Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis

Background Previous studies have shown low rupture rates for small aneurysms (<10 mm), suggesting that the risk of treatment could exceed the benefits. However, evidence has changed, showing crescent rates of aneurysmal subarachnoid hemorrhage (aSAH) associated with small aneurysms. We report tre...

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Autores:
Figueredo, Luisa F.
Pedraza Ciro, María Camila
Lopez McCormick, Juan Sebastian
Rueda Esteban, Roberto Javier
Mejía Cordovez, Juan Armando
Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/1676
Acceso en línea:
http://hdl.handle.net/20.500.12495/1676
https://doi.org/10.1016/j.wnsx.2019.100038
Palabra clave:
Uso de tabaco
Vasoespasmo cerebral
Mortalidad
Intracranial aneurysm
Menopausal
Small aneurysm
Rights
License
Attribution-NonCommercial-NoDerivatives 4.0 International
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oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/1676
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
title Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
spellingShingle Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
Uso de tabaco
Vasoespasmo cerebral
Mortalidad
Intracranial aneurysm
Menopausal
Small aneurysm
title_short Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
title_full Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
title_fullStr Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
title_full_unstemmed Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
title_sort Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysis
dc.creator.fl_str_mv Figueredo, Luisa F.
Pedraza Ciro, María Camila
Lopez McCormick, Juan Sebastian
Rueda Esteban, Roberto Javier
Mejía Cordovez, Juan Armando
dc.contributor.author.none.fl_str_mv Figueredo, Luisa F.
Pedraza Ciro, María Camila
Lopez McCormick, Juan Sebastian
Rueda Esteban, Roberto Javier
Mejía Cordovez, Juan Armando
dc.subject.decs.spa.fl_str_mv Uso de tabaco
Vasoespasmo cerebral
Mortalidad
topic Uso de tabaco
Vasoespasmo cerebral
Mortalidad
Intracranial aneurysm
Menopausal
Small aneurysm
dc.subject.keywords.spa.fl_str_mv Intracranial aneurysm
Menopausal
Small aneurysm
description Background Previous studies have shown low rupture rates for small aneurysms (<10 mm), suggesting that the risk of treatment could exceed the benefits. However, evidence has changed, showing crescent rates of aneurysmal subarachnoid hemorrhage (aSAH) associated with small aneurysms. We report trends in size, localization, clinical characteristics, and outcomes of intracranial aneurysms (IAs). Methods In this retrospective study, a total of 200 clinical histories of patients diagnosed with IAs over an 8-year period were analyzed. Variables considered included age, sex, tobacco consumption, morphological characteristics of the aneurysm, complications, vasospasm, and mortality. Qualitative variables were assessed by measurements of absolute and relative frequency. Smoking behavior, aneurysm size, and aneurysm rupture (AR) were compared using 1-way analysis of variance. Categorical variables were analyzed using Pearson's χ2 test. Results The average age at presentation was 58 years. The average size of ruptured aneurysms in the general group was 2.5–7.5 mm, and AR was most common in women (76%) and in patients age 50–60 years (33%). The rate of vasospasm was 19%, and mortality was 37%. Smokers composed 32% of the cohort. Heavy smokers had a 57% rate of aSAH, with an average size of rupture of 5 mm. The most common location of aneurysms and AR was the AComA (33%). Conclusions Our results suggest increasing AR rates in aneurysms smaller than 10 mm. This trend is seen especially in individuals with heavy tobacco consumption and in women of perimenopausal age. Our findings show a tendency of AR in accordance with previous results and are expected to serve as basis for further research on aneurysm management.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-09-12T22:05:04Z
dc.date.available.none.fl_str_mv 2019-09-12T22:05:04Z
dc.date.issued.none.fl_str_mv 2019
dc.type.spa.fl_str_mv article
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 2590-1397
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/1676
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.wnsx.2019.100038
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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identifier_str_mv 2590-1397
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url http://hdl.handle.net/20.500.12495/1676
https://doi.org/10.1016/j.wnsx.2019.100038
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv World Neurosurgery: X, 2590-1397, Vol, 4, 2019, p. 1-8
dc.relation.uri.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S2590139719300699?via%3Dihub#!
