Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors

Objective Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient ne...

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Autores:
Jalali, Rozita
Guy, Franck
Ghazanfari, Samaneh
Lyaruu, Don
Ruijven, Leo van
DenBesten, Pamela
Martignon, Stefania
Castiblanco, Gina
Bronckers, Antonius L.J.J.
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3652
Acceso en línea:
http://hdl.handle.net/20.500.12495/3652
https://doi.org/10.1016/j.archoralbio.2017.07.018
https://repositorio.unbosque.edu.co
Palabra clave:
Hypomineralization
Dental fluorosis
Enamel development
Hypermineralization
Rights
openAccess
License
Acceso abierto
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dc.title.spa.fl_str_mv Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
dc.title.translated.spa.fl_str_mv Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
title Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
spellingShingle Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
Hypomineralization
Dental fluorosis
Enamel development
Hypermineralization
title_short Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
title_full Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
title_fullStr Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
title_full_unstemmed Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
title_sort Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
dc.creator.fl_str_mv Jalali, Rozita
Guy, Franck
Ghazanfari, Samaneh
Lyaruu, Don
Ruijven, Leo van
DenBesten, Pamela
Martignon, Stefania
Castiblanco, Gina
Bronckers, Antonius L.J.J.
dc.contributor.author.none.fl_str_mv Jalali, Rozita
Guy, Franck
Ghazanfari, Samaneh
Lyaruu, Don
Ruijven, Leo van
DenBesten, Pamela
Martignon, Stefania
Castiblanco, Gina
Bronckers, Antonius L.J.J.
dc.contributor.orcid.none.fl_str_mv Martignon, Stefania [0000-0002-6505-8356]
dc.subject.keywords.spa.fl_str_mv Hypomineralization
Dental fluorosis
Enamel development
Hypermineralization
topic Hypomineralization
Dental fluorosis
Enamel development
Hypermineralization
description Objective Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines. Design Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride. Result Micro-CT analysis of hypomineralized enamel from human fluorotic molars graded by the Thylstrup–Fejerskov (TF) Index as III–IV showed weak hypermineralized lines and hypermineralized patches not seen in TF-I/II grade enamel. The mesio-distal sides of these molar teeth were significantly smaller (∼18%, p = 0.02) than in TF-I/II teeth. Conclusion The patterns of changes observed in human fluorotic teeth were similar to those in fluorotic rodent incisors. The data are consistent with the hypothesis that also in developing human teeth fluoride-stimulated local acidification of enamel could be a mechanism for developing fluorotic enamel.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-08-03T14:55:53Z
dc.date.available.none.fl_str_mv 2020-08-03T14:55:53Z
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 0003-9969
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/3652
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.archoralbio.2017.07.018
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv https://repositorio.unbosque.edu.co
identifier_str_mv 0003-9969
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
url http://hdl.handle.net/20.500.12495/3652
https://doi.org/10.1016/j.archoralbio.2017.07.018
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Archives of Oral Biology, 0003-9969, Vol. 83, 2017, p. 214-221
dc.relation.uri.none.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S000399691730239X?via%3Dihub
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
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dc.rights.creativecommons.none.fl_str_mv 2017-11
rights_invalid_str_mv Acceso abierto
http://purl.org/coar/access_right/c_abf2
2017-11
eu_rights_str_mv openAccess
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.journal.spa.fl_str_mv Archives of Oral Biology
institution Universidad El Bosque
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spelling Jalali, RozitaGuy, FranckGhazanfari, SamanehLyaruu, DonRuijven, Leo vanDenBesten, PamelaMartignon, StefaniaCastiblanco, GinaBronckers, Antonius L.J.J.Martignon, Stefania [0000-0002-6505-8356]2020-08-03T14:55:53Z2020-08-03T14:55:53Z0003-9969http://hdl.handle.net/20.500.12495/3652https://doi.org/10.1016/j.archoralbio.2017.07.018instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengElsevierArchives of Oral BiologyArchives of Oral Biology, 0003-9969, Vol. 83, 2017, p. 214-221https://www.sciencedirect.com/science/article/abs/pii/S000399691730239X?via%3DihubMineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisorsMineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisorsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85HypomineralizationDental fluorosisEnamel developmentHypermineralizationObjective Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines. Design Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride. Result Micro-CT analysis of hypomineralized enamel from human fluorotic molars graded by the Thylstrup–Fejerskov (TF) Index as III–IV showed weak hypermineralized lines and hypermineralized patches not seen in TF-I/II grade enamel. The mesio-distal sides of these molar teeth were significantly smaller (∼18%, p = 0.02) than in TF-I/II teeth. Conclusion The patterns of changes observed in human fluorotic teeth were similar to those in fluorotic rodent incisors. The data are consistent with the hypothesis that also in developing human teeth fluoride-stimulated local acidification of enamel could be a mechanism for developing fluorotic enamel.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2017-11ORIGINALJalali Rozita.pdfJalali Rozita.pdfapplication/pdf1315409https://repositorio.unbosque.edu.co/bitstreams/77a9d74f-9f96-4e18-bb1e-6fdde17a8b16/download5e055c60645d54e42191358958852f76MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/3df8e40b-b7fc-4a5a-b96b-7946a939684b/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILJalali, Rozita.pdf.jpgJalali, Rozita.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/d2dde577-e073-4af4-b6e5-8f6dfef81503/download7210a811635d1799e7c05fee5d259be7MD53Jalali Rozita.pdf.jpgJalali Rozita.pdf.jpgIM Thumbnailimage/jpeg12129https://repositorio.unbosque.edu.co/bitstreams/7a32b7ff-2b2d-4400-848a-d0ea8ef02c97/download95d023cd15dab15523981134693731dbMD54TEXTJalali Rozita.pdf.txtJalali Rozita.pdf.txtExtracted texttext/plain45042https://repositorio.unbosque.edu.co/bitstreams/af1513b9-548c-4f1b-bc22-57f3f0852e18/download97441eb53eb2c404825600d58510d035MD5520.500.12495/3652oai:repositorio.unbosque.edu.co:20.500.12495/36522024-02-07 08:30:14.032restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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