Seronegative paraneoplastic limbic encephalitis associated with thymoma

Paraneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, a...

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Autores:
Toro, Jaime
Cuellar-Giraldo, David
Duque, Alejandra
Minota, Karla
Patiño, Jorge E.
Garciá, Manuel
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3391
Acceso en línea:
http://hdl.handle.net/20.500.12495/3391
https://doi.org/10.1097/wnn.0000000000000134
https://repositorio.unbosque.edu.co
Palabra clave:
Líquido cefalorraquídeo
Encefalitis límbica
Espectroscopía de resonancia magnética
Paraneoplastic limbic encephalitis
Seronegative
Thymoma
Rights
openAccess
License
Acceso abierto
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dc.title.spa.fl_str_mv Seronegative paraneoplastic limbic encephalitis associated with thymoma
dc.title.translated.spa.fl_str_mv Seronegative paraneoplastic limbic encephalitis associated with thymoma
title Seronegative paraneoplastic limbic encephalitis associated with thymoma
spellingShingle Seronegative paraneoplastic limbic encephalitis associated with thymoma
Líquido cefalorraquídeo
Encefalitis límbica
Espectroscopía de resonancia magnética
Paraneoplastic limbic encephalitis
Seronegative
Thymoma
title_short Seronegative paraneoplastic limbic encephalitis associated with thymoma
title_full Seronegative paraneoplastic limbic encephalitis associated with thymoma
title_fullStr Seronegative paraneoplastic limbic encephalitis associated with thymoma
title_full_unstemmed Seronegative paraneoplastic limbic encephalitis associated with thymoma
title_sort Seronegative paraneoplastic limbic encephalitis associated with thymoma
dc.creator.fl_str_mv Toro, Jaime
Cuellar-Giraldo, David
Duque, Alejandra
Minota, Karla
Patiño, Jorge E.
Garciá, Manuel
dc.contributor.author.none.fl_str_mv Toro, Jaime
Cuellar-Giraldo, David
Duque, Alejandra
Minota, Karla
Patiño, Jorge E.
Garciá, Manuel
dc.contributor.orcid.none.fl_str_mv Toro, Jaime [0000-0001-7129-0058]
dc.subject.decs.spa.fl_str_mv Líquido cefalorraquídeo
Encefalitis límbica
Espectroscopía de resonancia magnética
topic Líquido cefalorraquídeo
Encefalitis límbica
Espectroscopía de resonancia magnética
Paraneoplastic limbic encephalitis
Seronegative
Thymoma
dc.subject.keywords.spa.fl_str_mv Paraneoplastic limbic encephalitis
Seronegative
Thymoma
description Paraneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, advances in the field now permit the diagnosis without autoantibody test results. In this case illustrating the new diagnostic criteria, we report a 70-year-old woman who was brought to the emergency room after the acute onset of cognitive impairment, altered mental status, and choreoathetoid movements. Brain magnetic resonance imaging showed hyperintense signals in both temporal lobes, and a chest computed tomogram revealed a thymoma. Because the patient met current diagnostic criteria for autoimmune limbic encephalitis, we were able to start treatment before her antibody tests were processed. The patient received immunotherapy and her tumor was resected. Her choreoathetoid movements disappeared and her other neurologic symptoms improved. Her cerebrospinal fluid proved to be negative for paraneoplastic limbic encephalitis antibodies. Most but not all patients with paraneoplastic limbic encephalitis associated with thymoma have evidence of paraneoplastic antibodies. Prompt management of the underlying malignancy determines whether patients survive and may minimize future cognitive and functional impairment. Practicing neurologists and psychiatrists should be aware of this diagnosis.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-07-09T19:48:12Z
dc.date.available.none.fl_str_mv 2020-07-09T19:48:12Z
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 1543-3641
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/3391
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1097/wnn.0000000000000134
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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identifier_str_mv 1543-3641
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
url http://hdl.handle.net/20.500.12495/3391
https://doi.org/10.1097/wnn.0000000000000134
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Cognitive and behavioral neurology, 1543-3641. Vol. 30, Nro. 3, 2017, p.125-128
dc.relation.uri.none.fl_str_mv https://journals.lww.com/cogbehavneurol/Fulltext/2017/09000/Seronegative_Paraneoplastic_Limbic_Encephalitis.6.aspx
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
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dc.rights.creativecommons.none.fl_str_mv 2017-09
rights_invalid_str_mv Acceso abierto
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2017-09
eu_rights_str_mv openAccess
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Wolters Kluwer Health
dc.publisher.journal.spa.fl_str_mv Cognitive and behavioral neurology
institution Universidad El Bosque
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spelling Toro, JaimeCuellar-Giraldo, DavidDuque, AlejandraMinota, KarlaPatiño, Jorge E.Garciá, ManuelToro, Jaime [0000-0001-7129-0058]2020-07-09T19:48:12Z2020-07-09T19:48:12Z1543-3641http://hdl.handle.net/20.500.12495/3391https://doi.org/10.1097/wnn.0000000000000134instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengWolters Kluwer HealthCognitive and behavioral neurologyCognitive and behavioral neurology, 1543-3641. Vol. 30, Nro. 3, 2017, p.125-128https://journals.lww.com/cogbehavneurol/Fulltext/2017/09000/Seronegative_Paraneoplastic_Limbic_Encephalitis.6.aspxSeronegative paraneoplastic limbic encephalitis associated with thymomaSeronegative paraneoplastic limbic encephalitis associated with thymomaArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Líquido cefalorraquídeoEncefalitis límbicaEspectroscopía de resonancia magnéticaParaneoplastic limbic encephalitisSeronegativeThymomaParaneoplastic limbic encephalitis is an autoimmune syndrome characterized by the acute or subacute onset of encephalopathy, memory loss, confusion, temporal lobe seizures, and behavioral and mood changes. Although most patients with paraneoplastic limbic encephalitis have antineuronal antibodies, advances in the field now permit the diagnosis without autoantibody test results. In this case illustrating the new diagnostic criteria, we report a 70-year-old woman who was brought to the emergency room after the acute onset of cognitive impairment, altered mental status, and choreoathetoid movements. Brain magnetic resonance imaging showed hyperintense signals in both temporal lobes, and a chest computed tomogram revealed a thymoma. Because the patient met current diagnostic criteria for autoimmune limbic encephalitis, we were able to start treatment before her antibody tests were processed. The patient received immunotherapy and her tumor was resected. Her choreoathetoid movements disappeared and her other neurologic symptoms improved. Her cerebrospinal fluid proved to be negative for paraneoplastic limbic encephalitis antibodies. Most but not all patients with paraneoplastic limbic encephalitis associated with thymoma have evidence of paraneoplastic antibodies. Prompt management of the underlying malignancy determines whether patients survive and may minimize future cognitive and functional impairment. Practicing neurologists and psychiatrists should be aware of this diagnosis.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2017-09ORIGINALToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdfToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdfapplication/pdf682344https://repositorio.unbosque.edu.co/bitstreams/d52cd169-b2a2-450e-99fa-eec8e9bc553f/download449a61fc724946599544506bd16aeab7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/ce826838-f09a-4922-860e-4788a58aea38/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.jpgToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/f43be7f4-693b-46cd-97bb-3b00b2bbdb56/download7210a811635d1799e7c05fee5d259be7MD53TEXTToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.txtToro, Jaime MD, FAAN, FACP; Cuéllar-Giraldo, David; Duque, Alejandra_2017.pdf.txtExtracted texttext/plain20948https://repositorio.unbosque.edu.co/bitstreams/14743a97-5b5a-4e89-be95-4ee14551c211/download35517e039d893ecda3b883bb03f41e4aMD5420.500.12495/3391oai:repositorio.unbosque.edu.co:20.500.12495/33912024-02-07 04:40:46.613restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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