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
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dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf448
dc.rights.creativecommons.none.fl_str_mv 2019
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Acceso abierto
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http://purl.org/coar/access_right/c_abf2
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.journal.spa.fl_str_mv World Neurosurgery: X
institution Universidad El Bosque
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spelling Figueredo, Luisa F.Pedraza Ciro, María CamilaLopez McCormick, Juan SebastianRueda Esteban, Roberto JavierMejía Cordovez, Juan Armando2019-09-12T22:05:04Z2019-09-12T22:05:04Z20192590-1397http://hdl.handle.net/20.500.12495/1676https://doi.org/10.1016/j.wnsx.2019.100038instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengElsevierWorld Neurosurgery: XWorld Neurosurgery: X, 2590-1397, Vol, 4, 2019, p. 1-8https://www.sciencedirect.com/science/article/pii/S2590139719300699?via%3Dihub#!Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf4482019http://purl.org/coar/access_right/c_abf2Aneurysmal subarachnoid hemorrhage associated with small aneurysms in smokers and women: A retrospective analysisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Uso de tabacoVasoespasmo cerebralMortalidadIntracranial aneurysmMenopausalSmall aneurysmBackground Previous studies have shown low rupture rates for small aneurysms (<10 mm), suggesting that the risk of treatment could exceed the benefits. However, evidence has changed, showing crescent rates of aneurysmal subarachnoid hemorrhage (aSAH) associated with small aneurysms. We report trends in size, localization, clinical characteristics, and outcomes of intracranial aneurysms (IAs). Methods In this retrospective study, a total of 200 clinical histories of patients diagnosed with IAs over an 8-year period were analyzed. Variables considered included age, sex, tobacco consumption, morphological characteristics of the aneurysm, complications, vasospasm, and mortality. Qualitative variables were assessed by measurements of absolute and relative frequency. Smoking behavior, aneurysm size, and aneurysm rupture (AR) were compared using 1-way analysis of variance. Categorical variables were analyzed using Pearson's χ2 test. Results The average age at presentation was 58 years. The average size of ruptured aneurysms in the general group was 2.5–7.5 mm, and AR was most common in women (76%) and in patients age 50–60 years (33%). The rate of vasospasm was 19%, and mortality was 37%. Smokers composed 32% of the cohort. Heavy smokers had a 57% rate of aSAH, with an average size of rupture of 5 mm. The most common location of aneurysms and AR was the AComA (33%). Conclusions Our results suggest increasing AR rates in aneurysms smaller than 10 mm. This trend is seen especially in individuals with heavy tobacco consumption and in women of perimenopausal age. Our findings show a tendency of AR in accordance with previous results and are expected to serve as basis for further research on aneurysm management.ORIGINALFigueredo L.F., Camila Pedraza-Ciro M_2019.pdfFigueredo L.F., Camila Pedraza-Ciro M_2019.pdfapplication/pdf878429https://repositorio.unbosque.edu.co/bitstreams/90e4fdea-bfac-4985-a517-6095ebf05bc7/download63d425f669721a6ac58d5435a6c90013MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805https://repositorio.unbosque.edu.co/bitstreams/8c4af030-3343-4fdb-98b5-0fad871d6284/download4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/6e94e4f2-feca-44f0-85c1-6d87e3dffbef/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILFigueredo L.F., Camila Pedraza-Ciro M_2019.pdf.jpgFigueredo L.F., Camila Pedraza-Ciro M_2019.pdf.jpgIM Thumbnailimage/jpeg12240https://repositorio.unbosque.edu.co/bitstreams/91b05a30-bee0-46db-b517-2e6da18af7df/download4715b8e26d0edc2bed1fb0070d2e2518MD54TEXTFigueredo L.F., Camila Pedraza-Ciro M_2019.pdf.txtFigueredo L.F., Camila Pedraza-Ciro M_2019.pdf.txtExtracted texttext/plain41469https://repositorio.unbosque.edu.co/bitstreams/f7bbbbdb-9fea-46ca-9caa-8c2850fd4b35/downloadd3683ca532392166b249c2f614d28022MD5520.500.12495/1676oai:repositorio.unbosque.edu.co:20.500.12495/16762024-02-07 09:31:48.037http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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