Could Increase Levels of Dickkopf-1 Protein be Considered As a Potential Biomarker for Bone Resorption in Joint and Periodontal Disease in Patients with Early Rheumatoid Arthritis?
Periodontitis and rheumatoid arthritis (RA) are chronic destructive inflammatory diseases with significant worldwide prevalence. They are characterized by inflammatory lesions adjacent to bone destruction involving connective tissue and bone. Dickkopf-1 (DKK-1) is a major regulator of bone mass; how...
- Autores:
-
Heredia Palau, Ana Maria
Giraldo Quintero, Sebastian
De Avila, Juliette
Chila Moreno, Lorena
Lafaurie, Gloria
Rodriguez, Constanza
Bautista Molano, Wilson
Chalem Choueka, Phillipe
Bello Gualteros, Juan Manuel
Valle Oñate, Rafael
Romero Sánchez, Consuelo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/7343
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/7343
- Palabra clave:
- Rights
- openAccess
- License
- Acceso abierto
| Summary: | Periodontitis and rheumatoid arthritis (RA) are chronic destructive inflammatory diseases with significant worldwide prevalence. They are characterized by inflammatory lesions adjacent to bone destruction involving connective tissue and bone. Dickkopf-1 (DKK-1) is a major regulator of bone mass; however, their involvement in local bone resorption is largely unknown. The aim of this study was to assess the utility of DKK-1 levels in gingival crevicular fluid (GCF) and serum as a potential predictor of bone loss in periodontal disease and/or early RA. |
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