Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages

Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamste...

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Autores:
Prada Arismendy, Jeanette
Rincón Forero, Verónica del Pilar
Castellanos, Jaime
Tipo de recurso:
Fecha de publicación:
2012
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/1656
Acceso en línea:
http://hdl.handle.net/20.500.12495/1656
http://doi.org/10.1155/2012/950303
Palabra clave:
Virus del dengue
Genética microbiana
Infecciones por flavivirus
Rights
License
Attribution 4.0 International
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dc.title.spa.fl_str_mv Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
title Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
spellingShingle Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
Virus del dengue
Genética microbiana
Infecciones por flavivirus
title_short Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
title_full Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
title_fullStr Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
title_full_unstemmed Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
title_sort Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages
dc.creator.fl_str_mv Prada Arismendy, Jeanette
Rincón Forero, Verónica del Pilar
Castellanos, Jaime
dc.contributor.author.none.fl_str_mv Prada Arismendy, Jeanette
Rincón Forero, Verónica del Pilar
Castellanos, Jaime
dc.contributor.orcid.none.fl_str_mv Castellanos, Jaime [0000-0003-1596-8383]
dc.subject.decs.spa.fl_str_mv Virus del dengue
Genética microbiana
Infecciones por flavivirus
topic Virus del dengue
Genética microbiana
Infecciones por flavivirus
description Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamster and guinea pig macrophages to infection by dengue virus 2 (DENV2). The results established that macrophages derived from the BALB/c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus. Other molecular mechanisms related to flavivirus susceptibility remain to be explored.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2019-08-27T13:34:19Z
dc.date.available.none.fl_str_mv 2019-08-27T13:34:19Z
dc.type.spa.fl_str_mv article
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 1687-9694
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/1656
dc.identifier.doi.none.fl_str_mv http://doi.org/10.1155/2012/950303
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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identifier_str_mv 1687-9694
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/1656
http://doi.org/10.1155/2012/950303
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Journal of Tropical Medicine, 1687-9686, 2012, p. 1-7
dc.relation.uri.none.fl_str_mv https://www.hindawi.com/journals/jtm/2012/950303/
dc.rights.*.fl_str_mv Attribution 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf264
dc.rights.creativecommons.none.fl_str_mv 2012
rights_invalid_str_mv Attribution 4.0 International
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Acceso abierto
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2012
http://purl.org/coar/access_right/c_abf2
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dc.publisher.spa.fl_str_mv Hindawi Publishing Corporation
dc.publisher.journal.spa.fl_str_mv Journal of Tropical Medicine
institution Universidad El Bosque
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spelling Prada Arismendy, JeanetteRincón Forero, Verónica del PilarCastellanos, JaimeCastellanos, Jaime [0000-0003-1596-8383]2019-08-27T13:34:19Z2019-08-27T13:34:19Z20121687-9694http://hdl.handle.net/20.500.12495/1656http://doi.org/10.1155/2012/950303instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengHindawi Publishing CorporationJournal of Tropical MedicineJournal of Tropical Medicine, 1687-9686, 2012, p. 1-7https://www.hindawi.com/journals/jtm/2012/950303/Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2642012http://purl.org/coar/access_right/c_abf2Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophagesarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Virus del dengueGenética microbianaInfecciones por flavivirusInfection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamster and guinea pig macrophages to infection by dengue virus 2 (DENV2). The results established that macrophages derived from the BALB/c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus. 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