Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática

Los fármacos antineoplásicos son compuestos utilizados en diversos procedimientos terapéuticos, siendo la quimioterapia uno de los tratamientos primarios para el cáncer. Sin embargo, el creciente uso de estos medicamentos ha generado preocupaciones ambientales, ya que pueden ingresar al medio ambien...

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Autores:
Cruz Ramírez, Diana Vanessa
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2024
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/13268
Acceso en línea:
https://hdl.handle.net/20.500.12495/13268
Palabra clave:
Fármacos antineoplásicos
Cáncer
Técnica analítica
Aguas residuales
Medio ambiente
Toxicidad
615.19
Antineoplastic drugs
Cancer
Analytical technique
Wastewater
Environmental
Toxicity
Rights
License
Acceso abierto
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network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
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dc.title.none.fl_str_mv Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
dc.title.translated.none.fl_str_mv Antineoplastic drugs and their toxic effects on human health and aquatic organisms: systematic review
title Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
spellingShingle Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
Fármacos antineoplásicos
Cáncer
Técnica analítica
Aguas residuales
Medio ambiente
Toxicidad
615.19
Antineoplastic drugs
Cancer
Analytical technique
Wastewater
Environmental
Toxicity
title_short Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
title_full Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
title_fullStr Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
title_full_unstemmed Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
title_sort Fármacos antineoplásicos y sus efectos tóxicos en la salud humana y organismos acuáticos: revisión sistemática
dc.creator.fl_str_mv Cruz Ramírez, Diana Vanessa
dc.contributor.advisor.none.fl_str_mv Becerra Figueroa , Liliana Marcela
dc.contributor.author.none.fl_str_mv Cruz Ramírez, Diana Vanessa
dc.subject.none.fl_str_mv Fármacos antineoplásicos
Cáncer
Técnica analítica
Aguas residuales
Medio ambiente
Toxicidad
topic Fármacos antineoplásicos
Cáncer
Técnica analítica
Aguas residuales
Medio ambiente
Toxicidad
615.19
Antineoplastic drugs
Cancer
Analytical technique
Wastewater
Environmental
Toxicity
dc.subject.ddc.none.fl_str_mv 615.19
dc.subject.keywords.none.fl_str_mv Antineoplastic drugs
Cancer
Analytical technique
Wastewater
Environmental
Toxicity
description Los fármacos antineoplásicos son compuestos utilizados en diversos procedimientos terapéuticos, siendo la quimioterapia uno de los tratamientos primarios para el cáncer. Sin embargo, el creciente uso de estos medicamentos ha generado preocupaciones ambientales, ya que pueden ingresar al medio ambiente a través de las aguas residuales de los hospitales. Asimismo, la detección de contaminantes anticancerígenos a concentraciones traza (ng/L) representa un desafío analítico debido a la falta de pruebas específicas y métodos estandarizados. Las técnicas más comúnmente utilizadas para el análisis son LC-MS/MS y HPLC-QqQ-MS. Entre los agentes citotóxicos de amplio espectro como la ciclofosfamida y la ifosfamida, clasificados, según la Directiva 93/67/EEC, como no tóxicos para ciertas especies acuáticas en pruebas agudas, pueden requerir activación enzimática para manifestar su toxicidad. Por un lado, el 5-fluorouracilo es altamente tóxico para varias especies acuáticas, incluidas bacterias, crustáceos y algas, con concentraciones efectivas medias (EC50) inferiores a 1 mg/L. Por el otro lado, el cisplatino representa un riesgo significativo debido a su capacidad para causar daño en el ADN y afectar el desarrollo celular, mientras que el tamoxifeno destaca por su potencial para inducir estrés oxidativo y bioacumularse en tejidos críticos como el hígado.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-11-20T15:54:19Z
dc.date.available.none.fl_str_mv 2024-11-20T15:54:19Z
dc.date.issued.none.fl_str_mv 2024-10
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.none.fl_str_mv Tesis/Trabajo de grado - Monografía - Pregrado
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12495/13268
dc.identifier.instname.spa.fl_str_mv Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
url https://hdl.handle.net/20.500.12495/13268
identifier_str_mv Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
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language spa
dc.relation.references.none.fl_str_mv A. for R. on Cancer, “Cancer today,” Disponible en linea: https://gco.iarc.fr/today/fact-sheets-cancers (Consultado 10 de julio de 2024)
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M. A. Vaudreuil, S. Vo Duy, G. Munoz, A. Furtos, and S. Sauvé, “A framework for the analysis of polar anticancer drugs in wastewater: On-line extraction coupled to HILIC or reverse phase LC-MS/MS,” Talanta 2020, vol. 220. pp. 5-6
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N. Vyas, A. Turner, and G. Sewell, “Platinum-based anticancer drugs in waste waters of a major UK hospital and predicted concentrations in recipient surface waters,” Sci. Total Environ. 2014, vol. 493, pp. 324–329.
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F. Ribeiro, L. Costa-Lotufo, S. Loureiro, and M. D. Pavlaki, “Environmental Hazard of Anticancer Drugs: State of the Art and Future Perspective for Marine Organisms,” Environ. Toxicol. Chem. 2022, vol. 41, no. 8, pp. 1793–1807
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C. Nassour, S. Nabhani-Gebara, S. J. Barton, and J. Barker, “Determination of Anticancer Drugs in the Aquatic Environment by SPE–LC–MS/MS—A Lebanese Case Study,” Water (Switzerland), 2023, vol. 15, no. 8, pp.2-5.
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spelling Becerra Figueroa , Liliana MarcelaCruz Ramírez, Diana Vanessa2024-11-20T15:54:19Z2024-11-20T15:54:19Z2024-10https://hdl.handle.net/20.500.12495/13268Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coLos fármacos antineoplásicos son compuestos utilizados en diversos procedimientos terapéuticos, siendo la quimioterapia uno de los tratamientos primarios para el cáncer. Sin embargo, el creciente uso de estos medicamentos ha generado preocupaciones ambientales, ya que pueden ingresar al medio ambiente a través de las aguas residuales de los hospitales. Asimismo, la detección de contaminantes anticancerígenos a concentraciones traza (ng/L) representa un desafío analítico debido a la falta de pruebas específicas y métodos estandarizados. Las técnicas más comúnmente utilizadas para el análisis son LC-MS/MS y HPLC-QqQ-MS. Entre los agentes citotóxicos de amplio espectro como la ciclofosfamida y la ifosfamida, clasificados, según la Directiva 93/67/EEC, como no tóxicos para ciertas especies acuáticas en pruebas agudas, pueden requerir activación enzimática para manifestar su toxicidad. Por un lado, el 5-fluorouracilo es altamente tóxico para varias especies acuáticas, incluidas bacterias, crustáceos y algas, con concentraciones efectivas medias (EC50) inferiores a 1 mg/L. Por el otro lado, el cisplatino representa un riesgo significativo debido a su capacidad para causar daño en el ADN y afectar el desarrollo celular, mientras que el tamoxifeno destaca por su potencial para inducir estrés oxidativo y bioacumularse en tejidos críticos como el hígado.PregradoQuímico FarmacéuticoAntineoplastic drugs are compounds used in various therapeutic procedures, with chemotherapy being one of the primary treatments for cancer. However, the increasing use of these drugs has raised environmental concerns, as they can enter the environment through hospital wastewater. Furthermore, the detection of anticancer contaminants at trace concentrations (ng/L) represents an analytical challenge due to the lack of specific tests and standardized methods. The most commonly used techniques for analysis are LC-MS/MS and HPLC-QqQ-MS. Among broad-spectrum cytotoxic agents such as cyclophosphamide and ifosfamide, classified, according to Directive 93/67/EEC, as non-toxic for certain aquatic species in acute tests, they may require enzymatic activation to manifest their toxicity. On the one hand, 5-fluorouracil is highly toxic to several aquatic species, including bacteria, crustaceans and algae, with mean effective concentrations (EC50) less than 1 mg/L. 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Isidori, “Acute and chronic toxicity of six anticancer drugs on rotifers and crustaceans,” Chemosphere, 2024, vol. 115, no. 1, pp. 59–66.Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2spaLICENSElicense.txtlicense.txttext/plain; charset=utf-82000https://repositorio.unbosque.edu.co/bitstreams/75201f33-c78b-4905-af45-91f2db5996a4/download17cc15b951e7cc6b3728a574117320f9MD51Acta de aprobacion.pdfapplication/pdf1664114https://repositorio.unbosque.edu.co/bitstreams/ce9fe49c-7020-480f-a4a9-ae426a56a409/downloadadfac439c6a3d8664b5db85bf8fb5ffdMD53Carta de autorizacion.pdfapplication/pdf233215https://repositorio.unbosque.edu.co/bitstreams/f901de35-a8b1-4057-8179-7f8145e55994/download44876a3d81463606a7906f648c2fe376MD54ORIGINALTrabajo de grado.pdfTrabajo de grado.pdfapplication/pdf861526https://repositorio.unbosque.edu.co/bitstreams/ebcde7ef-1910-4c20-8270-504fbf7f53ad/download76c3f6f3d00be65171a466eb8187af6aMD52TEXTTrabajo de grado.pdf.txtTrabajo de grado.pdf.txtExtracted texttext/plain99359https://repositorio.unbosque.edu.co/bitstreams/bd3eb850-75f1-46d0-9465-c3cb2dc6f2b7/download4de52afb12c3a6f8b522a70ad81b2777MD55THUMBNAILTrabajo de grado.pdf.jpgTrabajo de grado.pdf.jpgGenerated Thumbnailimage/jpeg5294https://repositorio.unbosque.edu.co/bitstreams/58df7300-d20e-4331-857d-67d345579e25/download514371658724d4d4724d74834cfce00eMD5620.500.12495/13268oai:repositorio.unbosque.edu.co:20.500.12495/132682024-11-21 03:05:46.613open.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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