Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide

Antecedentes: Los estudios de asociación de AR han dirigido su atención hacia las fases preclínicas o asintomáticas en individuos sanos con alto riesgo de desarrollar AR. Datos previos demuestran que los familiares en primer grado de pacientes con AR (FPG) presentan una condición periodontal inflama...

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Autores:
Unriza-Puin, Sonia R.
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/6049
Acceso en línea:
http://hdl.handle.net/20.500.12495/6049
Palabra clave:
Periodontitis
Artritis reumatoide
Obesidad
Péptido citrulinado cíclico
Familiares primer grado
Periodontitis
Artritis reumatoide
Obesidad
Periodontitis
Rheumatoid arthritis
Obesity
Antibodies anticitrullinated peptides
Relatives
WU 100
Rights
openAccess
License
Attribution-NonCommercial-ShareAlike 4.0 International
id UNBOSQUE2_995a8193851c0147e8e49d33b596158f
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/6049
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
dc.title.translated.spa.fl_str_mv Periodontal status and levels of antibody anti-P. gingivalis in individuals with higher risk to develop rheumatoid arthritis
title Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
spellingShingle Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
Periodontitis
Artritis reumatoide
Obesidad
Péptido citrulinado cíclico
Familiares primer grado
Periodontitis
Artritis reumatoide
Obesidad
Periodontitis
Rheumatoid arthritis
Obesity
Antibodies anticitrullinated peptides
Relatives
WU 100
title_short Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
title_full Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
title_fullStr Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
title_full_unstemmed Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
title_sort Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoide
dc.creator.fl_str_mv Unriza-Puin, Sonia R.
dc.contributor.advisor.none.fl_str_mv Romero Sánchez, María Consuelo
Bautista Molano, Wilson Armando
Lafaurie, Gloria Ines
dc.contributor.author.none.fl_str_mv Unriza-Puin, Sonia R.
dc.subject.spa.fl_str_mv Periodontitis
Artritis reumatoide
Obesidad
Péptido citrulinado cíclico
Familiares primer grado
topic Periodontitis
Artritis reumatoide
Obesidad
Péptido citrulinado cíclico
Familiares primer grado
Periodontitis
Artritis reumatoide
Obesidad
Periodontitis
Rheumatoid arthritis
Obesity
Antibodies anticitrullinated peptides
Relatives
WU 100
dc.subject.decs.spa.fl_str_mv Periodontitis
Artritis reumatoide
Obesidad
dc.subject.keywords.spa.fl_str_mv Periodontitis
Rheumatoid arthritis
Obesity
Antibodies anticitrullinated peptides
Relatives
dc.subject.nlm.none.fl_str_mv WU 100
description Antecedentes: Los estudios de asociación de AR han dirigido su atención hacia las fases preclínicas o asintomáticas en individuos sanos con alto riesgo de desarrollar AR. Datos previos demuestran que los familiares en primer grado de pacientes con AR (FPG) presentan una condición periodontal inflamatoria significativa que podría modular la severidad de la presentación clínica de la AR. Comparar la condición clínica periodontal y los niveles de anticuerpos contra Porphyromona gingivalis (Pg) en individuos FPG de pacientes con AR y controles sanos. Se evaluaron 100 individuos FPG y 200 individuos sanos como grupo control, pareados por edad y género. Se realizó valoración reumatológica y periodontal. Se midieron anticuerpos contra Pg y anticuerpos antipéptido citrulinado (anti-CCP). Se compararon los grupos aplicando pruebas de McNemar y de Signos de Wilcoxon y se realizaron modelos de regresión logística condicional para establecer asociaciones de EP y otros factores asociados al riesgo a AR en FPG. El 79% del grupo FPG presentó EP comparado con un 56% del grupo control (p=0.001). Siendo el 15% EP severa en el grupo FPG vs 9% en el grupo control (p=0.009). Se observó asociación significativa de la presencia de EP en el grupo FPG (OR: 3, 95% CI 1.89–7.29). Un 17% de obesidad en el grupo FPG comparado con un 7.5% del grupo control (p=0.008); observándose una asociación significativa para la presencia de obesidad en FPG (OR: 2.9, 95% CI .03-8.28). La presencia de anticuerpos anti-CCP fue del 7% en FPG vs 2.5% del grupo control, mostrando una asociación significativa en el análisis bivariado (p=0.038). Aunque en el análisis multivariado no logró soportar la asociación (OR: 2.4, 95% CI 0.7-8.32), los resultados parecen indicar una tendencia a su incremento en individuos FPG. Los anticuerpos anti-Pg (IgG1-IgG2) no mostraron diferencias significativas, entre los grupos. La presencia de EP, la obesidad y la presencia de anticuerpos anti-CCP pueden ser variables que condicionan el riesgo en individuos FPG.
