The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis

Background: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. Objective: To establish the association between serum levels of potential biomarkers with the presence of factors relate...

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Autores:
Londoño, John
Romero-Sánchez, Consuelo
Torres, Viviana Garcia
Bautista-Molano, Wilson Armando
Fernandez, Diego Jaimes
De Avila, Juliette
Valle-Oñate, Rafael Raúl
Santos Granados, Ana Maria
Medina, Juan Francisco
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
por
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/3765
Acceso en línea:
http://hdl.handle.net/20.500.12495/3765
https://doi.org/10.1590/S0482-50042012000400006
https://repositorio.unbosque.edu.co
Palabra clave:
Ankylosing spondylitis
Ankylosing spondyloarthritis
Arthritis
Biomarkers
Enthesopathy
Rights
openAccess
License
Acceso abierto
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dc.title.spa.fl_str_mv The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
dc.title.translated.spa.fl_str_mv The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
spellingShingle The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
Ankylosing spondylitis
Ankylosing spondyloarthritis
Arthritis
Biomarkers
Enthesopathy
title_short The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_full The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_fullStr The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_full_unstemmed The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
title_sort The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritis
dc.creator.fl_str_mv Londoño, John
Romero-Sánchez, Consuelo
Torres, Viviana Garcia
Bautista-Molano, Wilson Armando
Fernandez, Diego Jaimes
De Avila, Juliette
Valle-Oñate, Rafael Raúl
Santos Granados, Ana Maria
Medina, Juan Francisco
dc.contributor.author.none.fl_str_mv Londoño, John
Romero-Sánchez, Consuelo
Torres, Viviana Garcia
Bautista-Molano, Wilson Armando
Fernandez, Diego Jaimes
De Avila, Juliette
Valle-Oñate, Rafael Raúl
Santos Granados, Ana Maria
Medina, Juan Francisco
dc.contributor.orcid.none.fl_str_mv Romero-Sánchez, Consuelo [0000-0002-6973-7639]
Bautista-Molano, Wilson Armando [0000-0003-0684-9542]
Bautista-Molano, Wilson Armando [0000-0003-0684-9542]
Bautista-Molano, Wilson Armando [0000-0003-0684-9542]
dc.subject.keywords.spa.fl_str_mv Ankylosing spondylitis
Ankylosing spondyloarthritis
Arthritis
Biomarkers
Enthesopathy
topic Ankylosing spondylitis
Ankylosing spondyloarthritis
Arthritis
Biomarkers
Enthesopathy
description Background: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. Objective: To establish the association between serum levels of potential biomarkers with the presence of factors related to clinical activity and poor prognosis in spondyloarthritis. Methods: Sixty-two patients were included: 13 with reactive arthritis, 19 with ankylosing spondylitis, and 30 with undifferentiated spondyloarthritis. The results were compared with those from 46 healthy controls. Clinical, radiological, and laboratory characteristics were assessed. The results were analyzed based on the presence of uveitis, enthesitis, inflammatory back pain, arthritis, HLA-B27 and sacroiliac involvement. The analyzed biomarkers included ESR, US-CRP, SAA, LBP, FSC-M, and MMP-3; and cytokine serum levels measured were: IL-17, IL-6, IL-1α, TNF-α, IFN-γ, and IL-23. Results: Forty-three (69.4%) patients were male. The average age was 31.9 ± 9.9 years and the age at the onset of symptoms was 26.9 ± 7.3 years. HLA-B27 was positive in 26 (41.9%) patients, inflammatory back pain in 42 (67.7%), arthritis in 44 (71.0%), and enthesitis in 34 (54.8%). IL-17, IL-23, TNF-α, IL-6, IL-1α, and US-CRP levels were significantly higher in patients with SpA when compared to controls. US-CRP (P = 0.04), IL-6 (P = 0.003), IL-1α (P = 0.03), and LBP (P = 0.03) levels were associated with presence of HLA-B27, inflammatory back pain, and arthritis. Conclusion: An increase in serum levels of US-CRP, IL-6, IL-1α, and LBP was correlated with factors associated with clinical activity and poor prognosis in spondyloarthritis.
publishDate 2012
dc.date.issued.none.fl_str_mv 2012
dc.date.accessioned.none.fl_str_mv 2020-08-11T21:19:33Z
dc.date.available.none.fl_str_mv 2020-08-11T21:19:33Z
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 1809-4570
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/3765
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1590/S0482-50042012000400006
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
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url http://hdl.handle.net/20.500.12495/3765
https://doi.org/10.1590/S0482-50042012000400006
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
por
language eng
por
dc.relation.ispartofseries.spa.fl_str_mv Revista brasileira de reumatologia, 1809-4570, Vol. 52, Nro. 4, 2012, p, 536-544
dc.relation.uri.none.fl_str_mv https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042012000400006
dc.rights.local.spa.fl_str_mv Acceso abierto
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.journal.spa.fl_str_mv Revista brasileira de reumatologia
institution Universidad El Bosque
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spelling Londoño, JohnRomero-Sánchez, ConsueloTorres, Viviana GarciaBautista-Molano, Wilson ArmandoFernandez, Diego JaimesDe Avila, JulietteValle-Oñate, Rafael RaúlSantos Granados, Ana MariaMedina, Juan FranciscoRomero-Sánchez, Consuelo [0000-0002-6973-7639]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]Bautista-Molano, Wilson Armando [0000-0003-0684-9542]2020-08-11T21:19:33Z2020-08-11T21:19:33Z20121809-4570http://hdl.handle.net/20.500.12495/3765https://doi.org/10.1590/S0482-50042012000400006instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengporElsevierRevista brasileira de reumatologiaRevista brasileira de reumatologia, 1809-4570, Vol. 52, Nro. 4, 2012, p, 536-544https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042012000400006The association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritisThe association between serum levels of potential biomarkers with the presence of factors related to the clinical activity and poor prognosis in spondyloarthritisArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Ankylosing spondylitisAnkylosing spondyloarthritisArthritisBiomarkersEnthesopathyBackground: Serum biomarkers traditionally associated with inflammatory activity and a poor prognosis in rheumatic diseases do not show the same relationship in spondyloarthritis. Objective: To establish the association between serum levels of potential biomarkers with the presence of factors related to clinical activity and poor prognosis in spondyloarthritis. Methods: Sixty-two patients were included: 13 with reactive arthritis, 19 with ankylosing spondylitis, and 30 with undifferentiated spondyloarthritis. The results were compared with those from 46 healthy controls. Clinical, radiological, and laboratory characteristics were assessed. The results were analyzed based on the presence of uveitis, enthesitis, inflammatory back pain, arthritis, HLA-B27 and sacroiliac involvement. The analyzed biomarkers included ESR, US-CRP, SAA, LBP, FSC-M, and MMP-3; and cytokine serum levels measured were: IL-17, IL-6, IL-1α, TNF-α, IFN-γ, and IL-23. Results: Forty-three (69.4%) patients were male. The average age was 31.9 ± 9.9 years and the age at the onset of symptoms was 26.9 ± 7.3 years. HLA-B27 was positive in 26 (41.9%) patients, inflammatory back pain in 42 (67.7%), arthritis in 44 (71.0%), and enthesitis in 34 (54.8%). IL-17, IL-23, TNF-α, IL-6, IL-1α, and US-CRP levels were significantly higher in patients with SpA when compared to controls. US-CRP (P = 0.04), IL-6 (P = 0.003), IL-1α (P = 0.03), and LBP (P = 0.03) levels were associated with presence of HLA-B27, inflammatory back pain, and arthritis. 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