Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors
Objective Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient ne...
- Autores:
-
Jalali, Rozita
Guy, Franck
Ghazanfari, Samaneh
Lyaruu, Don
Ruijven, Leo van
DenBesten, Pamela
Martignon, Stefania
Castiblanco, Gina
Bronckers, Antonius L.J.J.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/3652
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/3652
https://doi.org/10.1016/j.archoralbio.2017.07.018
https://repositorio.unbosque.edu.co
- Palabra clave:
- Hypomineralization
Dental fluorosis
Enamel development
Hypermineralization
- Rights
- openAccess
- License
- Acceso abierto
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Repositorio U. El Bosque |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
dc.title.translated.spa.fl_str_mv |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
title |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
spellingShingle |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors Hypomineralization Dental fluorosis Enamel development Hypermineralization |
title_short |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
title_full |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
title_fullStr |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
title_full_unstemmed |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
title_sort |
Mineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisors |
dc.creator.fl_str_mv |
Jalali, Rozita Guy, Franck Ghazanfari, Samaneh Lyaruu, Don Ruijven, Leo van DenBesten, Pamela Martignon, Stefania Castiblanco, Gina Bronckers, Antonius L.J.J. |
dc.contributor.author.none.fl_str_mv |
Jalali, Rozita Guy, Franck Ghazanfari, Samaneh Lyaruu, Don Ruijven, Leo van DenBesten, Pamela Martignon, Stefania Castiblanco, Gina Bronckers, Antonius L.J.J. |
dc.contributor.orcid.none.fl_str_mv |
Martignon, Stefania [0000-0002-6505-8356] |
dc.subject.keywords.spa.fl_str_mv |
Hypomineralization Dental fluorosis Enamel development Hypermineralization |
topic |
Hypomineralization Dental fluorosis Enamel development Hypermineralization |
description |
Objective Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines. Design Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride. Result Micro-CT analysis of hypomineralized enamel from human fluorotic molars graded by the Thylstrup–Fejerskov (TF) Index as III–IV showed weak hypermineralized lines and hypermineralized patches not seen in TF-I/II grade enamel. The mesio-distal sides of these molar teeth were significantly smaller (∼18%, p = 0.02) than in TF-I/II teeth. Conclusion The patterns of changes observed in human fluorotic teeth were similar to those in fluorotic rodent incisors. The data are consistent with the hypothesis that also in developing human teeth fluoride-stimulated local acidification of enamel could be a mechanism for developing fluorotic enamel. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-08-03T14:55:53Z |
dc.date.available.none.fl_str_mv |
2020-08-03T14:55:53Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
0003-9969 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/3652 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.archoralbio.2017.07.018 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
https://repositorio.unbosque.edu.co |
identifier_str_mv |
0003-9969 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque |
url |
http://hdl.handle.net/20.500.12495/3652 https://doi.org/10.1016/j.archoralbio.2017.07.018 https://repositorio.unbosque.edu.co |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Archives of Oral Biology, 0003-9969, Vol. 83, 2017, p. 214-221 |
dc.relation.uri.none.fl_str_mv |
https://www.sciencedirect.com/science/article/abs/pii/S000399691730239X?via%3Dihub |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
dc.rights.creativecommons.none.fl_str_mv |
2017-11 |
rights_invalid_str_mv |
Acceso abierto http://purl.org/coar/access_right/c_abf2 2017-11 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.publisher.journal.spa.fl_str_mv |
Archives of Oral Biology |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
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spelling |
Jalali, RozitaGuy, FranckGhazanfari, SamanehLyaruu, DonRuijven, Leo vanDenBesten, PamelaMartignon, StefaniaCastiblanco, GinaBronckers, Antonius L.J.J.Martignon, Stefania [0000-0002-6505-8356]2020-08-03T14:55:53Z2020-08-03T14:55:53Z0003-9969http://hdl.handle.net/20.500.12495/3652https://doi.org/10.1016/j.archoralbio.2017.07.018instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengElsevierArchives of Oral BiologyArchives of Oral Biology, 0003-9969, Vol. 83, 2017, p. 214-221https://www.sciencedirect.com/science/article/abs/pii/S000399691730239X?via%3DihubMineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisorsMineralization-defects are comparable in fluorotic impacted human teeth and fluorotic mouse incisorsArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85HypomineralizationDental fluorosisEnamel developmentHypermineralizationObjective Fluoride excess of 0.05–0.07 mg F/kg bw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines. Design Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride. Result Micro-CT analysis of hypomineralized enamel from human fluorotic molars graded by the Thylstrup–Fejerskov (TF) Index as III–IV showed weak hypermineralized lines and hypermineralized patches not seen in TF-I/II grade enamel. The mesio-distal sides of these molar teeth were significantly smaller (∼18%, p = 0.02) than in TF-I/II teeth. Conclusion The patterns of changes observed in human fluorotic teeth were similar to those in fluorotic rodent incisors. The data are consistent with the hypothesis that also in developing human teeth fluoride-stimulated local acidification of enamel could be a mechanism for developing fluorotic enamel.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2017-11ORIGINALJalali Rozita.pdfJalali Rozita.pdfapplication/pdf1315409https://repositorio.unbosque.edu.co/bitstreams/77a9d74f-9f96-4e18-bb1e-6fdde17a8b16/download5e055c60645d54e42191358958852f76MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/3df8e40b-b7fc-4a5a-b96b-7946a939684b/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILJalali, Rozita.pdf.jpgJalali, Rozita.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/d2dde577-e073-4af4-b6e5-8f6dfef81503/download7210a811635d1799e7c05fee5d259be7MD53Jalali Rozita.pdf.jpgJalali Rozita.pdf.jpgIM Thumbnailimage/jpeg12129https://repositorio.unbosque.edu.co/bitstreams/7a32b7ff-2b2d-4400-848a-d0ea8ef02c97/download95d023cd15dab15523981134693731dbMD54TEXTJalali Rozita.pdf.txtJalali Rozita.pdf.txtExtracted texttext/plain45042https://repositorio.unbosque.edu.co/bitstreams/af1513b9-548c-4f1b-bc22-57f3f0852e18/download97441eb53eb2c404825600d58510d035MD5520.500.12495/3652oai:repositorio.unbosque.edu.co:20.500.12495/36522024-02-07 08:30:14.032restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |