Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)

El cáncer colorrectal de presentación temprana (CCR-PT) es la primera causa de muerte por cáncer en hombres y la segunda en mujeres jóvenes. Su incidencia ha aumentado, a diferencia de lo que ocurre en la población mayor. Este estudio busca cerrar la brecha de información sobre CCR-PT en Colombia y...

Full description

Autores:: Cáceres Galvis, Camilo Ernesto

Tipo de recurso:: https://purl.org/coar/resource_type/c_7a1f

Fecha de publicación:: 2024

Institución:: Universidad El Bosque

Repositorio:: Repositorio U. El Bosque

Idioma:: spa

id	UNBOSQUE2_77703cf0410afd791f557787d4992d38
oai_identifier_str	oai:repositorio.unbosque.edu.co:20.500.12495/12765
network_acronym_str	UNBOSQUE2
network_name_str	Repositorio U. El Bosque
repository_id_str
dc.title.none.fl_str_mv	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)
dc.title.translated.none.fl_str_mv	Clinical, pathological and molecular characterization of early-onset colorectal cancer in a reference center in Colombia (2021-2023)
title	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)
spellingShingle	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023) Cáncer colorrectal Inestabilidad de microsatélites Neoplasias colorrectales hereditarias sin poliposis Poliposis adenomatosa del colon Colorectal neoplasms Colorectal cancer Colorectal neoplasms, hereditary nonpolyposis Microsatellite instability QZ 200
title_short	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)
title_full	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)
title_fullStr	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)
title_full_unstemmed	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)
title_sort	Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)
dc.creator.fl_str_mv	Cáceres Galvis, Camilo Ernesto
dc.contributor.advisor.none.fl_str_mv	Ballén, Diego Felipe Riaño, Julián
dc.contributor.author.none.fl_str_mv	Cáceres Galvis, Camilo Ernesto
dc.subject.none.fl_str_mv	Cáncer colorrectal Inestabilidad de microsatélites Neoplasias colorrectales hereditarias sin poliposis Poliposis adenomatosa del colon
topic	Cáncer colorrectal Inestabilidad de microsatélites Neoplasias colorrectales hereditarias sin poliposis Poliposis adenomatosa del colon Colorectal neoplasms Colorectal cancer Colorectal neoplasms, hereditary nonpolyposis Microsatellite instability QZ 200
dc.subject.keywords.none.fl_str_mv	Colorectal neoplasms Colorectal cancer Colorectal neoplasms, hereditary nonpolyposis Microsatellite instability
dc.subject.nlm.none.fl_str_mv	QZ 200
description	El cáncer colorrectal de presentación temprana (CCR-PT) es la primera causa de muerte por cáncer en hombres y la segunda en mujeres jóvenes. Su incidencia ha aumentado, a diferencia de lo que ocurre en la población mayor. Este estudio busca cerrar la brecha de información sobre CCR-PT en Colombia y América Latina. Se realizó un estudio observacional de corte transversal, incluyendo pacientes atendidos entre el 1 de enero de 2021 y el 30 de junio de 2023 en el Instituto Nacional de Cancerología en Bogotá, Colombia.
