Case report: gestational melioidosis through perinatal transmission

Burkholderia pseudomallei is an emerging pathogen in the Americas. Cases of mother-to-child transmission of B. pseudomallei are rare and probably occur by placental or perinatal infection. We report the first case of native gestational and neonatal melioidosis in the Western hemisphere. The isolated strains in the mother and newborn were confirmed by whole-genome sequencing and identified as a novel sequence type ST1748. The comparison of both genomes revealed a nucleotide similarity of 100%. Melioidosis should be considered within the differential diagnosis of febrile illness or pneumonia in pregnant women and newborns from endemic areas of the Americas.Burkholderia pseudomallei is an emerging pathogen in the Americas. Cases of mother-to-child transmission of B. pseudomallei are rare and probably occur by placental or perinatal infection. We report the first case of native gestational and neonatal melioidosis in the Western hemisphere. The isolated strains in the mother and newborn were confirmed by whole-genome sequencing and identified as a novel sequence type ST1748. The comparison of both genomes revealed a nucleotide similarity of 100%. Melioidosis should be considered within the differential diagnosis of febrile illness or pneumonia in pregnant women and newborns from endemic areas of the Americas.

• Autores: Rodriguez , Jose Yesid; Huertas Valero, Mónica Gabriela; Rodríguez Quintero, Gerson Jose; Vargas-Otalora, Sandra; Benítez-Peñuela, Miguel Ángel; Esquea, Kelin; Rios, Rafael; Mendoza, Laura R.; Diaz, Lorena; Reyes, Jinnethe; Álvarez Moreno, Carlos A.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/5276
• Acceso en línea: http://hdl.handle.net/20.500.12495/5276; https://doi.org/10.4269/ajtmh.20-0223
• Palabra clave: Melioidosis; Burkholderia pseudomallei; Muermo
• Rights: openAccess
• License: Acceso abierto