Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature
Lactococcus garvieae is an unusual cause of infective endocarditis (IE). No current diagnostic and therapeutic guidelines are available to treat IE caused by these organisms. Based on a case report, we provide a review of the literature of IE caused by L. garvieae and highlight diagnostic and treatm...
- Autores:
-
Malek, Alexandre
De la Hoz, Alejandro
Gómez-Villegas, Sara Isabel
Nowbakht, Cima
Arias, César A.
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/1561
- Palabra clave:
- Bacterias grampositivas
Endocarditis
Infecciones cardiovasculares
Cardiopatías
Lactococcus
Case report
Gram positive cocci
Infective endocarditis
- Rights
- License
- Attribution 4.0 International
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Repositorio U. El Bosque |
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dc.title.spa.fl_str_mv |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature |
title |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature |
spellingShingle |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature Bacterias grampositivas Endocarditis Infecciones cardiovasculares Cardiopatías Lactococcus Case report Gram positive cocci Infective endocarditis |
title_short |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature |
title_full |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature |
title_fullStr |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature |
title_full_unstemmed |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature |
title_sort |
Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literature |
dc.creator.fl_str_mv |
Malek, Alexandre De la Hoz, Alejandro Gómez-Villegas, Sara Isabel Nowbakht, Cima Arias, César A. |
dc.contributor.author.none.fl_str_mv |
Malek, Alexandre De la Hoz, Alejandro Gómez-Villegas, Sara Isabel Nowbakht, Cima Arias, César A. |
dc.subject.decs.spa.fl_str_mv |
Bacterias grampositivas Endocarditis Infecciones cardiovasculares Cardiopatías |
topic |
Bacterias grampositivas Endocarditis Infecciones cardiovasculares Cardiopatías Lactococcus Case report Gram positive cocci Infective endocarditis |
dc.subject.keywords.spa.fl_str_mv |
Lactococcus Case report Gram positive cocci Infective endocarditis |
description |
Lactococcus garvieae is an unusual cause of infective endocarditis (IE). No current diagnostic and therapeutic guidelines are available to treat IE caused by these organisms. Based on a case report, we provide a review of the literature of IE caused by L. garvieae and highlight diagnostic and treatment challenges of these infections and implications for management. A 50-year-old Asian male with mitral prosthetic valve presented to the hospital with intracranial haemorrhage, which was successfully treated. Three weeks later, he complained of generalized malaise. Further work up revealed blood cultures positive for Gram-positive cocci identified as L. garvieae by MALDI-TOF. An echocardiogram confirmed the diagnosis of IE. Susceptibility testing showed resistance only to clindamycin. Vancomycin plus gentamicin were started as empirical therapy and, subsequently, the combination of ceftriaxone plus gentamicin was used after susceptibility studies were available. After two weeks of combination therapy, ceftriaxone was continued as monotherapy for six additional weeks with good outcome. Twenty-five cases of IE by Lactococcus garvieae have been reported in the literature. Compared to other Gram-positive cocci, L. garvieae affects more frequently patients with prosthetic valves. IE presents in a subacute manner and the case fatality rate can be as high as 16%, comparable to that of streptococcal IE (15.7%). Reliable methods for identification of L. garvieae include MALDI-TOF, 16S RNA PCR, API 32 strep kit and BD Automated Phoenix System. Recommended antimicrobials for L. garvieae IE are ampicillin, amoxicillin, ceftriaxone or vancomycin in monotherapy or in combination with gentamicin. |
publishDate |
2019 |
dc.date.accessioned.none.fl_str_mv |
2019-07-24T15:10:22Z |
dc.date.available.none.fl_str_mv |
2019-07-24T15:10:22Z |
dc.date.issued.none.fl_str_mv |
2019 |
dc.type.spa.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.local.spa.fl_str_mv |
artículo |
dc.identifier.issn.none.fl_str_mv |
1471-2334 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/1561 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1186/s12879-019-3912-8 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1471-2334 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/1561 https://doi.org/10.1186/s12879-019-3912-8 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
