Native valve endocarditis caused by corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?

We describe a patient who developed Corynebacterium striatum native valve endocarditis after receiving two 6-week courses of daptomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteremia and osteomyelitis. The organism exhibited in vitro heteroresistance to daptomycin, with two subpopulations showing daptomycin susceptibility (MIC of ≤0.094 μg/ml) and high-level resistance to daptomycin (MIC of ≥256 μg/ml). The selection of daptomycin-resistant Gram-positive skin flora with the potential of causing invasive disease may be a concern during prolonged courses of daptomycin.

• Autores: Tran, Truc T.; Jaijakul, Siraya; Lewis, Cole T.; Diaz, Lorena; panesso, diana; Kaplan, Heidi B.; Beral, Valerie; Wanger, Audrey R.; Arias, César A.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2012
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/3644
• Acceso en línea: http://hdl.handle.net/20.500.12495/3644; http://dx.doi.org/10.1128/AAC.00046-12; https://repositorio.unbosque.edu.co
• Palabra clave: Cefotaxima; Staphylococcus aureus resistente a la meticilina; Antibacterianos
• Rights: openAccess
• License: Acceso abierto