publishDate 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2021-09-10T17:16:02Z
dc.date.available.none.fl_str_mv 2021-09-10T17:16:02Z
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Maestría
dc.type.hasversion.none.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/6049
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/6049
identifier_str_mv instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv spa
language spa
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spelling Romero Sánchez, María ConsueloBautista Molano, Wilson ArmandoLafaurie, Gloria InesUnriza-Puin, Sonia R.2021-09-10T17:16:02Z2021-09-10T17:16:02Z2016http://hdl.handle.net/20.500.12495/6049instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coAntecedentes: Los estudios de asociación de AR han dirigido su atención hacia las fases preclínicas o asintomáticas en individuos sanos con alto riesgo de desarrollar AR. Datos previos demuestran que los familiares en primer grado de pacientes con AR (FPG) presentan una condición periodontal inflamatoria significativa que podría modular la severidad de la presentación clínica de la AR. Comparar la condición clínica periodontal y los niveles de anticuerpos contra Porphyromona gingivalis (Pg) en individuos FPG de pacientes con AR y controles sanos. Se evaluaron 100 individuos FPG y 200 individuos sanos como grupo control, pareados por edad y género. Se realizó valoración reumatológica y periodontal. Se midieron anticuerpos contra Pg y anticuerpos antipéptido citrulinado (anti-CCP). Se compararon los grupos aplicando pruebas de McNemar y de Signos de Wilcoxon y se realizaron modelos de regresión logística condicional para establecer asociaciones de EP y otros factores asociados al riesgo a AR en FPG. El 79% del grupo FPG presentó EP comparado con un 56% del grupo control (p=0.001). Siendo el 15% EP severa en el grupo FPG vs 9% en el grupo control (p=0.009). Se observó asociación significativa de la presencia de EP en el grupo FPG (OR: 3, 95% CI 1.89–7.29). Un 17% de obesidad en el grupo FPG comparado con un 7.5% del grupo control (p=0.008); observándose una asociación significativa para la presencia de obesidad en FPG (OR: 2.9, 95% CI .03-8.28). La presencia de anticuerpos anti-CCP fue del 7% en FPG vs 2.5% del grupo control, mostrando una asociación significativa en el análisis bivariado (p=0.038). Aunque en el análisis multivariado no logró soportar la asociación (OR: 2.4, 95% CI 0.7-8.32), los resultados parecen indicar una tendencia a su incremento en individuos FPG. Los anticuerpos anti-Pg (IgG1-IgG2) no mostraron diferencias significativas, entre los grupos. La presencia de EP, la obesidad y la presencia de anticuerpos anti-CCP pueden ser variables que condicionan el riesgo en individuos FPG.Magíster en Ciencias OdontológicasMaestríaAssociation studies in rheumatoid arthritis (RA) have been focused in the pre-clinical phases of the disease in asymptomatic individuals with higher risk to develop RA. Previous data has shown that first degree relatives (FDR) of patients with RA have a periodontal condition that may modulate the severity and the clinical presentation of RA. To compare the periodontal condition and levels of antibody against Porphyromona gingivalis (Pg) between FDR individuals and healthy controls. In total, 100 FDR individuals and 200 healthy controls paired by age and gender were included. Rheumatologic and periodontal assessment was performed as well as antibodies anti-Pg and antibodies anti-citrullinated peptides (anti-CCP). The group-comparisons were analyzed using McNemar and Wilcoxon tests. A conditional logistic regression analyses was performed to establish associations between periodontitis and additional risk factors for RA in FDR. In the FDR-group 79% had periodontitis in comparison with control group 56% (p=0.001). Fifty percent of severe periodontitis was observed in FDR vs 9% in control group (p=0.009). A significant association was found in the FDR individuals regarding the presence of periodontitis (OR: 3, 95% CI 1.89–7.29). In the group of FDR 17% had obesity, compared to 7.5% of obesity in the control group. Additionally, there was association related to the presence of obesity in the FDR group (OR: 2.9, 95% CI .03-8.28). Anti –CCP antibodies was found in 7% in FDR group vs 2.5 % in control group; in the bivariate analysis a significant association (p=0.038) was found. Although the multivariate analysis did not support the association (OR: 2.4, 95% CI 0.7- 8.32), this results shows a trend towards the increase of anti-CCP antibodies in FDR group (OR: 2.4, 95% CI 0.7- 8.32). Regarding the antibodies anti Pg (IgG1-IgG2), no differences was found between the groups. The presence of periodontitis, obesity and the presence of anti-CCP antibodies may be factors influencing the risk in FDR of patients with RA.application/pdfspaAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf22016-05PeriodontitisArtritis reumatoideObesidadPéptido citrulinado cíclicoFamiliares primer gradoPeriodontitisArtritis reumatoideObesidadPeriodontitisRheumatoid arthritisObesityAntibodies anticitrullinated peptidesRelativesWU 100Comparación del estado clínico periodontal y niveles de anticuerpos contra P. gingivalis en individuos con riesgo de desarrollar artritis reumatoidePeriodontal status and levels of antibody anti-P. gingivalis in individuals with higher risk to develop rheumatoid arthritisMaestría en Ciencias OdontológicasUniversidad El BosqueFacultad de OdontologíaTesis/Trabajo de grado - Monografía - Maestríainfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesisAlvarez-Nemegyei J, et al. Asociación entre composición corporal y actividad inflamatoria en artritis reumatoide. Una revisión sistemática. Reumatol Clin 2015. http://dx.doi.org/10.1016/ j. reuma.2015.09.001.Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1–6.Arnson Y, Shoenfeld Y, Amital H. Effects of tobacco smoke on immunity, inflammation and autoimmunity. J Autoimmun 2010;34:J258-J265.Avouac J, Gossec L, Dougados M. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis 2006;65:845–851.Baeten D, Peene I, Union A, Meheus L, Sebbag M, Serre G. Specific of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. Arthritis Rheum 2001 44:2255-62.Baker JF, Ostergaard M, George M, et al. Greater body mass independently predicts less radiographic progression on X-ray and MRI over 1–2 years. 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