In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)

Achyrocline bogotensis has been traditionally used to treat infections of skin, respiratory, tract urinary and other infections, but not to treat viral gastrointestinal disease. In this study, this Colombian native medicinal plant was investigated by its in vitro anti-rotavirus and anti-astrovirus a...

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Autores:: Téllez Alfonso, Alba N.
Vélez, Fernando
Ulloa, Juan Carlos
Téllez-Duarte, Miguel A.

Tipo de recurso:

Fecha de publicación:: 2015

Institución:: Universidad El Bosque

Repositorio:: Repositorio U. El Bosque

Idioma:: eng

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dc.title.spa.fl_str_mv	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
dc.title.translated.none.fl_str_mv	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
title	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
spellingShingle	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae) Pruebas de toxicidad Antivirales Acciones farmacológicas Antiviral Rotavirus Astrovirus Achyrocline bogotensis
title_short	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
title_full	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
title_fullStr	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
title_full_unstemmed	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
title_sort	In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)
dc.creator.fl_str_mv	Téllez Alfonso, Alba N. Vélez, Fernando Ulloa, Juan Carlos Téllez-Duarte, Miguel A.
dc.contributor.author.none.fl_str_mv	Téllez Alfonso, Alba N. Vélez, Fernando Ulloa, Juan Carlos Téllez-Duarte, Miguel A.
dc.subject.decs.spa.fl_str_mv	Pruebas de toxicidad Antivirales Acciones farmacológicas
topic	Pruebas de toxicidad Antivirales Acciones farmacológicas Antiviral Rotavirus Astrovirus Achyrocline bogotensis
dc.subject.keywords.spa.fl_str_mv	Antiviral Rotavirus Astrovirus Achyrocline bogotensis
description	Achyrocline bogotensis has been traditionally used to treat infections of skin, respiratory, tract urinary and other infections, but not to treat viral gastrointestinal disease. In this study, this Colombian native medicinal plant was investigated by its in vitro anti-rotavirus and anti-astrovirus activity. Several extracts and fractions phytochemically obtained from A. bogotensis were evaluated initially for their cell toxicity on MA104 and Caco2 cells and then for their anti-rotavirus (RRV) and anti-astrovirus (Yuc8) activity following three strategies: pre-treatment of cells (blocking effect), direct viral activity (virucidal effect) and post-treatment of infected cells (reduction of viral yield post-infection). In addition qualitative chemical studies were developed for the active compounds. Non-toxic concentrations of a fraction obtained exhibited antiviral activity against both viruses characterized by a virucidal effect and by the reduction of the infectious particles produced post-infection. Steroids, sterols, terpenes, phenols, flavonoids and sesquiterpenlactones were identified qualitatively in the active fraction. A. bogotensis contains substances with in vitro antiviral activity against rotavirus and astrovirus. This study confirms their anti-microbial properties and describes by the first time its antiviral activity in vitro.
publishDate	2015
dc.date.issued.none.fl_str_mv	2015
dc.date.accessioned.none.fl_str_mv	2019-07-22T21:42:46Z
dc.date.available.none.fl_str_mv	2019-07-22T21:42:46Z
dc.type.spa.fl_str_mv	article
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dc.identifier.issn.none.fl_str_mv	1472-6882
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12495/1555
dc.identifier.doi.none.fl_str_mv	https://doi.org/10.1186/s12906-015-0949-0
dc.identifier.instname.spa.fl_str_mv	instname:Universidad El Bosque
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url	http://hdl.handle.net/20.500.12495/1555 https://doi.org/10.1186/s12906-015-0949-0
dc.language.iso.none.fl_str_mv	eng
language	eng
dc.relation.ispartofseries.spa.fl_str_mv	BMC Complementary and Alternative Medicine, 1472-6882, Vol.15, 2015, p. 10
dc.relation.uri.none.fl_str_mv	https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0949-0
dc.rights.*.fl_str_mv	Attribution 4.0 International
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dc.rights.uri.*.fl_str_mv	http://creativecommons.org/licenses/by/4.0/
dc.rights.local.spa.fl_str_mv	Acceso abierto
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dc.rights.creativecommons.none.fl_str_mv	2015
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dc.publisher.spa.fl_str_mv	BioMed Central
dc.publisher.journal.spa.fl_str_mv	BMC Complementary and Alternative Medicine
institution	Universidad El Bosque
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spelling	Téllez Alfonso, Alba N.Vélez, FernandoUlloa, Juan CarlosTéllez-Duarte, Miguel A.2019-07-22T21:42:46Z2019-07-22T21:42:46Z20151472-6882http://hdl.handle.net/20.500.12495/1555https://doi.org/10.1186/s12906-015-0949-0instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengBioMed CentralBMC Complementary and Alternative MedicineBMC Complementary and Alternative Medicine, 1472-6882, Vol.15, 2015, p. 10https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0949-0Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf3222015http://purl.org/coar/access_right/c_abf2In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)articleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Pruebas de toxicidadAntiviralesAcciones farmacológicasAntiviralRotavirusAstrovirusAchyrocline bogotensisAchyrocline bogotensis has been traditionally used to treat infections of skin, respiratory, tract urinary and other infections, but not to treat viral gastrointestinal disease. In this study, this Colombian native medicinal plant was investigated by its in vitro anti-rotavirus and anti-astrovirus activity. Several extracts and fractions phytochemically obtained from A. bogotensis were evaluated initially for their cell toxicity on MA104 and Caco2 cells and then for their anti-rotavirus (RRV) and anti-astrovirus (Yuc8) activity following three strategies: pre-treatment of cells (blocking effect), direct viral activity (virucidal effect) and post-treatment of infected cells (reduction of viral yield post-infection). In addition qualitative chemical studies were developed for the active compounds. Non-toxic concentrations of a fraction obtained exhibited antiviral activity against both viruses characterized by a virucidal effect and by the reduction of the infectious particles produced post-infection. Steroids, sterols, terpenes, phenols, flavonoids and sesquiterpenlactones were identified qualitatively in the active fraction. A. bogotensis contains substances with in vitro antiviral activity against rotavirus and astrovirus. This study confirms their anti-microbial properties and describes by the first time its antiviral activity in vitro.ORIGINALTéllez M.A., Téllez A.N., Vélez F., Ulloa J.C._2015.pdfTéllez M.A., Téllez A.N., Vélez F., Ulloa J.C._2015.pdfapplication/pdf2524328https://repositorio.unbosque.edu.co/bitstreams/f31d2119-97fe-4db2-ae5e-a1a781cee9c4/download749fb7dfc240cbd0b37bbfe7a8cc6963MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.unbosque.edu.co/bitstreams/08f4eef3-4d7b-40e4-82f0-270418f6bfd4/download0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/ffe9e60c-d438-414a-b9d1-1d51f51fb236/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILTéllez M.A., Téllez A.N., Vélez F., Ulloa J.C._2015.pdf.jpgTéllez M.A., Téllez A.N., Vélez F., Ulloa J.C._2015.pdf.jpgIM Thumbnailimage/jpeg11838https://repositorio.unbosque.edu.co/bitstreams/6c4e1a1c-2f13-4595-a70e-2f82b3aeba41/download4ef3731e000623c348951265cce7a577MD54TEXTTéllez M.A., Téllez A.N., Vélez F., Ulloa J.C._2015.pdf.txtTéllez M.A., Téllez A.N., Vélez F., Ulloa J.C._2015.pdf.txtExtracted texttext/plain42052https://repositorio.unbosque.edu.co/bitstreams/601b6983-1350-4fb7-9d3f-d13070805c49/download46d410d8e2466a556d0db3f097c9f1ddMD5520.500.12495/1555oai:repositorio.unbosque.edu.co:20.500.12495/15552024-02-06 22:45:08.313http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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

In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae)

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