Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population
Aim To compare the sensitivity and specificity of screening for preeclampsia and FGR including maternal characteristics, mean arterial blood pressure and uterine artery pulsatility index and the combined screening, which adds biochemical markers, such as placental growth factor (PlGF) and pregnancy‐...
- Autores:
-
Romero Infante, Ximena Carolina
Uriel Calvo, María Monserrat
Rincón Franco, Sara
Porras-Ramírez, Alexandra
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2021
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/5438
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/5438
https://doi.org/10.1111/jog.14605
- Palabra clave:
- Hipertensión inducida en el embarazo
Retardo del crecimiento fetal
Enfermedades fetales
Fetal growth restriction
Preeclampsia
Risk factors
Sensitivity
Specificity
- Rights
- closedAccess
- License
- Acceso cerrado
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|
dc.title.spa.fl_str_mv |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
dc.title.translated.spa.fl_str_mv |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
title |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
spellingShingle |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population Hipertensión inducida en el embarazo Retardo del crecimiento fetal Enfermedades fetales Fetal growth restriction Preeclampsia Risk factors Sensitivity Specificity |
title_short |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
title_full |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
title_fullStr |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
title_full_unstemmed |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
title_sort |
Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk population |
dc.creator.fl_str_mv |
Romero Infante, Ximena Carolina Uriel Calvo, María Monserrat Rincón Franco, Sara Porras-Ramírez, Alexandra |
dc.contributor.author.none.fl_str_mv |
Romero Infante, Ximena Carolina Uriel Calvo, María Monserrat Rincón Franco, Sara Porras-Ramírez, Alexandra |
dc.contributor.orcid.none.fl_str_mv |
Romero Infante, Ximena Carolina [0000-0002-7040-2705] Uriel, Montserrat [0000-0001-5987-8633] Porras-Ramírez, Alexandra [0000-0002-0800-1388] Rincón Franco, Sara [0000-0002-4594-9151] Uriel Calvo, María Monserrat [0000-0001-5987-8633] Rincón Franco, Sara [0000-0002-4594-9151] Uriel Calvo, María Monserrat [0000-0001-5987-8633] Rincón Franco, Sara [0000-0002-4594-9151] |
dc.subject.decs.spa.fl_str_mv |
Hipertensión inducida en el embarazo Retardo del crecimiento fetal Enfermedades fetales |
topic |
Hipertensión inducida en el embarazo Retardo del crecimiento fetal Enfermedades fetales Fetal growth restriction Preeclampsia Risk factors Sensitivity Specificity |
dc.subject.keywords.spa.fl_str_mv |
Fetal growth restriction Preeclampsia Risk factors Sensitivity Specificity |
description |
Aim To compare the sensitivity and specificity of screening for preeclampsia and FGR including maternal characteristics, mean arterial blood pressure and uterine artery pulsatility index and the combined screening, which adds biochemical markers, such as placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A), in a sample of high risk population for hypertensive disorders. Methods This is a prospective study with 527 singleton pregnancies at 11–14 weeks of gestation. Maternal characteristics, biochemical and biophysical markers were studied to determine the development of preeclampsia and FGR by using receiver operating characteristic curves. Results For preeclampsia, screening, including sociodemographic data plus biophysical markers, had a sensitivity and specificity of 70.3% (CI% 64.3–75.2) and 93.8% (CI% 90.9–96.8), respectively. Combined screening, which includes sociodemographic data, biophysical (mean blood pressure and uterine artery pulsatility index) and biochemical markers (PlGF and PAPP‐A), increased sensitivity and specificity up to 85.5% (CI% 80.2–90.3) and 96.3% (CI% 91.4–98.9), respectively. For FGR, sociodemographic data plus biophysical markers had a sensitivity and specificity of 57.8% (CI% 50.1–63.4) and 80.1% (CI% 74.3–85.9), respectively. Combined screening increased sensitivity and specificity up to 67.2% (CI% 52.1–71.3) and 82.7% (CI% 75.2–90.1), respectively. Conclusion Combined screening for preeclampsia and FGR at 11 to 14 weeks of gestation, which includes maternal characteristics, mean blood pressure, uterine artery pulsatility index, PAPP‐A and PlGF, has higher sensitivity and specificity than other screening options. Therefore, considering all these variables during screening is recommended for a superior opportunity of identifying pregnant women in risk for preeclampsia and FGR, especially in a high‐risk population. |
publishDate |
2021 |
dc.date.accessioned.none.fl_str_mv |
2021-02-25T18:21:09Z |
dc.date.available.none.fl_str_mv |
2021-02-25T18:21:09Z |
dc.date.issued.none.fl_str_mv |
2021 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1447-0756 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/5438 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1111/jog.14605 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1447-0756 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/5438 https://doi.org/10.1111/jog.14605 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Journal of Obstetrics and Gynaecology Research, 1447-0756, Vol. 47, Nro. 2, 2021, p. 765-773 |
dc.relation.uri.none.fl_str_mv |
https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.14605 |
dc.rights.local.spa.fl_str_mv |
Acceso cerrado |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/closedAccess http://purl.org/coar/access_right/c_14cb |
dc.rights.creativecommons.none.fl_str_mv |
2020-02 |
rights_invalid_str_mv |
Acceso cerrado http://purl.org/coar/access_right/c_14cb 2020-02 |
eu_rights_str_mv |
closedAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Japan Society of Obstetrics and Gynecology John Wiley & Sons, Inc |
dc.publisher.journal.spa.fl_str_mv |
Journal of Obstetrics and Gynaecology Research |
institution |
Universidad El Bosque |
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Romero Infante, Ximena CarolinaUriel Calvo, María MonserratRincón Franco, SaraPorras-Ramírez, AlexandraRomero Infante, Ximena Carolina [0000-0002-7040-2705]Uriel, Montserrat [0000-0001-5987-8633]Porras-Ramírez, Alexandra [0000-0002-0800-1388]Rincón Franco, Sara [0000-0002-4594-9151]Uriel Calvo, María Monserrat [0000-0001-5987-8633]Rincón Franco, Sara [0000-0002-4594-9151]Uriel Calvo, María Monserrat [0000-0001-5987-8633]Rincón Franco, Sara [0000-0002-4594-9151]2021-02-25T18:21:09Z2021-02-25T18:21:09Z20211447-0756http://hdl.handle.net/20.500.12495/5438https://doi.org/10.1111/jog.14605instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengJapan Society of Obstetrics and GynecologyJohn Wiley & Sons, IncJournal of Obstetrics and Gynaecology ResearchJournal of Obstetrics and Gynaecology Research, 1447-0756, Vol. 47, Nro. 2, 2021, p. 765-773https://obgyn.onlinelibrary.wiley.com/doi/epdf/10.1111/jog.14605Comparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk populationComparison of preeclampsia and fetal growth restriction screenings at first trimester in a high-risk populationArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Hipertensión inducida en el embarazoRetardo del crecimiento fetalEnfermedades fetalesFetal growth restrictionPreeclampsiaRisk factorsSensitivitySpecificityAim To compare the sensitivity and specificity of screening for preeclampsia and FGR including maternal characteristics, mean arterial blood pressure and uterine artery pulsatility index and the combined screening, which adds biochemical markers, such as placental growth factor (PlGF) and pregnancy‐associated plasma protein‐A (PAPP‐A), in a sample of high risk population for hypertensive disorders. Methods This is a prospective study with 527 singleton pregnancies at 11–14 weeks of gestation. Maternal characteristics, biochemical and biophysical markers were studied to determine the development of preeclampsia and FGR by using receiver operating characteristic curves. Results For preeclampsia, screening, including sociodemographic data plus biophysical markers, had a sensitivity and specificity of 70.3% (CI% 64.3–75.2) and 93.8% (CI% 90.9–96.8), respectively. Combined screening, which includes sociodemographic data, biophysical (mean blood pressure and uterine artery pulsatility index) and biochemical markers (PlGF and PAPP‐A), increased sensitivity and specificity up to 85.5% (CI% 80.2–90.3) and 96.3% (CI% 91.4–98.9), respectively. For FGR, sociodemographic data plus biophysical markers had a sensitivity and specificity of 57.8% (CI% 50.1–63.4) and 80.1% (CI% 74.3–85.9), respectively. Combined screening increased sensitivity and specificity up to 67.2% (CI% 52.1–71.3) and 82.7% (CI% 75.2–90.1), respectively. Conclusion Combined screening for preeclampsia and FGR at 11 to 14 weeks of gestation, which includes maternal characteristics, mean blood pressure, uterine artery pulsatility index, PAPP‐A and PlGF, has higher sensitivity and specificity than other screening options. Therefore, considering all these variables during screening is recommended for a superior opportunity of identifying pregnant women in risk for preeclampsia and FGR, especially in a high‐risk population.Acceso cerradoinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cb2020-02LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://18.204.144.38/bitstreams/daba1577-445f-4bcc-916a-7588081d99ee/download8a4605be74aa9ea9d79846c1fba20a33MD53ORIGINALRomero_Infante_Ximena_Carolina_2020.pdf.pdfRomero_Infante_Ximena_Carolina_2020.pdf.pdfapplication/pdf1037210http://18.204.144.38/bitstreams/df0af5e3-a1ae-4a98-836f-7e177e6be996/downloaded724e2318c72efbe59cba968d4214a9MD54THUMBNAILRomero_Infante_Ximena_Carolina_2020.pdf.pdf.jpgRomero_Infante_Ximena_Carolina_2020.pdf.pdf.jpgimage/jpeg5775http://18.204.144.38/bitstreams/2967bf61-4324-43e1-9f5b-e2b8cb34ef24/download7210a811635d1799e7c05fee5d259be7MD55TEXTRomero_Infante_Ximena_Carolina_2020.pdf.pdf.txtRomero_Infante_Ximena_Carolina_2020.pdf.pdf.txtExtracted texttext/plain34152http://18.204.144.38/bitstreams/4ab9a124-c2ad-481b-8db9-7f24e64ae244/download4ef863ebc20c9df7a044a81e0712a349MD5620.500.12495/5438oai:18.204.144.38:20.500.12495/54382024-02-06 22:20:17.072restrictedhttp://18.204.144.38DSpace Pre-instalado Biteca S.A.Sbibliotecas@biteca.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 |