Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions

High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations >2 μg/mL.

• Autores: Munita, Jose M.; Mishra, Nagendra N.; Alvarez, Danya; Tran, Truc T.; Diaz, Lorena; Panesso, Diana; Reyes, Jinnethe; Murray, Barbara E.; Adachi, Javier A.; Bayer, Arnold S.; Arias, Cesar A.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2014
• Institución: Universidad El Bosque
• Repositorio: Repositorio U. El Bosque
• Idioma: eng
• OAI Identifier: oai:repositorio.unbosque.edu.co:20.500.12495/3347
• Acceso en línea: http://hdl.handle.net/20.500.12495/3347; https://repositorio.unbosque.edu.co
• Palabra clave: Daptomicina; Enterococcus faecium; Tratamientos; Daptomycin; Enterococcus faecium; Resistance; Treatment failure
• Rights: openAccess
• License: Acceso abierto