Dissemination of high-risk clones of extensively drug-resistant pseudomonas aeruginosa in Colombia

The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strai...

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Autores:
Correa, Adriana
del Campo, Rosa
Perenguez, Marcela
Blanco, Victor M.
Rodríguez-Baños, Mercedes
Perez, Federico
Maya, Juan J.
Rojas, Laura
Cantón, Rafael
Arias, Cesar A.
Villegas, María Virginia
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3720
Acceso en línea:
http://hdl.handle.net/20.500.12495/3720
https://doi.org/10.1128/AAC.03926-14
https://repositorio.unbosque.edu.co
Palabra clave:
Infecciones por pseudomonas
Farmacorresistencia bacteriana
Colombia
Rights
openAccess
License
Acceso abierto
Description
Summary:The ability of Pseudomonas aeruginosa to develop resistance to most antimicrobials represents an important clinical threat worldwide. We report the dissemination in several Colombian hospitals of two predominant lineages of extensively drug-resistant (XDR) carbapenemase-producing P. aeruginosa strains. These lineages belong to the high-risk clones sequence type 111 (ST111) and ST235 and harbor blaVIM-2 on a class 1 integron and blaKPC-2 on a Tn4401 transposon, respectively. Additionally, P. aeruginosa ST1492, a novel single-locus variant of ST111, was identified. Clonal dissemination and the presence of mobile genetic elements likely explain the successful spread of XDR P. aeruginosa strains in Colombia.