Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis

Introduction: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of i...

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Autores:
Salas-Cuestas, Fabián
Bautista-Molano, Wilson Armando
Bello-Gualtero, Juan M.
Arias, Ivonne
Castillo, Diana M.
Chila, Lorena
Valle-Oñate, Rafael
Herrera, Daniel
Romero-Sánchez, Consuelo
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/1609
Acceso en línea:
http://hdl.handle.net/20.500.12495/1609
https://doi.org/10.3389/fimmu.2017.00476
Palabra clave:
Inmunoglobulina A
Antígeno HLA-B27
Índice de severidad de la enfermedad
Artritis reactiva
Spondyloarthritis
Ankylosing spondylitis
Ecretory immunoglobulin A
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License
Attribution 4.0 International
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repository_id_str
dc.title.spa.fl_str_mv Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
title Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
spellingShingle Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
Inmunoglobulina A
Antígeno HLA-B27
Índice de severidad de la enfermedad
Artritis reactiva
Spondyloarthritis
Ankylosing spondylitis
Ecretory immunoglobulin A
title_short Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
title_full Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
title_fullStr Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
title_full_unstemmed Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
title_sort Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
dc.creator.fl_str_mv Salas-Cuestas, Fabián
Bautista-Molano, Wilson Armando
Bello-Gualtero, Juan M.
Arias, Ivonne
Castillo, Diana M.
Chila, Lorena
Valle-Oñate, Rafael
Herrera, Daniel
Romero-Sánchez, Consuelo
dc.contributor.author.none.fl_str_mv Salas-Cuestas, Fabián
Bautista-Molano, Wilson Armando
Bello-Gualtero, Juan M.
Arias, Ivonne
Castillo, Diana M.
Chila, Lorena
Valle-Oñate, Rafael
Herrera, Daniel
Romero-Sánchez, Consuelo
dc.contributor.orcid.none.fl_str_mv Romero-Sánchez, Consuelo [0000-0002-6973-7639]
Bautista-Molano, Wilson Armando [0000-0003-0684-9542]
Bautista-Molano, Wilson Armando [0000-0003-0684-9542]
Bautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.subject.decs.spa.fl_str_mv Inmunoglobulina A
Antígeno HLA-B27
Índice de severidad de la enfermedad
Artritis reactiva
topic Inmunoglobulina A
Antígeno HLA-B27
Índice de severidad de la enfermedad
Artritis reactiva
Spondyloarthritis
Ankylosing spondylitis
Ecretory immunoglobulin A
dc.subject.keywords.spa.fl_str_mv Spondyloarthritis
Ankylosing spondylitis
Ecretory immunoglobulin A
description Introduction: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. Objective: To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects. Methods: This was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student’s t-test, Kruskal–Wallis test, and U Mann–Whitney test, with a multivariate evaluation by principal components analysis (PCA). A correlation analysis was carried out using the Pearson correlation coefficient and a linear regression models. All analysis were made using Stata version 11.2® for Windows, R V3.3.21. Statistical significance was defined a p-value <0.05. Results: In all, 46 patients (78.2% men; mean age, 34.8 ± 12.3 years) and 53 controls (41% men; mean age, 32 ± 11.4 years) were included in the study. The mean serum levels of SIgA were higher in SpA patients than in healthy subjects (p < 0.001). Only SIgA levels correlated with disease activity: BASDAI (r = −0.42, p = 0.0046), ASDAS-CRP (r = −0.37, p = 0.014), and ASDAS-ESR (r = −0.45, p = 0.0021). The negative correlation between SIgA and all activity indices was higher in HLA-B27-positive patients (BASDAI r = −0.70, p = 0.0009, ASDAS-CRP r = −0.58, p = 0.0093, and ASDAS-ESR r = −0.57, p = 0.0083). The PCA showed three factors: the first component was constituted by variables referred as clinical activity measures, the second did include the serological activity markers, and the last component was compounded by age and symptoms time. Conclusion: Elevated serum levels of SIgA were found to be related with low disease activity in patients with ReA and uSpA.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2019-08-14T16:28:01Z
dc.date.available.none.fl_str_mv 2019-08-14T16:28:01Z
dc.type.spa.fl_str_mv article
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/1609
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3389/fimmu.2017.00476
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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url http://hdl.handle.net/20.500.12495/1609
https://doi.org/10.3389/fimmu.2017.00476
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Frontiers in Immunology, 1664-3224, 2017
dc.relation.uri.none.fl_str_mv https://www.frontiersin.org/articles/10.3389/fimmu.2017.00476/full
dc.rights.*.fl_str_mv Attribution 4.0 International
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dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
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dc.rights.creativecommons.none.fl_str_mv 2017
rights_invalid_str_mv Attribution 4.0 International
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dc.publisher.journal.spa.fl_str_mv Frontiers in Immunology
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spelling Salas-Cuestas, FabiánBautista-Molano, Wilson ArmandoBello-Gualtero, Juan M.Arias, IvonneCastillo, Diana M.Chila, LorenaValle-Oñate, RafaelHerrera, DanielRomero-Sánchez, ConsueloRomero-Sánchez, Consuelo [0000-0002-6973-7639]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]2019-08-14T16:28:01Z2019-08-14T16:28:01Z20171664-3224http://hdl.handle.net/20.500.12495/1609https://doi.org/10.3389/fimmu.2017.00476instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengFrontiersFrontiers in ImmunologyFrontiers in Immunology, 1664-3224, 2017https://www.frontiersin.org/articles/10.3389/fimmu.2017.00476/fullAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf3062017http://purl.org/coar/access_right/c_abf2Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Inmunoglobulina AAntígeno HLA-B27Índice de severidad de la enfermedadArtritis reactivaSpondyloarthritisAnkylosing spondylitisEcretory immunoglobulin AIntroduction: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. Objective: To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects. Methods: This was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student’s t-test, Kruskal–Wallis test, and U Mann–Whitney test, with a multivariate evaluation by principal components analysis (PCA). A correlation analysis was carried out using the Pearson correlation coefficient and a linear regression models. All analysis were made using Stata version 11.2® for Windows, R V3.3.21. Statistical significance was defined a p-value <0.05. Results: In all, 46 patients (78.2% men; mean age, 34.8 ± 12.3 years) and 53 controls (41% men; mean age, 32 ± 11.4 years) were included in the study. The mean serum levels of SIgA were higher in SpA patients than in healthy subjects (p < 0.001). Only SIgA levels correlated with disease activity: BASDAI (r = −0.42, p = 0.0046), ASDAS-CRP (r = −0.37, p = 0.014), and ASDAS-ESR (r = −0.45, p = 0.0021). The negative correlation between SIgA and all activity indices was higher in HLA-B27-positive patients (BASDAI r = −0.70, p = 0.0009, ASDAS-CRP r = −0.58, p = 0.0093, and ASDAS-ESR r = −0.57, p = 0.0083). The PCA showed three factors: the first component was constituted by variables referred as clinical activity measures, the second did include the serological activity markers, and the last component was compounded by age and symptoms time. Conclusion: Elevated serum levels of SIgA were found to be related with low disease activity in patients with ReA and uSpA.ORIGINALSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdfSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdfapplication/pdf438632https://repositorio.unbosque.edu.co/bitstreams/f76dcb3b-a24b-48aa-91ac-ed4c22ef570e/download9b73fac52d37e59e4818ea9116ced0a0MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.unbosque.edu.co/bitstreams/cd6fb4fd-c422-4b2e-9758-b9c868975ee2/download0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/4830f615-da07-4830-ae73-6d2b2072ed69/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.jpgSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.jpgIM Thumbnailimage/jpeg12949https://repositorio.unbosque.edu.co/bitstreams/9cb1fb1d-cee0-4f2e-a589-4b5272816e98/download03cc860acd1e2ba9aff29a6de61467b4MD54TEXTSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.txtSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.txtExtracted texttext/plain68191https://repositorio.unbosque.edu.co/bitstreams/bc919b80-07ce-49a7-9597-63d76ceceb98/download36cdd5fcf6878207c0d15d86a46dba93MD5520.500.12495/1609oai:repositorio.unbosque.edu.co:20.500.12495/16092024-02-07 02:33:41.973http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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