Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional
Antecedentes: El estreñimiento crónico funcional (ECF) es frecuente en adultos mayores, afectando su calidad de vida. Aunque existen diversas opciones terapéuticas, no encontramos comparaciones directas entre la lubiprostona y los laxantes osmóticos. Objetivo: Comparar eficacia y seguridad de lubipr...
- Autores:
-
Agudelo Gil, Angie Mariana
González Mejía, Catalina
Saavedra Serrano, Gina Paola
- Tipo de recurso:
- https://purl.org/coar/resource_type/c_7a1f
- Fecha de publicación:
- 2025
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/14001
- Acceso en línea:
- https://hdl.handle.net/20.500.12495/14001
- Palabra clave:
- Estreñimiento
Lubiprostona
Laxantes osmóticos
Polietilenglicol
Adulto mayor/anciano
Resultado del tratamiento
Seguridad
Eficacia
Constipation
Lubiprostone
Osmotic laxatives
Polyethylene glycol
Elderly
Treatment outcome
Safety
Efficiency
WB 110
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional |
| dc.title.translated.none.fl_str_mv |
Efficacy and safety of lubiprostone versus osmotic laxatives in older adults with chronic functional constipation |
| title |
Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional |
| spellingShingle |
Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional Estreñimiento Lubiprostona Laxantes osmóticos Polietilenglicol Adulto mayor/anciano Resultado del tratamiento Seguridad Eficacia Constipation Lubiprostone Osmotic laxatives Polyethylene glycol Elderly Treatment outcome Safety Efficiency WB 110 |
| title_short |
Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional |
| title_full |
Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional |
| title_fullStr |
Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional |
| title_full_unstemmed |
Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional |
| title_sort |
Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcional |
| dc.creator.fl_str_mv |
Agudelo Gil, Angie Mariana González Mejía, Catalina Saavedra Serrano, Gina Paola |
| dc.contributor.advisor.none.fl_str_mv |
Burbano Delgado, Álvaro Fernando Toledo Arenas, José Daniel |
| dc.contributor.author.none.fl_str_mv |
Agudelo Gil, Angie Mariana González Mejía, Catalina Saavedra Serrano, Gina Paola |
| dc.contributor.orcid.none.fl_str_mv |
Agudelo Gil, Angie Mariana [0000-0002-5550-6450] González Mejía, Catalina [0000-0002-6469-6380] Saavedra Serrano, Gina Paola [0000-0003-31493162] |
| dc.subject.none.fl_str_mv |
Estreñimiento Lubiprostona Laxantes osmóticos Polietilenglicol Adulto mayor/anciano Resultado del tratamiento Seguridad Eficacia |
| topic |
Estreñimiento Lubiprostona Laxantes osmóticos Polietilenglicol Adulto mayor/anciano Resultado del tratamiento Seguridad Eficacia Constipation Lubiprostone Osmotic laxatives Polyethylene glycol Elderly Treatment outcome Safety Efficiency WB 110 |
| dc.subject.keywords.none.fl_str_mv |
Constipation Lubiprostone Osmotic laxatives Polyethylene glycol Elderly Treatment outcome Safety Efficiency |
| dc.subject.nlm.none.fl_str_mv |
WB 110 |
| description |
Antecedentes: El estreñimiento crónico funcional (ECF) es frecuente en adultos mayores, afectando su calidad de vida. Aunque existen diversas opciones terapéuticas, no encontramos comparaciones directas entre la lubiprostona y los laxantes osmóticos. Objetivo: Comparar eficacia y seguridad de lubiprostona frente a los laxantes osmóticos en el tratamiento del ECF en adultos mayores. Materiales y métodos: Revisión sistemática según lineamientos PRISMA, (enero de 2006 a junio de 2024). Las bases de datos consultadas incluyeron PubMed, Cochrane, Lilacs, ProQuest, OVID y Epistemonikos, mediante Cochrane Risk of Bias 2 y criterios PRISMA se realizó la evaluación, analizando, la frecuencia de Movimientos Intestinales Espontáneos (MIE) y los efectos adversos. Resultados: Se incluyeron 2 ensayos clínicos y 6 revisiones sistemáticas. La lubiprostona incrementó los MIE a 5.1-6.1 por semana frente a 3.8 con placebo (p = 0.046) y en otro estudio, a 5.3 frente a 2.9 con placebo (p < 0.002) esto es 54%. Las náuseas afectaron al 14%-16% de los pacientes tratados con lubiprostona. Los laxantes osmóticos mostraron éxito terapéutico en 52% frente a 11% con placebo (p < 0.001) y redujeron el riesgo de fracaso terapéutico en un 48% (RR = 0.52; IC 95%: 0.46-0.60). Aunque ambos tratamientos demostraron eficacia, los estudios no son comparativos, lo que limita las conclusiones definitivas. Conclusiones: Tanto lubiprostona como laxantes osmóticos son opciones viables para el manejo del ECF en adultos mayores, se requieren estudios comparativos directos para determinar su seguridad y eficacia relativa. Este estudio no recibió financiamiento externo ni fue registrado en PROSPERO. |
| publishDate |
2025 |
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2025-02-20T13:33:14Z |
| dc.date.available.none.fl_str_mv |
2025-02-20T13:33:14Z |
| dc.date.issued.none.fl_str_mv |
2025-01 |
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http://purl.org/coar/resource_type/c_7a1f |
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Tesis/Trabajo de grado - Monografía - Especialización |
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https://purl.org/coar/resource_type/c_7a1f |
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Barberio, B., Judge, C., Savarino, E. V., & Ford, A. C. (2021). Global prevalence of functional constipation according to the Rome criteria: a systematic review and meta-analysis. The Lancet. Gastroenterology & Hepatology, 6(8), 638–648. https://doi.org/10.1016/S2468-1253(21)00111-4 Belsey, J., Greenfield, S., Candy, D., & Geraint, M. (2010). Systematic review: Impact of constipation on quality of life in adults and children. In Alimentary Pharmacology and Therapeutics (Vol. 31, Issue 9, pp. 938–949). https://doi.org/10.1111/j.1365-2036.2010.04273.x Bharucha, A. E., Pemberton, J. H., & Locke, G. R. (2013). American gastroenterological association technical review on constipation. Gastroenterology, 144(1), 218–238. https://doi.org/10.1053/j.gastro.2012.10.028 Chassagne Philippe, & Corazziari Enrico. (2013). The Burden of Constipation in our Ageing Population Working Towards Better Solutions. https://ilcuk.org.uk/wp-content/uploads/2018/11/Burden-of-constipation-report.pdf Chavarría J. (2015). REVISTA MEDICA DE COSTA RICA Y CENTROAMERICA. 73–75. DiPalma, J. A., Cleveland, M. vB., McGowan, J., & Herrera, J. L. (2007). A Randomized, Multicenter, Placebo-Controlled Trial of Polyethylene Glycol Laxative for Chronic Treatment of Chronic Constipation. The American Journal of Gastroenterology, 102(7), 1436–1441. https://doi.org/10.1111/j.1572-0241.2007.01199.x Emmanuel, A., Mattace-Raso, F., Neri, M. C., Petersen, K.-U., Rey, E., & Rogers, J. (2017). Constipation in older people: A consensus statement. International Journal of Clinical Practice, 71(1). https://doi.org/10.1111/ijcp.12920 Ford, A. C., & Suares, N. C. (2011). Effect of laxatives and pharmacological therapies in chronic idiopathic constipation: Systematic review and meta-analysis. Gut, 60(2), 209–218. https://doi.org/10.1136/gut.2010.227132 Gandell, D., Straus, S. E., Bundookwala, M., Tsui, V., & Alibhai, S. M. H. (2013). Treatment of constipation in older people. In CMAJ. Canadian Medical Association Journal (Vol. 185, Issue 8, pp. 663–670). Canadian Medical Association. https://doi.org/10.1503/cmaj.120819 Giorgio, R. De, Ruggeri, E., Stanghellini, V., Eusebi, L. H., Bazzoli, F., & Chiarioni, G. (2015). Chronic constipation in the elderly: a primer for the gastroenterologist. BMC Gastroenterology, 15, 1–13. http://10.0.4.162/s12876-015-0366-3 Handa, Y., Fukushima, S., Yo, S., Osawa, M., Murao, T., Handa, O., Matsumoto, H., Umegaki, E., & Shiotani, A. (2021). Evaluation of efficacy and safety of lubiprostone in patients with chronic constipation. Scandinavian Journal of Gastroenterology, 56(10), 1140–1145. https://doi.org/10.1080/00365521.2021.1913758 Johanson, J. F., & Ueno, R. (2007). Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: A double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety. Alimentary Pharmacology and Therapeutics, 25(11), 1351–1361. https://doi.org/10.1111/j.1365-2036.2007.03320.x Jordi Mascaró. (2006). Evaluation and treatment of constipation in the elderly. Ke, M. Y. , & W. Y. K. (2010). Epidemiology and research progress of chronic constipation in the elderly. Pract Geriatr, 24, 92–94. Li, F., Fu, T., Tong, W. D., Liu, B. H., Li, C. X., Gao, Y., Wu, J. S., Wang, X. F., & Zhang, A. P. (2016). Lubiprostone Is Effective in the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Mayo Clinic Proceedings, 91(4), 456–468. https://doi.org/10.1016/j.mayocp.2016.01.015 Lim, J., Park, H., Lee, H., Lee, E., Lee, D., Hee-Won, J., & Il-Young, J. (2021). Higher frailty burden in older adults with chronic constipation. BMC Gastroenterology, 21, 1–7. https://doi.org/https://doi.org/10.1186/s12876-021-01684-x Lucak, S., Lunsford, T. N., & Harris, L. A. (2021). Evaluation and Treatment of Constipation in the Geriatric Population. Clinics in Geriatric Medicine, 37(1), 85–102. https://doi.org/10.1016/j.cger.2020.08.007 Mari, A., Mahamid, M., Amara, H., Baker, F. A., & Yaccob, A. (2020). Chronic constipation in the elderly patient: Updates in evaluation and management. Korean Journal of Family Medicine, 41(3), 139 – 145. https://doi.org/10.4082/kjfm.18.0182 Maruyama, M., Miida, S., Sato, T., Kimura, T., Watanabe, A., Watanabe, H., Nishizawa, M., Horikawa, K., Kajiwara, T., Karasawa, Y., Hasebe, Y., Nozawa, K., & Terai, S. (2023). Effectiveness and safety of lubiprostone after switching from stimulant laxatives in elderly patients with chronic constipation. JGH Open, 7(9), 610–617. https://doi.org/10.1002/jgh3.12956 McCrea, G. L., Miaskowski, C., Stotts, N. A., Macera, L., & Varma, M. G. (2009). A Review of the Literature on Gender and Age Differences in the Prevalence and Characteristics of Constipation in North America. In Journal of Pain and Symptom Management (Vol. 37, Issue 4, pp. 737–745). https://doi.org/10.1016/j.jpainsymman.2008.04.016 Mounsey, A., Raleigh, M., & Wilson, A. (2015). Management of constipation in older adults. American Family Physician, 92(6), 500–504. Nour-Eldein, H., Salama, H., Abdulmajeed, A., & Heissam, K. (2014). The effect of lifestyle modification on severity of constipation and quality of life of elders in nursing homes at Ismailia city, Egypt. Journal of Family and Community Medicine, 21(2), 100–106. https://doi.org/10.4103/2230-8229.134766 Rao, S. S. C., Seaton, K., Miller, M. J., Schulze, K., Brown, C. K., Paulson, J., & Zimmerman, B. (2007b). Psychological profiles and quality of life differ between patients with dyssynergia and those with slow transit constipation. Journal of Psychosomatic Research, 63(4), 441–449. https://doi.org/10.1016/J.JPSYCHORES.2007.05.016 Rao, S. S., Manabe, N., Karasawa, Y., Hasebe, Y., Nozawa, K., Nakajima, A., & Fukudo, S. (2024). Comparative profiles of lubiprostone, linaclotide, and elobixibat for chronic constipation: a systematic literature review with meta-analysis and number needed to treat/harm. BMC Gastroenterology, 24(1), 1–19. https://doi.org/10.1186/S12876-023-03104-8/FIGURES/5 Rivkin, A., & Chagan, L. (2006). Lubiprostone: Chloride Channel Activator for Chronic Constipation. In Clinical Therapeutics (Vol. 28). Roberts, M. (2003). Constipation, laxative use, and colon cancer in a North Carolina population. The American Journal of Gastroenterology, 98(4), 857–864. https://doi.org/10.1016/s0002-9270(03)00050-9 Roque, M. V., & Bouras, E. P. (2015). Epidemiology and management of chronic constipation in elderly patients. In Clinical Interventions in Aging (Vol. 10, pp. 919–930). Dove Medical Press Ltd. https://doi.org/10.2147/CIA.S54304 S., R. A. R., A., C. F. G., V.^, A. R., M., A. C., B., V. C., Gómez, Á. A., Núñez, E., T., Y. A. M., Pardo, R., R., W. O., & Sabbagh, L. (2015). Guía de práctica clínica para el diagnóstico y tratamiento del estreñimiento crónico funcional en población adulta. Revista Colombiana de Gastroenterología, 30, 57 https://login.ezproxy.unbosque.edu.co/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=116272796&lang=es&site=ehost-live Serra, J., Mascort-Roca, J., Marzo-Castillejo, M., Delgado Aros, S., Ferrándiz Santos, J., Rey Diaz Rubio, E., & Mearin Manrique, F. (2017). Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto. Parte 1: Definición, etiología y manifestaciones clínicas. In Gastroenterologia y Hepatologia (Vol. 40, Issue 3, pp. 132–141). Ediciones Doyma, S.L. https://doi.org/10.1016/j.gastrohep.2016.02.006 Serra Jordi, Mascort-Roca Juanjo, Marzo-Castillejo Mercè, Aros Silvia Delgado, Ferrándiz Santos Juan, Rey Diaz Rubio Enrique, & Mearin Manrique Fermín. (2017). Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto. Parte 2: Diagnóstico y tratamiento. In Gastroenterologia y Hepatologia (Vol. 40, Issue 4, pp. 303–316). Ediciones Doyma, S.L. https://doi.org/10.1016/j.gastrohep.2016.02.007 Sumida, K., Molnar, M. Z., Potukuchi, P. K., Thomas, F., Lu, J. L., Yamagata, K., Kalantar-Zadeh, K., & Kovesdy, C. P. (2019). Constipation and risk of death and cardiovascular events. Atherosclerosis, 281, 114–120. https://doi.org/10.1016/J.ATHEROSCLEROSIS.2018.12.021 Tashiro, N., & Budhathoki. (2011). Constipation and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. https://pubmed.ncbi.nlm.nih.gov/22292645/ Werth, B. L., & Christopher, S. A. (2021). Laxative use in the community: A literature review. Journal of Clinical Medicine, 10(1), 1–13. https://doi.org/10.3390/JCM10010143 Zheng, S., & Yao, J. (2018). Expert consensus on the assessment and treatment of chronic constipation in the elderly. Aging Medicine, 1(1), 8 – 17. https://doi.org/10.1002/agm2.12013 |
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Burbano Delgado, Álvaro FernandoToledo Arenas, José DanielAgudelo Gil, Angie MarianaGonzález Mejía, CatalinaSaavedra Serrano, Gina PaolaAgudelo Gil, Angie Mariana [0000-0002-5550-6450]González Mejía, Catalina [0000-0002-6469-6380]Saavedra Serrano, Gina Paola [0000-0003-31493162]2025-02-20T13:33:14Z2025-02-20T13:33:14Z2025-01https://hdl.handle.net/20.500.12495/14001instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coAntecedentes: El estreñimiento crónico funcional (ECF) es frecuente en adultos mayores, afectando su calidad de vida. Aunque existen diversas opciones terapéuticas, no encontramos comparaciones directas entre la lubiprostona y los laxantes osmóticos. Objetivo: Comparar eficacia y seguridad de lubiprostona frente a los laxantes osmóticos en el tratamiento del ECF en adultos mayores. Materiales y métodos: Revisión sistemática según lineamientos PRISMA, (enero de 2006 a junio de 2024). Las bases de datos consultadas incluyeron PubMed, Cochrane, Lilacs, ProQuest, OVID y Epistemonikos, mediante Cochrane Risk of Bias 2 y criterios PRISMA se realizó la evaluación, analizando, la frecuencia de Movimientos Intestinales Espontáneos (MIE) y los efectos adversos. Resultados: Se incluyeron 2 ensayos clínicos y 6 revisiones sistemáticas. La lubiprostona incrementó los MIE a 5.1-6.1 por semana frente a 3.8 con placebo (p = 0.046) y en otro estudio, a 5.3 frente a 2.9 con placebo (p < 0.002) esto es 54%. Las náuseas afectaron al 14%-16% de los pacientes tratados con lubiprostona. Los laxantes osmóticos mostraron éxito terapéutico en 52% frente a 11% con placebo (p < 0.001) y redujeron el riesgo de fracaso terapéutico en un 48% (RR = 0.52; IC 95%: 0.46-0.60). Aunque ambos tratamientos demostraron eficacia, los estudios no son comparativos, lo que limita las conclusiones definitivas. Conclusiones: Tanto lubiprostona como laxantes osmóticos son opciones viables para el manejo del ECF en adultos mayores, se requieren estudios comparativos directos para determinar su seguridad y eficacia relativa. Este estudio no recibió financiamiento externo ni fue registrado en PROSPERO.Especialista en Medicina FamiliarEspecializaciónBackground: Chronic functional constipation (SCD) is common in older adults, affecting their quality of life. There are several therapeutic options, without direct comparisons between lubiprostone and osmotic laxatives. Objective: To compare the efficacy and safety of lubiprostone versus osmotic laxatives in the treatment of SCD in older adults. Materials and methods: Systematic review according to PRISMA guidelines, (January 2006 to June 2024). The databases consulted included PubMed, Cochrane, Lilacs, ProQuest, OVID and Epistemonikos and using Cochrane Risk of Bias 2 and PRISMA criteria the data were evaluated using the frequency of Spontaneous Bowel Movements (MIE) and adverse effects as an outcome. Results: 2 clinical trials and 6 systematic reviews were included, in the first RCT lubiprostone increased MIE to 5.1-6.1 per week versus 3.8 with placebo (p = 0.046) and in the second study 5.3 versus 2.9 with placebo (p < 0.002). Nausea affected 14%-16% of patients treated with lubiprostone. Osmotic laxatives showed therapeutic success in 52% versus 11% with placebo (p < 0.001) and reduced the risk of treatment failure by 48% (RR = 0.52; 95% CI: 0.46-0.60). Although both treatments demonstrated efficacy, the studies are not comparative, limiting definitive conclusions. Conclusions: Both lubiprostone and osmotic laxatives are viable options for the management of SCD in older adults, direct comparative studies are required to determine their safety and relative efficacy. This study did not receive external funding nor was it registered in PROSPEROapplication/pdfAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2EstreñimientoLubiprostonaLaxantes osmóticosPolietilenglicolAdulto mayor/ancianoResultado del tratamientoSeguridadEficaciaConstipationLubiprostoneOsmotic laxativesPolyethylene glycolElderlyTreatment outcomeSafetyEfficiencyWB 110Eficacia y seguridad de lubiprostona frente a laxantes osmóticos en adultos mayores con estreñimiento crónico funcionalEfficacy and safety of lubiprostone versus osmotic laxatives in older adults with chronic functional constipationEspecialización en Medicina FamiliarUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aaBarberio, B., Judge, C., Savarino, E. 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