Establishment and multi drug resistance evolution of ST235 Pseudomonas aeruginosa strains in the intensive care unit of a Colombian hospital

Drug resistant Pseudomonas aeruginosa represents a therapeutic challenge. To assess the diversity of P. aeruginosa antibiotic resistant variants, isolates were recovered from hospital patients in Colombia. Thirty of 60 isolates contained class 1 integrons and five were of Sequence Type ST235 having appeared in a single intensive care unit. All five possessed an unusual integron but showed differences in gene cassette content and the presence/absence of insertion sequence IS26. This showed that differences can arise rapidly, even within a single ICU. Also, the emergence of IS26 in P. aeruginosa is contributing to the evolution of resistance in this bacterium.

• Autores: Martinez, Elena; Pérez, Javier Escobar; Buelvas, Francisco; Tovar, Catalina; Vanegas, Natasha; Stokes, H.W.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2014
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/3341
• Acceso en línea: http://hdl.handle.net/20.500.12495/3341; http://dx.doi.org/10.1016/j.resmic.2014.10.011; https://repositorio.unbosque.edu.co
• Palabra clave: Infecciones bacterianas; Farmacorresistencia microbiana; Pseudomonas aeruginosa; Pseudomonas aeruginosa ST235; IS26; Antibiotic resistance; Hospital acquired infections
• Rights: openAccess
• License: Acceso abierto