Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population

Aim To compare the sensitivity and specificity of screening for preeclampsia and FGR including maternal characteristics, mean arterial blood pressure and uterine artery pulsatility index and the combined screening, which adds biochemical markers, such as placental growth factor (PlGF) and pregnancy‐...

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Autores:
Romero Infante, Ximena Carolina
Uriel Calvo, María Monserrat
Rincón Franco, Sara
Porras-Ramírez, Alexandra
Tipo de recurso:
Article of journal
Fecha de publicación:
2021
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/5438
Acceso en línea:
http://hdl.handle.net/20.500.12495/5438
https://doi.org/10.1111/jog.14605
Palabra clave:
Hipertensión inducida en el embarazo
Retardo del crecimiento fetal
Enfermedades fetales
Fetal growth restriction
Preeclampsia
Risk factors
Sensitivity
Specificity
Rights
closedAccess
License
Acceso cerrado
id UNBOSQUE2_3d13e2ce9677b9adf504ecdf93c46a74
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/5438
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
dc.title.translated.spa.fl_str_mv Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
title Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
spellingShingle Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
Hipertensión inducida en el embarazo
Retardo del crecimiento fetal
Enfermedades fetales
Fetal growth restriction
Preeclampsia
Risk factors
Sensitivity
Specificity
title_short Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
title_full Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
title_fullStr Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
title_full_unstemmed Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
title_sort Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
dc.creator.fl_str_mv Romero Infante, Ximena Carolina
Uriel Calvo, María Monserrat
Rincón Franco, Sara
Porras-Ramírez, Alexandra
dc.contributor.author.none.fl_str_mv Romero Infante, Ximena Carolina
Uriel Calvo, María Monserrat
Rincón Franco, Sara
Porras-Ramírez, Alexandra
dc.contributor.orcid.none.fl_str_mv Romero Infante, Ximena Carolina [0000-0002-7040-2705]
Uriel, Montserrat [0000-0001-5987-8633]
Porras-Ramírez, Alexandra [0000-0002-0800-1388]
Rincón Franco, Sara [0000-0002-4594-9151]
Uriel Calvo, María Monserrat [0000-0001-5987-8633]
Rincón Franco, Sara [0000-0002-4594-9151]
Uriel Calvo, María Monserrat [0000-0001-5987-8633]
Rincón Franco, Sara [0000-0002-4594-9151]
dc.subject.decs.spa.fl_str_mv Hipertensión inducida en el embarazo
Retardo del crecimiento fetal
Enfermedades fetales
topic Hipertensión inducida en el embarazo
Retardo del crecimiento fetal
Enfermedades fetales
Fetal growth restriction
Preeclampsia
Risk factors
Sensitivity
Specificity
dc.subject.keywords.spa.fl_str_mv Fetal growth restriction
Preeclampsia
Risk factors
Sensitivity
Specificity
description Aim To compare the sensitivity and specificity of screening for preeclampsia and FGR including maternal characteristics, mean arterial blood pressure and uterine artery pulsatility index and the combined screening, which adds biochemical markers, such as placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A), in a sample of high risk population for hypertensive disorders. Methods This is a prospective study with 527 singleton pregnancies at 11–14 weeks of gestation. Maternal characteristics, biochemical and biophysical markers were studied to determine the development of preeclampsia and FGR by using receiver operating characteristic curves. Results For preeclampsia, screening, including sociodemographic data plus biophysical markers, had a sensitivity and specificity of 70.3% (CI% 64.3–75.2) and 93.8% (CI% 90.9–96.8), respectively. Combined screening, which includes sociodemographic data, biophysical (mean blood pressure and uterine artery pulsatility index) and biochemical markers (PlGF and PAPP‐A), increased sensitivity and specificity up to 85.5% (CI% 80.2–90.3) and 96.3% (CI% 91.4–98.9), respectively. For FGR, sociodemographic data plus biophysical markers had a sensitivity and specificity of 57.8% (CI% 50.1–63.4) and 80.1% (CI% 74.3–85.9), respectively. Combined screening increased sensitivity and specificity up to 67.2% (CI% 52.1–71.3) and 82.7% (CI% 75.2–90.1), respectively. Conclusion Combined screening for preeclampsia and FGR at 11 to 14 weeks of gestation, which includes maternal characteristics, mean blood pressure, uterine artery pulsatility index, PAPP‐A and PlGF, has higher sensitivity and specificity than other screening options. Therefore, considering all these variables during screening is recommended for a superior opportunity of identifying pregnant women in risk for preeclampsia and FGR, especially in a high‐risk population.
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2021-02-25T18:21:09Z
dc.date.available.none.fl_str_mv 2021-02-25T18:21:09Z
dc.date.issued.none.fl_str_mv 2021
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.none.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.none.fl_str_mv 1447-0756
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/5438
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1111/jog.14605
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 1447-0756
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/5438
https://doi.org/10.1111/jog.14605
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Journal of Obstetrics and Gynaecology Research, 1447-0756, Vol. 47, Nro. 2, 2021, p. 765-773
dc.relation.uri.none.fl_str_mv https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.14605
dc.rights.local.spa.fl_str_mv Acceso cerrado
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
http://purl.org/coar/access_right/c_14cb
dc.rights.creativecommons.none.fl_str_mv 2020-02
rights_invalid_str_mv Acceso cerrado
http://purl.org/coar/access_right/c_14cb
2020-02
eu_rights_str_mv closedAccess
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Japan Society of Obstetrics and Gynecology
John Wiley & Sons, Inc
dc.publisher.journal.spa.fl_str_mv Journal of Obstetrics and Gynaecology Research
institution Universidad El Bosque
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spelling Romero Infante, Ximena CarolinaUriel Calvo, María MonserratRincón Franco, SaraPorras-Ramírez, AlexandraRomero Infante, Ximena Carolina [0000-0002-7040-2705]Uriel, Montserrat [0000-0001-5987-8633]Porras-Ramírez, Alexandra [0000-0002-0800-1388]Rincón Franco, Sara [0000-0002-4594-9151]Uriel Calvo, María Monserrat [0000-0001-5987-8633]Rincón Franco, Sara [0000-0002-4594-9151]Uriel Calvo, María Monserrat [0000-0001-5987-8633]Rincón Franco, Sara [0000-0002-4594-9151]2021-02-25T18:21:09Z2021-02-25T18:21:09Z20211447-0756http://hdl.handle.net/20.500.12495/5438https://doi.org/10.1111/jog.14605instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengJapan Society of Obstetrics and GynecologyJohn Wiley & Sons, IncJournal of Obstetrics and Gynaecology ResearchJournal of Obstetrics and Gynaecology Research, 1447-0756, Vol. 47, Nro. 2, 2021, p. 765-773https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.14605Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk populationComparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk populationArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Hipertensión inducida en el embarazoRetardo del crecimiento fetalEnfermedades fetalesFetal growth restrictionPreeclampsiaRisk factorsSensitivitySpecificityAim To compare the sensitivity and specificity of screening for preeclampsia and FGR including maternal characteristics, mean arterial blood pressure and uterine artery pulsatility index and the combined screening, which adds biochemical markers, such as placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A), in a sample of high risk population for hypertensive disorders. Methods This is a prospective study with 527 singleton pregnancies at 11–14 weeks of gestation. Maternal characteristics, biochemical and biophysical markers were studied to determine the development of preeclampsia and FGR by using receiver operating characteristic curves. Results For preeclampsia, screening, including sociodemographic data plus biophysical markers, had a sensitivity and specificity of 70.3% (CI% 64.3–75.2) and 93.8% (CI% 90.9–96.8), respectively. Combined screening, which includes sociodemographic data, biophysical (mean blood pressure and uterine artery pulsatility index) and biochemical markers (PlGF and PAPP‐A), increased sensitivity and specificity up to 85.5% (CI% 80.2–90.3) and 96.3% (CI% 91.4–98.9), respectively. For FGR, sociodemographic data plus biophysical markers had a sensitivity and specificity of 57.8% (CI% 50.1–63.4) and 80.1% (CI% 74.3–85.9), respectively. Combined screening increased sensitivity and specificity up to 67.2% (CI% 52.1–71.3) and 82.7% (CI% 75.2–90.1), respectively. Conclusion Combined screening for preeclampsia and FGR at 11 to 14 weeks of gestation, which includes maternal characteristics, mean blood pressure, uterine artery pulsatility index, PAPP‐A and PlGF, has higher sensitivity and specificity than other screening options. Therefore, considering all these variables during screening is recommended for a superior opportunity of identifying pregnant women in risk for preeclampsia and FGR, especially in a high‐risk population.Acceso cerradoinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cb2020-02LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://18.204.144.38/bitstreams/daba1577-445f-4bcc-916a-7588081d99ee/download8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALRomero_Infante_Ximena_Carolina_2020.pdf.pdfRomero_Infante_Ximena_Carolina_2020.pdf.pdfapplication/pdf1037210http://18.204.144.38/bitstreams/df0af5e3-a1ae-4a98-836f-7e177e6be996/downloaded724e2318c72efbe59cba968d4214a9MD54THUMBNAILRomero_Infante_Ximena_Carolina_2020.pdf.pdf.jpgRomero_Infante_Ximena_Carolina_2020.pdf.pdf.jpgimage/jpeg5775http://18.204.144.38/bitstreams/2967bf61-4324-43e1-9f5b-e2b8cb34ef24/download7210a811635d1799e7c05fee5d259be7MD55TEXTRomero_Infante_Ximena_Carolina_2020.pdf.pdf.txtRomero_Infante_Ximena_Carolina_2020.pdf.pdf.txtExtracted texttext/plain34152http://18.204.144.38/bitstreams/4ab9a124-c2ad-481b-8db9-7f24e64ae244/download4ef863ebc20c9df7a044a81e0712a349MD5620.500.12495/5438oai:18.204.144.38:20.500.12495/54382024-02-06 22:20:17.072restrictedhttp://18.204.144.38DSpace Pre-instalado Biteca S.A.Sbibliotecas@biteca.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