Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis
Background. Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Ob...
- Autores:
-
Romero-Sánchez, Consuelo
Parra, Viviana
De Avila, Juliette
Rueda, Juan Camilo
Londoño, John Darío
Valle-Oñate, Rafael
Bautista-Molano, Wilson Armando
Bello-Gualtero, Juan M.
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/1647
- Palabra clave:
- Mucosa intestinal
Enfermedades reumáticas
Espondiloartritis
- Rights
- License
- Attribution 4.0 International
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Repositorio U. El Bosque |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis |
title |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis |
spellingShingle |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis Mucosa intestinal Enfermedades reumáticas Espondiloartritis |
title_short |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis |
title_full |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis |
title_fullStr |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis |
title_full_unstemmed |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis |
title_sort |
Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritis |
dc.creator.fl_str_mv |
Romero-Sánchez, Consuelo Parra, Viviana De Avila, Juliette Rueda, Juan Camilo Londoño, John Darío Valle-Oñate, Rafael Bautista-Molano, Wilson Armando Bello-Gualtero, Juan M. |
dc.contributor.author.none.fl_str_mv |
Romero-Sánchez, Consuelo Parra, Viviana De Avila, Juliette Rueda, Juan Camilo Londoño, John Darío Valle-Oñate, Rafael Bautista-Molano, Wilson Armando Bello-Gualtero, Juan M. |
dc.contributor.orcid.none.fl_str_mv |
Romero-Sánchez, Consuelo [0000-0002-6973-7639] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] |
dc.subject.decs.spa.fl_str_mv |
Mucosa intestinal Enfermedades reumáticas Espondiloartritis |
topic |
Mucosa intestinal Enfermedades reumáticas Espondiloartritis |
description |
Background. Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives. To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD). Methods. 102 SpA patients, 29 IBD patients, and 117 HS were included. Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured. The patients were assessed to evaluate clinical and gastrointestinal symptoms. An association analysis was performed using Chi square test and a logistic regression. Results. Significant ifferences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) (p = 0.029), as well as for ANAS in SpA (49.5%) and IBD (37.9%) (p < 0.001) and abdominal pain (p = 0.012) between SpA (54.3%) and IBD (27.5%). Significant associations were found between ASDAI > 4 and gastrointestinal symptoms (p < 0.05) and IgA (p = 0.007). The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14–13.56; p = 0.030). Conclusions. Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS. |
publishDate |
2017 |
dc.date.issued.none.fl_str_mv |
2017 |
dc.date.accessioned.none.fl_str_mv |
2019-08-26T17:17:03Z |
dc.date.available.none.fl_str_mv |
2019-08-26T17:17:03Z |
dc.type.spa.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.local.spa.fl_str_mv |
artículo |
dc.identifier.issn.none.fl_str_mv |
1687-9260 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/1647 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1155/2017/4029584 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
1687-9260 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/1647 https://doi.org/10.1155/2017/4029584 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
International Journal of Rheumatology, 1687-9260, 2017, p.1- 8 |
dc.relation.uri.none.fl_str_mv |
https://www.hindawi.com/journals/ijr/2017/4029584/ |
dc.rights.*.fl_str_mv |
Attribution 4.0 International |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf301 |
dc.rights.creativecommons.none.fl_str_mv |
2017 |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Acceso abierto http://purl.org/coar/access_right/c_abf301 2017 http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Hindawi Publishing Corporation |
dc.publisher.journal.spa.fl_str_mv |
International Journal of Rheumatology |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
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Romero-Sánchez, ConsueloParra, VivianaDe Avila, JulietteRueda, Juan CamiloLondoño, John DaríoValle-Oñate, RafaelBautista-Molano, Wilson ArmandoBello-Gualtero, Juan M.Romero-Sánchez, Consuelo [0000-0002-6973-7639]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]2019-08-26T17:17:03Z2019-08-26T17:17:03Z20171687-9260http://hdl.handle.net/20.500.12495/1647https://doi.org/10.1155/2017/4029584instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengHindawi Publishing CorporationInternational Journal of RheumatologyInternational Journal of Rheumatology, 1687-9260, 2017, p.1- 8https://www.hindawi.com/journals/ijr/2017/4029584/Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acceso abiertohttp://purl.org/coar/access_right/c_abf3012017http://purl.org/coar/access_right/c_abf2Gastrointestinal symptoms and elevated levels of anti- saccharomyces cerevisiae antibodies are associated with higher disease activity in Colombian patients with spondyloarthritisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Mucosa intestinalEnfermedades reumáticasEspondiloartritisBackground. Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives. To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD). Methods. 102 SpA patients, 29 IBD patients, and 117 HS were included. Autoantibodies as ASCA, ANCA, anti-tTG, anti-DGP, ANA, and IgA were measured. The patients were assessed to evaluate clinical and gastrointestinal symptoms. An association analysis was performed using Chi square test and a logistic regression. Results. Significant ifferences were found for ASCA levels in SpA (28.2%) compared to IBD (14.2%) and HS (6.0%) (p = 0.029), as well as for ANAS in SpA (49.5%) and IBD (37.9%) (p < 0.001) and abdominal pain (p = 0.012) between SpA (54.3%) and IBD (27.5%). Significant associations were found between ASDAI > 4 and gastrointestinal symptoms (p < 0.05) and IgA (p = 0.007). The association for abdominal bloating was maintained (OR: 3.93, CI-95%, 1.14–13.56; p = 0.030). Conclusions. Gastrointestinal symptoms, ASCA, ANAS, and IgA levels were associated with high disease activity in SpA compared with IBD and HS.ORIGINALRomero-Sánchez C., Bautista-Molano W., Parra V., De Avila J., Rueda J.C., Bello-Gualtero J.M., Londoño J., Valle-Oñate R._2017.pdfRomero-Sánchez C., Bautista-Molano W., Parra V., De Avila J., Rueda J.C., Bello-Gualtero J.M., Londoño J., Valle-Oñate R._2017.pdfapplication/pdf748615https://repositorio.unbosque.edu.co/bitstreams/278e5963-19a3-4021-9219-a41fa7eba11e/download6ddf6b3c187b5e7ad218651130423fccMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8908https://repositorio.unbosque.edu.co/bitstreams/4f4fdb30-c997-4593-a007-d22e8d1c39b7/download0175ea4a2d4caec4bbcc37e300941108MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/3f9b3582-ff88-4144-adec-2a7d070619c8/download8a4605be74aa9ea9d79846c1fba20a33MD53THUMBNAILRomero-Sánchez C., Bautista-Molano W., Parra V., De Avila J., Rueda J.C., Bello-Gualtero J.M., Londoño J., Valle-Oñate R._2017.pdf.jpgRomero-Sánchez C., Bautista-Molano W., Parra V., De Avila J., Rueda J.C., Bello-Gualtero J.M., Londoño J., Valle-Oñate R._2017.pdf.jpgIM Thumbnailimage/jpeg8355https://repositorio.unbosque.edu.co/bitstreams/cf8278d6-4d6d-4363-b8a4-1e4f79eb8151/download20dd15f2881b0e52f4b06d9511045f0bMD54TEXTRomero-Sánchez C., Bautista-Molano W., Parra V., De Avila J., Rueda J.C., Bello-Gualtero J.M., Londoño J., Valle-Oñate R._2017.pdf.txtRomero-Sánchez C., Bautista-Molano W., Parra V., De Avila J., Rueda J.C., Bello-Gualtero J.M., Londoño J., Valle-Oñate R._2017.pdf.txtExtracted texttext/plain39522https://repositorio.unbosque.edu.co/bitstreams/52eec18e-e8fd-4b1d-878f-987ab5d41536/download56326ff46fbb94a67f1682ed01b3ab88MD5520.500.12495/1647oai:repositorio.unbosque.edu.co:20.500.12495/16472024-02-07 13:22:59.496http://creativecommons.org/licenses/by/4.0/Attribution 4.0 Internationalopen.accesshttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |