Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model

In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was i...

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Autores:
Singh, Kavindra V.
Arias, Cesar A
Murray, Barbara
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/2327
Acceso en línea:
http://hdl.handle.net/20.500.12495/2327
https://doi.org/10.1128/AAC.02627-18
Palabra clave:
Staphylococcus aureus
Enterococcus faecalis
Linezolid
Enfermedades cutáneas Infecciosas
Tedizolid
Mouse peritonitis
Rights
License
Acceso cerrado
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network_name_str Repositorio U. El Bosque
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dc.title.spa.fl_str_mv Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
dc.title.translated.none.fl_str_mv Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
title Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
spellingShingle Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
Staphylococcus aureus
Enterococcus faecalis
Linezolid
Enfermedades cutáneas Infecciosas
Tedizolid
Mouse peritonitis
title_short Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
title_full Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
title_fullStr Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
title_full_unstemmed Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
title_sort Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
dc.creator.fl_str_mv Singh, Kavindra V.
Arias, Cesar A
Murray, Barbara
dc.contributor.author.none.fl_str_mv Singh, Kavindra V.
Arias, Cesar A
Murray, Barbara
dc.subject.decs.spa.fl_str_mv Staphylococcus aureus
Enterococcus faecalis
Linezolid
Enfermedades cutáneas Infecciosas
topic Staphylococcus aureus
Enterococcus faecalis
Linezolid
Enfermedades cutáneas Infecciosas
Tedizolid
Mouse peritonitis
dc.subject.keywords.spa.fl_str_mv Tedizolid
Mouse peritonitis
description In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an ∼4-fold lower MIC.
publishDate 2019
dc.date.issued.none.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2020-04-23T15:40:14Z
dc.date.available.none.fl_str_mv 2020-04-23T15:40:14Z
dc.type.spa.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 1098-6596
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/2327
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1128/AAC.02627-18
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 1098-6596
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/2327
https://doi.org/10.1128/AAC.02627-18
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Antimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 4, 2019, p. 1-4
dc.relation.uri.none.fl_str_mv https://aac.asm.org/content/63/4/e02627-18
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso cerrado
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf319
dc.rights.creativecommons.none.fl_str_mv 2019
rights_invalid_str_mv Acceso cerrado
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2019
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dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv American Society for Microbiology
dc.publisher.journal.spa.fl_str_mv Antimicrobial agents and chemotherapy,
institution Universidad El Bosque
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spelling Singh, Kavindra V.Arias, Cesar AMurray, Barbara2020-04-23T15:40:14Z2020-04-23T15:40:14Z20191098-6596http://hdl.handle.net/20.500.12495/2327https://doi.org/10.1128/AAC.02627-18instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengAmerican Society for MicrobiologyAntimicrobial agents and chemotherapy,Antimicrobial agents and chemotherapy, 1098-6596, Vol. 63, Nro. 4, 2019, p. 1-4https://aac.asm.org/content/63/4/e02627-18Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis modelEfficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis modelarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Staphylococcus aureusEnterococcus faecalisLinezolidEnfermedades cutáneas InfecciosasTedizolidMouse peritonitisIn a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an ∼4-fold lower MIC.Acceso cerradohttp://purl.org/coar/access_right/c_abf3192019http://purl.org/coar/access_right/c_abf2THUMBNAILSingh K.V., Arias C.A., Murray B.E._2019.pdf.jpgSingh K.V., Arias C.A., Murray B.E._2019.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/ac51dec2-215e-4739-a331-9c15dd218141/download7210a811635d1799e7c05fee5d259be7MD53ORIGINALSingh K.V., Arias C.A., Murray B.E._2019.pdfSingh K.V., Arias C.A., Murray B.E._2019.pdfapplication/pdf208901https://repositorio.unbosque.edu.co/bitstreams/3e9cac3e-9786-40a2-8502-b4bd5a888d66/downloadd4a5d39487930ea480da08c8c03406edMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/6e861752-7269-4772-8319-4dd079f31537/download8a4605be74aa9ea9d79846c1fba20a33MD52TEXTSingh K.V., Arias C.A., Murray B.E._2019.pdf.txtSingh K.V., Arias C.A., Murray B.E._2019.pdf.txtExtracted texttext/plain21829https://repositorio.unbosque.edu.co/bitstreams/49366db6-0fd1-4db4-8603-900828e0232a/downloadb406d4e99e034fe8face667d62737d2fMD5420.500.12495/2327oai:repositorio.unbosque.edu.co:20.500.12495/23272024-02-07 07:25:52.286restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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