Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis
Introduction: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of i...
- Autores:
-
Salas-Cuestas, Fabián
Bautista-Molano, Wilson Armando
Bello-Gualtero, Juan M.
Arias, Ivonne
Castillo, Diana M.
Chila, Lorena
Valle-Oñate, Rafael
Herrera, Daniel
Romero-Sánchez, Consuelo
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/1609
- Palabra clave:
- Inmunoglobulina A
Antígeno HLA-B27
Índice de severidad de la enfermedad
Artritis reactiva
Spondyloarthritis
Ankylosing spondylitis
Ecretory immunoglobulin A
- Rights
- License
- Attribution 4.0 International
id |
UNBOSQUE2_9ad46eeaba331daf7888dbbff9702562 |
---|---|
oai_identifier_str |
oai:repositorio.unbosque.edu.co:20.500.12495/1609 |
network_acronym_str |
UNBOSQUE2 |
network_name_str |
Repositorio U. El Bosque |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
title |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
spellingShingle |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis Inmunoglobulina A Antígeno HLA-B27 Índice de severidad de la enfermedad Artritis reactiva Spondyloarthritis Ankylosing spondylitis Ecretory immunoglobulin A |
title_short |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
title_full |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
title_fullStr |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
title_full_unstemmed |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
title_sort |
Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
dc.creator.fl_str_mv |
Salas-Cuestas, Fabián Bautista-Molano, Wilson Armando Bello-Gualtero, Juan M. Arias, Ivonne Castillo, Diana M. Chila, Lorena Valle-Oñate, Rafael Herrera, Daniel Romero-Sánchez, Consuelo |
dc.contributor.author.none.fl_str_mv |
Salas-Cuestas, Fabián Bautista-Molano, Wilson Armando Bello-Gualtero, Juan M. Arias, Ivonne Castillo, Diana M. Chila, Lorena Valle-Oñate, Rafael Herrera, Daniel Romero-Sánchez, Consuelo |
dc.contributor.orcid.none.fl_str_mv |
Romero-Sánchez, Consuelo [0000-0002-6973-7639] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] |
dc.subject.decs.spa.fl_str_mv |
Inmunoglobulina A Antígeno HLA-B27 Índice de severidad de la enfermedad Artritis reactiva |
topic |
Inmunoglobulina A Antígeno HLA-B27 Índice de severidad de la enfermedad Artritis reactiva Spondyloarthritis Ankylosing spondylitis Ecretory immunoglobulin A |
dc.subject.keywords.spa.fl_str_mv |
Spondyloarthritis Ankylosing spondylitis Ecretory immunoglobulin A |
description |
Introduction: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. Objective: To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects. Methods: This was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student’s t-test, Kruskal–Wallis test, and U Mann–Whitney test, with a multivariate evaluation by principal components analysis (PCA). A correlation analysis was carried out using the Pearson correlation coefficient and a linear regression models. All analysis were made using Stata version 11.2® for Windows, R V3.3.21. Statistical significance was defined a p-value <0.05. Results: In all, 46 patients (78.2% men; mean age, 34.8 ± 12.3 years) and 53 controls (41% men; mean age, 32 ± 11.4 years) were included in the study. The mean serum levels of SIgA were higher in SpA patients than in healthy subjects (p < 0.001). Only SIgA levels correlated with disease activity: BASDAI (r = −0.42, p = 0.0046), ASDAS-CRP (r = −0.37, p = 0.014), and ASDAS-ESR (r = −0.45, p = 0.0021). The negative correlation between SIgA and all activity indices was higher in HLA-B27-positive patients (BASDAI r = −0.70, p = 0.0009, ASDAS-CRP r = −0.58, p = 0.0093, and ASDAS-ESR r = −0.57, p = 0.0083). The PCA showed three factors: the first component was constituted by variables referred as clinical activity measures, the second did include the serological activity markers, and the last component was compounded by age and symptoms time. Conclusion: Elevated serum levels of SIgA were found to be related with low disease activity in patients with ReA and uSpA. |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2019-08-14T16:28:01Z |
dc.date.available.none.fl_str_mv |
2019-08-14T16:28:01Z |
dc.type.spa.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.local.spa.fl_str_mv |
artículo |
dc.identifier.issn.none.fl_str_mv |
1664-3224 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/1609 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3389/fimmu.2017.00476 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1664-3224 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/1609 https://doi.org/10.3389/fimmu.2017.00476 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Frontiers in Immunology, 1664-3224, 2017 |
dc.relation.uri.none.fl_str_mv |
https://www.frontiersin.org/articles/10.3389/fimmu.2017.00476/full |
dc.rights.*.fl_str_mv |
Attribution 4.0 International |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf306 |
dc.rights.creativecommons.none.fl_str_mv |
2017 |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf306 2017 http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Frontiers |
dc.publisher.journal.spa.fl_str_mv |
Frontiers in Immunology |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
https://repositorio.unbosque.edu.co/bitstreams/f76dcb3b-a24b-48aa-91ac-ed4c22ef570e/download https://repositorio.unbosque.edu.co/bitstreams/cd6fb4fd-c422-4b2e-9758-b9c868975ee2/download https://repositorio.unbosque.edu.co/bitstreams/4830f615-da07-4830-ae73-6d2b2072ed69/download https://repositorio.unbosque.edu.co/bitstreams/9cb1fb1d-cee0-4f2e-a589-4b5272816e98/download https://repositorio.unbosque.edu.co/bitstreams/bc919b80-07ce-49a7-9597-63d76ceceb98/download |
bitstream.checksum.fl_str_mv |
9b73fac52d37e59e4818ea9116ced0a0 0175ea4a2d4caec4bbcc37e300941108 8a4605be74aa9ea9d79846c1fba20a33 03cc860acd1e2ba9aff29a6de61467b4 36cdd5fcf6878207c0d15d86a46dba93 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad El Bosque |
repository.mail.fl_str_mv |
bibliotecas@biteca.com |
_version_ |
1814100744383496192 |
spelling |
Salas-Cuestas, FabiánBautista-Molano, Wilson ArmandoBello-Gualtero, Juan M.Arias, IvonneCastillo, Diana M.Chila, LorenaValle-Oñate, RafaelHerrera, DanielRomero-Sánchez, ConsueloRomero-Sánchez, Consuelo [0000-0002-6973-7639]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]2019-08-14T16:28:01Z2019-08-14T16:28:01Z20171664-3224http://hdl.handle.net/20.500.12495/1609https://doi.org/10.3389/fimmu.2017.00476instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengFrontiersFrontiers in ImmunologyFrontiers in Immunology, 1664-3224, 2017https://www.frontiersin.org/articles/10.3389/fimmu.2017.00476/fullAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf3062017http://purl.org/coar/access_right/c_abf2Higher levels of secretory IgA are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Inmunoglobulina AAntígeno HLA-B27Índice de severidad de la enfermedadArtritis reactivaSpondyloarthritisAnkylosing spondylitisEcretory immunoglobulin AIntroduction: Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood. Objective: To evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects. Methods: This was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student’s t-test, Kruskal–Wallis test, and U Mann–Whitney test, with a multivariate evaluation by principal components analysis (PCA). A correlation analysis was carried out using the Pearson correlation coefficient and a linear regression models. All analysis were made using Stata version 11.2® for Windows, R V3.3.21. Statistical significance was defined a p-value <0.05. Results: In all, 46 patients (78.2% men; mean age, 34.8 ± 12.3 years) and 53 controls (41% men; mean age, 32 ± 11.4 years) were included in the study. The mean serum levels of SIgA were higher in SpA patients than in healthy subjects (p < 0.001). Only SIgA levels correlated with disease activity: BASDAI (r = −0.42, p = 0.0046), ASDAS-CRP (r = −0.37, p = 0.014), and ASDAS-ESR (r = −0.45, p = 0.0021). The negative correlation between SIgA and all activity indices was higher in HLA-B27-positive patients (BASDAI r = −0.70, p = 0.0009, ASDAS-CRP r = −0.58, p = 0.0093, and ASDAS-ESR r = −0.57, p = 0.0083). The PCA showed three factors: the first component was constituted by variables referred as clinical activity measures, the second did include the serological activity markers, and the last component was compounded by age and symptoms time. Conclusion: Elevated serum levels of SIgA were found to be related with low disease activity in patients with ReA and uSpA.ORIGINALSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdfSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdfapplication/pdf438632https://repositorio.unbosque.edu.co/bitstreams/f76dcb3b-a24b-48aa-91ac-ed4c22ef570e/download9b73fac52d37e59e4818ea9116ced0a0MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.unbosque.edu.co/bitstreams/cd6fb4fd-c422-4b2e-9758-b9c868975ee2/download0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/4830f615-da07-4830-ae73-6d2b2072ed69/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.jpgSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.jpgIM Thumbnailimage/jpeg12949https://repositorio.unbosque.edu.co/bitstreams/9cb1fb1d-cee0-4f2e-a589-4b5272816e98/download03cc860acd1e2ba9aff29a6de61467b4MD54TEXTSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.txtSalas-Cuestas F., Bautista-Molano W., Bello-Gualtero J.M., Arias I., Castillo D.M._2017.pdf.txtExtracted texttext/plain68191https://repositorio.unbosque.edu.co/bitstreams/bc919b80-07ce-49a7-9597-63d76ceceb98/download36cdd5fcf6878207c0d15d86a46dba93MD5520.500.12495/1609oai:repositorio.unbosque.edu.co:20.500.12495/16092024-02-07 02:33:41.973http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |