Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective

Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the...

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Autores:
Denninghoff, Valeria
Russo, Alessandro
Miguel Pérez, Diego de
Malapelle, Umberto
Benyounes, Amin
Gittens, Allison
Cardona, Andres Felipe
Rolfo, Christian
Tipo de recurso:
Fecha de publicación:
2021
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/5849
Acceso en línea:
http://hdl.handle.net/20.500.12495/5849
https://doi.org/10.3390/cancers13071723
Palabra clave:
Small cell lung cancer
Gene pathway
Pathobiology
Targeted therapy
Rights
openAccess
License
Atribución 4.0 Internacional
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dc.title.spa.fl_str_mv Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
dc.title.translated.spa.fl_str_mv Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
title Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
spellingShingle Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
Small cell lung cancer
Gene pathway
Pathobiology
Targeted therapy
title_short Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
title_full Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
title_fullStr Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
title_full_unstemmed Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
title_sort Small cell lung cancer: State of the art of the molecular and genetic landscape and novel perspective
dc.creator.fl_str_mv Denninghoff, Valeria
Russo, Alessandro
Miguel Pérez, Diego de
Malapelle, Umberto
Benyounes, Amin
Gittens, Allison
Cardona, Andres Felipe
Rolfo, Christian
dc.contributor.author.none.fl_str_mv Denninghoff, Valeria
Russo, Alessandro
Miguel Pérez, Diego de
Malapelle, Umberto
Benyounes, Amin
Gittens, Allison
Cardona, Andres Felipe
Rolfo, Christian
dc.contributor.orcid.none.fl_str_mv Denninghoff, Valeria [0000-0002-3309-7801]
Russo, Alessandro [0000-0002-3365-1972]
Miguel Pérez, Diego de [0000-0002-2822-4466]
Malapelle, Umberto [0000-0003-3211-9957]
dc.subject.keywords.spa.fl_str_mv Small cell lung cancer
Gene pathway
Pathobiology
Targeted therapy
topic Small cell lung cancer
Gene pathway
Pathobiology
Targeted therapy
description Small cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. Understanding the molecular and genetic landscape of this heterogeneous and lethal disease will pave the way for novel drug development.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-05-10T17:35:28Z
dc.date.available.none.fl_str_mv 2021-05-10T17:35:28Z
dc.date.issued.none.fl_str_mv 2021-04-01
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 2072-6694
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/5849
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3390/cancers13071723
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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url http://hdl.handle.net/20.500.12495/5849
https://doi.org/10.3390/cancers13071723
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Cancers, 2072-6694, Vol. 13, Nro. 7, 2021
dc.relation.uri.none.fl_str_mv https://www.mdpi.com/2072-6694/13/7/1723
dc.rights.*.fl_str_mv Atribución 4.0 Internacional
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
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Acceso abierto
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Acceso abierto
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dc.publisher.spa.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.publisher.journal.spa.fl_str_mv Cancers
institution Universidad El Bosque
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spelling Denninghoff, ValeriaRusso, AlessandroMiguel Pérez, Diego deMalapelle, UmbertoBenyounes, AminGittens, AllisonCardona, Andres FelipeRolfo, ChristianDenninghoff, Valeria [0000-0002-3309-7801]Russo, Alessandro [0000-0002-3365-1972]Miguel Pérez, Diego de [0000-0002-2822-4466]Malapelle, Umberto [0000-0003-3211-9957]2021-05-10T17:35:28Z2021-05-10T17:35:28Z2021-04-012072-6694http://hdl.handle.net/20.500.12495/5849https://doi.org/10.3390/cancers13071723instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengMultidisciplinary Digital Publishing Institute (MDPI)CancersCancers, 2072-6694, Vol. 13, Nro. 7, 2021https://www.mdpi.com/2072-6694/13/7/1723Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abiertoSmall cell lung cancer: State of the art of the molecular and genetic landscape and novel perspectiveSmall cell lung cancer: State of the art of the molecular and genetic landscape and novel perspectiveArtículo de revistainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_2df8fbb1Small cell lung cancerGene pathwayPathobiologyTargeted therapySmall cell lung cancer (SCLC) is a highly proliferative lung cancer that is not amenable to surgery in most cases due to the high metastatic potential. Precision medicine has not yet improved patients’ survival due to the lack of actionable mutations. Intra- and intertumoral heterogeneity allow the neoplasms to adapt to various microenvironments and treatments. Further studying this heterogeneous cancer might yield the discovery of actionable mutations. First-line SCLC treatment has added immunotherapy to its armamentarium. There has been renewed interest in SCLC, and numerous clinical trials are underway with novel therapeutic approaches. 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