Seronegative paraneoplastic limbic encephalitis associated with thymoma
Paraneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, a...
- Autores:
-
Toro, Jaime
Cuellar-Giraldo, David
Duque, Alejandra
Minota, Karla
Patiño, Jorge E.
Garciá, Manuel
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/3391
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/3391
https://doi.org/10.1097/wnn.0000000000000134
https://repositorio.unbosque.edu.co
- Palabra clave:
- Líquido cefalorraquídeo
Encefalitis límbica
Espectroscopía de resonancia magnética
Paraneoplastic limbic encephalitis
Seronegative
Thymoma
- Rights
- openAccess
- License
- Acceso abierto
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oai:repositorio.unbosque.edu.co:20.500.12495/3391 |
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UNBOSQUE2 |
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Repositorio U. El Bosque |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
dc.title.translated.spa.fl_str_mv |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
title |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
spellingShingle |
Seronegative paraneoplastic limbic encephalitis associated with thymoma Líquido cefalorraquídeo Encefalitis límbica Espectroscopía de resonancia magnética Paraneoplastic limbic encephalitis Seronegative Thymoma |
title_short |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
title_full |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
title_fullStr |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
title_full_unstemmed |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
title_sort |
Seronegative paraneoplastic limbic encephalitis associated with thymoma |
dc.creator.fl_str_mv |
Toro, Jaime Cuellar-Giraldo, David Duque, Alejandra Minota, Karla Patiño, Jorge E. Garciá, Manuel |
dc.contributor.author.none.fl_str_mv |
Toro, Jaime Cuellar-Giraldo, David Duque, Alejandra Minota, Karla Patiño, Jorge E. Garciá, Manuel |
dc.contributor.orcid.none.fl_str_mv |
Toro, Jaime [0000-0001-7129-0058] |
dc.subject.decs.spa.fl_str_mv |
Líquido cefalorraquídeo Encefalitis límbica Espectroscopía de resonancia magnética |
topic |
Líquido cefalorraquídeo Encefalitis límbica Espectroscopía de resonancia magnética Paraneoplastic limbic encephalitis Seronegative Thymoma |
dc.subject.keywords.spa.fl_str_mv |
Paraneoplastic limbic encephalitis Seronegative Thymoma |
description |
Paraneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, advances in the field now permit the diagnosis without autoantibody test results. In this case illustrating the new diagnostic criteria, we report a 70-year-old woman who was brought to the emergency room after the acute onset of cognitive impairment, altered mental status, and choreoathetoid movements. Brain magnetic resonance imaging showed hyperintense signals in both temporal lobes, and a chest computed tomogram revealed a thymoma. Because the patient met current diagnostic criteria for autoimmune limbic encephalitis, we were able to start treatment before her antibody tests were processed. The patient received immunotherapy and her tumor was resected. Her choreoathetoid movements disappeared and her other neurologic symptoms improved. Her cerebrospinal fluid proved to be negative for paraneoplastic limbic encephalitis antibodies. Most but not all patients with paraneoplastic limbic encephalitis associated with thymoma have evidence of paraneoplastic antibodies. Prompt management of the underlying malignancy determines whether patients survive and may minimize future cognitive and functional impairment. Practicing neurologists and psychiatrists should be aware of this diagnosis. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-07-09T19:48:12Z |
dc.date.available.none.fl_str_mv |
2020-07-09T19:48:12Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1543-3641 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/3391 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1097/wnn.0000000000000134 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
https://repositorio.unbosque.edu.co |
identifier_str_mv |
1543-3641 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque |
url |
http://hdl.handle.net/20.500.12495/3391 https://doi.org/10.1097/wnn.0000000000000134 https://repositorio.unbosque.edu.co |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Cognitive and behavioral neurology, 1543-3641. Vol. 30, Nro. 3, 2017, p.125-128 |
dc.relation.uri.none.fl_str_mv |
https://journals.lww.com/cogbehavneurol/Fulltext/2017/09000/Seronegative_Paraneoplastic_Limbic_Encephalitis.6.aspx |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
dc.rights.creativecommons.none.fl_str_mv |
2017-09 |
rights_invalid_str_mv |
Acceso abierto http://purl.org/coar/access_right/c_abf2 2017-09 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Wolters Kluwer Health |
dc.publisher.journal.spa.fl_str_mv |
Cognitive and behavioral neurology |
institution |
Universidad El Bosque |
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Toro, JaimeCuellar-Giraldo, DavidDuque, AlejandraMinota, KarlaPatiño, Jorge E.Garciá, ManuelToro, Jaime [0000-0001-7129-0058]2020-07-09T19:48:12Z2020-07-09T19:48:12Z1543-3641http://hdl.handle.net/20.500.12495/3391https://doi.org/10.1097/wnn.0000000000000134instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengWolters Kluwer HealthCognitive and behavioral neurologyCognitive and behavioral neurology, 1543-3641. Vol. 30, Nro. 3, 2017, p.125-128https://journals.lww.com/cogbehavneurol/Fulltext/2017/09000/Seronegative_Paraneoplastic_Limbic_Encephalitis.6.aspxSeronegative paraneoplastic limbic encephalitis associated with thymomaSeronegative paraneoplastic limbic encephalitis associated with thymomaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Líquido cefalorraquídeoEncefalitis límbicaEspectroscopía de resonancia magnéticaParaneoplastic limbic encephalitisSeronegativeThymomaParaneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, advances in the field now permit the diagnosis without autoantibody test results. In this case illustrating the new diagnostic criteria, we report a 70-year-old woman who was brought to the emergency room after the acute onset of cognitive impairment, altered mental status, and choreoathetoid movements. Brain magnetic resonance imaging showed hyperintense signals in both temporal lobes, and a chest computed tomogram revealed a thymoma. Because the patient met current diagnostic criteria for autoimmune limbic encephalitis, we were able to start treatment before her antibody tests were processed. The patient received immunotherapy and her tumor was resected. Her choreoathetoid movements disappeared and her other neurologic symptoms improved. Her cerebrospinal fluid proved to be negative for paraneoplastic limbic encephalitis antibodies. Most but not all patients with paraneoplastic limbic encephalitis associated with thymoma have evidence of paraneoplastic antibodies. Prompt management of the underlying malignancy determines whether patients survive and may minimize future cognitive and functional impairment. Practicing neurologists and psychiatrists should be aware of this diagnosis.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2017-09ORIGINALToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdfToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdfapplication/pdf682344https://repositorio.unbosque.edu.co/bitstreams/d52cd169-b2a2-450e-99fa-eec8e9bc553f/download449a61fc724946599544506bd16aeab7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/ce826838-f09a-4922-860e-4788a58aea38/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.jpgToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/f43be7f4-693b-46cd-97bb-3b00b2bbdb56/download7210a811635d1799e7c05fee5d259be7MD53TEXTToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.txtToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.txtExtracted texttext/plain20948https://repositorio.unbosque.edu.co/bitstreams/14743a97-5b5a-4e89-be95-4ee14551c211/download35517e039d893ecda3b883bb03f41e4aMD5420.500.12495/3391oai:repositorio.unbosque.edu.co:20.500.12495/33912024-02-07 04:40:46.613restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |