Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis
Objective The evidence shows that previous infection with enteric pathogens is a requirement to develop pSpA. Based on our previous results, variances on regulation of SIgA might influence SpA activity; thus, the aim of this study was to correlate the levels of SIgA, IgA against some enteric bacteri...
- Autores:
-
Arias, Ivonne
Herrera, Daniel
Bautista-Molano, Wilson Armando
Bello-Gualtero, Juan Manuel
De Avila, Juliette
Salas-Cuestas, Fabián
Romero-Sánchez, Consuelo
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2020
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/4131
- Palabra clave:
- ASDAS
BASDAI
Intestinal disease
Secretory immunoglobulin A (SIgA)
Spondyloarthritis
- Rights
- openAccess
- License
- Acceso abierto
id |
UNBOSQUE2_30635c839d51102c16fd0960e7396704 |
---|---|
oai_identifier_str |
oai:repositorio.unbosque.edu.co:20.500.12495/4131 |
network_acronym_str |
UNBOSQUE2 |
network_name_str |
Repositorio U. El Bosque |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
dc.title.translated.spa.fl_str_mv |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
title |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
spellingShingle |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis ASDAS BASDAI Intestinal disease Secretory immunoglobulin A (SIgA) Spondyloarthritis |
title_short |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
title_full |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
title_fullStr |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
title_full_unstemmed |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
title_sort |
Increasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritis |
dc.creator.fl_str_mv |
Arias, Ivonne Herrera, Daniel Bautista-Molano, Wilson Armando Bello-Gualtero, Juan Manuel De Avila, Juliette Salas-Cuestas, Fabián Romero-Sánchez, Consuelo |
dc.contributor.author.none.fl_str_mv |
Arias, Ivonne Herrera, Daniel Bautista-Molano, Wilson Armando Bello-Gualtero, Juan Manuel De Avila, Juliette Salas-Cuestas, Fabián Romero-Sánchez, Consuelo |
dc.contributor.orcid.none.fl_str_mv |
Romero-Sánchez, Consuelo [0000-0002-6973-7639] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] |
dc.subject.keywords.spa.fl_str_mv |
ASDAS BASDAI Intestinal disease Secretory immunoglobulin A (SIgA) Spondyloarthritis |
topic |
ASDAS BASDAI Intestinal disease Secretory immunoglobulin A (SIgA) Spondyloarthritis |
description |
Objective The evidence shows that previous infection with enteric pathogens is a requirement to develop pSpA. Based on our previous results, variances on regulation of SIgA might influence SpA activity; thus, the aim of this study was to correlate the levels of SIgA, IgA against some enteric bacteria, and IL-17, IL-21, and IL-6 with clinical features in a group of SpA patients. Methods Twenty-six pSpA, 20 nr-axSpA, 60 healthy volunteers (HV), and 34 patients with inflammatory bowel diseases (IBD) were included. All subjects were assessed to measure SIgA, total and specific IgA for enteric bacteria, and IL-17, IL-21, and IL-6 levels and clinical variables. For SpA patients, the diagnosis was verified 5 years after first evaluation to assess the risk of developing r-axSpA. Results SIgA levels were significantly higher in SpA patients than in HV and IBD (p < 0.0001 and p = 0.047, respectively). However, no differences for SIgA neither total IgA were found among the SpA subtypes (p = 0.624). Only IL-6 was higher in SpA than HV (p = 0.013). An inverse correlation was demonstrated for SIgA and BASFI (r: − 0.45; p = 0.003), BASDAI (r: − 0.39; p = 0.0123), ASDAS-CRP (r: − 0.37; p = 0.014), and ASDAS-ESR (r: − 0.45; p = 0.0021). There was no evidence of risk of developing r-axSpA in patients who previously showed high levels of serum antibodies. Conclusion The results show that pSpA as well as nr-axSpA share a similar SIgA-intestinal involvement independently of a previous infection. This suggests that serum SIgA increases are evidence of subclinical intestinal compromise which could have influence on disease activity but not in this progression. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-09-21T21:58:10Z |
dc.date.available.none.fl_str_mv |
2020-09-21T21:58:10Z |
dc.date.issued.none.fl_str_mv |
2020 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1434-9949 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/4131 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/s10067-020-05369-w |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1434-9949 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/4131 https://doi.org/10.1007/s10067-020-05369-w |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Clinical rheumatology, 1434-9949, 2020 |
dc.relation.uri.none.fl_str_mv |
https://link.springer.com/article/10.1007/s10067-020-05369-w |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
dc.rights.creativecommons.none.fl_str_mv |
2020-09-02 |
rights_invalid_str_mv |
Acceso abierto http://purl.org/coar/access_right/c_abf2 2020-09-02 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Springer Nature |
dc.publisher.journal.spa.fl_str_mv |
Clinical rheumatology |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
https://repositorio.unbosque.edu.co/bitstreams/2d03d157-dc6f-44c7-8999-8cbdedef9c8c/download https://repositorio.unbosque.edu.co/bitstreams/0fd36ed3-66b7-44ed-8d9a-c8a69cab3b24/download https://repositorio.unbosque.edu.co/bitstreams/ca78692b-b9e0-4d7b-9033-6514788a0a6e/download https://repositorio.unbosque.edu.co/bitstreams/d691d5e9-e790-406a-a066-da8feec9d926/download |
bitstream.checksum.fl_str_mv |
9f602f01dc99c127b374e884a6e8ecff 8a4605be74aa9ea9d79846c1fba20a33 7210a811635d1799e7c05fee5d259be7 35db4202d5056de1ea66180f91558137 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio Institucional Universidad El Bosque |
repository.mail.fl_str_mv |
bibliotecas@biteca.com |
_version_ |
1814100718444871680 |
spelling |
Arias, IvonneHerrera, DanielBautista-Molano, Wilson ArmandoBello-Gualtero, Juan ManuelDe Avila, JulietteSalas-Cuestas, FabiánRomero-Sánchez, ConsueloRomero-Sánchez, Consuelo [0000-0002-6973-7639]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]2020-09-21T21:58:10Z2020-09-21T21:58:10Z20201434-9949http://hdl.handle.net/20.500.12495/4131https://doi.org/10.1007/s10067-020-05369-winstname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengSpringer NatureClinical rheumatologyClinical rheumatology, 1434-9949, 2020https://link.springer.com/article/10.1007/s10067-020-05369-wIncreasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritisIncreasing of SIgA serum levels may reflect subclinical intestinal involvement in non-radiographic axial and peripheral spondyloarthritisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85ASDASBASDAIIntestinal diseaseSecretory immunoglobulin A (SIgA)SpondyloarthritisObjective The evidence shows that previous infection with enteric pathogens is a requirement to develop pSpA. Based on our previous results, variances on regulation of SIgA might influence SpA activity; thus, the aim of this study was to correlate the levels of SIgA, IgA against some enteric bacteria, and IL-17, IL-21, and IL-6 with clinical features in a group of SpA patients. Methods Twenty-six pSpA, 20 nr-axSpA, 60 healthy volunteers (HV), and 34 patients with inflammatory bowel diseases (IBD) were included. All subjects were assessed to measure SIgA, total and specific IgA for enteric bacteria, and IL-17, IL-21, and IL-6 levels and clinical variables. For SpA patients, the diagnosis was verified 5 years after first evaluation to assess the risk of developing r-axSpA. Results SIgA levels were significantly higher in SpA patients than in HV and IBD (p < 0.0001 and p = 0.047, respectively). However, no differences for SIgA neither total IgA were found among the SpA subtypes (p = 0.624). Only IL-6 was higher in SpA than HV (p = 0.013). An inverse correlation was demonstrated for SIgA and BASFI (r: − 0.45; p = 0.003), BASDAI (r: − 0.39; p = 0.0123), ASDAS-CRP (r: − 0.37; p = 0.014), and ASDAS-ESR (r: − 0.45; p = 0.0021). There was no evidence of risk of developing r-axSpA in patients who previously showed high levels of serum antibodies. Conclusion The results show that pSpA as well as nr-axSpA share a similar SIgA-intestinal involvement independently of a previous infection. This suggests that serum SIgA increases are evidence of subclinical intestinal compromise which could have influence on disease activity but not in this progression.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2020-09-02ORIGINALIvonne Arias, Daniel Herrera, Wilson Bautista-Molano_2020.pdfIvonne Arias, Daniel Herrera, Wilson Bautista-Molano_2020.pdfapplication/pdf712613https://repositorio.unbosque.edu.co/bitstreams/2d03d157-dc6f-44c7-8999-8cbdedef9c8c/download9f602f01dc99c127b374e884a6e8ecffMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/0fd36ed3-66b7-44ed-8d9a-c8a69cab3b24/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILIvonne Arias, Daniel Herrera, Wilson Bautista-Molano_2020.pdf.jpgIvonne Arias, Daniel Herrera, Wilson Bautista-Molano_2020.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/ca78692b-b9e0-4d7b-9033-6514788a0a6e/download7210a811635d1799e7c05fee5d259be7MD53TEXTIvonne Arias, Daniel Herrera, Wilson Bautista-Molano_2020.pdf.txtIvonne Arias, Daniel Herrera, Wilson Bautista-Molano_2020.pdf.txtExtracted texttext/plain42832https://repositorio.unbosque.edu.co/bitstreams/d691d5e9-e790-406a-a066-da8feec9d926/download35db4202d5056de1ea66180f91558137MD5420.500.12495/4131oai:repositorio.unbosque.edu.co:20.500.12495/41312024-02-07 00:02:55.784restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |