Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular
El carcinoma escamocelular de pene (PSCC) es una malignidad agresiva en donde se ha demostrado que el compromiso ganglionar es el factor pronóstico más importante para predecir supervivencia global (OS) y supervivencia libre de recaída (RFS). En la última década ha surgido el Logaritmo ODDS (LODDS)...
- Autores:
-
Amaya Dueñas, Camilo Andres
Pardo Hernández, Luis Felipe
- Tipo de recurso:
- https://purl.org/coar/resource_type/c_7a1f
- Fecha de publicación:
- 2024
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/12762
- Acceso en línea:
- https://hdl.handle.net/20.500.12495/12762
- Palabra clave:
- Cáncer de pene
Ganglio linfático
Compromiso extranodal
Linfadenectomía
Penile Cancer
Lymph Node metastasis
Extranodal tumour deposit
Lymphadenectomy
WJ100
- Rights
- openAccess
- License
- Atribución-NoComercial-CompartirIgual 4.0 Internacional
| id |
UNBOSQUE2_5e209ce35387a83259dd10e0843ac7dc |
|---|---|
| oai_identifier_str |
oai:repositorio.unbosque.edu.co:20.500.12495/12762 |
| network_acronym_str |
UNBOSQUE2 |
| network_name_str |
Repositorio U. El Bosque |
| repository_id_str |
|
| dc.title.none.fl_str_mv |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular |
| dc.title.translated.none.fl_str_mv |
Predictive Capacity of the logarithm of Odds ( LODDS) vs Lymph Node Density in Overall and Recurrence-Free survival in Penile Squamous Cell Carcinoma |
| title |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular |
| spellingShingle |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular Cáncer de pene Ganglio linfático Compromiso extranodal Linfadenectomía Penile Cancer Lymph Node metastasis Extranodal tumour deposit Lymphadenectomy WJ100 |
| title_short |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular |
| title_full |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular |
| title_fullStr |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular |
| title_full_unstemmed |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular |
| title_sort |
Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelular |
| dc.creator.fl_str_mv |
Amaya Dueñas, Camilo Andres Pardo Hernández, Luis Felipe |
| dc.contributor.advisor.none.fl_str_mv |
De la hoz, Jose Antonio |
| dc.contributor.author.none.fl_str_mv |
Amaya Dueñas, Camilo Andres Pardo Hernández, Luis Felipe |
| dc.contributor.orcid.none.fl_str_mv |
Amaya Dueñas, Camilo Andres [0009-0001-5950-185X] Pardo Hernández, Luis Felipe [ 0000-0003-0608-3612] |
| dc.subject.none.fl_str_mv |
Cáncer de pene Ganglio linfático Compromiso extranodal Linfadenectomía |
| topic |
Cáncer de pene Ganglio linfático Compromiso extranodal Linfadenectomía Penile Cancer Lymph Node metastasis Extranodal tumour deposit Lymphadenectomy WJ100 |
| dc.subject.keywords.none.fl_str_mv |
Penile Cancer Lymph Node metastasis Extranodal tumour deposit Lymphadenectomy |
| dc.subject.nlm.none.fl_str_mv |
WJ100 |
| description |
El carcinoma escamocelular de pene (PSCC) es una malignidad agresiva en donde se ha demostrado que el compromiso ganglionar es el factor pronóstico más importante para predecir supervivencia global (OS) y supervivencia libre de recaída (RFS). En la última década ha surgido el Logaritmo ODDS (LODDS) cómo una herramienta importante para predecir OS y RFS. Se busca definir la utilidad de LODDS cómo herramienta pronóstica en pacientes con PSCC. Estudio retrospectivo que incluyó pacientes con PSCC y compromiso ganglionar, sometidos a linfadenectomía inguinal (ILND) entre el 2007-2021 en el Instituto Nacional de Cancerología. Se incluyeron pacientes ≥18 años, sin otra variante histológica y sin evidencia de enfermedad metastásica. Se realizó análisis de supervivencia para predecir OS y la RFS. |
| publishDate |
2024 |
| dc.date.accessioned.none.fl_str_mv |
2024-07-30T13:14:24Z |
| dc.date.available.none.fl_str_mv |
2024-07-30T13:14:24Z |
| dc.date.issued.none.fl_str_mv |
2024-07 |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_7a1f |
| dc.type.local.spa.fl_str_mv |
Tesis/Trabajo de grado - Monografía - Especialización |
| dc.type.coar.none.fl_str_mv |
https://purl.org/coar/resource_type/c_7a1f |
| dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
| dc.type.coarversion.none.fl_str_mv |
https://purl.org/coar/version/c_ab4af688f83e57aa |
| format |
https://purl.org/coar/resource_type/c_7a1f |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12495/12762 |
| dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
| dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
| dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
| url |
https://hdl.handle.net/20.500.12495/12762 |
| identifier_str_mv |
instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
| dc.language.iso.fl_str_mv |
spa |
| language |
spa |
| dc.relation.references.none.fl_str_mv |
1. Leijte JAP, Kirrander P, Antonini N, Windahl T, Horenblas S. Recurrence Patterns of Squamous Cell Carcinoma of the Penis: Recommendations for Follow-Up Based on a Two-Centre Analysis of 700 Patients. Eur Urol. 2008 Jul;54(1):161–9. doi: 10.3389/fonc.2021.706531 2. Patel KN, Salunke A, Bhatt S, Sharma M, Jain A, Puj K, et al. Log ODDS (LODDS) of positive lymph nodes as a predictor of overall survival in squamous cell carcinoma of the penis. J Surg Oncol. 2021 Jun;123(8):1836–44. doi: 10.1002/jso.26454 3.Christodoulidou M, Sahdev V, Houssein S, Muneer A. Epidemiology of penile cancer.Curr Probl Cancer. 2015 May;39(3):126–36. doi: 10.1016/j.currproblcancer.2015.03.010 4. Chipollini J, Azizi M, Lo Vullo S, Mariani L, Zhu Y, Ye DW, et al. Identifying an optimal lymph node yield for penile squamous cell carcinoma: prognostic impact of surgical dissection. BJU Int. 2020 Jan;125(1):82–8. doi: 10.1111/bju.14883. 5. Qi F, Wei X, Zheng Y, Ren X, Li X, Zhao E. Incidence trends and survival outcomes of penile squamous cell carcinoma: evidence from the Surveillance, Epidemiology and End Results population-based data. Ann Transl Med. 2020 Nov;8(21):1428–1428. doi:10.21037/atm-20-1802 6. Pham MN, Deal AM, Ferguson JE, Wang Y, Smith AB, Nielsen ME, et al. Contemporary survival trends in penile cancer: Results from the National Cancer Database. Urol Oncol Semin Orig Investig. 2017 Dec;35(12):674.e1-674.e9. doi: 10.1016/j.urolonc.2017.08.009 7. Zheng W, Li K, Zhu W, Ding Y, Wu Q, Tang Q, et al. Nomogram prediction of overall survival based on log odds of positive lymph nodes for patients with penile squamous cell carcinoma. Cancer Med. 2020 Aug;9(15):5425–35. doi: 10.1002/cam4.3232 8. Wen J, Chen J, Chen D, Jabbour SK, Xue T, Guo X, et al. Comprehensive analysis of prognostic value of lymph node classifications in esophageal squamous cell carcinoma: a large real-world multicenter study. Ther Adv Med Oncol. 2021 Jan;13:175883592110548. doi: 10.1177/17588359211054895. 9. Jian-hui C, Shi-rong C, Hui W, Si-le C, Jian-bo X, Er-tao Z, et al. Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy. Tumor Biol. 2016 Aug;37(8):11105–13. doi:10.1007/s13277-015-4191-7 10. Lin NC, Su IH, Hsu JT, Chang YJ, Tsai KY. Comparison of different lymph node staging systems in patients with positive lymph nodes in oral squamous cell carcinoma. Oral Oncol. 2021 Mar;114:105146. doi: 10.1016/j.oraloncology.2020.105146 11. Meng X, Hao F, Wang N, Qin P, Ju Z, Sun D. Log odds of positive lymph nodes (LODDS)-based novel nomogram for survival estimation in patients with invasive micropapillary carcinoma of the breast. BMC Med Res Methodol. 2024 Apr 18;24(1):90. doi: 10.1186/s12874-024-02218-1. 12. Cao J, Yuan P, Ma H, Ye P, Wang Y, Yuan X, et al. Log Odds of Positive Lymph Nodes Predicts Survival in Patients After Resection for Esophageal Cancer. Ann Thorac Surg.2016 Aug;102(2):424–32. doi: 10.1016/j.athoracsur.2016.03.030. 13. Chavarriaga J, Camacho D, Suso-Palau D, Godoy F, Cabrera M, Forero J, et al. Inguinal lymph node density as a powerful predictor of cancer specific survival in patients with node-positive penile cancer. Urol Oncol Semin Orig Investig. 2021 Dec;39(12):839.e1-839.e8. doi: 10.1016/j.urolonc.2021.07.017. 14. Reddy JP, Pettaway CA, Levy LB, Pagliaro LC, Tamboli P, Rao P, et al. Factors associated with regional recurrence after lymph node dissection for penile squamous cell carcinoma. BJU Int. 2017 Apr;119(4):591–7. doi: 10.1111/bju.13686. 15. Svatek RS, Munsell M, Kincaid JM, Hegarty P, Slaton JW, Busby JE, et al. Association Between Lymph Node Density and Disease Specific Survival in Patients With Penile Cancer. J Urol. 2009 Dec;182(6):2721–7. doi: 10.1016/j.juro.2009.08.029 16. Ball MW, Schwen ZR, Ko JS, Meyer A, Netto GJ, Burnett AL, et al. Lymph node density predicts recurrence and death after inguinal lymph node dissection for penile cancer. Investig Clin Urol. 2017;58(1):20. doi: 10.4111/icu.2017.58.1.20 17. Johnson TV, Hsiao W, Delman KA, Jani AB, Brawley OW, Master VA. Extensive inguinal lymphadenectomy improves overall 5‐year survival in penile cancer patients:Results from the Surveillance, Epidemiology, and End Results program. Cancer. 2010 Jun 15;116(12):2960–6. doi: 10.1002/cncr.25091. 18. Li Z shang, Yao K, Chen P, Zou Z jun, Qin ZK, Liu ZW, et al. Disease-specific survival after radical lymphadenectomy for penile cancer: Prediction by lymph node count and density This work was supported by the Science and Technology Foundation of the Guangdong Province (2012B031800079 to H. Han).2Zai-shang Li and Kai Yao contributed equally to this article. Urol Oncol Semin Orig Investig. 2014 Aug;32(6):893–900. doi: 10.1016/j.urolonc.2013.11.008 19. Gao P, Zhu T, Gao J, Li H, Liu X, Zhang X. Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer. Front Oncol. 2021 Jul 7;11:706531. doi: 10.3389/fonc.2021.706531. |
| dc.rights.none.fl_str_mv |
Atribución-NoComercial-CompartirIgual 4.0 Internacional |
| dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| dc.rights.uri.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.rights.local.spa.fl_str_mv |
Acceso abierto |
| dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.mimetype.none.fl_str_mv |
application/pdf |
| dc.publisher.program.spa.fl_str_mv |
Especialización en Urología |
| dc.publisher.grantor.spa.fl_str_mv |
Universidad El Bosque |
| dc.publisher.faculty.spa.fl_str_mv |
Facultad de Medicina |
| institution |
Universidad El Bosque |
| bitstream.url.fl_str_mv |
https://repositorio.unbosque.edu.co/bitstreams/e63c71ee-fc58-4266-b9fc-284dcb9fdfb0/download https://repositorio.unbosque.edu.co/bitstreams/83e80858-a498-4101-9547-93f3cd7c695e/download https://repositorio.unbosque.edu.co/bitstreams/908ed801-8020-441b-827a-7dd34ac7f0fb/download https://repositorio.unbosque.edu.co/bitstreams/24ac18f8-7ea4-41d9-b725-3f871cb9b120/download https://repositorio.unbosque.edu.co/bitstreams/5d89a3da-4a51-49ec-bf50-f75da114e2db/download https://repositorio.unbosque.edu.co/bitstreams/78650f4a-dbd2-47e1-b65f-1695bcd5ea34/download |
| bitstream.checksum.fl_str_mv |
f2ec35ddc5e734cb09a1c8d7f117e3b4 17cc15b951e7cc6b3728a574117320f9 e9d87caff469a4e4b33e6ca5c6f71acf 63b1541c405c77d42543afcb7200dabc 4f3e4bb0848f81ddc77e6a413d914a5a 0488f5a3797f5ca94599e515a23b74b0 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad El Bosque |
| repository.mail.fl_str_mv |
bibliotecas@biteca.com |
| _version_ |
1814100707877322752 |
| spelling |
De la hoz, Jose AntonioAmaya Dueñas, Camilo AndresPardo Hernández, Luis FelipeAmaya Dueñas, Camilo Andres [0009-0001-5950-185X]Pardo Hernández, Luis Felipe [ 0000-0003-0608-3612]2024-07-30T13:14:24Z2024-07-30T13:14:24Z2024-07https://hdl.handle.net/20.500.12495/12762instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coEl carcinoma escamocelular de pene (PSCC) es una malignidad agresiva en donde se ha demostrado que el compromiso ganglionar es el factor pronóstico más importante para predecir supervivencia global (OS) y supervivencia libre de recaída (RFS). En la última década ha surgido el Logaritmo ODDS (LODDS) cómo una herramienta importante para predecir OS y RFS. Se busca definir la utilidad de LODDS cómo herramienta pronóstica en pacientes con PSCC. Estudio retrospectivo que incluyó pacientes con PSCC y compromiso ganglionar, sometidos a linfadenectomía inguinal (ILND) entre el 2007-2021 en el Instituto Nacional de Cancerología. Se incluyeron pacientes ≥18 años, sin otra variante histológica y sin evidencia de enfermedad metastásica. Se realizó análisis de supervivencia para predecir OS y la RFS.Instituto Nacional de CancerologiaEspecialista en UrologíaEspecializaciónPenile squamous cell carcinoma (PSCC) is an aggressive malignancy, where nodal involvement has been shown to be the most important prognostic factor for predicting overall survival (OS). In the last decade, the Log Odds (LODDS) has emerged as an important tool for predicting OS and RFS. The aim is to define the utility of LODDS as a prognostic tool in patients with PSCC. Methods. This is a retrospective and analytical study that included PSCC patients with nodal involvement who underwent inguinal lymphadenectomy (ILND) between 2007-2021 at our institution. Patients ≥18 years, without other histological variants, and without evidence of metastatic disease were included. Survival analysis was performed to predict OS and RFS. Concordance was evaluated using Harrell's C-index.application/pdfAtribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/Acceso abiertoinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cáncer de peneGanglio linfáticoCompromiso extranodalLinfadenectomíaPenile CancerLymph Node metastasisExtranodal tumour depositLymphadenectomyWJ100Capacidad predictiva del Logaritmo de ODDS (LODDS) vs. densidad ganglionar en supervivencia global y libre de recurrencia en cáncer de pene escamocelularPredictive Capacity of the logarithm of Odds ( LODDS) vs Lymph Node Density in Overall and Recurrence-Free survival in Penile Squamous Cell CarcinomaEspecialización en UrologíaUniversidad El BosqueFacultad de MedicinaTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aa1. Leijte JAP, Kirrander P, Antonini N, Windahl T, Horenblas S. Recurrence Patterns of Squamous Cell Carcinoma of the Penis: Recommendations for Follow-Up Based on a Two-Centre Analysis of 700 Patients. Eur Urol. 2008 Jul;54(1):161–9. doi: 10.3389/fonc.2021.7065312. Patel KN, Salunke A, Bhatt S, Sharma M, Jain A, Puj K, et al. Log ODDS (LODDS) of positive lymph nodes as a predictor of overall survival in squamous cell carcinoma of the penis. J Surg Oncol. 2021 Jun;123(8):1836–44. doi: 10.1002/jso.264543.Christodoulidou M, Sahdev V, Houssein S, Muneer A. Epidemiology of penile cancer.Curr Probl Cancer. 2015 May;39(3):126–36. doi: 10.1016/j.currproblcancer.2015.03.0104. Chipollini J, Azizi M, Lo Vullo S, Mariani L, Zhu Y, Ye DW, et al. Identifying an optimal lymph node yield for penile squamous cell carcinoma: prognostic impact of surgical dissection. BJU Int. 2020 Jan;125(1):82–8. doi: 10.1111/bju.14883.5. Qi F, Wei X, Zheng Y, Ren X, Li X, Zhao E. Incidence trends and survival outcomes of penile squamous cell carcinoma: evidence from the Surveillance, Epidemiology and End Results population-based data. Ann Transl Med. 2020 Nov;8(21):1428–1428. doi:10.21037/atm-20-18026. Pham MN, Deal AM, Ferguson JE, Wang Y, Smith AB, Nielsen ME, et al. Contemporary survival trends in penile cancer: Results from the National Cancer Database. Urol Oncol Semin Orig Investig. 2017 Dec;35(12):674.e1-674.e9. doi: 10.1016/j.urolonc.2017.08.0097. Zheng W, Li K, Zhu W, Ding Y, Wu Q, Tang Q, et al. Nomogram prediction of overall survival based on log odds of positive lymph nodes for patients with penile squamous cell carcinoma. Cancer Med. 2020 Aug;9(15):5425–35. doi: 10.1002/cam4.32328. Wen J, Chen J, Chen D, Jabbour SK, Xue T, Guo X, et al. Comprehensive analysis of prognostic value of lymph node classifications in esophageal squamous cell carcinoma: a large real-world multicenter study. Ther Adv Med Oncol. 2021 Jan;13:175883592110548. doi: 10.1177/17588359211054895.9. Jian-hui C, Shi-rong C, Hui W, Si-le C, Jian-bo X, Er-tao Z, et al. Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy. Tumor Biol. 2016 Aug;37(8):11105–13. doi:10.1007/s13277-015-4191-710. Lin NC, Su IH, Hsu JT, Chang YJ, Tsai KY. Comparison of different lymph node staging systems in patients with positive lymph nodes in oral squamous cell carcinoma. Oral Oncol. 2021 Mar;114:105146. doi: 10.1016/j.oraloncology.2020.10514611. Meng X, Hao F, Wang N, Qin P, Ju Z, Sun D. Log odds of positive lymph nodes (LODDS)-based novel nomogram for survival estimation in patients with invasive micropapillary carcinoma of the breast. BMC Med Res Methodol. 2024 Apr 18;24(1):90. doi: 10.1186/s12874-024-02218-1.12. Cao J, Yuan P, Ma H, Ye P, Wang Y, Yuan X, et al. Log Odds of Positive Lymph Nodes Predicts Survival in Patients After Resection for Esophageal Cancer. Ann Thorac Surg.2016 Aug;102(2):424–32. doi: 10.1016/j.athoracsur.2016.03.030.13. Chavarriaga J, Camacho D, Suso-Palau D, Godoy F, Cabrera M, Forero J, et al. Inguinal lymph node density as a powerful predictor of cancer specific survival in patients with node-positive penile cancer. Urol Oncol Semin Orig Investig. 2021 Dec;39(12):839.e1-839.e8. doi: 10.1016/j.urolonc.2021.07.017.14. Reddy JP, Pettaway CA, Levy LB, Pagliaro LC, Tamboli P, Rao P, et al. Factors associated with regional recurrence after lymph node dissection for penile squamous cell carcinoma. BJU Int. 2017 Apr;119(4):591–7. doi: 10.1111/bju.13686.15. Svatek RS, Munsell M, Kincaid JM, Hegarty P, Slaton JW, Busby JE, et al. Association Between Lymph Node Density and Disease Specific Survival in Patients With Penile Cancer. J Urol. 2009 Dec;182(6):2721–7. doi: 10.1016/j.juro.2009.08.02916. Ball MW, Schwen ZR, Ko JS, Meyer A, Netto GJ, Burnett AL, et al. Lymph node density predicts recurrence and death after inguinal lymph node dissection for penile cancer. Investig Clin Urol. 2017;58(1):20. doi: 10.4111/icu.2017.58.1.2017. Johnson TV, Hsiao W, Delman KA, Jani AB, Brawley OW, Master VA. Extensive inguinal lymphadenectomy improves overall 5‐year survival in penile cancer patients:Results from the Surveillance, Epidemiology, and End Results program. Cancer. 2010 Jun 15;116(12):2960–6. doi: 10.1002/cncr.25091.18. Li Z shang, Yao K, Chen P, Zou Z jun, Qin ZK, Liu ZW, et al. Disease-specific survival after radical lymphadenectomy for penile cancer: Prediction by lymph node count and density This work was supported by the Science and Technology Foundation of the Guangdong Province (2012B031800079 to H. Han).2Zai-shang Li and Kai Yao contributed equally to this article. Urol Oncol Semin Orig Investig. 2014 Aug;32(6):893–900. doi: 10.1016/j.urolonc.2013.11.00819. Gao P, Zhu T, Gao J, Li H, Liu X, Zhang X. Impact of Examined Lymph Node Count and Lymph Node Density on Overall Survival of Penile Cancer. Front Oncol. 2021 Jul 7;11:706531. doi: 10.3389/fonc.2021.706531.spaORIGINALTrabajo de grado.pdfTrabajo de grado.pdfapplication/pdf607407https://repositorio.unbosque.edu.co/bitstreams/e63c71ee-fc58-4266-b9fc-284dcb9fdfb0/downloadf2ec35ddc5e734cb09a1c8d7f117e3b4MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82000https://repositorio.unbosque.edu.co/bitstreams/83e80858-a498-4101-9547-93f3cd7c695e/download17cc15b951e7cc6b3728a574117320f9MD54Carta de autorización.pdfapplication/pdf168349https://repositorio.unbosque.edu.co/bitstreams/908ed801-8020-441b-827a-7dd34ac7f0fb/downloade9d87caff469a4e4b33e6ca5c6f71acfMD55Acta de grado.pdfapplication/pdf169844https://repositorio.unbosque.edu.co/bitstreams/24ac18f8-7ea4-41d9-b725-3f871cb9b120/download63b1541c405c77d42543afcb7200dabcMD56TEXTTrabajo de grado.pdf.txtTrabajo de grado.pdf.txtExtracted texttext/plain60455https://repositorio.unbosque.edu.co/bitstreams/5d89a3da-4a51-49ec-bf50-f75da114e2db/download4f3e4bb0848f81ddc77e6a413d914a5aMD57THUMBNAILTrabajo de grado.pdf.jpgTrabajo de grado.pdf.jpgGenerated Thumbnailimage/jpeg2821https://repositorio.unbosque.edu.co/bitstreams/78650f4a-dbd2-47e1-b65f-1695bcd5ea34/download0488f5a3797f5ca94599e515a23b74b0MD5820.500.12495/12762oai:repositorio.unbosque.edu.co:20.500.12495/127622024-08-01 03:02:11.049http://creativecommons.org/licenses/by-nc-sa/4.0/Atribución-NoComercial-CompartirIgual 4.0 Internacionalembargo2025-07-29https://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |