The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
Background: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. Objective: To establish the association between serum levels of potential biomarkers with the presence of factors relate...
- Autores:
-
Londoño, John
Romero-Sánchez, Consuelo
Torres, Viviana Garcia
Bautista-Molano, Wilson Armando
Fernandez, Diego Jaimes
De Avila, Juliette
Valle-Oñate, Rafael Raúl
Santos Granados, Ana Maria
Medina, Juan Francisco
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2012
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
por
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/3765
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/3765
https://doi.org/10.1590/S0482-50042012000400006
https://repositorio.unbosque.edu.co
- Palabra clave:
- Ankylosing spondylitis
Ankylosing spondyloarthritis
Arthritis
Biomarkers
Enthesopathy
- Rights
- openAccess
- License
- Acceso abierto
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|
dc.title.spa.fl_str_mv |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
dc.title.translated.spa.fl_str_mv |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
title |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
spellingShingle |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis Ankylosing spondylitis Ankylosing spondyloarthritis Arthritis Biomarkers Enthesopathy |
title_short |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
title_full |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
title_fullStr |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
title_full_unstemmed |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
title_sort |
The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis |
dc.creator.fl_str_mv |
Londoño, John Romero-Sánchez, Consuelo Torres, Viviana Garcia Bautista-Molano, Wilson Armando Fernandez, Diego Jaimes De Avila, Juliette Valle-Oñate, Rafael Raúl Santos Granados, Ana Maria Medina, Juan Francisco |
dc.contributor.author.none.fl_str_mv |
Londoño, John Romero-Sánchez, Consuelo Torres, Viviana Garcia Bautista-Molano, Wilson Armando Fernandez, Diego Jaimes De Avila, Juliette Valle-Oñate, Rafael Raúl Santos Granados, Ana Maria Medina, Juan Francisco |
dc.contributor.orcid.none.fl_str_mv |
Romero-Sánchez, Consuelo [0000-0002-6973-7639] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] Bautista-Molano, Wilson Armando [0000-0003-0684-9542] |
dc.subject.keywords.spa.fl_str_mv |
Ankylosing spondylitis Ankylosing spondyloarthritis Arthritis Biomarkers Enthesopathy |
topic |
Ankylosing spondylitis Ankylosing spondyloarthritis Arthritis Biomarkers Enthesopathy |
description |
Background: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. Objective: To establish the association between serum levels of potential biomarkers with the presence of factors related to clinical activity and poor prognosis in spondyloarthritis. Methods: Sixty-two patients were included: 13 with reactive arthritis, 19 with ankylosing spondylitis, and 30 with undifferentiated spondyloarthritis. The results were compared with those from 46 healthy controls. Clinical, radiological, and laboratory characteristics were assessed. The results were analyzed based on the presence of uveitis, enthesitis, inflammatory back pain, arthritis, HLA-B27 and sacroiliac involvement. The analyzed biomarkers included ESR, US-CRP, SAA, LBP, FSC-M, and MMP-3; and cytokine serum levels measured were: IL-17, IL-6, IL-1α, TNF-α, IFN-γ, and IL-23. Results: Forty-three (69.4%) patients were male. The average age was 31.9 ± 9.9 years and the age at the onset of symptoms was 26.9 ± 7.3 years. HLA-B27 was positive in 26 (41.9%) patients, inflammatory back pain in 42 (67.7%), arthritis in 44 (71.0%), and enthesitis in 34 (54.8%). IL-17, IL-23, TNF-α, IL-6, IL-1α, and US-CRP levels were significantly higher in patients with SpA when compared to controls. US-CRP (P = 0.04), IL-6 (P = 0.003), IL-1α (P = 0.03), and LBP (P = 0.03) levels were associated with presence of HLA-B27, inflammatory back pain, and arthritis. Conclusion: An increase in serum levels of US-CRP, IL-6, IL-1α, and LBP was correlated with factors associated with clinical activity and poor prognosis in spondyloarthritis. |
publishDate |
2012 |
dc.date.issued.none.fl_str_mv |
2012 |
dc.date.accessioned.none.fl_str_mv |
2020-08-11T21:19:33Z |
dc.date.available.none.fl_str_mv |
2020-08-11T21:19:33Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1809-4570 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/3765 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1590/S0482-50042012000400006 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
https://repositorio.unbosque.edu.co |
identifier_str_mv |
1809-4570 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque |
url |
http://hdl.handle.net/20.500.12495/3765 https://doi.org/10.1590/S0482-50042012000400006 https://repositorio.unbosque.edu.co |
dc.language.iso.none.fl_str_mv |
eng por |
language |
eng por |
dc.relation.ispartofseries.spa.fl_str_mv |
Revista brasileira de reumatologia, 1809-4570, Vol. 52, Nro. 4, 2012, p, 536-544 |
dc.relation.uri.none.fl_str_mv |
https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042012000400006 |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
dc.rights.creativecommons.none.fl_str_mv |
2012-08 |
rights_invalid_str_mv |
Acceso abierto http://purl.org/coar/access_right/c_abf2 2012-08 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.publisher.journal.spa.fl_str_mv |
Revista brasileira de reumatologia |
institution |
Universidad El Bosque |
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Londoño, JohnRomero-Sánchez, ConsueloTorres, Viviana GarciaBautista-Molano, Wilson ArmandoFernandez, Diego JaimesDe Avila, JulietteValle-Oñate, Rafael RaúlSantos Granados, Ana MariaMedina, Juan FranciscoRomero-Sánchez, Consuelo [0000-0002-6973-7639]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]2020-08-11T21:19:33Z2020-08-11T21:19:33Z20121809-4570http://hdl.handle.net/20.500.12495/3765https://doi.org/10.1590/S0482-50042012000400006instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengporElsevierRevista brasileira de reumatologiaRevista brasileira de reumatologia, 1809-4570, Vol. 52, Nro. 4, 2012, p, 536-544https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042012000400006The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritisThe association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Ankylosing spondylitisAnkylosing spondyloarthritisArthritisBiomarkersEnthesopathyBackground: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. Objective: To establish the association between serum levels of potential biomarkers with the presence of factors related to clinical activity and poor prognosis in spondyloarthritis. Methods: Sixty-two patients were included: 13 with reactive arthritis, 19 with ankylosing spondylitis, and 30 with undifferentiated spondyloarthritis. The results were compared with those from 46 healthy controls. Clinical, radiological, and laboratory characteristics were assessed. The results were analyzed based on the presence of uveitis, enthesitis, inflammatory back pain, arthritis, HLA-B27 and sacroiliac involvement. The analyzed biomarkers included ESR, US-CRP, SAA, LBP, FSC-M, and MMP-3; and cytokine serum levels measured were: IL-17, IL-6, IL-1α, TNF-α, IFN-γ, and IL-23. Results: Forty-three (69.4%) patients were male. The average age was 31.9 ± 9.9 years and the age at the onset of symptoms was 26.9 ± 7.3 years. HLA-B27 was positive in 26 (41.9%) patients, inflammatory back pain in 42 (67.7%), arthritis in 44 (71.0%), and enthesitis in 34 (54.8%). IL-17, IL-23, TNF-α, IL-6, IL-1α, and US-CRP levels were significantly higher in patients with SpA when compared to controls. US-CRP (P = 0.04), IL-6 (P = 0.003), IL-1α (P = 0.03), and LBP (P = 0.03) levels were associated with presence of HLA-B27, inflammatory back pain, and arthritis. Conclusion: An increase in serum levels of US-CRP, IL-6, IL-1α, and LBP was correlated with factors associated with clinical activity and poor prognosis in spondyloarthritis.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2012-08ORIGINALJohn Londono, Maria Consuelo Romero-Sanchez, Viviana Garcia_2012_ENG.pdfJohn Londono, Maria Consuelo Romero-Sanchez, Viviana Garcia_2012_ENG.pdfapplication/pdf686281https://repositorio.unbosque.edu.co/bitstreams/5c4190f8-c739-4c2b-8b5b-ad138dbb60b3/downloadfbf36d62a57484dbafa62a3921e50ce7MD51John Londono, Maria Consuelo Romero-Sanchez, Viviana Garcia_2012_PORT.pdfJohn Londono, Maria Consuelo Romero-Sanchez, Viviana Garcia_2012_PORT.pdfapplication/pdf675309https://repositorio.unbosque.edu.co/bitstreams/d288f472-d5dd-410e-98f6-689371e25925/download38ae4b540825b68e2d02f884d71145bdMD52LICENSElicense.txtlicense.txttext/plain; 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