Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris

We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris. A precisi...

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Autores:
Ayesha, Khan
Shropshire, William
Arias, Cesar A
Hanson, Blake
Wanger, Audrey
Dinh, An
Miller, William
Ostrosky-Zeichner, Luis
Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/1934
Acceso en línea:
http://hdl.handle.net/20.500.12495/1934
https://doi.org/10.1128/AAC.01466-19
Palabra clave:
Infecciones bacterianas
Análisis de secuencia de ADN
Resistencia a medicamentos
Candida auris
Enterobacteriaceae
Pseudomonas aeruginosa
Carbapenemase
Rights
License
Acceso cerrado
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oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/1934
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
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dc.title.spa.fl_str_mv Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
title Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
spellingShingle Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
Infecciones bacterianas
Análisis de secuencia de ADN
Resistencia a medicamentos
Candida auris
Enterobacteriaceae
Pseudomonas aeruginosa
Carbapenemase
title_short Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
title_full Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
title_fullStr Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
title_full_unstemmed Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
title_sort Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida auris
dc.creator.fl_str_mv Ayesha, Khan
Shropshire, William
Arias, Cesar A
Hanson, Blake
Wanger, Audrey
Dinh, An
Miller, William
Ostrosky-Zeichner, Luis
dc.contributor.author.none.fl_str_mv Ayesha, Khan
Shropshire, William
Arias, Cesar A
Hanson, Blake
Wanger, Audrey
Dinh, An
Miller, William
Ostrosky-Zeichner, Luis
dc.subject.decs.spa.fl_str_mv Infecciones bacterianas
Análisis de secuencia de ADN
Resistencia a medicamentos
topic Infecciones bacterianas
Análisis de secuencia de ADN
Resistencia a medicamentos
Candida auris
Enterobacteriaceae
Pseudomonas aeruginosa
Carbapenemase
dc.subject.keywords.spa.fl_str_mv Candida auris
Enterobacteriaceae
Pseudomonas aeruginosa
Carbapenemase
description We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris. A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-02-13T19:52:27Z
dc.date.available.none.fl_str_mv 2020-02-13T19:52:27Z
dc.date.issued.none.fl_str_mv 2020
dc.type.spa.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 1098-6596
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/1934
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1128/AAC.01466-19
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 1098-6596
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/1934
https://doi.org/10.1128/AAC.01466-19
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv American Society for Microbiology Journals,1098-6596, Vol.64, Nro. 2, 2020, p. 1-6
dc.relation.uri.none.fl_str_mv https://aac.asm.org/content/64/2/e01466-19
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso cerrado
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dc.rights.creativecommons.none.fl_str_mv 2020
rights_invalid_str_mv Acceso cerrado
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2020
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dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv American Society for Microbiology
dc.publisher.journal.spa.fl_str_mv American Society for Microbiology Journals
institution Universidad El Bosque
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spelling Ayesha, KhanShropshire, WilliamArias, Cesar AHanson, BlakeWanger, AudreyDinh, AnMiller, WilliamOstrosky-Zeichner, Luis2020-02-13T19:52:27Z2020-02-13T19:52:27Z20201098-6596http://hdl.handle.net/20.500.12495/1934https://doi.org/10.1128/AAC.01466-19instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengAmerican Society for MicrobiologyAmerican Society for Microbiology JournalsAmerican Society for Microbiology Journals,1098-6596, Vol.64, Nro. 2, 2020, p. 1-6https://aac.asm.org/content/64/2/e01466-19Simultaneous infection with enterobacteriaceae and pseudomonas aeruginosa harboring multiple carbapenemases in a returning traveler colonized with candida aurisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Infecciones bacterianasAnálisis de secuencia de ADNResistencia a medicamentosCandida aurisEnterobacteriaceaePseudomonas aeruginosaCarbapenemaseWe report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris. A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy.Acceso cerradohttp://purl.org/coar/access_right/c_abf3712020http://purl.org/coar/access_right/c_abf2ORIGINALKhan, A., Shropshire, W.,Hanson, B._2020.pdfKhan, A., Shropshire, W.,Hanson, B._2020.pdfapplication/pdf667917https://repositorio.unbosque.edu.co/bitstreams/efe80f9f-92fe-445a-a84a-b902b9644bd4/download7b1734f57c289332dfcd1a7bddb4d3daMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/600a731a-d08b-40ab-abee-b5f8c1307534/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILKhan, A., Shropshire, W.,Hanson, B._2020.pdf.jpgKhan, A., Shropshire, W.,Hanson, B._2020.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/8923b9be-8e99-4260-bba6-cf01e9508e22/download7210a811635d1799e7c05fee5d259be7MD53TEXTKhan, A., Shropshire, W.,Hanson, B._2020.pdf.txtKhan, A., Shropshire, W.,Hanson, B._2020.pdf.txtExtracted texttext/plain29395https://repositorio.unbosque.edu.co/bitstreams/b640f528-75b9-4899-9dc3-4b68bde20005/download73e96bb57fa6bed8b59a1a9e29ca22b0MD5420.500.12495/1934oai:repositorio.unbosque.edu.co:20.500.12495/19342024-02-06 22:42:54.114restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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