Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
An unusual increase in infections caused by vancomycin-resistant Enterococcus gallinarum (VREG) was identified in May 2004, in a Colombian tertiary care teaching hospital. A case-control study was subsequently designed to identify risk factors associated with the development of infections due to the...
- Autores:
-
Contreras, G. A.
DiazGranados, C. A.
Cortes, L.
Reyes, J
Vanegas, S.
Panesso, Diana
Rincón, S.
Díaz, L.
Prada, G.
Murray, B. E.
Arias, C. A.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2008
- Institución:
- Universidad El Bosque
- Repositorio:
- Repositorio U. El Bosque
- Idioma:
- eng
- OAI Identifier:
- oai:repositorio.unbosque.edu.co:20.500.12495/5321
- Acceso en línea:
- http://hdl.handle.net/20.500.12495/5321
https://doi.org/10.1016/j.jhin.2008.07.012
https://repositorio.unbosque.edu.co
- Palabra clave:
- Enterococcus gallinarum
Infection control
Nosocomial infection
Outbreak
Vancomycin
- Rights
- openAccess
- License
- Acceso abierto
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|
dc.title.spa.fl_str_mv |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
dc.title.translated.spa.fl_str_mv |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
title |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
spellingShingle |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci Enterococcus gallinarum Infection control Nosocomial infection Outbreak Vancomycin |
title_short |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
title_full |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
title_fullStr |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
title_full_unstemmed |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
title_sort |
Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci |
dc.creator.fl_str_mv |
Contreras, G. A. DiazGranados, C. A. Cortes, L. Reyes, J Vanegas, S. Panesso, Diana Rincón, S. Díaz, L. Prada, G. Murray, B. E. Arias, C. A. |
dc.contributor.author.none.fl_str_mv |
Contreras, G. A. DiazGranados, C. A. Cortes, L. Reyes, J Vanegas, S. Panesso, Diana Rincón, S. Díaz, L. Prada, G. Murray, B. E. Arias, C. A. |
dc.contributor.orcid.none.fl_str_mv |
Panesso, Diana [0000-0002-4049-9702] |
dc.subject.keywords.spa.fl_str_mv |
Enterococcus gallinarum Infection control Nosocomial infection Outbreak Vancomycin |
topic |
Enterococcus gallinarum Infection control Nosocomial infection Outbreak Vancomycin |
description |
An unusual increase in infections caused by vancomycin-resistant Enterococcus gallinarum (VREG) was identified in May 2004, in a Colombian tertiary care teaching hospital. A case-control study was subsequently designed to identify risk factors associated with the development of infections due to these organisms. All VREG isolates were subjected to antimicrobial susceptibility testing, vancomycin resistance gene detection and pulsed-field gel electrophoresis (PFGE) typing. Additionally, the presence of genes associated with an acquired pathogenicity island of E. faecalis and a hyl-like gene of E. faecium was assessed by hybridisation assays. Eleven cases of VREG were identified between May through June 2004. VREG was isolated from blood (N=4), surgical secretions (N=4), paranasal sinus secretion (N=1), lung abscess (N=1) and urine (N=1). Infections with VREG were associated with mucositis, hospitalisation in the haematology ward and surgical unit, length of hospital stay prior to culture and invasive procedures within 30 days prior to the culture. Logistic regression found that female sex and hospitalisation in the surgical unit were independent factors for VREG infection. All isolates were identified as E. gallinarum, harboured the vanC1 gene and exhibited indistinguishable restriction patterns by PFGE. Virulence-associated genes were not detected. This is the first documented hospital-wide outbreak of VREG and highlights the fact that uncommon species of enterococci are capable of nosocomial dissemination. |
publishDate |
2008 |
dc.date.issued.none.fl_str_mv |
2008 |
dc.date.accessioned.none.fl_str_mv |
2021-02-15T14:05:47Z |
dc.date.available.none.fl_str_mv |
2021-02-15T14:05:47Z |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.local.none.fl_str_mv |
Artículo de revista |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
http://purl.org/coar/resource_type/c_6501 |
dc.identifier.issn.none.fl_str_mv |
1532-2939 |
dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/20.500.12495/5321 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.jhin.2008.07.012 |
dc.identifier.instname.spa.fl_str_mv |
instname:Universidad El Bosque |
dc.identifier.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional Universidad El Bosque |
dc.identifier.repourl.none.fl_str_mv |
https://repositorio.unbosque.edu.co |
identifier_str_mv |
1532-2939 instname:Universidad El Bosque reponame:Repositorio Institucional Universidad El Bosque |
url |
http://hdl.handle.net/20.500.12495/5321 https://doi.org/10.1016/j.jhin.2008.07.012 https://repositorio.unbosque.edu.co |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.spa.fl_str_mv |
Journal of Hospital Infection, 1532-2939, Vol. 70, Nro. 4, 2008 p. 346-352 |
dc.relation.uri.none.fl_str_mv |
https://www.journalofhospitalinfection.com/article/S0195-6701(08)00312-5/fulltext |
dc.rights.local.spa.fl_str_mv |
Acceso abierto |
dc.rights.accessrights.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 info:eu-repo/semantics/openAccess Acceso abierto |
dc.rights.creativecommons.none.fl_str_mv |
2008 |
rights_invalid_str_mv |
Acceso abierto http://purl.org/coar/access_right/c_abf2 2008 |
eu_rights_str_mv |
openAccess |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Elsevier |
dc.publisher.journal.spa.fl_str_mv |
Journal of Hospital Infection |
institution |
Universidad El Bosque |
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spelling |
Contreras, G. A.DiazGranados, C. A.Cortes, L.Reyes, JVanegas, S.Panesso, DianaRincón, S.Díaz, L.Prada, G.Murray, B. E.Arias, C. A.Panesso, Diana [0000-0002-4049-9702]2021-02-15T14:05:47Z2021-02-15T14:05:47Z20081532-2939http://hdl.handle.net/20.500.12495/5321https://doi.org/10.1016/j.jhin.2008.07.012instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengElsevierJournal of Hospital InfectionJournal of Hospital Infection, 1532-2939, Vol. 70, Nro. 4, 2008 p. 346-352https://www.journalofhospitalinfection.com/article/S0195-6701(08)00312-5/fulltextNosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococciNosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococciArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Enterococcus gallinarumInfection controlNosocomial infectionOutbreakVancomycinAn unusual increase in infections caused by vancomycin-resistant Enterococcus gallinarum (VREG) was identified in May 2004, in a Colombian tertiary care teaching hospital. A case-control study was subsequently designed to identify risk factors associated with the development of infections due to these organisms. All VREG isolates were subjected to antimicrobial susceptibility testing, vancomycin resistance gene detection and pulsed-field gel electrophoresis (PFGE) typing. Additionally, the presence of genes associated with an acquired pathogenicity island of E. faecalis and a hyl-like gene of E. faecium was assessed by hybridisation assays. Eleven cases of VREG were identified between May through June 2004. VREG was isolated from blood (N=4), surgical secretions (N=4), paranasal sinus secretion (N=1), lung abscess (N=1) and urine (N=1). Infections with VREG were associated with mucositis, hospitalisation in the haematology ward and surgical unit, length of hospital stay prior to culture and invasive procedures within 30 days prior to the culture. Logistic regression found that female sex and hospitalisation in the surgical unit were independent factors for VREG infection. All isolates were identified as E. gallinarum, harboured the vanC1 gene and exhibited indistinguishable restriction patterns by PFGE. Virulence-associated genes were not detected. This is the first documented hospital-wide outbreak of VREG and highlights the fact that uncommon species of enterococci are capable of nosocomial dissemination.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2008ORIGINALContreras_G_A_2008.pdfContreras_G_A_2008.pdfapplication/pdf566247https://repositorio.unbosque.edu.co/bitstreams/e05d0ab0-abd9-4946-87c6-ba26c045d3ea/downloadea56e255cac55298e3eeedb5a57b87a8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/a3c66ab6-30b8-4871-8493-6685ee0faee6/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILContreras_G_A_2008.pdf.jpgContreras_G_A_2008.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/924e5857-b700-4da7-ba79-2f2dd75ef4d7/download7210a811635d1799e7c05fee5d259be7MD53TEXTContreras_G_A_2008.pdf.txtContreras_G_A_2008.pdf.txtExtracted texttext/plain29738https://repositorio.unbosque.edu.co/bitstreams/1197fc7e-4100-4002-b282-86ffb139b796/downloadce33e79e082d9b167f390a1d6dc72226MD5420.500.12495/5321oai:repositorio.unbosque.edu.co:20.500.12495/53212024-02-07 10:08:29.781restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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 |