Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia
La pandemia por SARS COV 2 resultó un punto de inflexión en diversas condiciones de salud, dentro de las cuales se encuentran las infecciones respiratorias agudas, cambiando la etiología viral común tanto en epidemiología como en severidad. Objetivos: Establecer la prevalencia de virus comunes causa...
- Autores:
-
Chaparro Arce, Diego Fernando
Li Zeng, Diana Si Hua
Camacho Moreno, Germán
Villamil, Milena
Restrepo Gualteros, Sonia María
Manrique, Juliana
Cruz, Juan
Alejo, David
Quintero, Paula
- Tipo de recurso:
- https://purl.org/coar/resource_type/c_7a1f
- Fecha de publicación:
- 2024
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/12811
- Acceso en línea:
- https://hdl.handle.net/20.500.12495/12811
- Palabra clave:
- Virus sincitial respiratorio
Influenza
Adenovirus humano
Epidemiología
Pandemias
Lactante
Preescolar
Respiratory syncytial virus
Influenza
Human Adenovirus
Epidemiology
Pandemic
Infant
Preschool
WS 100
- Rights
- License
- Attribution-NonCommercial-NoDerivatives 4.0 International
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Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia |
| dc.title.translated.none.fl_str_mv |
Epidemiological behavior of respiratory viruses in children under 5 years of age from 2019 to 2022 in a pediatric referral institution |
| title |
Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia |
| spellingShingle |
Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia Virus sincitial respiratorio Influenza Adenovirus humano Epidemiología Pandemias Lactante Preescolar Respiratory syncytial virus Influenza Human Adenovirus Epidemiology Pandemic Infant Preschool WS 100 |
| title_short |
Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia |
| title_full |
Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia |
| title_fullStr |
Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia |
| title_full_unstemmed |
Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia |
| title_sort |
Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referencia |
| dc.creator.fl_str_mv |
Chaparro Arce, Diego Fernando Li Zeng, Diana Si Hua Camacho Moreno, Germán Villamil, Milena Restrepo Gualteros, Sonia María Manrique, Juliana Cruz, Juan Alejo, David Quintero, Paula |
| dc.contributor.advisor.none.fl_str_mv |
Restrepo Gualteros, Sonia María Villamil, Milena Báez Camacho, Martha |
| dc.contributor.author.none.fl_str_mv |
Chaparro Arce, Diego Fernando Li Zeng, Diana Si Hua Camacho Moreno, Germán Villamil, Milena Restrepo Gualteros, Sonia María Manrique, Juliana Cruz, Juan Alejo, David Quintero, Paula |
| dc.contributor.orcid.none.fl_str_mv |
Chaparro Arce, Diego Fernando [0000-0002-1064-9191] Li Zeng, Diana Si Hua [0000-0001-8562-4960] Camacho Moreno, Germán [0000-0003-0472-798X] Villamil, Milena [0000-0002-5454-5984] Restrepo Gualteros, Sonia María [0000-0003-3870-4102] Manrique, Juliana [0009-0001-8282-8893] Cruz, Juan [0009-0000-7443-9153] Alejo, David [0009-0000-0434-0588] Quintero, Paula [0009-0002-3826-707X] |
| dc.subject.none.fl_str_mv |
Virus sincitial respiratorio Influenza Adenovirus humano Epidemiología Pandemias Lactante Preescolar |
| topic |
Virus sincitial respiratorio Influenza Adenovirus humano Epidemiología Pandemias Lactante Preescolar Respiratory syncytial virus Influenza Human Adenovirus Epidemiology Pandemic Infant Preschool WS 100 |
| dc.subject.keywords.none.fl_str_mv |
Respiratory syncytial virus Influenza Human Adenovirus Epidemiology Pandemic Infant Preschool |
| dc.subject.nlm.none.fl_str_mv |
WS 100 |
| description |
La pandemia por SARS COV 2 resultó un punto de inflexión en diversas condiciones de salud, dentro de las cuales se encuentran las infecciones respiratorias agudas, cambiando la etiología viral común tanto en epidemiología como en severidad. Objetivos: Establecer la prevalencia de virus comunes causantes de síntomas respiratorios en menores de 5 años, determinar coinfección viral y comportamiento a través del tiempo de cada virus común (VSR, ADV e Influenza), en un hospital pediátrico de referencia durante el periodo de 2019 a 2022. Resultados: Se obtuvieron datos de 21.688 de menores de 5 años con síntomas respiratorios a quienes se les tomó antígeno respiratorio o FilmArray, entre los años 2019 a 2022. Predominio de sexo masculino 56,4%, prueba de antígeno 96,53% con evidencia de aumento de requerimiento de toma de FilmArray a través del tiempo, y una positividad general de 40,97%. No se encontraron diferencias significativas por género. ADV y VSR mostraron predominancia para el grupo entre 6 meses a menos de 2 años en 2019 con un cambio para 2022 predominando entre los 2 años a 5 años; Influenza mantuvo predominancia a través del tiempo entre los 2 y los 5 años. Variaciones estadísticamente significativas. Por otro lado, tanto la positividad para un virus como para dos concomitantes se mantuvo predominantemente entres los 6 meses y los dos años, sin embargo, para 2022 la predominancia se vio entre los 2 y los 5 años, con valor estadísticamente significativo. Discusión y conclusiones: Las medidas implementadas en el aislamiento por SARS COV 2 influyeron en las dinámicas de los virus respiratorios comunes, representado en la disminución de la positividad durante el aislamiento y el aumento considerable posterior a la reapertura de los colegios, comportamiento que se evidenció en diferentes países con fluctuaciones similares. Es necesario evaluar los cambios en la inmunidad y la posibilidad interacciones virales que influyan en las nuevas presentaciones clínicas reportadas en la literatura. |
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2024 |
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2024-08-02T20:29:20Z |
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2024-08-02T20:29:20Z |
| dc.date.issued.none.fl_str_mv |
2024-07 |
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Tesis/Trabajo de grado - Monografía - Especialización |
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Wiese AD, Everson J, Grijalva CG. Social Distancing Measures: Evidence of Interruption of Seasonal Influenza Activity and Early Lessons of the SARS-CoV-2 Pandemic. Vol. 73, Clinical Infectious Diseases. Oxford University Press; 2021. p. E141–3. Oster Y, Michael-Gayego A, Rivkin M, Levinson L, Wolf DG, Nir-Paz R. Decreased prevalence rate of respiratory pathogens in hospitalized patients during the COVID-19 pandemic: possible role for public health containment measures? Vol. 27, Clinical Microbiology and Infection. Elsevier B.V.; 2021. p. 811–2. Nagakumar P, Chadwick CL, Bush A, Gupta A, Bush abush A. Collateral impact of COVID-19: why should children continue to suffer? Eur J Pediatr [Internet]. 2021;180:1975–9. Available from: https://doi.org/10.1007/s00431-021-03963-x Van Brusselen D, De Troeyer K, ter Haar E, Vander Auwera A, Poschet K, Van Nuijs S, et al. Bronchiolitis in COVID-19 times: a nearly absent disease? Eur J Pediatr [Internet]. 2021;180:1969–73. Available from: https://www.cdc.gov/coronavirus/2019-ncov/more/ Sullivan1 SG, Carlson2 S, Cheng AC, Chilver5 MB, Dwyer6 DE, Irwin7 M, et al. Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia,March to September 2020 [Internet]. 2020. Available from: www.eurosurveillance.org Maglione M, Pascarella A, Botti C, Ricci G, Morelli F, Camelia F, et al. Changing Epidemiology of Acute Viral Respiratory Infections in Hospitalized Children: The Post-Lockdown Effect. Children. 2022 Aug 1;9(8). Hsu HT, Huang FL, Ting PJ, Chang CC, Chen PY. The epidemiological features of pediatric viral respiratory infection during the COVID-19 pandemic in Taiwan. Journal of Microbiology, Immunology and Infection. 2022 Dec 1;55(6):1101–7. Zarur-Torralvo S, Stand-Niño I, Flórez-García V, Mendoza H, Viana-Cárdenas E. Viruses responsible for acute respiratory infections before (2016–2019) and during (2021) circulation of the SARS-CoV-2 virus in pediatric patients in a reference center at Barranquilla Colombia: A pattern analysis. J Med Virol. 2023 Jan 1;95(1). Ye Q, Liu H. Impact of non-pharmaceutical interventions during the COVID-19 pandemic on common childhood respiratory viruses – A epidemiological study based on hospital data. Microbes Infect. 2022 Feb 1;24(1). Grochowska M, Ambrożej D, Wachnik A, Demkow U, Podsiadły E, Feleszko W. The Impact of the COVID-19 Pandemic Lockdown on Pediatric Infections—A Single-Center Retrospective Study. Microorganisms. 2022 Jan 1;10(1). Torres-Fernandez D, Casellas A, Mellado MJ, Calvo C, Bassat Q. Acute bronchiolitis and respiratory syncytial virus seasonal transmission during the COVID-19 pandemic in Spain: A national perspective from the pediatric Spanish Society (AEP). Journal of Clinical Virology. 2021 Dec 1;145. Park S, Michelow IC, Choe YJ. Shifting patterns of respiratory virus activity following social distancing measures for COVID-19 in South Korea. Horemheb-Rubio G, Eggeling R, Schmeiβer N, Pfeifer N, Lengauer T, Gärtner BC, et al. Respiratory viruses dynamics and interactions: ten years of surveillance in central Europe. BMC Public Health. 2022 Dec 1;22(1). Lin CX, Lian H Bin, Lin GY, Zhang DG, Cai XY, Cai ZW, et al. Pathogen spectrum changes of respiratory tract infections in children in Chaoshan area under the influence of COVID-19. Epidemiol Infect. 2021. Dagan R, van der Beek BA, Ben-Shimol S, Greenberg D, Shemer-Avni Y, Weinberger DM, et al. The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study. EBioMedicine. 2023 Apr;90:104493. Danino D, Ben-Shimol S, Adriaan Van Der Beek B, Givon-Lavi N, Avni YS, Greenberg D, et al. Decline in Pneumococcal Disease in Young Children during the COVID-19 Pandemic in Israel Associated with Suppression of seasonal Respiratory Viruses, despite Persistent Pneumococcal Carriage: A Prospective Cohort Study. Clin Infect Dis. 2022;75(1):1154–64. Gutierrez-Tobar IF, Beltran-Arroyave C, Díaz A, Londoño JP, Jimenez KL, Zamora CG, et al. Adenovirus Respiratory Infections Post Pandemic in Colombia: An Old Enemy With Increased Severity in Pediatric Population? Vol. 42, Pediatric Infectious Disease Journal. Lippincott Williams and Wilkins; 2023. p. E133–4. Ye Q, Wang D. Epidemiological changes of common respiratory viruses in children during the COVID-19 pandemic. J Med Virol. 2022 May 1;94(5):1990–7. Wang F, Zhu R, Qian Y, Sun Y, Chen D, Wang F, et al. The changed endemic pattern of human adenovirus from species B to C among pediatric patients under the pressure of non-pharmaceutical interventions against COVID-19 in Beijing, China. Virol J. 2023 Dec 1;20(1). Chen Y, Lin T, Wang CB, Liang WL, Lian GW, Zanin M, et al. Human adenovirus (HAdV) infection in children with acute respiratory tract infections in Guangzhou, China, 2010–2021: a molecular epidemiology study. World Journal of Pediatrics. 2022 Aug 1;18(8):545–52. Wang H, Zheng Y, de Jonge MI, Wang R, Verhagen LM, Chen Y, et al. Lockdown measures during the COVID-19 pandemic strongly impacted the circulation of respiratory pathogens in Southern China. Sci Rep. 2022 Dec 1;12(1). Kim D, Hwang N, Ham J, Song K, Lee N. Changes in the Distribution of Respiratory Microorganisms before and during the COVID-19 Pandemic, Daegu, Korea. Clin Lab. 2022;68(02/2022). Alaib H, Algariri N, Ahmed H, Bebars A, Alamri F, Durmush R, et al. Frequency and Seasonal Variations of Viruses Causing Respiratory Tract Infections in Children Pre- and Post-COVID-19 Pandemic in Riyadh (2017–2022). Cureus. 2023 Jan 7. Eisen AKA, Gularte JS, Demoliner M, de Abreu Goés Pereira VM, Heldt FH, Filippi M, et al. Low circulation of Influenza A and coinfection with SARS-CoV-2 among other respiratory viruses during the COVID-19 pandemic in a region of southern Brazil. J Med Virol. 2021 Jul 1;93(7):4392–8. |
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Restrepo Gualteros, Sonia MaríaVillamil, MilenaBáez Camacho, MarthaChaparro Arce, Diego FernandoLi Zeng, Diana Si HuaCamacho Moreno, GermánVillamil, MilenaRestrepo Gualteros, Sonia MaríaManrique, JulianaCruz, JuanAlejo, DavidQuintero, PaulaChaparro Arce, Diego Fernando [0000-0002-1064-9191]Li Zeng, Diana Si Hua [0000-0001-8562-4960]Camacho Moreno, Germán [0000-0003-0472-798X]Villamil, Milena [0000-0002-5454-5984]Restrepo Gualteros, Sonia María [0000-0003-3870-4102]Manrique, Juliana [0009-0001-8282-8893]Cruz, Juan [0009-0000-7443-9153]Alejo, David [0009-0000-0434-0588]Quintero, Paula [0009-0002-3826-707X]2024-08-02T20:29:20Z2024-08-02T20:29:20Z2024-07https://hdl.handle.net/20.500.12495/12811instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coLa pandemia por SARS COV 2 resultó un punto de inflexión en diversas condiciones de salud, dentro de las cuales se encuentran las infecciones respiratorias agudas, cambiando la etiología viral común tanto en epidemiología como en severidad. Objetivos: Establecer la prevalencia de virus comunes causantes de síntomas respiratorios en menores de 5 años, determinar coinfección viral y comportamiento a través del tiempo de cada virus común (VSR, ADV e Influenza), en un hospital pediátrico de referencia durante el periodo de 2019 a 2022. Resultados: Se obtuvieron datos de 21.688 de menores de 5 años con síntomas respiratorios a quienes se les tomó antígeno respiratorio o FilmArray, entre los años 2019 a 2022. Predominio de sexo masculino 56,4%, prueba de antígeno 96,53% con evidencia de aumento de requerimiento de toma de FilmArray a través del tiempo, y una positividad general de 40,97%. No se encontraron diferencias significativas por género. ADV y VSR mostraron predominancia para el grupo entre 6 meses a menos de 2 años en 2019 con un cambio para 2022 predominando entre los 2 años a 5 años; Influenza mantuvo predominancia a través del tiempo entre los 2 y los 5 años. Variaciones estadísticamente significativas. Por otro lado, tanto la positividad para un virus como para dos concomitantes se mantuvo predominantemente entres los 6 meses y los dos años, sin embargo, para 2022 la predominancia se vio entre los 2 y los 5 años, con valor estadísticamente significativo. Discusión y conclusiones: Las medidas implementadas en el aislamiento por SARS COV 2 influyeron en las dinámicas de los virus respiratorios comunes, representado en la disminución de la positividad durante el aislamiento y el aumento considerable posterior a la reapertura de los colegios, comportamiento que se evidenció en diferentes países con fluctuaciones similares. Es necesario evaluar los cambios en la inmunidad y la posibilidad interacciones virales que influyan en las nuevas presentaciones clínicas reportadas en la literatura.Universidad Nacional de ColombiaFundación Hospital Pediátrico la MisericordiaEspecialista en PediatríaEspecializaciónThe SARS COV 2 pandemic was a turning point in several health conditions, including acute respiratory infections, changing the common viral etiology both in epidemiology and severity. Objectives: To establish the prevalence of common viruses causing respiratory symptoms in children under 5 years of age, determine viral coinfection and behavior over time of each common virus (RSV, ADV and Influenza), in a pediatric referral hospital during the period from 2019 to 2022. Results: Data were obtained from 21,688 children under 5 years of age with respiratory symptoms who underwent respiratory antigen or FilmArray testing between 2019 and 2022. Predominance of male sex 56.4%, antigen test 96.53% with evidence of increasing requirement for FilmArray taking over time, and an overall positivity of 40.97%. No significant differences were found by gender. ADV and RSV showed predominance for the group between 6 months to less than 2 years in 2019 with a shift by 2022 predominating between 2 years to 5 years; Influenza maintained predominance over time between 2 and 5 years. Statistically significant variations. On the other hand, both positivity for one virus and two concomitants remained predominant between 6 months and 2 years, however, by 2022 predominance was seen between 2 and 5 years, with statistically significant value. Discussion and conclusions: The measures implemented in isolation for SARS COV 2 influenced the dynamics of common respiratory viruses, represented in the decrease of positivity during isolation and the considerable increase after the reopening of schools, behavior that was evidenced in different countries with similar fluctuations. It is necessary to evaluate the changes in immunity and the possibility of viral interactions that influence the new clinical presentations reported in the literature.application/pdfAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2Virus