Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit

Croton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacit...

Full description

Autores:
Páez, María Teresa
Rodríguez, Diana Catalina
López, Daniel Fernando
Castañeda, Jorge Arturo
Guerrero, Mario Francisco
Buitrago Ramírez, Diana Marcela
Cuca, Luis Enrique
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/1581
Acceso en línea:
http://hdl.handle.net/20.500.12495/1581
http://dx.doi.org/10.1590/S1984-82502013000400027
Palabra clave:
Hipertensión
Plantas medicinales
Extractos vegetales
Croton schiedeanus/pharmacognosy
Almizelillo/use/hypertension prevention
Nitric oxide/deficit
Rights
License
Attribution-NonCommercial 4.0 International
id UNBOSQUE2_2cc6e8a9d93fa366d6eb9e85d9f21c6e
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/1581
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
title Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
spellingShingle Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
Hipertensión
Plantas medicinales
Extractos vegetales
Croton schiedeanus/pharmacognosy
Almizelillo/use/hypertension prevention
Nitric oxide/deficit
title_short Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
title_full Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
title_fullStr Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
title_full_unstemmed Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
title_sort Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
dc.creator.fl_str_mv Páez, María Teresa
Rodríguez, Diana Catalina
López, Daniel Fernando
Castañeda, Jorge Arturo
Guerrero, Mario Francisco
Buitrago Ramírez, Diana Marcela
Cuca, Luis Enrique
dc.contributor.author.none.fl_str_mv Páez, María Teresa
Rodríguez, Diana Catalina
López, Daniel Fernando
Castañeda, Jorge Arturo
Guerrero, Mario Francisco
Buitrago Ramírez, Diana Marcela
Cuca, Luis Enrique
dc.contributor.orcid.none.fl_str_mv Buitrago Ramírez, Diana Marcela [0000-0001-6283-7656]
dc.subject.decs.spa.fl_str_mv Hipertensión
Plantas medicinales
Extractos vegetales
topic Hipertensión
Plantas medicinales
Extractos vegetales
Croton schiedeanus/pharmacognosy
Almizelillo/use/hypertension prevention
Nitric oxide/deficit
dc.subject.keywords.spa.fl_str_mv Croton schiedeanus/pharmacognosy
Almizelillo/use/hypertension prevention
Nitric oxide/deficit
description Croton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacity of a 96% EtOH extract to prevent the hypertension induced by nitric oxide (NO) deficiency in rats. The NO synthase inhibitor L-NAME (10 mg/kg/d, i.p) was administered during five weeks to three groups of rats (6-7 animals): C. Schiedeanus (200 mg/kg/d, p.o), enalapril (reference, 10 mg/kg/d, p.o) and vehicle (control: olive oil 1 ml/kg/d, p.o). In addition, the blank group received only vehicle. The arterial blood pressure (BP) and heart rate (HR) were measured daily for six weeks. After sacrificing the animals, the aortic rings were isolated, contraction was triggered with phenylephrine (PE 10-6 M) and relaxant responses were achieved with cumulative concentrations of acetylcholine (ACh, 10-10 - 10-4 M). L-NAME increased the systolic arterial pressure in the control group, attaining mean values of 131 mm Hg at week 5, whereas the C. schiedeanus, enalapril and blank groups maintained blood pressure under 100 mm Hg. The capacity of PE to contract aortic rings was greater in the C. schiedeanus, enalapril and blank groups than in the control group (2157, 2005, 1910 and 1646 mg, respectively). The pEC50 values for ACh were as follows: C. Schiedeanus (6.89) >enalapril (6.39) > blank (5.68) > control (5.09). These results give support to C. Schiedeanus as a natural antihypertensive source.
publishDate 2013
dc.date.issued.none.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2019-08-01T20:40:53Z
dc.date.available.none.fl_str_mv 2019-08-01T20:40:53Z
dc.type.spa.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 1471-2466
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/1581
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1590/S1984-82502013000400027
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 1471-2466
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/1581
http://dx.doi.org/10.1590/S1984-82502013000400027
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Brazilian Journal of Pharmaceutical Sciences, 2175-9790, Vol. 49, Num. 4, 2013, p.865-871
dc.relation.uri.none.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400027&lng=en&tlng=en
dc.rights.*.fl_str_mv Attribution-NonCommercial 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.local.spa.fl_str_mv Acceso abierto
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf246
dc.rights.creativecommons.none.fl_str_mv 2013
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
Acceso abierto
http://purl.org/coar/access_right/c_abf246
2013
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
dc.publisher.journal.spa.fl_str_mv Brazilian Journal of Pharmaceutical Sciences
institution Universidad El Bosque
bitstream.url.fl_str_mv https://repositorio.unbosque.edu.co/bitstreams/135224bc-8c97-4ed3-925b-64a200e1b35f/download
https://repositorio.unbosque.edu.co/bitstreams/1b55d4bd-dd8b-48be-a975-431c7b5a2246/download
https://repositorio.unbosque.edu.co/bitstreams/2efd4a16-e006-4724-8351-c76dc8acf886/download
https://repositorio.unbosque.edu.co/bitstreams/33ce17f9-5ce1-44a4-8681-52e373074031/download
https://repositorio.unbosque.edu.co/bitstreams/31c7c6cd-2003-4be7-add4-570a803a913e/download
bitstream.checksum.fl_str_mv 088a5a975425fed8359bb2506b043b48
24013099e9e6abb1575dc6ce0855efd5
8a4605be74aa9ea9d79846c1fba20a33
77c519175630fedb71034dd04599f6fd
f072674b8bcd11c572bf998149439501
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional Universidad El Bosque
repository.mail.fl_str_mv bibliotecas@biteca.com
_version_ 1814100723789463552
spelling Páez, María TeresaRodríguez, Diana CatalinaLópez, Daniel FernandoCastañeda, Jorge ArturoGuerrero, Mario FranciscoBuitrago Ramírez, Diana MarcelaCuca, Luis EnriqueBuitrago Ramírez, Diana Marcela [0000-0001-6283-7656]2019-08-01T20:40:53Z2019-08-01T20:40:53Z20131471-2466http://hdl.handle.net/20.500.12495/1581http://dx.doi.org/10.1590/S1984-82502013000400027instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical SciencesBrazilian Journal of Pharmaceutical Sciences, 2175-9790, Vol. 49, Num. 4, 2013, p.865-871http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400027&lng=en&tlng=enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2462013http://purl.org/coar/access_right/c_abf2Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficitarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501HipertensiónPlantas medicinalesExtractos vegetalesCroton schiedeanus/pharmacognosyAlmizelillo/use/hypertension preventionNitric oxide/deficitCroton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacity of a 96% EtOH extract to prevent the hypertension induced by nitric oxide (NO) deficiency in rats. The NO synthase inhibitor L-NAME (10 mg/kg/d, i.p) was administered during five weeks to three groups of rats (6-7 animals): C. Schiedeanus (200 mg/kg/d, p.o), enalapril (reference, 10 mg/kg/d, p.o) and vehicle (control: olive oil 1 ml/kg/d, p.o). In addition, the blank group received only vehicle. The arterial blood pressure (BP) and heart rate (HR) were measured daily for six weeks. After sacrificing the animals, the aortic rings were isolated, contraction was triggered with phenylephrine (PE 10-6 M) and relaxant responses were achieved with cumulative concentrations of acetylcholine (ACh, 10-10 - 10-4 M). L-NAME increased the systolic arterial pressure in the control group, attaining mean values of 131 mm Hg at week 5, whereas the C. schiedeanus, enalapril and blank groups maintained blood pressure under 100 mm Hg. The capacity of PE to contract aortic rings was greater in the C. schiedeanus, enalapril and blank groups than in the control group (2157, 2005, 1910 and 1646 mg, respectively). The pEC50 values for ACh were as follows: C. Schiedeanus (6.89) >enalapril (6.39) > blank (5.68) > control (5.09). These results give support to C. Schiedeanus as a natural antihypertensive source.ORIGINALPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdfPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdfapplication/pdf533514https://repositorio.unbosque.edu.co/bitstreams/135224bc-8c97-4ed3-925b-64a200e1b35f/download088a5a975425fed8359bb2506b043b48MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.unbosque.edu.co/bitstreams/1b55d4bd-dd8b-48be-a975-431c7b5a2246/download24013099e9e6abb1575dc6ce0855efd5MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/2efd4a16-e006-4724-8351-c76dc8acf886/download8a4605be74aa9ea9d79846c1fba20a33MD55THUMBNAILPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.jpgPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.jpgIM Thumbnailimage/jpeg11949https://repositorio.unbosque.edu.co/bitstreams/33ce17f9-5ce1-44a4-8681-52e373074031/download77c519175630fedb71034dd04599f6fdMD56TEXTPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.txtPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.txtExtracted texttext/plain30607https://repositorio.unbosque.edu.co/bitstreams/31c7c6cd-2003-4be7-add4-570a803a913e/downloadf072674b8bcd11c572bf998149439501MD5720.500.12495/1581oai:repositorio.unbosque.edu.co:20.500.12495/15812024-02-07 00:39:54.383http://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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