Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis

Rabies virus is the etiological agent of an acute encephalitis, which in absence of post exposure treatment is fatal in almost all cases. Virus lethality rests on its ability to evade the immune response. In this study, we analyzed the role of the immuno-inhibitory molecule B7-H1 in this virus strat...

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Autores:
Lafon, Monique
Mégret, Françoise
Meuth, Sven G.
Simon, Ole
Velandia-Romero, Myriam Lucía
Lafage, Mireille
Chen, Lieping
Alexopoulou, Lena
Flavell, Richard A.
Prehaud, Prehaud
Wiendl, Heinz
Tipo de recurso:
Article of journal
Fecha de publicación:
2008
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3894
Acceso en línea:
http://hdl.handle.net/20.500.12495/3894
https://doi.org/10.4049/jimmunol.180.11.7506
https://repositorio.unbosque.edu.co
Palabra clave:
Virus de la rabia
Virus ARN
Virus de la encefalitis
Rights
openAccess
License
Acceso abierto
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network_name_str Repositorio U. El Bosque
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dc.title.spa.fl_str_mv Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
dc.title.translated.spa.fl_str_mv Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
title Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
spellingShingle Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
Virus de la rabia
Virus ARN
Virus de la encefalitis
title_short Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
title_full Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
title_fullStr Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
title_full_unstemmed Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
title_sort Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
dc.creator.fl_str_mv Lafon, Monique
Mégret, Françoise
Meuth, Sven G.
Simon, Ole
Velandia-Romero, Myriam Lucía
Lafage, Mireille
Chen, Lieping
Alexopoulou, Lena
Flavell, Richard A.
Prehaud, Prehaud
Wiendl, Heinz
dc.contributor.author.none.fl_str_mv Lafon, Monique
Mégret, Françoise
Meuth, Sven G.
Simon, Ole
Velandia-Romero, Myriam Lucía
Lafage, Mireille
Chen, Lieping
Alexopoulou, Lena
Flavell, Richard A.
Prehaud, Prehaud
Wiendl, Heinz
dc.contributor.orcid.none.fl_str_mv Velandia-Romero, Myriam Lucía [0000-0002-3340-7304]
dc.subject.decs.spa.fl_str_mv Virus de la rabia
Virus ARN
Virus de la encefalitis
topic Virus de la rabia
Virus ARN
Virus de la encefalitis
description Rabies virus is the etiological agent of an acute encephalitis, which in absence of post exposure treatment is fatal in almost all cases. Virus lethality rests on its ability to evade the immune response. In this study, we analyzed the role of the immuno-inhibitory molecule B7-H1 in this virus strategy. We showed that in the brain and spinal cord of mice, rabies virus infection resulted in significant up-regulation of B7-H1 expression, which is specifically expressed in infected neurons. Correlatively, clinical rabies in B7-H1−/− mice is markedly less severe than in wild-type mice. B7-H1−/− mice display resistance to rabies. Virus invasion is reduced and the level of migratory CD8 T cells increases into the nervous system, while CD4/CD8 ratio remains unchanged in the periphery. In vivo, neuronal B7-H1 expression is critically depending on TLR3 signaling and IFN-β, because TLR3−/− mice—in which IFN-β production is reduced—showed only a limited increase of B7-H1 transcripts after infection. These data provide evidence that neurons can express the B7-H1 molecule after viral stress or exposure to a particular cytokine environment. They show that the B7-H1/PD-1 pathway can be exploited locally and in an organ specific manner—here the nervous system—by a neurotropic virus to promote successful host invasion.
publishDate 2008
dc.date.issued.none.fl_str_mv 2008
dc.date.accessioned.none.fl_str_mv 2020-08-31T11:19:22Z
dc.date.available.none.fl_str_mv 2020-08-31T11:19:22Z
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 1550-6606
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/3894
dc.identifier.doi.none.fl_str_mv https://doi.org/10.4049/jimmunol.180.11.7506
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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url http://hdl.handle.net/20.500.12495/3894
https://doi.org/10.4049/jimmunol.180.11.7506
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv The Journal of Immunology, 1550-6606, Vol. 180, Nro. 11, 2008 p. 7506-7515
dc.relation.uri.none.fl_str_mv https://www.jimmunol.org/content/180/11/7506.long
dc.rights.local.spa.fl_str_mv Acceso abierto
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rights_invalid_str_mv Acceso abierto
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2008-06
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dc.publisher.spa.fl_str_mv The American Association of Immunologists
dc.publisher.journal.spa.fl_str_mv The Journal of Immunology
institution Universidad El Bosque
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spelling Lafon, MoniqueMégret, FrançoiseMeuth, Sven G.Simon, OleVelandia-Romero, Myriam LucíaLafage, MireilleChen, LiepingAlexopoulou, LenaFlavell, Richard A.Prehaud, PrehaudWiendl, HeinzVelandia-Romero, Myriam Lucía [0000-0002-3340-7304]2020-08-31T11:19:22Z2020-08-31T11:19:22Z20081550-6606http://hdl.handle.net/20.500.12495/3894https://doi.org/10.4049/jimmunol.180.11.7506instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengThe American Association of ImmunologistsThe Journal of ImmunologyThe Journal of Immunology, 1550-6606, Vol. 180, Nro. 11, 2008 p. 7506-7515https://www.jimmunol.org/content/180/11/7506.longDetrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitisDetrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Virus de la rabiaVirus ARNVirus de la encefalitisRabies virus is the etiological agent of an acute encephalitis, which in absence of post exposure treatment is fatal in almost all cases. Virus lethality rests on its ability to evade the immune response. In this study, we analyzed the role of the immuno-inhibitory molecule B7-H1 in this virus strategy. We showed that in the brain and spinal cord of mice, rabies virus infection resulted in significant up-regulation of B7-H1 expression, which is specifically expressed in infected neurons. Correlatively, clinical rabies in B7-H1−/− mice is markedly less severe than in wild-type mice. B7-H1−/− mice display resistance to rabies. Virus invasion is reduced and the level of migratory CD8 T cells increases into the nervous system, while CD4/CD8 ratio remains unchanged in the periphery. In vivo, neuronal B7-H1 expression is critically depending on TLR3 signaling and IFN-β, because TLR3−/− mice—in which IFN-β production is reduced—showed only a limited increase of B7-H1 transcripts after infection. These data provide evidence that neurons can express the B7-H1 molecule after viral stress or exposure to a particular cytokine environment. They show that the B7-H1/PD-1 pathway can be exploited locally and in an organ specific manner—here the nervous system—by a neurotropic virus to promote successful host invasion.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2008-06ORIGINALLafon_Monique_2008.pdfLafon_Monique_2008.pdfapplication/pdf444564https://repositorio.unbosque.edu.co/bitstreams/4761bc92-e607-471f-9c16-2dab39b6c79e/downloadd08c869082870202cbc630eb6e2629a8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/bead27b9-a741-4a7c-84ae-3ea422c5ba31/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILLafon_Monique_2008.pdf.jpgLafon_Monique_2008.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/c8655b55-7484-4cc1-a85b-4357f69b2164/download7210a811635d1799e7c05fee5d259be7MD53TEXTLafon_Monique_2008.pdf.txtLafon_Monique_2008.pdf.txtExtracted texttext/plain58715https://repositorio.unbosque.edu.co/bitstreams/f6ffba47-1ed7-4b5a-a3c4-192463214c22/download64ef51c2072e276c55d6b75519a55944MD5420.500.12495/3894oai:repositorio.unbosque.edu.co:20.500.12495/38942024-02-06 23:41:54.015restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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