Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis

Epstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. Methods: We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and...

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Autores:
Toro, Jaime
Reyes, Saúl
Díaz-Cruz, Camilo
Burbano, Lisseth Estefania
Cuellar-Giraldo, David
Duque, Alejandra
Reyes-Mantilla, María I
Torres, Camilo
Ríos, Jorge
Rivera Pérez, Juan Sebastián
Cortés-Muñoz, Fabián
Patiño, Jorge
Noriega, Daniel
Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/2004
Acceso en línea:
http://hdl.handle.net/20.500.12495/2004
https://doi.org/10.1016/j.msard.2020.101983
Palabra clave:
Factores de riesgo
Esclerosis múltiple
Luz Solar
Epstein-Barr virus
Vitamin D
Smoking
Rights
License
Acceso cerrado
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oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/2004
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.spa.fl_str_mv Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
title Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
spellingShingle Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
Factores de riesgo
Esclerosis múltiple
Luz Solar
Epstein-Barr virus
Vitamin D
Smoking
title_short Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
title_full Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
title_fullStr Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
title_full_unstemmed Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
title_sort Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
dc.creator.fl_str_mv Toro, Jaime
Reyes, Saúl
Díaz-Cruz, Camilo
Burbano, Lisseth Estefania
Cuellar-Giraldo, David
Duque, Alejandra
Reyes-Mantilla, María I
Torres, Camilo
Ríos, Jorge
Rivera Pérez, Juan Sebastián
Cortés-Muñoz, Fabián
Patiño, Jorge
Noriega, Daniel
dc.contributor.author.none.fl_str_mv Toro, Jaime
Reyes, Saúl
Díaz-Cruz, Camilo
Burbano, Lisseth Estefania
Cuellar-Giraldo, David
Duque, Alejandra
Reyes-Mantilla, María I
Torres, Camilo
Ríos, Jorge
Rivera Pérez, Juan Sebastián
Cortés-Muñoz, Fabián
Patiño, Jorge
Noriega, Daniel
dc.contributor.orcid.none.fl_str_mv Toro, Jaime [0000-0001-7129-0058]
Rivera Pérez, Juan Sebastián [0000-0002-7767-1289]
Rivera Pérez, Juan Sebastián [0000-0002-7767-1289]
dc.subject.decs.spa.fl_str_mv Factores de riesgo
Esclerosis múltiple
Luz Solar
topic Factores de riesgo
Esclerosis múltiple
Luz Solar
Epstein-Barr virus
Vitamin D
Smoking
dc.subject.keywords.spa.fl_str_mv Epstein-Barr virus
Vitamin D
Smoking
description Epstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. Methods: We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and duration of smoking, sunlight exposure, physical activity, and personal and family history in individuals with and without multiple sclerosis during adolescence. A multivariable logistic regression model was then performed to explore the association between vitamin D status and MS. Results: : A total of 87 individuals with MS (mean age 40.9 years; 65.52% females) and 87 without MS (mean age 55 years; 65.52% females) were included in the analysis. In the multivariable analysis, after controlling for supplementation vitamin D levels did not differ between both groups and no difference was found regarding tobacco smoke exposure. The proportion of individuals who tested positive for anti-EBV nuclear antigen was significantly higher in individuals with MS (95.4% vs 82.76%, p = 0.028) Conclusion: We did not find a statistically significant association between MS and vitamin D levels while antiEBV nuclear antigen titers behaved as previously described in the literature. This study provides new evidence of the association between MS and different risk factors in our country, reinforcing the hypothesis that the pathogenesis of MS is multifactorial. Further studies are needed to better define the association between environmental factors and the development of MS in low prevalence areas.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-03-07T13:42:07Z
dc.date.available.none.fl_str_mv 2020-03-07T13:42:07Z
dc.type.spa.fl_str_mv article
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dc.type.local.spa.fl_str_mv artículo
dc.identifier.issn.none.fl_str_mv 2211-0348
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/2004
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.msard.2020.101983
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
dc.identifier.repourl.none.fl_str_mv repourl:https://repositorio.unbosque.edu.co
identifier_str_mv 2211-0348
instname:Universidad El Bosque
reponame:Repositorio Institucional Universidad El Bosque
repourl:https://repositorio.unbosque.edu.co
url http://hdl.handle.net/20.500.12495/2004
https://doi.org/10.1016/j.msard.2020.101983
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Multiple Sclerosis and Related Disorders, 2211-0348, Vol. 41, 2020
dc.relation.uri.none.fl_str_mv https://www.msard-journal.com/article/S2211-0348(20)30059-6/abstract
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.local.spa.fl_str_mv Acceso cerrado
dc.rights.accessrights.none.fl_str_mv http://purl.org/coar/access_right/c_abf324
dc.rights.creativecommons.none.fl_str_mv 2020
rights_invalid_str_mv Acceso cerrado
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2020
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dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.journal.spa.fl_str_mv Multiple Sclerosis and Related Disorders
institution Universidad El Bosque
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spelling Toro, JaimeReyes, SaúlDíaz-Cruz, CamiloBurbano, Lisseth EstefaniaCuellar-Giraldo, DavidDuque, AlejandraReyes-Mantilla, María ITorres, CamiloRíos, JorgeRivera Pérez, Juan SebastiánCortés-Muñoz, FabiánPatiño, JorgeNoriega, DanielToro, Jaime [0000-0001-7129-0058]Rivera Pérez, Juan Sebastián [0000-0002-7767-1289]Rivera Pérez, Juan Sebastián [0000-0002-7767-1289]2020-03-07T13:42:07Z2020-03-07T13:42:07Z2211-0348http://hdl.handle.net/20.500.12495/2004https://doi.org/10.1016/j.msard.2020.101983instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengElsevierMultiple Sclerosis and Related DisordersMultiple Sclerosis and Related Disorders, 2211-0348, Vol. 41, 2020https://www.msard-journal.com/article/S2211-0348(20)30059-6/abstractVitamin D and other environmental risk factors in Colombian patients with multiple sclerosisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Factores de riesgoEsclerosis múltipleLuz SolarEpstein-Barr virusVitamin DSmokingEpstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. Methods: We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and duration of smoking, sunlight exposure, physical activity, and personal and family history in individuals with and without multiple sclerosis during adolescence. A multivariable logistic regression model was then performed to explore the association between vitamin D status and MS. Results: : A total of 87 individuals with MS (mean age 40.9 years; 65.52% females) and 87 without MS (mean age 55 years; 65.52% females) were included in the analysis. In the multivariable analysis, after controlling for supplementation vitamin D levels did not differ between both groups and no difference was found regarding tobacco smoke exposure. The proportion of individuals who tested positive for anti-EBV nuclear antigen was significantly higher in individuals with MS (95.4% vs 82.76%, p = 0.028) Conclusion: We did not find a statistically significant association between MS and vitamin D levels while antiEBV nuclear antigen titers behaved as previously described in the literature. This study provides new evidence of the association between MS and different risk factors in our country, reinforcing the hypothesis that the pathogenesis of MS is multifactorial. Further studies are needed to better define the association between environmental factors and the development of MS in low prevalence areas.Acceso cerradohttp://purl.org/coar/access_right/c_abf3242020http://purl.org/coar/access_right/c_abf2ORIGINALToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdfToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdfapplication/pdf231568https://repositorio.unbosque.edu.co/bitstreams/0394dd06-7599-4fdf-97f4-5230c33c0c46/download4c331f4fddaac080da12049fc08371e3MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/2aa7ce3f-5a26-496f-99e7-20329eb7e386/download8a4605be74aa9ea9d79846c1fba20a33MD54THUMBNAILToro J., Reyes ... llar-Giraldo D.F_2020.jpg.jpgToro J., Reyes ... llar-Giraldo D.F_2020.jpg.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/804dc07d-2514-49a2-89d3-4572f1c934c3/download7210a811635d1799e7c05fee5d259be7MD55Toro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.jpgToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.jpgIM Thumbnailimage/jpeg12322https://repositorio.unbosque.edu.co/bitstreams/da918270-34dd-42bd-b381-5b65dd373404/downloadf38827f49671e8d99f9dc3a120859f60MD56TEXTToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.txtToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.txtExtracted texttext/plain36228https://repositorio.unbosque.edu.co/bitstreams/3fb15d73-156a-4c7f-8582-f27f3961f390/downloadaca061914f3b78add6bd4b17039d2d9cMD5720.500.12495/2004oai:repositorio.unbosque.edu.co:20.500.12495/20042024-02-07 13:35:55.033restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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