Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam

El objetivo de esta monografía fue brindar la información necesaria para comprender e identificar la ectasia corneal postquirúrgica refractiva y su progresión mediante el Pentacam. Esta monografía se basó en la investigación bibliográfica en bases de datos en idioma inglés, español, portugués y ruso...

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Autores:
Bueno Monterrosa, Ricardo de Jesús
Gutiérrez Torres, Ruby Nohelia
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2024
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/13007
Acceso en línea:
https://hdl.handle.net/20.500.12495/13007
Palabra clave:
Queratocono
Procedimientos Quirúrgicos Refractivos
Tomografía
Córnea
Progresión de la Enfermedad
WW704
Keratoconus
Refractive Surgical Procedures
Tomography
Cornea
Disease Progression
Rights
License
Attribution 4.0 International
id UNBOSQUE2_6b9f42c2410422c2b7197bfe66ccbd97
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/13007
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.none.fl_str_mv Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
dc.title.translated.none.fl_str_mv Measurement of the progression of post-surgical corneal ectasias using the Pentacam tomograph
title Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
spellingShingle Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
Queratocono
Procedimientos Quirúrgicos Refractivos
Tomografía
Córnea
Progresión de la Enfermedad
WW704
Keratoconus
Refractive Surgical Procedures
Tomography
Cornea
Disease Progression
title_short Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
title_full Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
title_fullStr Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
title_full_unstemmed Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
title_sort Medición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo Pentacam
dc.creator.fl_str_mv Bueno Monterrosa, Ricardo de Jesús
Gutiérrez Torres, Ruby Nohelia
dc.contributor.advisor.none.fl_str_mv García Lozada, Diana
Carrizosa Murcia, Marcelo
dc.contributor.author.none.fl_str_mv Bueno Monterrosa, Ricardo de Jesús
Gutiérrez Torres, Ruby Nohelia
dc.subject.none.fl_str_mv Queratocono
Procedimientos Quirúrgicos Refractivos
Tomografía
Córnea
Progresión de la Enfermedad
topic Queratocono
Procedimientos Quirúrgicos Refractivos
Tomografía
Córnea
Progresión de la Enfermedad
WW704
Keratoconus
Refractive Surgical Procedures
Tomography
Cornea
Disease Progression
dc.subject.ddc.none.fl_str_mv WW704
dc.subject.keywords.none.fl_str_mv Keratoconus
Refractive Surgical Procedures
Tomography
Cornea
Disease Progression
description El objetivo de esta monografía fue brindar la información necesaria para comprender e identificar la ectasia corneal postquirúrgica refractiva y su progresión mediante el Pentacam. Esta monografía se basó en la investigación bibliográfica en bases de datos en idioma inglés, español, portugués y ruso utilizando tesauros, operadores booleanos y truncadores como estrategia de búsqueda. Se definió la progresión de la ectasia como un cambio constante de al menos dos parámetros como el empinamiento de la superficie corneal anterior, la posterior o el adelgazamiento y/o aumento en la tasa de cambio del espesor corneal. La ectasia corneal postquirúrgica se define como un encorvamiento en topografía de 5 D o más en comparación con el aspecto postoperatorio, pérdida de ≥ 2 líneas de Snellen de agudeza visual no corregida y un cambio en la refracción de ≥ 2 D en esfera o cilindro. Se ha descrito una incidencia variable del 0,04%, del 0,2% o del 0,66%. La miopía alta (> -8.00 D), las córneas delgadas (< 500 µm), el queratocono preexistente, antecedentes alérgicos, traumatismos oculares y frotamiento de ojo se encontraron como factores de riesgo. Se señalaron parámetros e índices de Pentacam, así como la pantalla ABCD para la progresión de la ectasia corneal. La pantalla de progresión ABCD permite la comparación de diferentes tomas a lo largo del tiempo, resaltando cambios en la cara anterior y posterior, paquimetría y agudeza visual con respecto a la población normativa y queratocónica.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-09-20T19:34:27Z
dc.date.available.none.fl_str_mv 2024-09-20T19:34:27Z
dc.date.issued.none.fl_str_mv 2024-08
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Pregrado
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dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12495/13007
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
url https://hdl.handle.net/20.500.12495/13007
identifier_str_mv instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
dc.language.iso.fl_str_mv spa
language spa
dc.relation.references.none.fl_str_mv 1. Tabbara KF, Kotb AA. Risk factors for corneal ectasia after LASIK. Ophthalmology [Internet]. 2006;113(9):1618–22. Available from: https://www.sciencedirect.com/science/article/pii/S0161642006004593
2. Mas Tur V, MacGregor C, Jayaswal R, O’Brart D, Maycock N. A review of keratoconus: Diagnosis, pathophysiology, and genetics. Surv Ophthalmol [Internet]. 2017;62(6):770–83. Available from: https://www.sciencedirect.com/science/article/pii/S0039625717300462
3. Margines J Ben, Rabinowitz YS, Li X, Gaster RN. Results of corneal collagen cross-linking in patients with corneal ectasia after laser refractive surgery—A prospective study. Photodiagnosis Photodyn Ther [Internet]. 2023;42:103521. Available from: https://www.sciencedirect.com/science/article/pii/S1572100023002491
4. Wang YC, Zolnik OB, Yasuda S, Yeh LK, Yuan Y, Kao W, et al. Transforming growth factor beta receptor 2 (Tgfbr2) deficiency in keratocytes results in corneal ectasia. Ocul Surf [Internet]. 2023;29:557–65. Available from: https://www.sciencedirect.com/science/article/pii/S1542012423000848
5. Barraquer-Coll C, Barrera RE., Molano N. Prevalencia de pacientes con queratocono en la Clínica Barraquer en Bogotá, Colombia. Bogotá; 2020.
6. Liu YC, Konstantopoulos A, Riau AK, Bhayani R, Lwin NC, Teo EPW, et al. Repeatability and reproducibility of corneal biometric measurements using the visante omni and a rabbit experimental model of post-surgical corneal ectasia. Transl Vis Sci Technol [Internet]. 2015 Apr 28;4(2):16. Available from: https://doi.org/10.1167/tvst.4.2.16
7. Moshirfar M, Stoakes IM, Bruce EG, Ali A, Payne CJ, Furhiman D, et al. Allogenic lenticular implantation for correction of refractive error and ectasia: narrative review. Ophthalmol Ther [Internet]. 2023;12(5):2361–79. Available from: https://doi.org/10.1007/s40123-023-00765-2
8. Lo ACQ, Lo CCW. The association between keratoconus and the risk factors of eye rubbing, atopy and other allergic diseases (conjunctivitis, rhinitis, asthma and eczema): a meta-analysis. Int Ophthalmol [Internet]. 2023;43(5):1451–2. Available from: https://www.embase.com/search/results?subaction=viewrecord&id=L2019180063&from=export
9. Naderan M, Jahanrad A, Farjadnia M. Clinical biomicroscopy and retinoscopy findings of keratoconus in a Middle Eastern population. Clin Exp Optom [Internet]. 2018 Jan 1;101(1):46–51. Available from: https://doi.org/10.1111/cxo.12579
10. Villa C, Santodomingo J. La córnea. Parte I.: Estructura, función y anatomía microscópica. In 2010. Available from: https://api.semanticscholar.org/CorpusID:17204914430
11. Sridhar, Mittanamalli S. Anatomy of cornea and ocular surface. Indian J Ophthalmol [Internet]. 2018;66(2). Available from: https://journals.lww.com/ijo/fulltext/2018/66020/anatomy_of_cornea_and_ocular_surface.4.a spx
12. Falgayrettes N, Patoor E, Cleymand F, Zevering Y, Perone JM. Biomechanics of keratoconus: Two numerical studies. Riveiro Rodríguez A, editor. PLoS One [Internet]. 2023 Feb 2 [cited 2024 May 19];18(2):e0278455. Available from: https://dx.plos.org/10.1371/journal.pone.0278455
13. Marfurt CF, Cox J, Deek S, Dvorscak L. Anatomy of the human corneal innervation. Exp Eye Res [Internet]. 2010;90(4):478–92. Available from: https://www.sciencedirect.com/science/article/pii/S0014483509003571
14. Dubbelman M, Sicam VADP, Van der Heijde GL. The shape of the anterior and posterior surface of the aging human cornea. Vision Res [Internet]. 2006;46(6):993–1001. Available from: https://www.sciencedirect.com/science/article/pii/S0042698905004906
15. Martin R. Cornea and anterior eye assessment with placido-disc keratoscopy, slit scanning evaluation topography and scheimpflug imaging tomography. Indian J Ophthalmol [Internet]. 2018;66(3). Available from: https://journals.lww.com/ijo/fulltext/2018/66030/cornea_and_anterior_eye_assessment_with. 4.aspx
16. Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol [Internet]. 1984 Jan 1;28(4):293–322. Available from: https://doi.org/10.1016/0039-6257(84)90094-8
17. Gomes JAP, Tan D, Rapuano CJ, Belin MW, Ambrósio RJ, Guell JL, et al. Global consensus on keratoconus and ectatic diseases. Cornea [Internet]. 2015;34(4). Available from: https://journals.lww.com/corneajrnl/fulltext/2015/04000/global_consensus_on_keratoconus_a nd_ectatic.1.aspx
18. Xu L, Wang YX, Guo Y, You QS, Jonas JB, Group the BES. Prevalence and Associations of Steep Cornea/Keratoconus in Greater Beijing. The Beijing Eye Study. Yu FS, editor. PLoS One [Internet]. 2012 Jul 6 [cited 2024 Apr 28];7(7):e39313. Available from: https://dx.plos.org/10.1371/journal.pone.0039313
19. Grzybowski A, Mcghee CN. The early history of keratoconus prior to Nottingham’s landmark 1854 treatise on conical cornea: a review. Clin Exp Optom [Internet]. 2013 Mar 1;96(2):140–5. Available from: https://doi.org/10.1111/cxo.12035
20. Santodomingo-Rubido J, Carracedo G, Suzaki A, Villa-Collar C, Vincent SJ, Wolffsohn JS. Keratoconus: An updated review. Contact Lens and Anterior Eye [Internet]. 2022;45(3):101559. Available from: https://www.sciencedirect.com/science/article/pii/S1367048421002058
21. Sánchez V, Lincoln S, Álvarez P, Benavides P, Sánchez R, Zambrano D. El queratocono, su diagnóstico y manejo. Una revisión bibliográfica. Enfermería Investiga [Internet]. 2018 Sep 1;3(1 Sup):1–8. Available from: https://revistas.uta.edu.ec/erevista/index.php/enfi/article/view/423
22. Lopes BT, Ramos IC, Dawson DG, Belin MW, Ambrósio R. Detection of ectatic corneal diseases based on pentacam. Z Med Phys [Internet]. 2016;26(2):136–42. Available from: https://www.sciencedirect.com/science/article/pii/S0939388915001476
23. Wallang BS, Das S. Keratoglobus. Eye [Internet]. 2013;27(9):1004–12. Available from: https://doi.org/10.1038/eye.2013.13031
24. Koenekoop RK. An overview of leber congenital amaurosis: a model to understand human retinal development. Surv Ophthalmol [Internet]. 2004 Jul 1;49(4):379–98. Available from: https://doi.org/10.1016/j.survophthal.2004.04.003
25. Nelson ME, Talbot JF. Keratoglobus in the Rubinstein-Taybi syndrome. British Journal of Ophthalmology [Internet]. 1989 May 1;73(5):385. Available from: http://bjo.bmj.com/content/73/5/385.abstract
26. Gregoratos ND, Bartsocas CS, Papas K. Blue sclerae with keratoglobus and brittle cornea. British Journal of Ophthalmology [Internet]. 1971 Jun 1;55(6):424. Available from: http://bjo.bmj.com/content/55/6/424.abstract
27. Castro K, Zayas Y, Hernández M. Queratoglobo o ectasia corneal globular. Informe de caso. Revista Médica Electrónica de Ciego de Ávila. 2020;
28. Jacobs DS, Green WR, Maumenee AE. Acquired Keratoglobus. Am J Ophthalmol [Internet]. 1974 Mar 1;77(3):393–9. Available from: https://doi.org/10.1016/0002-9394(74)90747-8
29. Cameron JA. Keratoglobus. Cornea [Internet]. 1993;12(2). Available from: https://journals.lww.com/corneajrnl/fulltext/1993/03000/keratoglobus.6.aspx
30. Pouliquen Y, Dhermy P, Espinasse MA, Savoldelli M. Keratoglobus. J Fr Ophtalmol [Internet]. 1985;8(1):43–54. Available from: http://europepmc.org/abstract/MED/3889124
31. Hyams SW, Kar H, Neumann E. Blue sclerae and keratoglobus. Ocular signs of a systemic connective tissue disorder. British Journal of Ophthalmology [Internet]. 1969 Jan 1;53(1):53. Available from: http://bjo.bmj.com/content/53/1/53.abstract
32. Singh B, Sharma S, Bharti N, Ranjan R, Bharti S. Hypermature intumescent cataract in advanced keratoglobus. Int Med Case Rep J [Internet]. 2020 Oct 12;13(null):507–11. Available from: https://www.tandfonline.com/doi/abs/10.2147/IMCRJ.S275335
33. Sridhar MS, Mahesh S, Bansal AK, Nutheti R, Rao GN. Pellucid marginal corneal degeneration. Ophthalmology [Internet]. 2004;111(6):1102–7. Available from: https://www.sciencedirect.com/science/article/pii/S0161642004000247
34. Belin MW, Asota IM, Ambrosio Jr. R, Khachikian SS. What’s in a name: Keratoconus, pellucid marginal degeneration, and related thinning disorders. Am J Ophthalmol. 2011;152(2).
35. Basak SK, Hazra TK, Bhattacharya D, Sinha TK. Unilateral pellucid marginal degeneration. Indian J Ophthalmol. 2000;48(3):233–4.
36. Martínez-Abad A, Piñero DP. Pellucid marginal degeneration: Detection, discrimination from other corneal ectatic disorders and progression. Contact Lens and Anterior Eye [Internet]. 2019 Aug 1;42(4):341–9. Available from: https://doi.org/10.1016/j.clae.2018.11.010
37. Jinabhai A, Radhakrishnan H, O’Donnell C. Pellucid corneal marginal degeneration: A review. Contact Lens and Anterior Eye [Internet]. 2011;34(2):56–63. Available from: https://www.sciencedirect.com/science/article/pii/S1367048410001530
38. Lee BW, Jurkunas U V, Harissi-Dagher M, Poothullil AM, Tobaigy FM, Azar DT. Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol [Internet]. 2007;144(1):154-156.e3. Available from: https://www.sciencedirect.com/science/article/pii/S0002939407001985
39. Bajracharya L, Agrawal N, Dhungel S, Parajuli R, Adhikari S. A teenager with vernal keratoconjunctivitis and pellucid marginal degeneration, presenting with exotropia. Int Med Case Rep J. 2020;13:399–408.
40. Randleman JB, Russell B, Ward MA, Thompson KP, Stulting RD. Risk factors and prognosis for corneal ectasia after LASIK. Ophthalmology. 2003 Feb 1;110(2):267–75.
41. Martínez CP, Martínez JA. Capítulo 15 - Ectasias corneales posquirúrgicas. ¿La medida de la biomecánica corneal aporta algo? In: del Buey Sayas Ma Á, Martínez CP, editors. 32 Biomecánica y arquitectura corneal [Internet]. Madrid: Elsevier; 2014. p. 185–96. Available from: https://www.sciencedirect.com/science/article/pii/B9788490226490500223
42. Roy S, Yadav S, Dasgupta T, Chawla S, Tandon R, Ghosh S. Interplay between hereditary and environmental factors to establish an in vitro disease model of keratoconus. Drug Discov Today [Internet]. 2019;24(2):403–16. Available from: https://www.sciencedirect.com/science/article/pii/S1359644618301466
43. Paulina L. Estudio de secuenciación del gen miR-184 en pacientes con ectasias corneales primarias [Internet]. [Barcelona]: Universidad Autónoma de Barcelona; 2019 [cited 2023 Nov 24]. Available from: https://www.educacion.gob.es/teseo/imprimirFicheroTesis.do?idFichero=b%2BmC%2FXawJ nc%3D
44. Li X, Yang H, Rabinowitz YS. Longitudinal study of keratoconus progression. Exp Eye Res [Internet]. 2007;85(4):502–7. Available from: https://www.sciencedirect.com/science/article/pii/S0014483507001741
45. García M. Centro de ciencias de la salud departamento de optometría tesis cambios refractivos y morfológicos en pacientes con queratocono sometidos a crosslinking [Internet]. 2015 [cited 2023 Nov 24]. Available from: http://hdl.handle.net/11317/354
46. Tatar MG, Aylin Kantarci F, Yildirim A, Uslu H, Colak HN, Goker H, et al. Risk factors in post-LASIK corneal ectasia. Diakonis VF, editor. J Ophthalmol [Internet]. 2014;2014:204191. Available from: https://doi.org/10.1155/2014/204191
47. Brenner LF, Alió JL, Vega-Estrada A, Baviera J, Beltrán J, Cobo-Soriano R. Indications for intrastromal corneal ring segments in ectasia after laser in situ keratomileusis. J Cataract Refract Surg [Internet]. 2012;38(12). Available from: https://journals.lww.com/jcrs/fulltext/2012/12000/indications_for_intrastromal_corneal_ring_s egments.10.aspx
48. Moshirfar M, Tukan AN, Bundogji N, Liu HY, McCabe SE, Ronquillo YC, et al. Ectasia after corneal refractive surgery: a systematic review. Ophthalmol Ther [Internet]. 2021;10(4):753–76. Available from: https://doi.org/10.1007/s40123-021-00383-w
49. Lema I, Durán JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology [Internet]. 2005;112(4):654–9. Available from: https://www.sciencedirect.com/science/article/pii/S0161642004019189
50. Jiang Y, Li Y, Yang S, Lu TC. Tuck-in Lamellar keratoplasty with an lenticule obtained by small incision lenticule extraction for treatment of Post- LASIK Ectasia. Sci Rep [Internet]. 2017;7(1):17806. Available from: https://doi.org/10.1038/s41598-017-18201-4
51. Mahmoud MMI, Hamdy AM, Mohamed AB, Diaa El Din YA. An updated overview of keratoconus management: Review article. Egypt J Hosp Med [Internet]. 2022;88(1):2777–80. Available from: https://ejhm.journals.ekb.eg/article_241951.html
52. Ang M, Gatinel D, Reinstein DZ, Mertens E, Alió del Barrio JL, Alió JL. Refractive surgery beyond 2020. Eye [Internet]. 2021;35(2):362–82. Available from: https://doi.org/10.1038/s41433-020-1096-5
53. Avetisov SE. Radial keratotomy: History and current state. Vestn Oftalmol. 2021 Mar 1;137(2):123–31.
54. Soler F. De PRK a LASEK y de LASEK a PRK. Arch Soc Esp Oftalmol. 2003;78:239–40.
55. Naderi M, Sabour S, Khodakarim S, Daneshgar F. Studying the factors related to refractive error regression after PRK surgery. BMC Ophthalmol [Internet]. 2018;18(1):198. Available from: https://doi.org/10.1186/s12886-018-0879-y 33
56. Wallerstein A, Jackson WB, Chambers J, Moezzi AM, Lin H, Simmons PA. Management of post-LASIK dry eye: A multicenter randomized comparison of a new multi-ingredient artificial tear to carboxymethylcellulose. Clinical Ophthalmology. 2018 May 7;12:839–48.
57. Bohac M, Koncarevic M, Pasalic A, Biscevic A, Merlak M, Gabric N, et al. Incidence and clinical characteristics of post LASIK ectasia: A review of over 30,000 LASIK cases. Semin Ophthalmol [Internet]. 2018 Nov 17;33(7–8):869–77. Available from: https://doi.org/10.1080/08820538.2018.1539183
58. Zhao LQ, Wei RL, Cheng JW, Li Y, Cai JP, Ma XY. Meta-analysis: Clinical outcomes of laser-assisted subepithelial keratectomy and photorefractive keratectomy in myopia. Ophthalmology. 2010 Oct;117(10):1912–22.
59. OCULUS Pentacam [Internet]. [cited 2023 Nov 24]. Available from: https://www.pentacam.com/index.php?id=286&L=2
60. Belin MW, Villavicencio OF, Ambrósio RRJ. Tomographic parameters for the detection of keratoconus: suggestions for screening and treatment parameters. Eye Contact Lens [Internet]. 2014;40(6). Available from: https://journals.lww.com/claojournal/fulltext/2014/11000/tomographic_parameters_for_the_d etection_of.2.aspx
61. Ambrósio R, Machado AP, Leão E, Lyra JMG, Salomão MQ, Esporcatte LGP, et al. Optimized artificial intelligence for enhanced ectasia detection using Scheimpflug-based corneal tomography and biomechanical data. Am J Ophthalmol [Internet]. 2023;251:126–42. Available from: https://www.sciencedirect.com/science/article/pii/S0002939422005062
62. Orucoglu F, Toker E. Comparative analysis of anterior segment parameters in normal and keratoconus eyes generated by Scheimpflug tomography. Moshirfar MM, editor. J Ophthalmol [Internet]. 2015;2015:925414. Available from: https://doi.org/10.1155/2015/925414
63. Fan R, Chan TCY, Prakash G, Jhanji V. Applications of corneal topography and tomography: a review. Clin Exp Ophthalmol [Internet]. 2018 Mar 1;46(2):133–46. Available from: https://doi.org/10.1111/ceo.13136
64. Hashemi H, Beiranvand A, Yekta A, Maleki A, Yazdani N, Khabazkhoob M. Pentacam top indices for diagnosing subclinical and definite keratoconus. J Curr Ophthalmol [Internet]. 2016;28(1):21–6. Available from: https://www.sciencedirect.com/science/article/pii/S2452232515300160
65. Sedaghat MR, Mohammad Zadeh V, Fadakar K, Kadivar S, Abrishami M. Normative values and contralateral comparison of anterior chamber parameters measured by Pentacam and its correlation with corneal biomechanical factors. Saudi Journal of Ophthalmology [Internet]. 2017;31(1):7–10. Available from: https://www.sciencedirect.com/science/article/pii/S1319453416300728
66. OCULUS. Interpretation guide 3rd edition [Internet]. 2005. Available from: www.oculus.de
67. Belin MW, Alizadeh R, Torres-Netto EA, Hafezi F, Ambrósio R, Pajic B. Determining progression in ectatic corneal disease. Asia-Pacific Journal of Ophthalmology [Internet]. 2020;9(6):541–8. Available from: https://www.sciencedirect.com/science/article/pii/S2162098923001615
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spelling García Lozada, DianaCarrizosa Murcia, MarceloBueno Monterrosa, Ricardo de JesúsGutiérrez Torres, Ruby Nohelia2024-09-20T19:34:27Z2024-09-20T19:34:27Z2024-08https://hdl.handle.net/20.500.12495/13007instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coEl objetivo de esta monografía fue brindar la información necesaria para comprender e identificar la ectasia corneal postquirúrgica refractiva y su progresión mediante el Pentacam. Esta monografía se basó en la investigación bibliográfica en bases de datos en idioma inglés, español, portugués y ruso utilizando tesauros, operadores booleanos y truncadores como estrategia de búsqueda. Se definió la progresión de la ectasia como un cambio constante de al menos dos parámetros como el empinamiento de la superficie corneal anterior, la posterior o el adelgazamiento y/o aumento en la tasa de cambio del espesor corneal. La ectasia corneal postquirúrgica se define como un encorvamiento en topografía de 5 D o más en comparación con el aspecto postoperatorio, pérdida de ≥ 2 líneas de Snellen de agudeza visual no corregida y un cambio en la refracción de ≥ 2 D en esfera o cilindro. Se ha descrito una incidencia variable del 0,04%, del 0,2% o del 0,66%. La miopía alta (> -8.00 D), las córneas delgadas (< 500 µm), el queratocono preexistente, antecedentes alérgicos, traumatismos oculares y frotamiento de ojo se encontraron como factores de riesgo. Se señalaron parámetros e índices de Pentacam, así como la pantalla ABCD para la progresión de la ectasia corneal. La pantalla de progresión ABCD permite la comparación de diferentes tomas a lo largo del tiempo, resaltando cambios en la cara anterior y posterior, paquimetría y agudeza visual con respecto a la población normativa y queratocónica.OptómetraPregradoThe objective of this monograph was to provide the information necessary to understand and identify refractive postsurgical corneal ectasia and its progression using the Pentacam. This monograph was based on bibliographic research in databases in English, Spanish, Portuguese and Russian using thesaurus, boolean operators and truncator as a search strategy. The progression of ectasia was defined as a constant change in at least two parameters such as steepening of the anterior and posterior corneal surface or thinning and/or increase in the rate of change of corneal thickness. Postoperative corneal ectasia is defined as a curve in topography of 5 D or more compared to the postoperative appearance, loss of ≥ 2 Snellen lines of uncorrected visual acuity, and a change in refraction of ≥ 2 D in sphere or cylinder. A variable incidence of 0.04%, 0.2% or 0.66% has been described. High myopia (> -8.00 D), thin corneas (< 500 µm), preexisting keratoconus, allergic history, ocular trauma, and eye rubbing were found as risk factors. Pentacam parameters and indices were noted, as well as the ABCD display for the progression of corneal ectasia. The ABCD progression display allows comparison of different shots over time, highlighting changes in anterior and posterior aspects, pachymetry and visual acuity relative to the normative and keratoconic population.application/pdfAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2QueratoconoProcedimientos Quirúrgicos RefractivosTomografíaCórneaProgresión de la EnfermedadWW704KeratoconusRefractive Surgical ProceduresTomographyCorneaDisease ProgressionMedición de la progresión de las ectasias corneales postquirúrgicas mediante el tomógrafo PentacamMeasurement of the progression of post-surgical corneal ectasias using the Pentacam tomographOptometríaUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Pregradohttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. Tabbara KF, Kotb AA. Risk factors for corneal ectasia after LASIK. Ophthalmology [Internet]. 2006;113(9):1618–22. Available from: https://www.sciencedirect.com/science/article/pii/S01616420060045932. Mas Tur V, MacGregor C, Jayaswal R, O’Brart D, Maycock N. A review of keratoconus: Diagnosis, pathophysiology, and genetics. Surv Ophthalmol [Internet]. 2017;62(6):770–83. Available from: https://www.sciencedirect.com/science/article/pii/S00396257173004623. Margines J Ben, Rabinowitz YS, Li X, Gaster RN. Results of corneal collagen cross-linking in patients with corneal ectasia after laser refractive surgery—A prospective study. Photodiagnosis Photodyn Ther [Internet]. 2023;42:103521. Available from: https://www.sciencedirect.com/science/article/pii/S15721000230024914. Wang YC, Zolnik OB, Yasuda S, Yeh LK, Yuan Y, Kao W, et al. Transforming growth factor beta receptor 2 (Tgfbr2) deficiency in keratocytes results in corneal ectasia. Ocul Surf [Internet]. 2023;29:557–65. Available from: https://www.sciencedirect.com/science/article/pii/S15420124230008485. Barraquer-Coll C, Barrera RE., Molano N. Prevalencia de pacientes con queratocono en la Clínica Barraquer en Bogotá, Colombia. Bogotá; 2020.6. Liu YC, Konstantopoulos A, Riau AK, Bhayani R, Lwin NC, Teo EPW, et al. Repeatability and reproducibility of corneal biometric measurements using the visante omni and a rabbit experimental model of post-surgical corneal ectasia. Transl Vis Sci Technol [Internet]. 2015 Apr 28;4(2):16. Available from: https://doi.org/10.1167/tvst.4.2.167. Moshirfar M, Stoakes IM, Bruce EG, Ali A, Payne CJ, Furhiman D, et al. Allogenic lenticular implantation for correction of refractive error and ectasia: narrative review. Ophthalmol Ther [Internet]. 2023;12(5):2361–79. Available from: https://doi.org/10.1007/s40123-023-00765-28. Lo ACQ, Lo CCW. The association between keratoconus and the risk factors of eye rubbing, atopy and other allergic diseases (conjunctivitis, rhinitis, asthma and eczema): a meta-analysis. Int Ophthalmol [Internet]. 2023;43(5):1451–2. Available from: https://www.embase.com/search/results?subaction=viewrecord&id=L2019180063&from=export9. Naderan M, Jahanrad A, Farjadnia M. Clinical biomicroscopy and retinoscopy findings of keratoconus in a Middle Eastern population. Clin Exp Optom [Internet]. 2018 Jan 1;101(1):46–51. Available from: https://doi.org/10.1111/cxo.1257910. Villa C, Santodomingo J. La córnea. Parte I.: Estructura, función y anatomía microscópica. In 2010. Available from: https://api.semanticscholar.org/CorpusID:1720491443011. Sridhar, Mittanamalli S. Anatomy of cornea and ocular surface. Indian J Ophthalmol [Internet]. 2018;66(2). Available from: https://journals.lww.com/ijo/fulltext/2018/66020/anatomy_of_cornea_and_ocular_surface.4.a spx12. Falgayrettes N, Patoor E, Cleymand F, Zevering Y, Perone JM. Biomechanics of keratoconus: Two numerical studies. Riveiro Rodríguez A, editor. PLoS One [Internet]. 2023 Feb 2 [cited 2024 May 19];18(2):e0278455. Available from: https://dx.plos.org/10.1371/journal.pone.027845513. Marfurt CF, Cox J, Deek S, Dvorscak L. Anatomy of the human corneal innervation. Exp Eye Res [Internet]. 2010;90(4):478–92. Available from: https://www.sciencedirect.com/science/article/pii/S001448350900357114. Dubbelman M, Sicam VADP, Van der Heijde GL. The shape of the anterior and posterior surface of the aging human cornea. Vision Res [Internet]. 2006;46(6):993–1001. Available from: https://www.sciencedirect.com/science/article/pii/S004269890500490615. Martin R. Cornea and anterior eye assessment with placido-disc keratoscopy, slit scanning evaluation topography and scheimpflug imaging tomography. Indian J Ophthalmol [Internet]. 2018;66(3). Available from: https://journals.lww.com/ijo/fulltext/2018/66030/cornea_and_anterior_eye_assessment_with. 4.aspx16. Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol [Internet]. 1984 Jan 1;28(4):293–322. Available from: https://doi.org/10.1016/0039-6257(84)90094-817. Gomes JAP, Tan D, Rapuano CJ, Belin MW, Ambrósio RJ, Guell JL, et al. Global consensus on keratoconus and ectatic diseases. Cornea [Internet]. 2015;34(4). Available from: https://journals.lww.com/corneajrnl/fulltext/2015/04000/global_consensus_on_keratoconus_a nd_ectatic.1.aspx18. Xu L, Wang YX, Guo Y, You QS, Jonas JB, Group the BES. Prevalence and Associations of Steep Cornea/Keratoconus in Greater Beijing. The Beijing Eye Study. Yu FS, editor. PLoS One [Internet]. 2012 Jul 6 [cited 2024 Apr 28];7(7):e39313. Available from: https://dx.plos.org/10.1371/journal.pone.003931319. Grzybowski A, Mcghee CN. The early history of keratoconus prior to Nottingham’s landmark 1854 treatise on conical cornea: a review. Clin Exp Optom [Internet]. 2013 Mar 1;96(2):140–5. Available from: https://doi.org/10.1111/cxo.1203520. Santodomingo-Rubido J, Carracedo G, Suzaki A, Villa-Collar C, Vincent SJ, Wolffsohn JS. Keratoconus: An updated review. Contact Lens and Anterior Eye [Internet]. 2022;45(3):101559. Available from: https://www.sciencedirect.com/science/article/pii/S136704842100205821. Sánchez V, Lincoln S, Álvarez P, Benavides P, Sánchez R, Zambrano D. El queratocono, su diagnóstico y manejo. Una revisión bibliográfica. Enfermería Investiga [Internet]. 2018 Sep 1;3(1 Sup):1–8. Available from: https://revistas.uta.edu.ec/erevista/index.php/enfi/article/view/42322. Lopes BT, Ramos IC, Dawson DG, Belin MW, Ambrósio R. Detection of ectatic corneal diseases based on pentacam. Z Med Phys [Internet]. 2016;26(2):136–42. Available from: https://www.sciencedirect.com/science/article/pii/S093938891500147623. Wallang BS, Das S. Keratoglobus. Eye [Internet]. 2013;27(9):1004–12. Available from: https://doi.org/10.1038/eye.2013.1303124. Koenekoop RK. An overview of leber congenital amaurosis: a model to understand human retinal development. Surv Ophthalmol [Internet]. 2004 Jul 1;49(4):379–98. Available from: https://doi.org/10.1016/j.survophthal.2004.04.00325. Nelson ME, Talbot JF. Keratoglobus in the Rubinstein-Taybi syndrome. British Journal of Ophthalmology [Internet]. 1989 May 1;73(5):385. Available from: http://bjo.bmj.com/content/73/5/385.abstract26. Gregoratos ND, Bartsocas CS, Papas K. Blue sclerae with keratoglobus and brittle cornea. British Journal of Ophthalmology [Internet]. 1971 Jun 1;55(6):424. Available from: http://bjo.bmj.com/content/55/6/424.abstract27. Castro K, Zayas Y, Hernández M. Queratoglobo o ectasia corneal globular. Informe de caso. Revista Médica Electrónica de Ciego de Ávila. 2020;28. Jacobs DS, Green WR, Maumenee AE. Acquired Keratoglobus. Am J Ophthalmol [Internet]. 1974 Mar 1;77(3):393–9. Available from: https://doi.org/10.1016/0002-9394(74)90747-829. Cameron JA. Keratoglobus. Cornea [Internet]. 1993;12(2). Available from: https://journals.lww.com/corneajrnl/fulltext/1993/03000/keratoglobus.6.aspx30. Pouliquen Y, Dhermy P, Espinasse MA, Savoldelli M. Keratoglobus. J Fr Ophtalmol [Internet]. 1985;8(1):43–54. Available from: http://europepmc.org/abstract/MED/388912431. Hyams SW, Kar H, Neumann E. Blue sclerae and keratoglobus. Ocular signs of a systemic connective tissue disorder. British Journal of Ophthalmology [Internet]. 1969 Jan 1;53(1):53. Available from: http://bjo.bmj.com/content/53/1/53.abstract32. Singh B, Sharma S, Bharti N, Ranjan R, Bharti S. Hypermature intumescent cataract in advanced keratoglobus. Int Med Case Rep J [Internet]. 2020 Oct 12;13(null):507–11. Available from: https://www.tandfonline.com/doi/abs/10.2147/IMCRJ.S27533533. Sridhar MS, Mahesh S, Bansal AK, Nutheti R, Rao GN. Pellucid marginal corneal degeneration. Ophthalmology [Internet]. 2004;111(6):1102–7. Available from: https://www.sciencedirect.com/science/article/pii/S016164200400024734. Belin MW, Asota IM, Ambrosio Jr. R, Khachikian SS. What’s in a name: Keratoconus, pellucid marginal degeneration, and related thinning disorders. Am J Ophthalmol. 2011;152(2).35. Basak SK, Hazra TK, Bhattacharya D, Sinha TK. Unilateral pellucid marginal degeneration. Indian J Ophthalmol. 2000;48(3):233–4.36. Martínez-Abad A, Piñero DP. Pellucid marginal degeneration: Detection, discrimination from other corneal ectatic disorders and progression. Contact Lens and Anterior Eye [Internet]. 2019 Aug 1;42(4):341–9. Available from: https://doi.org/10.1016/j.clae.2018.11.01037. Jinabhai A, Radhakrishnan H, O’Donnell C. Pellucid corneal marginal degeneration: A review. Contact Lens and Anterior Eye [Internet]. 2011;34(2):56–63. Available from: https://www.sciencedirect.com/science/article/pii/S136704841000153038. Lee BW, Jurkunas U V, Harissi-Dagher M, Poothullil AM, Tobaigy FM, Azar DT. Ectatic disorders associated with a claw-shaped pattern on corneal topography. Am J Ophthalmol [Internet]. 2007;144(1):154-156.e3. Available from: https://www.sciencedirect.com/science/article/pii/S000293940700198539. Bajracharya L, Agrawal N, Dhungel S, Parajuli R, Adhikari S. A teenager with vernal keratoconjunctivitis and pellucid marginal degeneration, presenting with exotropia. Int Med Case Rep J. 2020;13:399–408.40. Randleman JB, Russell B, Ward MA, Thompson KP, Stulting RD. Risk factors and prognosis for corneal ectasia after LASIK. Ophthalmology. 2003 Feb 1;110(2):267–75.41. Martínez CP, Martínez JA. Capítulo 15 - Ectasias corneales posquirúrgicas. ¿La medida de la biomecánica corneal aporta algo? In: del Buey Sayas Ma Á, Martínez CP, editors. 32 Biomecánica y arquitectura corneal [Internet]. Madrid: Elsevier; 2014. p. 185–96. Available from: https://www.sciencedirect.com/science/article/pii/B978849022649050022342. Roy S, Yadav S, Dasgupta T, Chawla S, Tandon R, Ghosh S. Interplay between hereditary and environmental factors to establish an in vitro disease model of keratoconus. Drug Discov Today [Internet]. 2019;24(2):403–16. Available from: https://www.sciencedirect.com/science/article/pii/S135964461830146643. Paulina L. Estudio de secuenciación del gen miR-184 en pacientes con ectasias corneales primarias [Internet]. [Barcelona]: Universidad Autónoma de Barcelona; 2019 [cited 2023 Nov 24]. Available from: https://www.educacion.gob.es/teseo/imprimirFicheroTesis.do?idFichero=b%2BmC%2FXawJ nc%3D44. Li X, Yang H, Rabinowitz YS. Longitudinal study of keratoconus progression. Exp Eye Res [Internet]. 2007;85(4):502–7. Available from: https://www.sciencedirect.com/science/article/pii/S001448350700174145. García M. Centro de ciencias de la salud departamento de optometría tesis cambios refractivos y morfológicos en pacientes con queratocono sometidos a crosslinking [Internet]. 2015 [cited 2023 Nov 24]. Available from: http://hdl.handle.net/11317/35446. Tatar MG, Aylin Kantarci F, Yildirim A, Uslu H, Colak HN, Goker H, et al. Risk factors in post-LASIK corneal ectasia. Diakonis VF, editor. J Ophthalmol [Internet]. 2014;2014:204191. Available from: https://doi.org/10.1155/2014/20419147. Brenner LF, Alió JL, Vega-Estrada A, Baviera J, Beltrán J, Cobo-Soriano R. Indications for intrastromal corneal ring segments in ectasia after laser in situ keratomileusis. J Cataract Refract Surg [Internet]. 2012;38(12). Available from: https://journals.lww.com/jcrs/fulltext/2012/12000/indications_for_intrastromal_corneal_ring_s egments.10.aspx48. Moshirfar M, Tukan AN, Bundogji N, Liu HY, McCabe SE, Ronquillo YC, et al. Ectasia after corneal refractive surgery: a systematic review. Ophthalmol Ther [Internet]. 2021;10(4):753–76. Available from: https://doi.org/10.1007/s40123-021-00383-w49. Lema I, Durán JA. Inflammatory molecules in the tears of patients with keratoconus. Ophthalmology [Internet]. 2005;112(4):654–9. Available from: https://www.sciencedirect.com/science/article/pii/S016164200401918950. Jiang Y, Li Y, Yang S, Lu TC. Tuck-in Lamellar keratoplasty with an lenticule obtained by small incision lenticule extraction for treatment of Post- LASIK Ectasia. Sci Rep [Internet]. 2017;7(1):17806. Available from: https://doi.org/10.1038/s41598-017-18201-451. Mahmoud MMI, Hamdy AM, Mohamed AB, Diaa El Din YA. An updated overview of keratoconus management: Review article. Egypt J Hosp Med [Internet]. 2022;88(1):2777–80. Available from: https://ejhm.journals.ekb.eg/article_241951.html52. Ang M, Gatinel D, Reinstein DZ, Mertens E, Alió del Barrio JL, Alió JL. Refractive surgery beyond 2020. Eye [Internet]. 2021;35(2):362–82. Available from: https://doi.org/10.1038/s41433-020-1096-553. Avetisov SE. Radial keratotomy: History and current state. Vestn Oftalmol. 2021 Mar 1;137(2):123–31.54. Soler F. De PRK a LASEK y de LASEK a PRK. Arch Soc Esp Oftalmol. 2003;78:239–40.55. Naderi M, Sabour S, Khodakarim S, Daneshgar F. Studying the factors related to refractive error regression after PRK surgery. BMC Ophthalmol [Internet]. 2018;18(1):198. Available from: https://doi.org/10.1186/s12886-018-0879-y 3356. Wallerstein A, Jackson WB, Chambers J, Moezzi AM, Lin H, Simmons PA. Management of post-LASIK dry eye: A multicenter randomized comparison of a new multi-ingredient artificial tear to carboxymethylcellulose. Clinical Ophthalmology. 2018 May 7;12:839–48.57. Bohac M, Koncarevic M, Pasalic A, Biscevic A, Merlak M, Gabric N, et al. Incidence and clinical characteristics of post LASIK ectasia: A review of over 30,000 LASIK cases. Semin Ophthalmol [Internet]. 2018 Nov 17;33(7–8):869–77. Available from: https://doi.org/10.1080/08820538.2018.153918358. Zhao LQ, Wei RL, Cheng JW, Li Y, Cai JP, Ma XY. Meta-analysis: Clinical outcomes of laser-assisted subepithelial keratectomy and photorefractive keratectomy in myopia. Ophthalmology. 2010 Oct;117(10):1912–22.59. OCULUS Pentacam [Internet]. [cited 2023 Nov 24]. Available from: https://www.pentacam.com/index.php?id=286&L=260. Belin MW, Villavicencio OF, Ambrósio RRJ. Tomographic parameters for the detection of keratoconus: suggestions for screening and treatment parameters. Eye Contact Lens [Internet]. 2014;40(6). Available from: https://journals.lww.com/claojournal/fulltext/2014/11000/tomographic_parameters_for_the_d etection_of.2.aspx61. Ambrósio R, Machado AP, Leão E, Lyra JMG, Salomão MQ, Esporcatte LGP, et al. Optimized artificial intelligence for enhanced ectasia detection using Scheimpflug-based corneal tomography and biomechanical data. Am J Ophthalmol [Internet]. 2023;251:126–42. Available from: https://www.sciencedirect.com/science/article/pii/S000293942200506262. Orucoglu F, Toker E. Comparative analysis of anterior segment parameters in normal and keratoconus eyes generated by Scheimpflug tomography. Moshirfar MM, editor. J Ophthalmol [Internet]. 2015;2015:925414. Available from: https://doi.org/10.1155/2015/92541463. Fan R, Chan TCY, Prakash G, Jhanji V. Applications of corneal topography and tomography: a review. Clin Exp Ophthalmol [Internet]. 2018 Mar 1;46(2):133–46. Available from: https://doi.org/10.1111/ceo.1313664. Hashemi H, Beiranvand A, Yekta A, Maleki A, Yazdani N, Khabazkhoob M. Pentacam top indices for diagnosing subclinical and definite keratoconus. J Curr Ophthalmol [Internet]. 2016;28(1):21–6. Available from: https://www.sciencedirect.com/science/article/pii/S245223251530016065. Sedaghat MR, Mohammad Zadeh V, Fadakar K, Kadivar S, Abrishami M. Normative values and contralateral comparison of anterior chamber parameters measured by Pentacam and its correlation with corneal biomechanical factors. Saudi Journal of Ophthalmology [Internet]. 2017;31(1):7–10. Available from: https://www.sciencedirect.com/science/article/pii/S131945341630072866. OCULUS. Interpretation guide 3rd edition [Internet]. 2005. Available from: www.oculus.de67. Belin MW, Alizadeh R, Torres-Netto EA, Hafezi F, Ambrósio R, Pajic B. Determining progression in ectatic corneal disease. Asia-Pacific Journal of Ophthalmology [Internet]. 2020;9(6):541–8. 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