Efficacy of tedizolid against enterococci and staphylococci, including cfr+ strains, in a mouse peritonitis model
In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was i...
- Autores:
-
Singh, Kavindra V.
Arias, Cesar A
Murray, Barbara
- Tipo de recurso:
- Fecha de publicación:
- 2019
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/2327
- Palabra clave:
- Staphylococcus aureus
Enterococcus faecalis
Linezolid
Enfermedades cutáneas Infecciosas
Tedizolid
Mouse peritonitis
- Rights
- License
- Acceso cerrado
| Summary: | In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B)+ E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an ∼4-fold lower MIC. |
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