sincitial respiratorioInfluenzaAdenovirus humanoEpidemiologíaPandemiasLactantePreescolarRespiratory syncytial virusInfluenzaHuman AdenovirusEpidemiologyPandemicInfantPreschoolWS 100Comportamiento epidemiológico de virus respiratorios, en menores de 5 Años entre 2019 A 2022, en una institución pediátrica de referenciaEpidemiological behavior of respiratory viruses in children under 5 years of age from 2019 to 2022 in a pediatric referral institutionEspecialización en PediatríaUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aaWiese AD, Everson J, Grijalva CG. Social Distancing Measures: Evidence of Interruption of Seasonal Influenza Activity and Early Lessons of the SARS-CoV-2 Pandemic. Vol. 73, Clinical Infectious Diseases. Oxford University Press; 2021. p. E141–3.Oster Y, Michael-Gayego A, Rivkin M, Levinson L, Wolf DG, Nir-Paz R. Decreased prevalence rate of respiratory pathogens in hospitalized patients during the COVID-19 pandemic: possible role for public health containment measures? Vol. 27, Clinical Microbiology and Infection. Elsevier B.V.; 2021. p. 811–2.Nagakumar P, Chadwick CL, Bush A, Gupta A, Bush abush A. Collateral impact of COVID-19: why should children continue to suffer? Eur J Pediatr [Internet]. 2021;180:1975–9. Available from: https://doi.org/10.1007/s00431-021-03963-xVan Brusselen D, De Troeyer K, ter Haar E, Vander Auwera A, Poschet K, Van Nuijs S, et al. Bronchiolitis in COVID-19 times: a nearly absent disease? Eur J Pediatr [Internet]. 2021;180:1969–73. Available from: https://www.cdc.gov/coronavirus/2019-ncov/more/Sullivan1 SG, Carlson2 S, Cheng AC, Chilver5 MB, Dwyer6 DE, Irwin7 M, et al. Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia,March to September 2020 [Internet]. 2020. Available from: www.eurosurveillance.orgMaglione M, Pascarella A, Botti C, Ricci G, Morelli F, Camelia F, et al. Changing Epidemiology of Acute Viral Respiratory Infections in Hospitalized Children: The Post-Lockdown Effect. Children. 2022 Aug 1;9(8).Hsu HT, Huang FL, Ting PJ, Chang CC, Chen PY. The epidemiological features of pediatric viral respiratory infection during the COVID-19 pandemic in Taiwan. Journal of Microbiology, Immunology and Infection. 2022 Dec 1;55(6):1101–7.Zarur-Torralvo S, Stand-Niño I, Flórez-García V, Mendoza H, Viana-Cárdenas E. Viruses responsible for acute respiratory infections before (2016–2019) and during (2021) circulation of the SARS-CoV-2 virus in pediatric patients in a reference center at Barranquilla Colombia: A pattern analysis. J Med Virol. 2023 Jan 1;95(1).Ye Q, Liu H. Impact of non-pharmaceutical interventions during the COVID-19 pandemic on common childhood respiratory viruses – A epidemiological study based on hospital data. Microbes Infect. 2022 Feb 1;24(1).Grochowska M, Ambrożej D, Wachnik A, Demkow U, Podsiadły E, Feleszko W. The Impact of the COVID-19 Pandemic Lockdown on Pediatric Infections—A Single-Center Retrospective Study. Microorganisms. 2022 Jan 1;10(1).Torres-Fernandez D, Casellas A, Mellado MJ, Calvo C, Bassat Q. Acute bronchiolitis and respiratory syncytial virus seasonal transmission during the COVID-19 pandemic in Spain: A national perspective from the pediatric Spanish Society (AEP). Journal of Clinical Virology. 2021 Dec 1;145.Park S, Michelow IC, Choe YJ. Shifting patterns of respiratory virus activity following social distancing measures for COVID-19 in South Korea.Horemheb-Rubio G, Eggeling R, Schmeiβer N, Pfeifer N, Lengauer T, Gärtner BC, et al. Respiratory viruses dynamics and interactions: ten years of surveillance in central Europe. BMC Public Health. 2022 Dec 1;22(1).Lin CX, Lian H Bin, Lin GY, Zhang DG, Cai XY, Cai ZW, et al. Pathogen spectrum changes of respiratory tract infections in children in Chaoshan area under the influence of COVID-19. Epidemiol Infect. 2021.Dagan R, van der Beek BA, Ben-Shimol S, Greenberg D, Shemer-Avni Y, Weinberger DM, et al. The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study. EBioMedicine. 2023 Apr;90:104493.Danino D, Ben-Shimol S, Adriaan Van Der Beek B, Givon-Lavi N, Avni YS, Greenberg D, et al. 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