Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis

Introducción: El declive cognitivo es un marcador de la aparición y avance de la enfermedad de Alzheimer (EA). Actualmente, la modificación de factores de riesgo, como la nutrición, son promisorios para el tratamiento de la EA. El objetivo fue identificar el efecto de la suplementación de vitaminas...

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Autores:: Diaz Muñoz, Gustavo Alfonso
García Rairána, Luis Alejandro
Corredor Torres, Valentina
Gonzalez Cruz, Maria Angelica
Useche Aroca, Diana Sofia
Wilches Perez, Nohora Fernanda
Wilches Perez, Laura Stephania

Tipo de recurso:: https://purl.org/coar/resource_type/c_7a1f

Fecha de publicación:: 2023

Institución:: Universidad El Bosque

Repositorio:: Repositorio U. El Bosque

Idioma:: spa

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repository_id_str
dc.title.none.fl_str_mv	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis
dc.title.translated.none.fl_str_mv	Effect of B-vitamins supplementation on cognitive decline in patients with Alzheimer’s disease. A systematic review and meta-analysis
title	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis
spellingShingle	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis Enfermedad de Alzheimer Declive Cognitivo Vitaminas del Complejo B Metaanálisis Alzheimer’s disease Cognitive Decline B vitamins Meta-analysis W100
title_short	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis
title_full	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis
title_fullStr	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis
title_full_unstemmed	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis
title_sort	Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis
dc.creator.fl_str_mv	Diaz Muñoz, Gustavo Alfonso García Rairána, Luis Alejandro Corredor Torres, Valentina Gonzalez Cruz, Maria Angelica Useche Aroca, Diana Sofia Wilches Perez, Nohora Fernanda Wilches Perez, Laura Stephania
dc.contributor.advisor.none.fl_str_mv	Diaz Muñoz, Gustavo Alfonso
dc.contributor.author.none.fl_str_mv	Diaz Muñoz, Gustavo Alfonso García Rairána, Luis Alejandro Corredor Torres, Valentina Gonzalez Cruz, Maria Angelica Useche Aroca, Diana Sofia Wilches Perez, Nohora Fernanda Wilches Perez, Laura Stephania
dc.contributor.orcid.none.fl_str_mv	Wilches Perez, Laura Stephania [0000-0001-7872-2693]
dc.subject.none.fl_str_mv	Enfermedad de Alzheimer Declive Cognitivo Vitaminas del Complejo B Metaanálisis
topic	Enfermedad de Alzheimer Declive Cognitivo Vitaminas del Complejo B Metaanálisis Alzheimer’s disease Cognitive Decline B vitamins Meta-analysis W100
dc.subject.keywords.none.fl_str_mv	Alzheimer’s disease Cognitive Decline B vitamins Meta-analysis
dc.subject.nlm.none.fl_str_mv	W100
description	Introducción: El declive cognitivo es un marcador de la aparición y avance de la enfermedad de Alzheimer (EA). Actualmente, la modificación de factores de riesgo, como la nutrición, son promisorios para el tratamiento de la EA. El objetivo fue identificar el efecto de la suplementación de vitaminas del complejo B sobre el declive cognitivo en pacientes con daño cognitivo o EA. Metodología: Revisión sistemática y metaanálisis de la literatura en cinco buscadores (PROSPERO CRD42021247743). Se incluyeron experimentos controlados, en adultos de 60 o más años, con medición del estado cognitivo (ADAS-Cog, Clinical dementia ratin-CDR y/o Mini Mental State Examination-MMSE) y uso de suplementos de vitaminas del complejo B de manera individual o combinada con otras vitaminas o fármacos. La evaluación de la calidad se hizo con la herramienta RoB-2. La selección, extracción y evaluación se hizo por tres investigadores de manera independiente. El metaanálisis empleó la diferencia media y modelos de efectos aleatorios. Resultados: La búsqueda arrojó 247 referencias y finalmente se incluyeron 12 para el metaanálisis. No se encontraron sesgos de publicación. La calidad de los estudios es adecuada. El suplemento de vitamina B no mostró efecto sobre el declive cognitivo medido por ADAS-Cog (DM: 0,01; IC95%: -0,7 a 0,72), CDR (DM: -0,06; IC95% -0,48 a 0,36) y MMSE (DM: 0,3; IC95%: -0.01 a 0.61). Conclusiones: El declive cognitivo es invariable ante la suplementación de vitaminas del complejo B en adultos con daño cognitivo o enfermedad de Alzheimer. Futuras investigaciones deben enfocarse hacia estrategias multi intervención.
publishDate	2023
dc.date.issued.none.fl_str_mv	2023-02
dc.date.accessioned.none.fl_str_mv	2025-05-29T16:06:44Z
dc.date.available.none.fl_str_mv	2025-05-29T16:06:44Z
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv	Tesis/Trabajo de grado - Monografía - Pregrado
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(19) Li S, Guo Y, Men J, Fu H, Xu T The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis. BMC Geriatr. 2021; 21(1): 1-14. doi: 10.1186/S12877-021-02253-3/FIGURES/7. (20) Xu W, Tan L, Wang H-F, Jiang T, Tan M-S, Tan L, et al. Metaanalysis of modifiable risk factors for Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2015; 86(12): 1299-306. doi: 10.1136/jnnp-2015-310548. (21) McCleery J, Abraham RP, Denton DA, Rutjes AW, Chong L-Y, Al-Assaf AS, et al. Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment. Cochrane Database Syst Rev. 2018; 11(11): CD011905. doi: 10.1002/14651858.CD011905. pub2. (22) Chen H, Liu S, Ge B, Zhou D, Li M, Li W, et al. Effects of Folic Acid and Vitamin B12 Supplementation on Cognitive Impairment and Inflammation in Patients with Alzheimer’s Disease: A Randomized, Single-Blinded, Placebo-Controlled Trial. J Prev Alzheimers Dis. 2021. doi: 10.14283/jpad.2021.22 (23) Gibson GE, Luchsinger JA, Cirio R, Chen H, Franchino-Elder J, Hirsch JA, et al. Benfotiamine and Cognitive Decline in Alzheimer’s Disease: Results of a Randomized Placebo- Controlled Phase IIa Clinical Trial. J Alzheimers Dis. 2020; 78(3): 989-1010. doi: 10.3233/JAD-200896. (24) Chen H, Liu S, Ji L, Wu T, Ji Y, Zhou Y, et al. Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial. Mediators Inflamm. 2016; 2016: 5912146. doi: 10.1155/2016/5912146. (25) Remington R, Bechtel C, Larsen D, Samar A, Doshanjh L, Fishman P, et al. A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimer’s Disease. J Alzheimers Dis. 2015; 45(2): 395-405, doi: 10.3233/ JAD-142499. (26) De Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry. 2012; 27(6): 592-600. doi: 10.1002/GPS.2758. (27) Ford AH, Flicker L, Alfonso H, Thomas J, Clarnette R, Martins R, et al. Vitamins B12, B6, and folic acid for cognition in older men. Neurology. 2010; 75(17): 1540-7. doi: 10.1212/ WNL.0b013e3181f962c4. (28) Scheltens P, Kamphuis PJGH, Verhey FRJ, Olde Rikkert MGM, Wurtman RJ, Wilkinson D, et al. Efficacy of a medical food in mild Alzheimer’s disease: A randomized, controlled trial. Alzheimers Dement. 2010; 6(1). doi: 10.1016/j.jalz.2009.10.003. (29) van Dyck CH, Lyness JM, Rohrbaugh RM, Siegal AP Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home study. Int Psychogeriatr. 2009; 21(1): 138-47. (30) Manders M, De Groot LCPGM, Hoefnagels WHL, Dhonukshe- Rutten RAM, Wouters-Wesseling W, Mulders AJMJ, et al. The effect of a nutrient dense drink on mental and physical function in institutionalized elderly people. J Nutr Health Aging. 2009; 13(9): 760-7. doi: 10.1007/s12603-009-0211-x. (31) Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, et al. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. JAMA. 2008; 300(15): 1774-83. doi: 10.1001/ jama.300.15.1774. (32) Connelly PJ, Prentice NP, Cousland G, Bonham J. A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer’s disease. Int J Geriatr Psychiatry. 2008; 23(2): 155-60. doi: 10.1002/gps.1856. (33) Sun Y, Lu CJ, Chien KL, Chen ST, Chen RC. Efficacy of Multivitamin Supplementation Containing Vitamins B6 and B12 and Folic Acid as Adjunctive Treatment with a Cholinesterase Inhibitor in Alzheimer’s Disease: A 26-Week, Randomized, Double-Blind, Placebo-Controlled Study in Taiwanese Patients. Clin Ther. 2007; 29(10): 2204-14. doi: 10.1016/j.clinthera.2007.10.012. (34) Zhang C, Luo J, Yuan C, Ding D. Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2020; 77(2): 781-94. doi: 10.3233/JAD-200534. (35) Bai D, Fan J, Li M, Dong C, Gao Y, Fu M, et al. Effects of Folic Acid Combined with DHA Supplementation on Cognitive Function and Amyloid-β-Related Biomarkers in Older Adults with Mild Cognitive Impairment by a Randomized, Double Blind, Placebo-Controlled Trial. J Alzheimers Dis. 2021; 81(1): 155-67. doi: 10.3233/JAD-200997. (36) Rainey-Smith SR, Gu Y, Gardener SL, Doecke JD, Villemagne VL, Brown BM, et al. Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Transl Psychiatry. 2018; 8(1): 238. doi: 10.1038/s41398-018-0293-5. (37) Díaz G, Lengele L, Sourdet S, Soriano G, de Souto Barreto P. Nutrients and amyloid β status in the brain: a narrative review. Ageing Res Rev. 2022; 81: 101728. doi: https://doi. org/10.1016/j.arr.2022.101728. (38) Li M-M, Yu J-T, Wang H-F, Jiang T, Wang J, Meng X-F, et al. Efficacy of vitamins B supplementation on mild cognitive impairment and Alzheimer’s disease: A systematic review and meta-analysis. Curr Alzheimer Res. 2014; 11(9): 844-52. doi: 10. 2174/1567205011666141001114140. (39) Munoz Fernandez SS, Ivanauskas T, Lima Ribeiro SM. Nutritional Strategies in the Management of Alzheimer Disease: Systematic Review With Network Meta-Analysis. J Am Med Dir Assoc. 2017; 18(10). doi: 10.1016/j. jamda.2017.06.015. (40) Wang Z, Zhu W, Xing Y, Jia J, Tang Y. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis. Nutr Rev. 2022; 80(4): 931-49. doi: 10.1093/nutrit/nuab057. (41) Ford AH, Almeida OP. Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis. Drugs Aging. 2019; 36(5): 419-34. doi: 10.1007/ s40266-019-00649-w (42) Liu KY, Schneider LS, Howard R. The need to show minimum clinically important differences in Alzheimer’s disease trials. Lancet Psychiatry. 2021; 8(11): 1013-6. doi: 10.1016/S2215- 0366(21)00197-8. (43) McGrattan A, van Aller C, Narytnyk A, Reidpath D, Keage H, Mohan D, et al. Nutritional interventions for the prevention of cognitive impairment and dementia in developing economies in East-Asia: a systematic review and metaanalysis. Crit Rev Food Sci Nutr. 2022; 62(7): 1838-55. doi: 10.1080/10408398.2020.1848785. (45) Arevalo-Rodriguez I, Smailagic N, Roqué-Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, et al. Mini- Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2021; 7(7): CD010783. doi: 10.1002/14651858.CD010783.pub3. (46) Wessels AM, Dowsett SA, Sims JR Detecting Treatment Group Differences in Alzheimer’s Disease Clinical Trials: A Comparison of Alzheimer’s Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) and the Clinical Dementia Rating - Sum of Boxes (CDR-SB). J Prev Alzheimers Dis. 2018; 5(1): 15-20. doi: 10.14283/jpad.2018.2. (47) Jiang Y, Yang H, Zhao J, Wu Y, Zhou X, Cheng Z Reliability and concurrent validity of Alzheimer’s disease assessment scale - Cognitive subscale, Chinese version (ADASCog- C) among Chinese community-dwelling older people population. Clin Neuropsychol. 2020; 34(sup1): 43-53. doi: 10.1080/13854046.2020.1750704. (48) Kwok T, Lee J, Ma RC, Wong SY, Kung K, Lam A, et al. A randomized placebo controlled trial of vitamin B(12) supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B(12). Clin Nutr. 2017; 36(6): 1509-15. doi: 10.1016/j.clnu.2016.10.018. (49) Szczechowiak K, Diniz BS, Leszek J. Diet and Alzheimer’s dementia – Nutritional approach to modulate inflammation. Pharmacol Biochem Behav. 2019; 184: 172743. doi: 10.1016/j. pbb.2019.172743. (50) Calfio C, Gonzalez A, Singh SK, Rojo LE, MacCioni RB. The Emerging Role of Nutraceuticals and Phytochemicals in the Prevention and Treatment of Alzheimer’s Disease. J Alzheimers Dis. 2020; 77(1): 33-51. doi: 10.3233/JAD-200443. (51) Jin-Tai Y, Xu W, Chen-Chen T, Andrieu S, Suckling J, Evangelou E, et al. Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020; 91(11): 1201-9. doi: http://dx.doi.org/10.1136/jnnp-2019-321913. (52) Serrano-Pozo A, Growdon JH. Is Alzheimer’s Disease Risk Modifiable? J Alzheimers Dis. 2019; 67(3): 795-819. doi: 10.3233/JAD181028. (53) Lauer AA, Grimm HS, Apel B, Golobrodska N, Kruse L, Ratanski E, et al. Mechanistic Link between Vitamin B12 and Alzheimer’s Disease. Biomolecules. 2022; 12(1): 129. doi: 10.3390/ BIOM12010129. (54) Solfrizzi V, Agosti P, Lozupone M, Custodero C, Schilardi A, Valiani V, et al. Nutritional interventions and cognitive-related outcomes in patients with late-life cognitive disorders: A systematic review. Neurosci Biobehav Rev. 2018; 95: 480-98. doi: 10.1016/j.neubiorev.2018.10.022.
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spelling	Diaz Muñoz, Gustavo AlfonsoDiaz Muñoz, Gustavo AlfonsoGarcía Rairána, Luis AlejandroCorredor Torres, ValentinaGonzalez Cruz, Maria AngelicaUseche Aroca, Diana SofiaWilches Perez, Nohora FernandaWilches Perez, Laura StephaniaWilches Perez, Laura Stephania [0000-0001-7872-2693]2025-05-29T16:06:44Z2025-05-29T16:06:44Z2023-02https://hdl.handle.net/20.500.12495/14508instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coIntroducción: El declive cognitivo es un marcador de la aparición y avance de la enfermedad de Alzheimer (EA). Actualmente, la modificación de factores de riesgo, como la nutrición, son promisorios para el tratamiento de la EA. El objetivo fue identificar el efecto de la suplementación de vitaminas del complejo B sobre el declive cognitivo en pacientes con daño cognitivo o EA. Metodología: Revisión sistemática y metaanálisis de la literatura en cinco buscadores (PROSPERO CRD42021247743). Se incluyeron experimentos controlados, en adultos de 60 o más años, con medición del estado cognitivo (ADAS-Cog, Clinical dementia ratin-CDR y/o Mini Mental State Examination-MMSE) y uso de suplementos de vitaminas del complejo B de manera individual o combinada con otras vitaminas o fármacos. La evaluación de la calidad se hizo con la herramienta RoB-2. La selección, extracción y evaluación se hizo por tres investigadores de manera independiente. El metaanálisis empleó la diferencia media y modelos de efectos aleatorios. Resultados: La búsqueda arrojó 247 referencias y finalmente se incluyeron 12 para el metaanálisis. No se encontraron sesgos de publicación. La calidad de los estudios es adecuada. El suplemento de vitamina B no mostró efecto sobre el declive cognitivo medido por ADAS-Cog (DM: 0,01; IC95%: -0,7 a 0,72), CDR (DM: -0,06; IC95% -0,48 a 0,36) y MMSE (DM: 0,3; IC95%: -0.01 a 0.61). Conclusiones: El declive cognitivo es invariable ante la suplementación de vitaminas del complejo B en adultos con daño cognitivo o enfermedad de Alzheimer. Futuras investigaciones deben enfocarse hacia estrategias multi intervención.Médico CirujanoPregradoIntroduction: Cognitive decline is a marker for the onset and progression of Alzheimer’s disease (AD). Currently, modification of risk factors, such as nutrition, are promising for the treatment of AD. The objective was to identify the effect of B-vitamin supplementation on cognitive decline in patients with mild cognitive impairment and AD. Methodology: Systematic review and meta-analysis of the literature in five search engines (PROSPERO CRD42021247743). Controlled experiments were included, in adults aged 60 years or older, with measurement of cognitive status (ADAS-Cog, Clinical dementia rating-CDR and/ or Mini Mental State Examination-MMSE) and use of B-complex vitamin supplements individually or combined with other vitamins or drugs. Quality assessment was done with the RoB-2 tool. Independently, three investigators made the selection, extraction, and evaluation of the data. The meta-analyses used mean difference and random effect model. Results: The search found 247 references and 12 references were included for the metaanalysis. The publication bias was not found. The quality of the studies was adequate. B-vitamin supplementation had no effect on cognitive decline by ADAS-Cog (MD: 0.01; CI95%: -0.7 to 0.72), CDR (MD: -0.06; CI95% -0.48 to 0.36), and MMSE (MD: 0.3; CI95%: -0.01 to 0.61). Conclusions: Cognitive decline was invariant following B-vitamin supplementation in adults with cognitive impairment or Alzheimer’s disease. Future research should focus on multi-intervention strategies.application/pdfAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso cerradohttp://purl.org/coar/access_right/c_14cbhttps://purl.org/coar/access_right/c_abf2Enfermedad de AlzheimerDeclive CognitivoVitaminas del Complejo BMetaanálisisAlzheimer’s diseaseCognitive DeclineB vitaminsMeta-analysisW100Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisisEffect of B-vitamins supplementation on cognitive decline in patients with Alzheimer’s disease. 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Efecto de la suplementación con vitaminas del complejo B sobre el declive cognitivo en pacientes con enfermedad de Alzheimer. Revisión sistemática y metaanálisis

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