Emergence and management of drug-resistant enterococcal infections

The treatment of multidrug-resistant enterococcal infections continues to be a challenge for clinicians. Glycopeptide and beta-lactam resistance is now a common feature of the majority of Enterococcus faecium hospital isolates, and resistance to aminoglycosides, quinupristin-dalfopristin, linezolid...

Full description

Autores:
Arias, Cesar A.
Murray, Barbara E.
Tipo de recurso:
Article of journal
Fecha de publicación:
2008
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/5178
Acceso en línea:
http://hdl.handle.net/20.500.12495/5178
https://doi.org/10.1586/14787210.6.5.637
https://repositorio.unbosque.edu.co
Palabra clave:
Enterococcus spp.
Resistance
Therapy
Vancomycin resistance
Rights
openAccess
License
Acceso abierto
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dc.title.spa.fl_str_mv Emergence and management of drug-resistant enterococcal infections
dc.title.translated.spa.fl_str_mv Emergence and management of drug-resistant enterococcal infections
title Emergence and management of drug-resistant enterococcal infections
spellingShingle Emergence and management of drug-resistant enterococcal infections
Enterococcus spp.
Resistance
Therapy
Vancomycin resistance
title_short Emergence and management of drug-resistant enterococcal infections
title_full Emergence and management of drug-resistant enterococcal infections
title_fullStr Emergence and management of drug-resistant enterococcal infections
title_full_unstemmed Emergence and management of drug-resistant enterococcal infections
title_sort Emergence and management of drug-resistant enterococcal infections
dc.creator.fl_str_mv Arias, Cesar A.
Murray, Barbara E.
dc.contributor.author.none.fl_str_mv Arias, Cesar A.
Murray, Barbara E.
dc.subject.keywords.spa.fl_str_mv Enterococcus spp.
Resistance
Therapy
Vancomycin resistance
topic Enterococcus spp.
Resistance
Therapy
Vancomycin resistance
description The treatment of multidrug-resistant enterococcal infections continues to be a challenge for clinicians. Glycopeptide and beta-lactam resistance is now a common feature of the majority of Enterococcus faecium hospital isolates, and resistance to aminoglycosides, quinupristin-dalfopristin, linezolid and daptomycin further complicates the problem. New antibiotics, such as tigecycline, lipoglycopeptides (dalbavancin, oritavancin and telavancin) and cephalosporins with activity against Enterococcus faecalis (ceftobiprole and ceftaroline), may have potential activity against certain resistant enterococcal strains in specific clinical settings, as may some older antibiotics, such as ampicillin, chloramphenicol, doxycycline, minocycline and nitrofurantoin. However, the treatment of endovascular infections (particularly endocarditis, where bactericidal therapy is important for optimal cure rates) caused by resistant enterococci continues to be an immense challenge even with the availability of new agents. The optimal therapy for these infections is not well established and clinical data are usually limited to case reports with conflicting results. Therefore, treatment decisions may have to be based on animal models and sporadic experiences and the best approach is for the physician to consider carefully each patient on a case by case manner and gather all the clinical and microbiological information possible regarding species identification and susceptibilities in order to choose a therapeutic regimen that would appear to be active.
publishDate 2008
dc.date.issued.none.fl_str_mv 2008
dc.date.accessioned.none.fl_str_mv 2020-12-04T19:56:27Z
dc.date.available.none.fl_str_mv 2020-12-04T19:56:27Z
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dc.identifier.doi.none.fl_str_mv https://doi.org/10.1586/14787210.6.5.637
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
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https://doi.org/10.1586/14787210.6.5.637
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Expert Review of Anti-infective Therapy, 1744-8336, Vol. 6, Nro. 5, 2008 p. 637-655
dc.relation.uri.none.fl_str_mv https://www.tandfonline.com/doi/full/10.1586/14787210.6.5.637
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dc.publisher.spa.fl_str_mv Taylor & Francis
dc.publisher.journal.spa.fl_str_mv Expert Review of Anti-infective Therapy
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spelling Arias, Cesar A.Murray, Barbara E.2020-12-04T19:56:27Z2020-12-04T19:56:27Z20081744-8336http://hdl.handle.net/20.500.12495/5178https://doi.org/10.1586/14787210.6.5.637instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengTaylor & FrancisExpert Review of Anti-infective TherapyExpert Review of Anti-infective Therapy, 1744-8336, Vol. 6, Nro. 5, 2008 p. 637-655https://www.tandfonline.com/doi/full/10.1586/14787210.6.5.637Emergence and management of drug-resistant enterococcal infectionsEmergence and management of drug-resistant enterococcal infectionsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Enterococcus spp.ResistanceTherapyVancomycin resistanceThe treatment of multidrug-resistant enterococcal infections continues to be a challenge for clinicians. Glycopeptide and beta-lactam resistance is now a common feature of the majority of Enterococcus faecium hospital isolates, and resistance to aminoglycosides, quinupristin-dalfopristin, linezolid and daptomycin further complicates the problem. New antibiotics, such as tigecycline, lipoglycopeptides (dalbavancin, oritavancin and telavancin) and cephalosporins with activity against Enterococcus faecalis (ceftobiprole and ceftaroline), may have potential activity against certain resistant enterococcal strains in specific clinical settings, as may some older antibiotics, such as ampicillin, chloramphenicol, doxycycline, minocycline and nitrofurantoin. However, the treatment of endovascular infections (particularly endocarditis, where bactericidal therapy is important for optimal cure rates) caused by resistant enterococci continues to be an immense challenge even with the availability of new agents. The optimal therapy for these infections is not well established and clinical data are usually limited to case reports with conflicting results. 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