Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis
Epstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. Methods: We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and...
- Autores:
-
Toro, Jaime
Reyes, Saúl
Díaz-Cruz, Camilo
Burbano, Lisseth Estefania
Cuellar-Giraldo, David
Duque, Alejandra
Reyes-Mantilla, María I
Torres, Camilo
Ríos, Jorge
Rivera Pérez, Juan Sebastián
Cortés-Muñoz, Fabián
Patiño, Jorge
Noriega, Daniel
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/2004
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/2004
https://doi.org/10.1016/j.msard.2020.101983
- Palabra clave:
- Factores de riesgo
Esclerosis múltiple
Luz Solar
Epstein-Barr virus
Vitamin D
Smoking
- Rights
- License
- Acceso cerrado
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oai:repositorio.unbosque.edu.co:20.500.12495/2004 |
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Repositorio U. El Bosque |
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|
dc.title.spa.fl_str_mv |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis |
title |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis |
spellingShingle |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis Factores de riesgo Esclerosis múltiple Luz Solar Epstein-Barr virus Vitamin D Smoking |
title_short |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis |
title_full |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis |
title_fullStr |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis |
title_full_unstemmed |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis |
title_sort |
Vitamin D and other environmental risk factors in Colombian patients with multiple sclerosis |
dc.creator.fl_str_mv |
Toro, Jaime Reyes, Saúl Díaz-Cruz, Camilo Burbano, Lisseth Estefania Cuellar-Giraldo, David Duque, Alejandra Reyes-Mantilla, María I Torres, Camilo Ríos, Jorge Rivera Pérez, Juan Sebastián Cortés-Muñoz, Fabián Patiño, Jorge Noriega, Daniel |
dc.contributor.author.none.fl_str_mv |
Toro, Jaime Reyes, Saúl Díaz-Cruz, Camilo Burbano, Lisseth Estefania Cuellar-Giraldo, David Duque, Alejandra Reyes-Mantilla, María I Torres, Camilo Ríos, Jorge Rivera Pérez, Juan Sebastián Cortés-Muñoz, Fabián Patiño, Jorge Noriega, Daniel |
dc.contributor.orcid.none.fl_str_mv |
Toro, Jaime [0000-0001-7129-0058] Rivera Pérez, Juan Sebastián [0000-0002-7767-1289] Rivera Pérez, Juan Sebastián [0000-0002-7767-1289] |
dc.subject.decs.spa.fl_str_mv |
Factores de riesgo Esclerosis múltiple Luz Solar |
topic |
Factores de riesgo Esclerosis múltiple Luz Solar Epstein-Barr virus Vitamin D Smoking |
dc.subject.keywords.spa.fl_str_mv |
Epstein-Barr virus Vitamin D Smoking |
description |
Epstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. Methods: We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and duration of smoking, sunlight exposure, physical activity, and personal and family history in individuals with and without multiple sclerosis during adolescence. A multivariable logistic regression model was then performed to explore the association between vitamin D status and MS. Results: : A total of 87 individuals with MS (mean age 40.9 years; 65.52% females) and 87 without MS (mean age 55 years; 65.52% females) were included in the analysis. In the multivariable analysis, after controlling for supplementation vitamin D levels did not differ between both groups and no difference was found regarding tobacco smoke exposure. The proportion of individuals who tested positive for anti-EBV nuclear antigen was significantly higher in individuals with MS (95.4% vs 82.76%, p = 0.028) Conclusion: We did not find a statistically significant association between MS and vitamin D levels while antiEBV nuclear antigen titers behaved as previously described in the literature. This study provides new evidence of the association between MS and different risk factors in our country, reinforcing the hypothesis that the pathogenesis of MS is multifactorial. Further studies are needed to better define the association between environmental factors and the development of MS in low prevalence areas. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-03-07T13:42:07Z |
dc.date.available.none.fl_str_mv |
2020-03-07T13:42:07Z |
dc.type.spa.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.local.spa.fl_str_mv |
artículo |
dc.identifier.issn.none.fl_str_mv |
2211-0348 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/2004 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.msard.2020.101983 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
repourl:https://repositorio.unbosque.edu.co |
identifier_str_mv |
2211-0348 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque repourl:https://repositorio.unbosque.edu.co |
url |
http://hdl.handle.net/20.500.12495/2004 https://doi.org/10.1016/j.msard.2020.101983 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Multiple Sclerosis and Related Disorders, 2211-0348, Vol. 41, 2020 |
dc.relation.uri.none.fl_str_mv |
https://www.msard-journal.com/article/S2211-0348(20)30059-6/abstract |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.local.spa.fl_str_mv |
Acceso cerrado |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf324 |
dc.rights.creativecommons.none.fl_str_mv |
2020 |
rights_invalid_str_mv |
Acceso cerrado http://purl.org/coar/access_right/c_abf324 2020 http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.publisher.journal.spa.fl_str_mv |
Multiple Sclerosis and Related Disorders |
institution |
Universidad El Bosque |
bitstream.url.fl_str_mv |
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spelling |
Toro, JaimeReyes, SaúlDíaz-Cruz, CamiloBurbano, Lisseth EstefaniaCuellar-Giraldo, DavidDuque, AlejandraReyes-Mantilla, María ITorres, CamiloRíos, JorgeRivera Pérez, Juan SebastiánCortés-Muñoz, FabiánPatiño, JorgeNoriega, DanielToro, Jaime [0000-0001-7129-0058]Rivera Pérez, Juan Sebastián [0000-0002-7767-1289]Rivera Pérez, Juan Sebastián [0000-0002-7767-1289]2020-03-07T13:42:07Z2020-03-07T13:42:07Z2211-0348http://hdl.handle.net/20.500.12495/2004https://doi.org/10.1016/j.msard.2020.101983instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coapplication/pdfengElsevierMultiple Sclerosis and Related DisordersMultiple Sclerosis and Related Disorders, 2211-0348, Vol. 41, 2020https://www.msard-journal.com/article/S2211-0348(20)30059-6/abstractVitamin D and other environmental risk factors in Colombian patients with multiple sclerosisarticleartículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Factores de riesgoEsclerosis múltipleLuz SolarEpstein-Barr virusVitamin DSmokingEpstein-Barr virus (EBV) seropositivity and smoking history in a Colombian population. Methods: We conducted a cross-sectional study between 2017 and 2018. We measured vitamin D levels and EBV antibody titers and administered a questionnaire to assess dietary habits, smoking, second-hand smoking and duration of smoking, sunlight exposure, physical activity, and personal and family history in individuals with and without multiple sclerosis during adolescence. A multivariable logistic regression model was then performed to explore the association between vitamin D status and MS. Results: : A total of 87 individuals with MS (mean age 40.9 years; 65.52% females) and 87 without MS (mean age 55 years; 65.52% females) were included in the analysis. In the multivariable analysis, after controlling for supplementation vitamin D levels did not differ between both groups and no difference was found regarding tobacco smoke exposure. The proportion of individuals who tested positive for anti-EBV nuclear antigen was significantly higher in individuals with MS (95.4% vs 82.76%, p = 0.028) Conclusion: We did not find a statistically significant association between MS and vitamin D levels while antiEBV nuclear antigen titers behaved as previously described in the literature. This study provides new evidence of the association between MS and different risk factors in our country, reinforcing the hypothesis that the pathogenesis of MS is multifactorial. Further studies are needed to better define the association between environmental factors and the development of MS in low prevalence areas.Acceso cerradohttp://purl.org/coar/access_right/c_abf3242020http://purl.org/coar/access_right/c_abf2ORIGINALToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdfToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdfapplication/pdf231568https://repositorio.unbosque.edu.co/bitstreams/0394dd06-7599-4fdf-97f4-5230c33c0c46/download4c331f4fddaac080da12049fc08371e3MD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/2aa7ce3f-5a26-496f-99e7-20329eb7e386/download8a4605be74aa9ea9d79846c1fba20a33MD54THUMBNAILToro J., Reyes ... llar-Giraldo D.F_2020.jpg.jpgToro J., Reyes ... llar-Giraldo D.F_2020.jpg.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/804dc07d-2514-49a2-89d3-4572f1c934c3/download7210a811635d1799e7c05fee5d259be7MD55Toro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.jpgToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.jpgIM Thumbnailimage/jpeg12322https://repositorio.unbosque.edu.co/bitstreams/da918270-34dd-42bd-b381-5b65dd373404/downloadf38827f49671e8d99f9dc3a120859f60MD56TEXTToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.txtToro J., Reyes S., Díaz-Cruz C., Burbano L., Cuéllar-Giraldo_2020.pdf.txtExtracted texttext/plain36228https://repositorio.unbosque.edu.co/bitstreams/3fb15d73-156a-4c7f-8582-f27f3961f390/downloadaca061914f3b78add6bd4b17039d2d9cMD5720.500.12495/2004oai:repositorio.unbosque.edu.co:20.500.12495/20042024-02-07 13:35:55.033restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |