Mechanisms of antibiotic resistance in enterococci

Multidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibi...

Full description

Autores:
Miller, William R.
Munita, Jose M.
Arias, Cesar A.
Tipo de recurso:
Article of journal
Fecha de publicación:
2014
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/4604
Acceso en línea:
http://hdl.handle.net/20.500.12495/4604
https://dx.doi.org/10.1586%2F14787210.2014.956092
Palabra clave:
Antimicrobial resistance
Enterococcus
Mechanisms of resistance
Vancomycin-resistant enterococci
Rights
openAccess
License
Acceso abierto
id UNBOSQUE2_2e8ad8a3b791bc068bc757f579799f3b
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/4604
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Mechanisms of antibiotic resistance in enterococci
dc.title.translated.spa.fl_str_mv Mechanisms of antibiotic resistance in enterococci
title Mechanisms of antibiotic resistance in enterococci
spellingShingle Mechanisms of antibiotic resistance in enterococci
Antimicrobial resistance
Enterococcus
Mechanisms of resistance
Vancomycin-resistant enterococci
title_short Mechanisms of antibiotic resistance in enterococci
title_full Mechanisms of antibiotic resistance in enterococci
title_fullStr Mechanisms of antibiotic resistance in enterococci
title_full_unstemmed Mechanisms of antibiotic resistance in enterococci
title_sort Mechanisms of antibiotic resistance in enterococci
dc.creator.fl_str_mv Miller, William R.
Munita, Jose M.
Arias, Cesar A.
dc.contributor.author.none.fl_str_mv Miller, William R.
Munita, Jose M.
Arias, Cesar A.
dc.subject.keywords.spa.fl_str_mv Antimicrobial resistance
Enterococcus
Mechanisms of resistance
Vancomycin-resistant enterococci
topic Antimicrobial resistance
Enterococcus
Mechanisms of resistance
Vancomycin-resistant enterococci
description Multidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.
publishDate 2014
dc.date.issued.none.fl_str_mv 2014
dc.date.accessioned.none.fl_str_mv 2020-10-30T20:08:12Z
dc.date.available.none.fl_str_mv 2020-10-30T20:08:12Z
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.local.none.fl_str_mv Artículo de revista
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
format http://purl.org/coar/resource_type/c_6501
dc.identifier.issn.none.fl_str_mv 1744-8336
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/4604
dc.identifier.doi.none.fl_str_mv https://dx.doi.org/10.1586%2F14787210.2014.956092
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 1744-8336
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/4604
https://dx.doi.org/10.1586%2F14787210.2014.956092
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Expert Review of Anti-Infective Therapy, 1744-8336, Vol. 12, No. 10, 2014, p. 1221-1236
dc.relation.uri.none.fl_str_mv https://www.tandfonline.com/doi/abs/10.1586/14787210.2014.956092?journalCode=ierz20
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
Acceso abierto
dc.rights.creativecommons.none.fl_str_mv 2014
rights_invalid_str_mv Acceso abierto
http://purl.org/coar/access_right/c_abf2
2014
eu_rights_str_mv openAccess
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Taylor & Francis
dc.publisher.journal.spa.fl_str_mv Expert Review of Anti-Infective Therapy
institution Universidad El Bosque
bitstream.url.fl_str_mv https://repositorio.unbosque.edu.co/bitstreams/4c03c37a-45ae-4dc8-b688-483506a1fdd1/download
https://repositorio.unbosque.edu.co/bitstreams/3cc16457-dd69-48fc-a6cf-c417925ea1b8/download
https://repositorio.unbosque.edu.co/bitstreams/9b40adfc-d2eb-4db9-b4b6-c7bc02f06f0b/download
https://repositorio.unbosque.edu.co/bitstreams/d1404301-a90a-49df-96a4-fcfb56dbb346/download
bitstream.checksum.fl_str_mv f515f528b3dbb39c45d02692ee6c192b
8a4605be74aa9ea9d79846c1fba20a33
d31ca039e5ca76b454acb5497f48095f
8c5ccc2bd921d7c726f060dee7312ead
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad El Bosque
repository.mail.fl_str_mv bibliotecas@biteca.com
_version_ 1814100787273400320
spelling Miller, William R.Munita, Jose M.Arias, Cesar A.2020-10-30T20:08:12Z2020-10-30T20:08:12Z20141744-8336http://hdl.handle.net/20.500.12495/4604https://dx.doi.org/10.1586%2F14787210.2014.956092instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengTaylor & FrancisExpert Review of Anti-Infective TherapyExpert Review of Anti-Infective Therapy, 1744-8336, Vol. 12, No. 10, 2014, p. 1221-1236https://www.tandfonline.com/doi/abs/10.1586/14787210.2014.956092?journalCode=ierz20Mechanisms of antibiotic resistance in enterococciMechanisms of antibiotic resistance in enterococciArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Antimicrobial resistanceEnterococcusMechanisms of resistanceVancomycin-resistant enterococciMultidrug-resistant (MDR) enterococci are important nosocomial pathogens and a growing clinical challenge. These organisms have developed resistance to virtually all antimicrobials currently used in clinical practice using a diverse number of genetic strategies. Due to this ability to recruit antibiotic resistance determinants, MDR enterococci display a wide repertoire of antibiotic resistance mechanisms including modification of drug targets, inactivation of therapeutic agents, overexpression of efflux pumps and a sophisticated cell envelope adaptive response that promotes survival in the human host and the nosocomial environment. MDR enterococci are well adapted to survive in the gastrointestinal tract and can become the dominant flora under antibiotic pressure, predisposing the severely ill and immunocompromised patient to invasive infections. A thorough understanding of the mechanisms underlying antibiotic resistance in enterococci is the first step for devising strategies to control the spread of these organisms and potentially establish novel therapeutic approaches.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2014ORIGINALMiller_William_R._2014.pdfMiller_William_R._2014.pdfapplication/pdf313617https://repositorio.unbosque.edu.co/bitstreams/4c03c37a-45ae-4dc8-b688-483506a1fdd1/downloadf515f528b3dbb39c45d02692ee6c192bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/3cc16457-dd69-48fc-a6cf-c417925ea1b8/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILMiller_William_R._2014.pdf.jpgMiller_William_R._2014.pdf.jpgIM Thumbnailimage/jpeg9611https://repositorio.unbosque.edu.co/bitstreams/9b40adfc-d2eb-4db9-b4b6-c7bc02f06f0b/downloadd31ca039e5ca76b454acb5497f48095fMD53TEXTMiller_William_R._2014.pdf.txtMiller_William_R._2014.pdf.txtExtracted texttext/plain100496https://repositorio.unbosque.edu.co/bitstreams/d1404301-a90a-49df-96a4-fcfb56dbb346/download8c5ccc2bd921d7c726f060dee7312eadMD5420.500.12495/4604oai:repositorio.unbosque.edu.co:20.500.12495/46042024-02-07 05:56:27.193open.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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