publishDate	2024
dc.date.accessioned.none.fl_str_mv	2024-07-30T15:34:42Z
dc.date.available.none.fl_str_mv	2024-07-30T15:34:42Z
dc.date.issued.none.fl_str_mv	2024-07
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv	Tesis/Trabajo de grado - Monografía - Especialización
dc.type.coar.none.fl_str_mv	https://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bachelorThesis
dc.type.coarversion.none.fl_str_mv	https://purl.org/coar/version/c_ab4af688f83e57aa
format	https://purl.org/coar/resource_type/c_7a1f
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12495/12765
dc.identifier.instname.spa.fl_str_mv	instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv	reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv	repourl:https://repositorio.unbosque.edu.co
url	https://hdl.handle.net/20.500.12495/12765
identifier_str_mv	instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co
dc.language.iso.fl_str_mv	spa
language	spa
dc.relation.references.none.fl_str_mv	1. Global burden of gastrointestinal cancers [Internet]. [cited 2024 Jun 25]. Available from: https://gco.iarc.fr/stories/gastro-intestinal/en 2. Siegel Mph RL, Giaquinto AN, Ahmedin \|, Dvm J, Siegel RL. Cancer statistics, 2024. CA Cancer J Clin [Internet]. 2024 Jan 1 [cited 2024 Jun 27];74(1):12–49. Available from: https://onlinelibrary.wiley.com/doi/full/10.3322/caac.21820 3. Magnitude, trend and access to health services in people with high-cost diseases 2023 - High Cost Account [Internet]. [cited 2024 Jun 25]. Available from: https://cuentadealtocosto.org/publicaciones/magnitude-tendencia-y-acceso-a-los-servicios-de-salud-en-las-personas-con-enfermedades-de-alto-costo-2023/ 4. Cavestro GM, Mannucci A, Balaguer F, Hampel H, Kupfer SS, Repici A, et al. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines. Clin Gastroenterol Hepatol [Internet]. 2023 Mar 1 [cited 2024 Jun 26];21(3):581-603.e33. Available from: https://pubmed.ncbi.nlm.nih.gov/36549470/ 5. Bailey CE, Hu CY, You YN, Bednarski BK, Rodriguez-Bigas MA, Skibber JM, et al. Increasing Disparities in the Age-Related Incidences of Colon and Rectal Cancers in the United States, 1975-2010. JAMA Surg [Internet]. 2015 Jan 1 [cited 2024 Jun 27];150(1):17–22. Available from: https://jamanetwork.com/journals/jamasurgery/fullarticle/1920838 6. Ustáriz ACM, Macías SG, Sánchez RB, Pardo JC, Guerrero AB, Mora MG, et al. Update on colorectal cancer screening. Rev Colomb Cancerol [Internet]. 2023 Jul 27 [cited 2024 Jun 25];27:291–300. Available from: https://www.revistacancercol.org/index.php/cancer/article/view/931 7. Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, et al. Rising incidence of early-onset colorectal cancer - a call to action. Nat Rev Clin Oncol [Internet]. 2021 Apr 1 [cited 2024 Jun 25];18(4):230–43. Available from: https://pubmed.ncbi.nlm.nih.gov/33219329/ 8. Lieu CH, Golemis EA, Serebriiskii IG, Newberg J, Hemmerich A, Connelly C, et al. Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer. Clin Cancer Res [Internet]. 2019 Oct 1 [cited 2024 Jun 28];25(19):5852–8. Available from: https://pubmed.ncbi.nlm.nih.gov/31243121/ 9. Zaborowski AM, Abdile A, Adamina M, Aigner F, D'Allens L, Allmer C, et al. Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review. JAMA Surg [Internet]. 2021 Sep 1 [cited 2024 Jun 25];156(9):865–74. Available from: https://pubmed.ncbi.nlm.nih.gov/34190968/ 10. Done JZ, Fang SH. Young-onset colorectal cancer: A review. World J Gastrointest Oncol [Internet]. 2021 [cited 2024 Jun 25];13(8):856–66. Available from: https://pubmed.ncbi.nlm.nih.gov/34457191/ 11. Baez-Duarte JP, Chaves JJ, Chaves-Cabezas V, Africano-Lopez F, Ochoa-Vera M, Tovar-Fierro G. Early-onset colorectal cancer: a study in a Colombian population. Rev Colomb Gastroenterol. 2024 Mar 20;39(1):29–36. 12. Silva ACB, Vicentini MFB, Mendoza EZ, Fujiki FK, da Fonseca LG, Braghiroli MIFM, et al. Young-age onset colorectal cancer in Brazil: Analysis of incidence, clinical features, and outcomes in a tertiary cancer center. Curr Probl Cancer [Internet]. 2019 Oct 1 [cited 2024 Jul 3];43(5):477–86. Available from: https://pubmed.ncbi.nlm.nih.gov/30826126/ 13. Calderillo-Ruiz G, Herrera M, Itzel V, Carbajal-López B, Muñoz W, Perez Yepez E, et al. P-160 Young Latin American population with colorectal cancer: Characteristics of bad prognosis. Ann Oncol [Internet]. 2021 Jul 1 [cited 2024 Jul 3];32:S154. Available from: http://www.annalsofoncology.org/article/S0923753421014046/fulltext 14. Rutherford C, Ju A, Kim B, Wiltink L, Acret L, White K. How consequences of colorectal cancer treatment are managed: a qualitative study of stakeholder experiences about supportive care and current practices. Support Care Cancer. 2023 May 1;31(5). 15. Bruheim K, Guren MG, Skovlund E, Hjermstad MJ, Dahl O, Frykholm G, et al. Late side effects and quality of life after radiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys [Internet]. 2010 Mar 15 [cited 2024 Jul 7];76(4):1005–11. Available from: https://pubmed.ncbi.nlm.nih.gov/19540058/ 16. Cancer situation in the adult population served in the SGSSS of Colombia 2022 - High Cost Account [Internet]. [cited 2024 Jul 7]. Available from: https://cuentadealtocosto.org/publicaciones/situacion-del-cancer-en-la-poblacion-adulta-atendida-en-el-sgsss-de-colombia-2022/ 17. Cercek A, Chatila WK, Yaeger R, Walch H, Fernandes GDS, Krishnan A, et al. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J Natl Cancer Inst [Internet]. 2021 Dec 1 [cited 2024 Jun 25];113(12):1683–92. Available from: https://pubmed.ncbi.nlm.nih.gov/34405229/ 18. Gottschalk Z, Redman MW, Baker KK, Ulrich CM, Siegel EM, Figueiredo JC, et al. Comparison of the disease presentation of early- vs. later-onset colorectal cancer within the prospective ColoCare study. J Clin Oncol. 2024 Jan 20;42(3_suppl):91–91. 19. Yarden RI, Newcomer KL, Board NTYA. Abstract 3347: Young onset colorectal cancer patients are diagnosed with advanced disease after multiple misdiagnoses. Cancer Res. 2019 Jul 1;79(13_Supplement):3347–3347. 20. Fontana E, Jones C, Misch A, Schlauch D, Spigel DR, Arkenau HT, et al. Early-onset colorectal cancer: Real-world genomic data from the community-based Sarah Cannon Cancer Centers Network. J Clin Oncol. 2022 Feb 1;40(4_suppl):198–198. 21. Antelo M, Balaguer F, Shia J, Shen Y, Hur K, Moreira L, et al. A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer. PLoS One [Internet]. 2012 Sep 25 [cited 2024 Jun 28];7(9):e45357. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045357 22. Perea J, Marti M, Espin E, Hernandez-Villafranca S, Orihuela P, Vidal Tocino R, et al. Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain. BMJ Open [Internet]. 2021 Dec 1 [cited 2024 Jun 28];11(12):e055409. Available from: https://bmjopen.bmj.com/content/11/12/e055409 23. Catalano V, Loupakis F, Graziano F, Bisonni R, Torresi U, Vincenzi B, et al. Prognosis of mucinous histology for patients with radically resected stage II and III colon cancer. Ann Oncol [Internet]. 2012 Jan 1 [cited 2024 Jun 28];23(1):135–41. Available from: http://www.annalsofoncology.org/article/S0923753419390544/fulltext 24. Pearlman R, Frankel WL, Swanson B, Zhao W, Yilmaz A, Miller K, et al. Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer. JAMA Oncol [Internet]. 2017 Apr 1 [cited 2024 Jun 28];3(4):464–71. Available from: https://pubmed.ncbi.nlm.nih.gov/27978560/ 25. Mork ME, You YN, Ying J, Bannon SA, Lynch PM, Rodriguez-Bigas MA, et al. High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer. J Clin Oncol [Internet]. 2015 Nov 1 [cited 2024 Jul 7];33(31):3544–9. Available from: https://pubmed.ncbi.nlm.nih.gov/26195711/ 26. Seagle HM, Keller SR, Tavtigian S V., Horton C, Holowatyj AN. Clinical Multigene Panel Testing Identifies Racial and Ethnic Differences in Germline Pathogenic Variants Among Patients With Early-Onset Colorectal Cancer. J Clin Oncol [Internet]. 2023 Sep 10 [cited 2024 Jul 6];41(26):4279–89. Available from: https://pubmed.ncbi.nlm.nih.gov/37319387/ 27. Willauer AN, Liu Y, Pereira AAL, Lam M, Morris JS, Raghav KPS, et al. Clinical and molecular characterization of early-onset colorectal cancer. Cancer [Internet]. 2019 Jun 15 [cited 2024 Jun 29];125(12):2002–10. Available from: https://pubmed.ncbi.nlm.nih.gov/30854646/ 28. Lander EM, Rivero-Hinojosa S, Aushev VN, Jurdi AA, Liu MC, Eng C. Evaluation of genomic alterations in early-onset versus late-onset colorectal cancer. https://doi.org/101200/JCO20234116_suppl3511 [Internet]. 2023 May 31 [cited 2024 Jun 28];41(16_suppl):3511–3511. Available from: https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.3511
dc.rights.en.fl_str_mv	Atribución-NoComercial-CompartirIgual 4.0 Internacional
dc.rights.coar.fl_str_mv	http://purl.org/coar/access_right/c_abf2
dc.rights.uri.none.fl_str_mv	http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.local.spa.fl_str_mv	Acceso abierto
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.mimetype.none.fl_str_mv	application/pdf
dc.publisher.program.spa.fl_str_mv	Especialización en Oncología Clínica
dc.publisher.grantor.spa.fl_str_mv	Universidad El Bosque
dc.publisher.faculty.spa.fl_str_mv	Facultad de Medicina
institution	Universidad El Bosque
bitstream.url.fl_str_mv	https://repositorio.unbosque.edu.co/bitstreams/4554442d-96a6-4003-a05e-c14e43ad85fc/download https://repositorio.unbosque.edu.co/bitstreams/c4be23f6-225f-4da1-86ca-67d87b0ae0b3/download https://repositorio.unbosque.edu.co/bitstreams/1bea537e-46e1-4821-81cf-8940ffaf0cdd/download https://repositorio.unbosque.edu.co/bitstreams/3ad28bcc-8c8b-4e4b-9a69-b9662e081663/download https://repositorio.unbosque.edu.co/bitstreams/31415bca-129c-4279-be69-165b78432ae4/download https://repositorio.unbosque.edu.co/bitstreams/83624234-d95c-49ae-bb88-c1527f4b117a/download
bitstream.checksum.fl_str_mv	87b3e9a431f4c5407bbbd40a779284f7 3b6ce8e9e36c89875e8cf39962fe8920 17cc15b951e7cc6b3728a574117320f9 dac8445379c4c5fb9398fc96e9aea5cb adb48c8caa6364924a943732f4feb923 be2f7dde325543ed5274dc6e98a204de
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositorio Institucional Universidad El Bosque
repository.mail.fl_str_mv	bibliotecas@biteca.com
_version_	1814100716855230464
spelling	Ballén, Diego FelipeRiaño, JuliánCáceres Galvis, Camilo Ernesto2024-07-30T15:34:42Z2024-07-30T15:34:42Z2024-07https://hdl.handle.net/20.500.12495/12765instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coEl cáncer colorrectal de presentación temprana (CCR-PT) es la primera causa de muerte por cáncer en hombres y la segunda en mujeres jóvenes. Su incidencia ha aumentado, a diferencia de lo que ocurre en la población mayor. Este estudio busca cerrar la brecha de información sobre CCR-PT en Colombia y América Latina. Se realizó un estudio observacional de corte transversal, incluyendo pacientes atendidos entre el 1 de enero de 2021 y el 30 de junio de 2023 en el Instituto Nacional de Cancerología en Bogotá, Colombia.Instituto Nacional de CancerologíaEspecialista en Oncología ClínicaEspecializaciónEarly-onset colorectal cancer (EO-CRC) is the leading cause of cancer death in men and the second in young women. Its incidence has increased, unlike what happens in the older population. This study aims to close the information gap on EO-CRC in Colombia and Latin America. A cross-sectional observational study was carried out, including patients seen between January 1, 2021 and June 30, 2023 at the National Cancer Institute in Bogotá, Colombia.application/pdfAtribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cáncer colorrectalInestabilidad de microsatélitesNeoplasias colorrectales hereditarias sin poliposisPoliposis adenomatosa del colonColorectal neoplasmsColorectal cancerColorectal neoplasms, hereditary nonpolyposisMicrosatellite instabilityQZ 200Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)Clinical, pathological and molecular characterization of early-onset colorectal cancer in a reference center in Colombia (2021-2023)Especialización en Oncología ClínicaUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. Global burden of gastrointestinal cancers [Internet]. [cited 2024 Jun 25]. Available from: https://gco.iarc.fr/stories/gastro-intestinal/en2. Siegel Mph RL, Giaquinto AN, Ahmedin \|, Dvm J, Siegel RL. Cancer statistics, 2024. CA Cancer J Clin [Internet]. 2024 Jan 1 [cited 2024 Jun 27];74(1):12–49. Available from: https://onlinelibrary.wiley.com/doi/full/10.3322/caac.218203. Magnitude, trend and access to health services in people with high-cost diseases 2023 - High Cost Account [Internet]. [cited 2024 Jun 25]. Available from: https://cuentadealtocosto.org/publicaciones/magnitude-tendencia-y-acceso-a-los-servicios-de-salud-en-las-personas-con-enfermedades-de-alto-costo-2023/4. Cavestro GM, Mannucci A, Balaguer F, Hampel H, Kupfer SS, Repici A, et al. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines. Clin Gastroenterol Hepatol [Internet]. 2023 Mar 1 [cited 2024 Jun 26];21(3):581-603.e33. Available from: https://pubmed.ncbi.nlm.nih.gov/36549470/5. Bailey CE, Hu CY, You YN, Bednarski BK, Rodriguez-Bigas MA, Skibber JM, et al. Increasing Disparities in the Age-Related Incidences of Colon and Rectal Cancers in the United States, 1975-2010. JAMA Surg [Internet]. 2015 Jan 1 [cited 2024 Jun 27];150(1):17–22. Available from: https://jamanetwork.com/journals/jamasurgery/fullarticle/19208386. Ustáriz ACM, Macías SG, Sánchez RB, Pardo JC, Guerrero AB, Mora MG, et al. Update on colorectal cancer screening. Rev Colomb Cancerol [Internet]. 2023 Jul 27 [cited 2024 Jun 25];27:291–300. Available from: https://www.revistacancercol.org/index.php/cancer/article/view/9317. Akimoto N, Ugai T, Zhong R, Hamada T, Fujiyoshi K, Giannakis M, et al. Rising incidence of early-onset colorectal cancer - a call to action. Nat Rev Clin Oncol [Internet]. 2021 Apr 1 [cited 2024 Jun 25];18(4):230–43. Available from: https://pubmed.ncbi.nlm.nih.gov/33219329/8. Lieu CH, Golemis EA, Serebriiskii IG, Newberg J, Hemmerich A, Connelly C, et al. Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer. Clin Cancer Res [Internet]. 2019 Oct 1 [cited 2024 Jun 28];25(19):5852–8. Available from: https://pubmed.ncbi.nlm.nih.gov/31243121/9. Zaborowski AM, Abdile A, Adamina M, Aigner F, D'Allens L, Allmer C, et al. Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review. JAMA Surg [Internet]. 2021 Sep 1 [cited 2024 Jun 25];156(9):865–74. Available from: https://pubmed.ncbi.nlm.nih.gov/34190968/10. Done JZ, Fang SH. Young-onset colorectal cancer: A review. World J Gastrointest Oncol [Internet]. 2021 [cited 2024 Jun 25];13(8):856–66. Available from: https://pubmed.ncbi.nlm.nih.gov/34457191/11. Baez-Duarte JP, Chaves JJ, Chaves-Cabezas V, Africano-Lopez F, Ochoa-Vera M, Tovar-Fierro G. Early-onset colorectal cancer: a study in a Colombian population. Rev Colomb Gastroenterol. 2024 Mar 20;39(1):29–36.12. Silva ACB, Vicentini MFB, Mendoza EZ, Fujiki FK, da Fonseca LG, Braghiroli MIFM, et al. Young-age onset colorectal cancer in Brazil: Analysis of incidence, clinical features, and outcomes in a tertiary cancer center. Curr Probl Cancer [Internet]. 2019 Oct 1 [cited 2024 Jul 3];43(5):477–86. Available from: https://pubmed.ncbi.nlm.nih.gov/30826126/13. Calderillo-Ruiz G, Herrera M, Itzel V, Carbajal-López B, Muñoz W, Perez Yepez E, et al. P-160 Young Latin American population with colorectal cancer: Characteristics of bad prognosis. Ann Oncol [Internet]. 2021 Jul 1 [cited 2024 Jul 3];32:S154. Available from: http://www.annalsofoncology.org/article/S0923753421014046/fulltext14. Rutherford C, Ju A, Kim B, Wiltink L, Acret L, White K. How consequences of colorectal cancer treatment are managed: a qualitative study of stakeholder experiences about supportive care and current practices. Support Care Cancer. 2023 May 1;31(5).15. Bruheim K, Guren MG, Skovlund E, Hjermstad MJ, Dahl O, Frykholm G, et al. Late side effects and quality of life after radiotherapy for rectal cancer. Int J Radiat Oncol Biol Phys [Internet]. 2010 Mar 15 [cited 2024 Jul 7];76(4):1005–11. Available from: https://pubmed.ncbi.nlm.nih.gov/19540058/16. Cancer situation in the adult population served in the SGSSS of Colombia 2022 - High Cost Account [Internet]. [cited 2024 Jul 7]. Available from: https://cuentadealtocosto.org/publicaciones/situacion-del-cancer-en-la-poblacion-adulta-atendida-en-el-sgsss-de-colombia-2022/17. Cercek A, Chatila WK, Yaeger R, Walch H, Fernandes GDS, Krishnan A, et al. A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. J Natl Cancer Inst [Internet]. 2021 Dec 1 [cited 2024 Jun 25];113(12):1683–92. Available from: https://pubmed.ncbi.nlm.nih.gov/34405229/18. Gottschalk Z, Redman MW, Baker KK, Ulrich CM, Siegel EM, Figueiredo JC, et al. Comparison of the disease presentation of early- vs. later-onset colorectal cancer within the prospective ColoCare study. J Clin Oncol. 2024 Jan 20;42(3_suppl):91–91.19. Yarden RI, Newcomer KL, Board NTYA. Abstract 3347: Young onset colorectal cancer patients are diagnosed with advanced disease after multiple misdiagnoses. Cancer Res. 2019 Jul 1;79(13_Supplement):3347–3347.20. Fontana E, Jones C, Misch A, Schlauch D, Spigel DR, Arkenau HT, et al. Early-onset colorectal cancer: Real-world genomic data from the community-based Sarah Cannon Cancer Centers Network. J Clin Oncol. 2022 Feb 1;40(4_suppl):198–198.21. Antelo M, Balaguer F, Shia J, Shen Y, Hur K, Moreira L, et al. A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer. PLoS One [Internet]. 2012 Sep 25 [cited 2024 Jun 28];7(9):e45357. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.004535722. Perea J, Marti M, Espin E, Hernandez-Villafranca S, Orihuela P, Vidal Tocino R, et al. Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain. BMJ Open [Internet]. 2021 Dec 1 [cited 2024 Jun 28];11(12):e055409. Available from: https://bmjopen.bmj.com/content/11/12/e05540923. Catalano V, Loupakis F, Graziano F, Bisonni R, Torresi U, Vincenzi B, et al. Prognosis of mucinous histology for patients with radically resected stage II and III colon cancer. Ann Oncol [Internet]. 2012 Jan 1 [cited 2024 Jun 28];23(1):135–41. Available from: http://www.annalsofoncology.org/article/S0923753419390544/fulltext24. Pearlman R, Frankel WL, Swanson B, Zhao W, Yilmaz A, Miller K, et al. Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer. JAMA Oncol [Internet]. 2017 Apr 1 [cited 2024 Jun 28];3(4):464–71. Available from: https://pubmed.ncbi.nlm.nih.gov/27978560/25. Mork ME, You YN, Ying J, Bannon SA, Lynch PM, Rodriguez-Bigas MA, et al. High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer. J Clin Oncol [Internet]. 2015 Nov 1 [cited 2024 Jul 7];33(31):3544–9. Available from: https://pubmed.ncbi.nlm.nih.gov/26195711/26. Seagle HM, Keller SR, Tavtigian S V., Horton C, Holowatyj AN. Clinical Multigene Panel Testing Identifies Racial and Ethnic Differences in Germline Pathogenic Variants Among Patients With Early-Onset Colorectal Cancer. J Clin Oncol [Internet]. 2023 Sep 10 [cited 2024 Jul 6];41(26):4279–89. Available from: https://pubmed.ncbi.nlm.nih.gov/37319387/27. Willauer AN, Liu Y, Pereira AAL, Lam M, Morris JS, Raghav KPS, et al. Clinical and molecular characterization of early-onset colorectal cancer. Cancer [Internet]. 2019 Jun 15 [cited 2024 Jun 29];125(12):2002–10. Available from: https://pubmed.ncbi.nlm.nih.gov/30854646/28. Lander EM, Rivero-Hinojosa S, Aushev VN, Jurdi AA, Liu MC, Eng C. Evaluation of genomic alterations in early-onset versus late-onset colorectal cancer. https://doi.org/101200/JCO20234116_suppl3511 [Internet]. 2023 May 31 [cited 2024 Jun 28];41(16_suppl):3511–3511. Available from: https://ascopubs.org/doi/10.1200/JCO.2023.41.16_suppl.3511spaORIGINALTrabajo de grado.pdfTrabajo de grado.pdfapplication/pdf1082598https://repositorio.unbosque.edu.co/bitstreams/4554442d-96a6-4003-a05e-c14e43ad85fc/download87b3e9a431f4c5407bbbd40a779284f7MD52CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8899https://repositorio.unbosque.edu.co/bitstreams/c4be23f6-225f-4da1-86ca-67d87b0ae0b3/download3b6ce8e9e36c89875e8cf39962fe8920MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-82000https://repositorio.unbosque.edu.co/bitstreams/1bea537e-46e1-4821-81cf-8940ffaf0cdd/download17cc15b951e7cc6b3728a574117320f9MD54Carta de autorización.pdfapplication/pdf352417https://repositorio.unbosque.edu.co/bitstreams/3ad28bcc-8c8b-4e4b-9a69-b9662e081663/downloaddac8445379c4c5fb9398fc96e9aea5cbMD55TEXTTrabajo de grado.pdf.txtTrabajo de grado.pdf.txtExtracted texttext/plain102112https://repositorio.unbosque.edu.co/bitstreams/31415bca-129c-4279-be69-165b78432ae4/downloadadb48c8caa6364924a943732f4feb923MD56THUMBNAILTrabajo de grado.pdf.jpgTrabajo de grado.pdf.jpgGenerated Thumbnailimage/jpeg3327https://repositorio.unbosque.edu.co/bitstreams/83624234-d95c-49ae-bb88-c1527f4b117a/downloadbe2f7dde325543ed5274dc6e98a204deMD5720.500.12495/12765oai:repositorio.unbosque.edu.co:20.500.12495/127652024-08-01 03:02:44.188http://creativecommons.org/licenses/by-nc-sa/4.0/Atribución-NoComercial-CompartirIgual 4.0 Internacionalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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

Caracterización clínica, patológica y molecular del cáncer colorrectal de presentación temprana en un centro de referencia de Colombia (2021-2023)

Publicaciones similares