Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit
Croton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacit...
- Autores:
-
Páez, María Teresa
Rodríguez, Diana Catalina
López, Daniel Fernando
Castañeda, Jorge Arturo
Guerrero, Mario Francisco
Buitrago Ramírez, Diana Marcela
Cuca, Luis Enrique
- Tipo de recurso:
- Fecha de publicación:
- 2013
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/1581
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/1581
http://dx.doi.org/10.1590/S1984-82502013000400027
- Palabra clave:
- Hipertensión
Plantas medicinales
Extractos vegetales
Croton schiedeanus/pharmacognosy
Almizelillo/use/hypertension prevention
Nitric oxide/deficit
- Rights
- License
- Attribution-NonCommercial 4.0 International
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Repositorio U. El Bosque |
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|
dc.title.spa.fl_str_mv |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit |
title |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit |
spellingShingle |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit Hipertensión Plantas medicinales Extractos vegetales Croton schiedeanus/pharmacognosy Almizelillo/use/hypertension prevention Nitric oxide/deficit |
title_short |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit |
title_full |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit |
title_fullStr |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit |
title_full_unstemmed |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit |
title_sort |
Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficit |
dc.creator.fl_str_mv |
Páez, María Teresa Rodríguez, Diana Catalina López, Daniel Fernando Castañeda, Jorge Arturo Guerrero, Mario Francisco Buitrago Ramírez, Diana Marcela Cuca, Luis Enrique |
dc.contributor.author.none.fl_str_mv |
Páez, María Teresa Rodríguez, Diana Catalina López, Daniel Fernando Castañeda, Jorge Arturo Guerrero, Mario Francisco Buitrago Ramírez, Diana Marcela Cuca, Luis Enrique |
dc.contributor.orcid.none.fl_str_mv |
Buitrago Ramírez, Diana Marcela [0000-0001-6283-7656] |
dc.subject.decs.spa.fl_str_mv |
Hipertensión Plantas medicinales Extractos vegetales |
topic |
Hipertensión Plantas medicinales Extractos vegetales Croton schiedeanus/pharmacognosy Almizelillo/use/hypertension prevention Nitric oxide/deficit |
dc.subject.keywords.spa.fl_str_mv |
Croton schiedeanus/pharmacognosy Almizelillo/use/hypertension prevention Nitric oxide/deficit |
description |
Croton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacity of a 96% EtOH extract to prevent the hypertension induced by nitric oxide (NO) deficiency in rats. The NO synthase inhibitor L-NAME (10 mg/kg/d, i.p) was administered during five weeks to three groups of rats (6-7 animals): C. Schiedeanus (200 mg/kg/d, p.o), enalapril (reference, 10 mg/kg/d, p.o) and vehicle (control: olive oil 1 ml/kg/d, p.o). In addition, the blank group received only vehicle. The arterial blood pressure (BP) and heart rate (HR) were measured daily for six weeks. After sacrificing the animals, the aortic rings were isolated, contraction was triggered with phenylephrine (PE 10-6 M) and relaxant responses were achieved with cumulative concentrations of acetylcholine (ACh, 10-10 - 10-4 M). L-NAME increased the systolic arterial pressure in the control group, attaining mean values of 131 mm Hg at week 5, whereas the C. schiedeanus, enalapril and blank groups maintained blood pressure under 100 mm Hg. The capacity of PE to contract aortic rings was greater in the C. schiedeanus, enalapril and blank groups than in the control group (2157, 2005, 1910 and 1646 mg, respectively). The pEC50 values for ACh were as follows: C. Schiedeanus (6.89) >enalapril (6.39) > blank (5.68) > control (5.09). These results give support to C. Schiedeanus as a natural antihypertensive source. |
publishDate |
2013 |
dc.date.issued.none.fl_str_mv |
2013 |
dc.date.accessioned.none.fl_str_mv |
2019-08-01T20:40:53Z |
dc.date.available.none.fl_str_mv |
2019-08-01T20:40:53Z |
dc.type.spa.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.local.spa.fl_str_mv |
artículo |
dc.identifier.issn.none.fl_str_mv |
1471-2466 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/1581 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1590/S1984-82502013000400027 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1471-2466 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/1581 http://dx.doi.org/10.1590/S1984-82502013000400027 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences, 2175-9790, Vol. 49, Num. 4, 2013, p.865-871 |
dc.relation.uri.none.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400027&lng=en&tlng=en |
dc.rights.*.fl_str_mv |
Attribution-NonCommercial 4.0 International |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc/4.0/ |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf246 |
dc.rights.creativecommons.none.fl_str_mv |
2013 |
rights_invalid_str_mv |
Attribution-NonCommercial 4.0 International http://creativecommons.org/licenses/by-nc/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf246 2013 http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
dc.publisher.journal.spa.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
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Páez, María TeresaRodríguez, Diana CatalinaLópez, Daniel FernandoCastañeda, Jorge ArturoGuerrero, Mario FranciscoBuitrago Ramírez, Diana MarcelaCuca, Luis EnriqueBuitrago Ramírez, Diana Marcela [0000-0001-6283-7656]2019-08-01T20:40:53Z2019-08-01T20:40:53Z20131471-2466http://hdl.handle.net/20.500.12495/1581http://dx.doi.org/10.1590/S1984-82502013000400027instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasBrazilian Journal of Pharmaceutical SciencesBrazilian Journal of Pharmaceutical Sciences, 2175-9790, Vol. 49, Num. 4, 2013, p.865-871http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400027&lng=en&tlng=enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf2462013http://purl.org/coar/access_right/c_abf2Croton schiedeanus Schltd prevents experimental hypertension in rats induced by nitric oxide deficitarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501HipertensiónPlantas medicinalesExtractos vegetalesCroton schiedeanus/pharmacognosyAlmizelillo/use/hypertension preventionNitric oxide/deficitCroton schiedeanus Schltd (N.V.: "almizclillo") is a plant used in traditional medicine as an antihypertensive in Colombia. It contains flavonoid, diterpenoid and fenilbutanoid metabolites that have vasodilatation effects linked to the NO/cGMP pathway. This work aimed to assess the capacity of a 96% EtOH extract to prevent the hypertension induced by nitric oxide (NO) deficiency in rats. The NO synthase inhibitor L-NAME (10 mg/kg/d, i.p) was administered during five weeks to three groups of rats (6-7 animals): C. Schiedeanus (200 mg/kg/d, p.o), enalapril (reference, 10 mg/kg/d, p.o) and vehicle (control: olive oil 1 ml/kg/d, p.o). In addition, the blank group received only vehicle. The arterial blood pressure (BP) and heart rate (HR) were measured daily for six weeks. After sacrificing the animals, the aortic rings were isolated, contraction was triggered with phenylephrine (PE 10-6 M) and relaxant responses were achieved with cumulative concentrations of acetylcholine (ACh, 10-10 - 10-4 M). L-NAME increased the systolic arterial pressure in the control group, attaining mean values of 131 mm Hg at week 5, whereas the C. schiedeanus, enalapril and blank groups maintained blood pressure under 100 mm Hg. The capacity of PE to contract aortic rings was greater in the C. schiedeanus, enalapril and blank groups than in the control group (2157, 2005, 1910 and 1646 mg, respectively). The pEC50 values for ACh were as follows: C. Schiedeanus (6.89) >enalapril (6.39) > blank (5.68) > control (5.09). These results give support to C. Schiedeanus as a natural antihypertensive source.ORIGINALPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdfPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdfapplication/pdf533514https://repositorio.unbosque.edu.co/bitstreams/135224bc-8c97-4ed3-925b-64a200e1b35f/download088a5a975425fed8359bb2506b043b48MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.unbosque.edu.co/bitstreams/1b55d4bd-dd8b-48be-a975-431c7b5a2246/download24013099e9e6abb1575dc6ce0855efd5MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/2efd4a16-e006-4724-8351-c76dc8acf886/download8a4605be74aa9ea9d79846c1fba20a33MD55THUMBNAILPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.jpgPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.jpgIM Thumbnailimage/jpeg11949https://repositorio.unbosque.edu.co/bitstreams/33ce17f9-5ce1-44a4-8681-52e373074031/download77c519175630fedb71034dd04599f6fdMD56TEXTPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.txtPáez M.T., Rodríguez D.C., López D.F., Castañeda J.A., Buitrago D.M., Cuca L.E., Guerrero M.F._2013.pdf.txtExtracted texttext/plain30607https://repositorio.unbosque.edu.co/bitstreams/31c7c6cd-2003-4be7-add4-570a803a913e/downloadf072674b8bcd11c572bf998149439501MD5720.500.12495/1581oai:repositorio.unbosque.edu.co:20.500.12495/15812024-02-07 00:39:54.383http://creativecommons.org/licenses/by-nc/4.0/Attribution-NonCommercial 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |