Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis

Background The heterogeneity of Trypanosoma cruzi infection rates among triatomines insects and animal reservoirs has been studied in independent studies, but little information has been systematised to allow pooled and comparative estimates. Unravelling the main patterns of this heterogeneity could...

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Autores:
Rodríguez Monguí, Eliana
Cantillo Barraza, Omar
Prieto Alvarado, Franklin Edwin
Cucunubá, Zulma M.
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/1667
Acceso en línea:
http://hdl.handle.net/20.500.12495/1667
https://doi.org/10.1186/s13071-019-3541-5
Palabra clave:
Heterogeneidad genética
Reservas naturales
Enfermedades ambientales
Chagas disease
Trypanosoma cruzi
Triatomines
Rights
License
Attribution 4.0 International
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dc.title.spa.fl_str_mv Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
title Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
spellingShingle Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
Heterogeneidad genética
Reservas naturales
Enfermedades ambientales
Chagas disease
Trypanosoma cruzi
Triatomines
title_short Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
title_full Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
title_fullStr Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
title_full_unstemmed Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
title_sort Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysis
dc.creator.fl_str_mv Rodríguez Monguí, Eliana
Cantillo Barraza, Omar
Prieto Alvarado, Franklin Edwin
Cucunubá, Zulma M.
dc.contributor.author.none.fl_str_mv Rodríguez Monguí, Eliana
Cantillo Barraza, Omar
Prieto Alvarado, Franklin Edwin
Cucunubá, Zulma M.
dc.subject.decs.spa.fl_str_mv Heterogeneidad genética
Reservas naturales
Enfermedades ambientales
topic Heterogeneidad genética
Reservas naturales
Enfermedades ambientales
Chagas disease
Trypanosoma cruzi
Triatomines
dc.subject.keywords.spa.fl_str_mv Chagas disease
Trypanosoma cruzi
Triatomines
description Background The heterogeneity of Trypanosoma cruzi infection rates among triatomines insects and animal reservoirs has been studied in independent studies, but little information has been systematised to allow pooled and comparative estimates. Unravelling the main patterns of this heterogeneity could contribute to a further understanding of T. cruzi transmission in Colombia. Methods A systematic search was conducted in PubMed, Medline, LILACS, Embase, Web of Knowledge, Google Scholar and secondary sources with no filters of language or time and until April 2018. Based on selection criteria, all relevant studies reporting T. cruzi infection rates in reservoirs or triatomines were chosen. For pooled analyses, a random effects model for binomial distribution was used. Heterogeneity among studies is reported as I2. Subgroup analyses included: taxonomic classification, ecotope and diagnostic methods. Publication bias and sensitivity analyses were performed. Results Overall, 39 studies reporting infection rates in Colombia were found (22 for potential reservoirs and 28 for triatomine insects) for a total sample of 22,838 potential animals and 11,307 triatomines evaluated for T. cruzi infection. We have found evidence of 38/71 different animal species as potential T. cruzi reservoirs and 14/18 species as triatomine vectors for T. cruzi. Among animals, the species with the highest pooled prevalence were opossum (Didelphis marsupialis) with 48.0% (95% CI: 26–71%; I2 = 88%, τ2 = 0.07, P < 0.01) and domestic dog (Canis lupus familiaris) with 22.0% (95% CI: 4–48%; I2 = 96%, τ2 = 0.01, P < 0.01). Among triatomines, the highest prevalence was found for Triatoma maculata in the peridomestic ecotope (68.0%, 95% CI: 62–74%; I2 = 0%, τ2 = 0, P < 0.0001), followed by Rhodnius prolixus (62.0%, 95% CI: 38–84%; I2 = 95%, τ2 = 0.05, P < 0.01) and Rhodnius pallescens (54.0%, 95% CI: 37–71%; I2 = 86%, τ2 = 0.035, P < 0.01) in the sylvatic ecotope. Conclusions To our knowledge, this is the first systematic and quantitative analyses of triatomine insects and potential animal reservoirs for T. cruzi infection in Colombia. The results highlight a marked heterogeneity between species and provide initial estimates of infection rates heterogeneity.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-09-11T15:43:18Z
dc.date.available.none.fl_str_mv 2019-09-11T15:43:18Z
dc.date.issued.none.fl_str_mv 2019
dc.type.spa.fl_str_mv article
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 1756-3305
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/1667
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1186/s13071-019-3541-5
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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url http://hdl.handle.net/20.500.12495/1667
https://doi.org/10.1186/s13071-019-3541-5
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Parasites & vectors, 1756-3305, Vol. 12, Nro. 308, 2019 p. 1-19
dc.relation.uri.none.fl_str_mv https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3541-5
dc.rights.*.fl_str_mv Attribution 4.0 International
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dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
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dc.rights.creativecommons.none.fl_str_mv 2019
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dc.publisher.spa.fl_str_mv BioMed Central
dc.publisher.journal.spa.fl_str_mv Parasites & vectors
institution Universidad El Bosque
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spelling Rodríguez Monguí, ElianaCantillo Barraza, OmarPrieto Alvarado, Franklin EdwinCucunubá, Zulma M.2019-09-11T15:43:18Z2019-09-11T15:43:18Z20191756-3305http://hdl.handle.net/20.500.12495/1667https://doi.org/10.1186/s13071-019-3541-5instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengBioMed CentralParasites & vectorsParasites & vectors, 1756-3305, Vol. 12, Nro. 308, 2019 p. 1-19https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3541-5Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2902019http://purl.org/coar/access_right/c_abf2Heterogeneity of Trypanosoma cruzi infection rates in vectors and animal reservoirs in Colombia: a systematic review and meta-analysisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Heterogeneidad genéticaReservas naturalesEnfermedades ambientalesChagas diseaseTrypanosoma cruziTriatominesBackground The heterogeneity of Trypanosoma cruzi infection rates among triatomines insects and animal reservoirs has been studied in independent studies, but little information has been systematised to allow pooled and comparative estimates. Unravelling the main patterns of this heterogeneity could contribute to a further understanding of T. cruzi transmission in Colombia. Methods A systematic search was conducted in PubMed, Medline, LILACS, Embase, Web of Knowledge, Google Scholar and secondary sources with no filters of language or time and until April 2018. Based on selection criteria, all relevant studies reporting T. cruzi infection rates in reservoirs or triatomines were chosen. For pooled analyses, a random effects model for binomial distribution was used. Heterogeneity among studies is reported as I2. Subgroup analyses included: taxonomic classification, ecotope and diagnostic methods. Publication bias and sensitivity analyses were performed. Results Overall, 39 studies reporting infection rates in Colombia were found (22 for potential reservoirs and 28 for triatomine insects) for a total sample of 22,838 potential animals and 11,307 triatomines evaluated for T. cruzi infection. We have found evidence of 38/71 different animal species as potential T. cruzi reservoirs and 14/18 species as triatomine vectors for T. cruzi. Among animals, the species with the highest pooled prevalence were opossum (Didelphis marsupialis) with 48.0% (95% CI: 26–71%; I2 = 88%, τ2 = 0.07, P < 0.01) and domestic dog (Canis lupus familiaris) with 22.0% (95% CI: 4–48%; I2 = 96%, τ2 = 0.01, P < 0.01). Among triatomines, the highest prevalence was found for Triatoma maculata in the peridomestic ecotope (68.0%, 95% CI: 62–74%; I2 = 0%, τ2 = 0, P < 0.0001), followed by Rhodnius prolixus (62.0%, 95% CI: 38–84%; I2 = 95%, τ2 = 0.05, P < 0.01) and Rhodnius pallescens (54.0%, 95% CI: 37–71%; I2 = 86%, τ2 = 0.035, P < 0.01) in the sylvatic ecotope. Conclusions To our knowledge, this is the first systematic and quantitative analyses of triatomine insects and potential animal reservoirs for T. cruzi infection in Colombia. The results highlight a marked heterogeneity between species and provide initial estimates of infection rates heterogeneity.ORIGINALRodríguez-Monguí E., Cantillo-Barraza O., Prieto-Alvarado F.E., Cucunubá Z.M._2019.pdfRodríguez-Monguí E., Cantillo-Barraza O., Prieto-Alvarado F.E., Cucunubá Z.M._2019.pdfapplication/pdf2217870https://repositorio.unbosque.edu.co/bitstreams/d73cb9c3-484f-453d-9a00-a632a70e63ae/downloaddf48fba965a8a5b7af5a9f43e126f385MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.unbosque.edu.co/bitstreams/89529f91-e1c1-4b3e-aa98-ed32b10ffdbb/download0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/c1d9d918-68ef-4457-b881-038b7d5e72f4/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILRodríguez-Monguí E., Cantillo-Barraza O., Prieto-Alvarado F.E., Cucunubá Z.M._2019.pdf.jpgRodríguez-Monguí E., Cantillo-Barraza O., Prieto-Alvarado F.E., Cucunubá Z.M._2019.pdf.jpgIM Thumbnailimage/jpeg9764https://repositorio.unbosque.edu.co/bitstreams/18db8eb2-4d6e-43d0-b43f-5ea355bc47aa/downloadc0615caab824edd5b13f90f073f783f4MD54TEXTRodríguez-Monguí E., Cantillo-Barraza O., Prieto-Alvarado F.E., Cucunubá Z.M._2019.pdf.txtRodríguez-Monguí E., Cantillo-Barraza O., Prieto-Alvarado F.E., Cucunubá Z.M._2019.pdf.txtExtracted texttext/plain77165https://repositorio.unbosque.edu.co/bitstreams/d2d70fde-5853-430e-926a-dbfa787bcdde/download35a9e346694dd57dd2378d2eb7760d1cMD5520.500.12495/1667oai:repositorio.unbosque.edu.co:20.500.12495/16672024-02-07 10:57:12.028http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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