BMC Infectious Diseases, 1471-2334, Vol. 19, 2019, p. 10 |
dc.relation.uri.none.fl_str_mv |
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-3912-8 |
dc.rights.*.fl_str_mv |
Attribution 4.0 International |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf439 |
dc.rights.creativecommons.none.fl_str_mv |
2019 |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf439 2019 http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Biomed Central |
dc.publisher.journal.spa.fl_str_mv |
BMC Infectious Diseases |
institution |
Universidad El Bosque |
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Malek, AlexandreDe la Hoz, AlejandroGómez-Villegas, Sara IsabelNowbakht, CimaArias, César A.2019-07-24T15:10:22Z2019-07-24T15:10:22Z20191471-2334http://hdl.handle.net/20.500.12495/1561https://doi.org/10.1186/s12879-019-3912-8instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengBiomed CentralBMC Infectious DiseasesBMC Infectious Diseases, 1471-2334, Vol. 19, 2019, p. 10https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-3912-8Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf4392019http://purl.org/coar/access_right/c_abf2Lactococcus garvieae, an unusual pathogen in infective endocarditis: case report and review of the literaturearticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Bacterias grampositivasEndocarditisInfecciones cardiovascularesCardiopatíasLactococcusCase reportGram positive cocciInfective endocarditisLactococcus garvieae is an unusual cause of infective endocarditis (IE). No current diagnostic and therapeutic guidelines are available to treat IE caused by these organisms. Based on a case report, we provide a review of the literature of IE caused by L. garvieae and highlight diagnostic and treatment challenges of these infections and implications for management. A 50-year-old Asian male with mitral prosthetic valve presented to the hospital with intracranial haemorrhage, which was successfully treated. Three weeks later, he complained of generalized malaise. Further work up revealed blood cultures positive for Gram-positive cocci identified as L. garvieae by MALDI-TOF. An echocardiogram confirmed the diagnosis of IE. Susceptibility testing showed resistance only to clindamycin. Vancomycin plus gentamicin were started as empirical therapy and, subsequently, the combination of ceftriaxone plus gentamicin was used after susceptibility studies were available. After two weeks of combination therapy, ceftriaxone was continued as monotherapy for six additional weeks with good outcome. Twenty-five cases of IE by Lactococcus garvieae have been reported in the literature. Compared to other Gram-positive cocci, L. garvieae affects more frequently patients with prosthetic valves. IE presents in a subacute manner and the case fatality rate can be as high as 16%, comparable to that of streptococcal IE (15.7%). Reliable methods for identification of L. garvieae include MALDI-TOF, 16S RNA PCR, API 32 strep kit and BD Automated Phoenix System. Recommended antimicrobials for L. garvieae IE are ampicillin, amoxicillin, ceftriaxone or vancomycin in monotherapy or in combination with gentamicin.ORIGINALMalek A., De La Hoz A., Gomez-Villegas S.I., Nowbakht C., Arias C.A._2019.pdfMalek A., De La Hoz A., Gomez-Villegas S.I., Nowbakht C., Arias C.A._2019.pdfapplication/pdf580841https://repositorio.unbosque.edu.co/bitstreams/a893e089-3f17-4df7-a906-51a124dbb2db/download6b5cd3947744fd91edadc9dec07ec25eMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.unbosque.edu.co/bitstreams/cee10963-cb88-442e-8add-43cb758565bd/download0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/d2be132c-b5f8-49a7-8637-51cade861ee7/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILMalek A., De La Hoz A., Gomez-Villegas S.I., Nowbakht C., Arias C.A._2019.pdf.jpgMalek A., De La Hoz A., Gomez-Villegas S.I., Nowbakht C., Arias C.A._2019.pdf.jpgIM Thumbnailimage/jpeg10503https://repositorio.unbosque.edu.co/bitstreams/f1299eaa-f34d-4836-a1fc-da8cee57b963/download10fada8573a944bca2cc0f2e642e9f60MD54TEXTMalek A., De La Hoz A., Gomez-Villegas S.I., Nowbakht C., Arias C.A._2019.pdf.txtMalek A., De La Hoz A., Gomez-Villegas S.I., Nowbakht C., Arias C.A._2019.pdf.txtExtracted texttext/plain47719https://repositorio.unbosque.edu.co/bitstreams/4a46e320-546b-4366-b154-0a66e79a3ed6/download68f83c18c85bddb0c53ddb3e420eabf2MD5520.500.12495/1561oai:repositorio.unbosque.edu.co:20.500.12495/15612024-02-07 07:37:18.542http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |