021A low-cost electrochemical biosensor platform for C-reactive protein detectionA low-cost electrochemical biosensor platform for C-reactive protein detectionArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Electrochemical biosensorAntibiotic resistanceCRPPoint-of-care diagnosticsAntibiotic resistance is a worldwide problem aggravated by the overuse of prophylactic antibiotic therapies and lack of real-time biosensing equipment to differentiate viral from bacterial infections at the Point of Care (POC), particularly in rural areas with limited access to clinical laboratory facilities. As recent studies reveal the potential of C-Reactive Protein (CRP) and other acute phase biomarkers to achieve early determination of etiology in acute febrile illness, novel biosensing equipment become a plausible approach in preventing the unnecessary prescription of antibiotics. A low-cost experimental platform was engineered to measure CRP concentrations in 50 μL samples of buffer and enriched plasma, using label-free antigenic probes, legacy electrochemical methods and open-source hardware. The prototype presents a portable, cost-effective device for use at the POC with a simplified user interface that can be used wirelessly by healthcare professionals using a mobile phone or laptop. 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