Mechanisms of antibiotic resistance in enterococci
Multidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibi...
- Autores:
-
Miller, William R.
Munita, Jose M.
Arias, Cesar A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2014
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/4604
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/4604
https://dx.doi.org/10.1586%2F14787210.2014.956092
- Palabra clave:
- Antimicrobial resistance
Enterococcus
Mechanisms of resistance
Vancomycin-resistant enterococci
- Rights
- openAccess
- License
- Acceso abierto
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dc.title.spa.fl_str_mv |
Mechanisms of antibiotic resistance in enterococci |
dc.title.translated.spa.fl_str_mv |
Mechanisms of antibiotic resistance in enterococci |
title |
Mechanisms of antibiotic resistance in enterococci |
spellingShingle |
Mechanisms of antibiotic resistance in enterococci Antimicrobial resistance Enterococcus Mechanisms of resistance Vancomycin-resistant enterococci |
title_short |
Mechanisms of antibiotic resistance in enterococci |
title_full |
Mechanisms of antibiotic resistance in enterococci |
title_fullStr |
Mechanisms of antibiotic resistance in enterococci |
title_full_unstemmed |
Mechanisms of antibiotic resistance in enterococci |
title_sort |
Mechanisms of antibiotic resistance in enterococci |
dc.creator.fl_str_mv |
Miller, William R. Munita, Jose M. Arias, Cesar A. |
dc.contributor.author.none.fl_str_mv |
Miller, William R. Munita, Jose M. Arias, Cesar A. |
dc.subject.keywords.spa.fl_str_mv |
Antimicrobial resistance Enterococcus Mechanisms of resistance Vancomycin-resistant enterococci |
topic |
Antimicrobial resistance Enterococcus Mechanisms of resistance Vancomycin-resistant enterococci |
description |
Multidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches. |
publishDate |
2014 |
dc.date.issued.none.fl_str_mv |
2014 |
dc.date.accessioned.none.fl_str_mv |
2020-10-30T20:08:12Z |
dc.date.available.none.fl_str_mv |
2020-10-30T20:08:12Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1744-8336 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/4604 |
dc.identifier.doi.none.fl_str_mv |
https://dx.doi.org/10.1586%2F14787210.2014.956092 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1744-8336 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/4604 https://dx.doi.org/10.1586%2F14787210.2014.956092 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Expert Review of Anti-Infective Therapy, 1744-8336, Vol. 12, No. 10, 2014, p. 1221-1236 |
dc.relation.uri.none.fl_str_mv |
https://www.tandfonline.com/doi/abs/10.1586/14787210.2014.956092?journalCode=ierz20 |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
dc.rights.creativecommons.none.fl_str_mv |
2014 |
rights_invalid_str_mv |
Acceso abierto http://purl.org/coar/access_right/c_abf2 2014 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Taylor & Francis |
dc.publisher.journal.spa.fl_str_mv |
Expert Review of Anti-Infective Therapy |
institution |
Universidad El Bosque |
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Miller, William R.Munita, Jose M.Arias, Cesar A.2020-10-30T20:08:12Z2020-10-30T20:08:12Z20141744-8336http://hdl.handle.net/20.500.12495/4604https://dx.doi.org/10.1586%2F14787210.2014.956092instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengTaylor & FrancisExpert Review of Anti-Infective TherapyExpert Review of Anti-Infective Therapy, 1744-8336, Vol. 12, No. 10, 2014, p. 1221-1236https://www.tandfonline.com/doi/abs/10.1586/14787210.2014.956092?journalCode=ierz20Mechanisms of antibiotic resistance in enterococciMechanisms of antibiotic resistance in enterococciArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Antimicrobial resistanceEnterococcusMechanisms of resistanceVancomycin-resistant enterococciMultidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2014ORIGINALMiller_William_R._2014.pdfMiller_William_R._2014.pdfapplication/pdf313617https://repositorio.unbosque.edu.co/bitstreams/4c03c37a-45ae-4dc8-b688-483506a1fdd1/downloadf515f528b3dbb39c45d02692ee6c192bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/3cc16457-dd69-48fc-a6cf-c417925ea1b8/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILMiller_William_R._2014.pdf.jpgMiller_William_R._2014.pdf.jpgIM Thumbnailimage/jpeg9611https://repositorio.unbosque.edu.co/bitstreams/9b40adfc-d2eb-4db9-b4b6-c7bc02f06f0b/downloadd31ca039e5ca76b454acb5497f48095fMD53TEXTMiller_William_R._2014.pdf.txtMiller_William_R._2014.pdf.txtExtracted texttext/plain100496https://repositorio.unbosque.edu.co/bitstreams/d1404301-a90a-49df-96a4-fcfb56dbb346/download8c5ccc2bd921d7c726f060dee7312eadMD5420.500.12495/4604oai:repositorio.unbosque.edu.co:20.500.12495/46042024-02-07 05:56:27.193open.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |