Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia

The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strai...

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Autores:
Correa, Adriana
del Campo, Rosa
Perenguez, Marcela
Blanco, Victor M.
Rodríguez-Baños, Mercedes
Perez, Federico
Maya, Juan J.
Rojas, Laura
Cantón, Rafael
Arias, Cesar A.
Villegas, María Virginia
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3720
Acceso en línea:
http://hdl.handle.net/20.500.12495/3720
https://doi.org/10.1128/AAC.03926-14
https://repositorio.unbosque.edu.co
Palabra clave:
Infecciones por pseudomonas
Farmacorresistencia bacteriana
Colombia
Rights
openAccess
License
Acceso abierto
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dc.title.spa.fl_str_mv Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
dc.title.translated.spa.fl_str_mv Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
title Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
spellingShingle Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
Infecciones por pseudomonas
Farmacorresistencia bacteriana
Colombia
title_short Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
title_full Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
title_fullStr Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
title_full_unstemmed Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
title_sort Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia
dc.creator.fl_str_mv Correa, Adriana
del Campo, Rosa
Perenguez, Marcela
Blanco, Victor M.
Rodríguez-Baños, Mercedes
Perez, Federico
Maya, Juan J.
Rojas, Laura
Cantón, Rafael
Arias, Cesar A.
Villegas, María Virginia
dc.contributor.author.none.fl_str_mv Correa, Adriana
del Campo, Rosa
Perenguez, Marcela
Blanco, Victor M.
Rodríguez-Baños, Mercedes
Perez, Federico
Maya, Juan J.
Rojas, Laura
Cantón, Rafael
Arias, Cesar A.
Villegas, María Virginia
dc.contributor.orcid.none.fl_str_mv Villegas, María Virginia [0000-0003-1898-9067]
dc.subject.decs.spa.fl_str_mv Infecciones por pseudomonas
Farmacorresistencia bacteriana
Colombia
topic Infecciones por pseudomonas
Farmacorresistencia bacteriana
Colombia
description The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2 on a class 1 integron and blaKPC-2 on a Tn4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-06T19:35:16Z
dc.date.available.none.fl_str_mv 2020-08-06T19:35:16Z
dc.date.issued.none.fl_str_mv 2020
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 0066-4804
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dc.identifier.doi.none.fl_str_mv https://doi.org/10.1128/AAC.03926-14
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
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identifier_str_mv 0066-4804
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
url http://hdl.handle.net/20.500.12495/3720
https://doi.org/10.1128/AAC.03926-14
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Antimicrobial agents and chemotherapy, 0066-4804, Vol. 59, Nro. 4, p. 2421-2425
dc.relation.uri.none.fl_str_mv https://aac.asm.org/content/59/4/2421.long
dc.rights.local.spa.fl_str_mv Acceso abierto
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dc.rights.creativecommons.none.fl_str_mv 2015-04
rights_invalid_str_mv Acceso abierto
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2015-04
eu_rights_str_mv openAccess
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dc.publisher.spa.fl_str_mv American Society for Microbiology
dc.publisher.journal.spa.fl_str_mv Antimicrobial agents and chemotherapy
institution Universidad El Bosque
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spelling Correa, Adrianadel Campo, RosaPerenguez, MarcelaBlanco, Victor M.Rodríguez-Baños, MercedesPerez, FedericoMaya, Juan J.Rojas, LauraCantón, RafaelArias, Cesar A.Villegas, María VirginiaVillegas, María Virginia [0000-0003-1898-9067]2020-08-06T19:35:16Z2020-08-06T19:35:16Z20200066-4804http://hdl.handle.net/20.500.12495/3720https://doi.org/10.1128/AAC.03926-14instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengAmerican Society for MicrobiologyAntimicrobial agents and chemotherapyAntimicrobial agents and chemotherapy, 0066-4804, Vol. 59, Nro. 4, p. 2421-2425https://aac.asm.org/content/59/4/2421.longDissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in ColombiaDissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in ColombiaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Infecciones por pseudomonasFarmacorresistencia bacterianaColombiaThe ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2 on a class 1 integron and blaKPC-2 on a Tn4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2015-04LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/621ad2d8-650d-4132-9a6e-f9cbe8d8d539/download8a4605be74aa9ea9d79846c1fba20a33MD52ORIGINALCorrea, Adriana.pdfCorrea, Adriana.pdfapplication/pdf186855https://repositorio.unbosque.edu.co/bitstreams/9243efc1-e82e-4f1d-9751-d64510c8ccfb/download5c5efb1f095da824a267b2a76424b167MD51THUMBNAILCorrea, Adriana.pdf.jpgCorrea, Adriana.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/e4568ea3-f245-4e95-be9b-b0cff65c761e/download7210a811635d1799e7c05fee5d259be7MD53TEXTCorrea, Adriana.pdf.txtCorrea, Adriana.pdf.txtExtracted texttext/plain34514https://repositorio.unbosque.edu.co/bitstreams/afa52974-2905-4f19-877d-d676686938b1/download15954e8ef321031f35e05cfad0f12031MD5420.500.12495/3720oai:repositorio.unbosque.edu.co:20.500.12495/37202024-02-07 00:40:55.858restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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