Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci

An unusual increase in infections caused by vancomycin-resistant Enterococcus gallinarum (VREG) was identified in May 2004, in a Colombian tertiary care teaching hospital. A case-control study was subsequently designed to identify risk factors associated with the development of infections due to the...

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Autores:
Contreras, G. A.
DiazGranados, C. A.
Cortes, L.
Reyes, J
Vanegas, S.
Panesso, Diana
Rincón, S.
Díaz, L.
Prada, G.
Murray, B. E.
Arias, C. A.
Tipo de recurso:
Article of journal
Fecha de publicación:
2008
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
eng
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/5321
Acceso en línea:
http://hdl.handle.net/20.500.12495/5321
https://doi.org/10.1016/j.jhin.2008.07.012
https://repositorio.unbosque.edu.co
Palabra clave:
Enterococcus gallinarum
Infection control
Nosocomial infection
Outbreak
Vancomycin
Rights
openAccess
License
Acceso abierto
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dc.title.spa.fl_str_mv Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
dc.title.translated.spa.fl_str_mv Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
title Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
spellingShingle Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
Enterococcus gallinarum
Infection control
Nosocomial infection
Outbreak
Vancomycin
title_short Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
title_full Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
title_fullStr Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
title_full_unstemmed Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
title_sort Nosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococci
dc.creator.fl_str_mv Contreras, G. A.
DiazGranados, C. A.
Cortes, L.
Reyes, J
Vanegas, S.
Panesso, Diana
Rincón, S.
Díaz, L.
Prada, G.
Murray, B. E.
Arias, C. A.
dc.contributor.author.none.fl_str_mv Contreras, G. A.
DiazGranados, C. A.
Cortes, L.
Reyes, J
Vanegas, S.
Panesso, Diana
Rincón, S.
Díaz, L.
Prada, G.
Murray, B. E.
Arias, C. A.
dc.contributor.orcid.none.fl_str_mv Panesso, Diana [0000-0002-4049-9702]
dc.subject.keywords.spa.fl_str_mv Enterococcus gallinarum
Infection control
Nosocomial infection
Outbreak
Vancomycin
topic Enterococcus gallinarum
Infection control
Nosocomial infection
Outbreak
Vancomycin
description An unusual increase in infections caused by vancomycin-resistant Enterococcus gallinarum (VREG) was identified in May 2004, in a Colombian tertiary care teaching hospital. A case-control study was subsequently designed to identify risk factors associated with the development of infections due to these organisms. All VREG isolates were subjected to antimicrobial susceptibility testing, vancomycin resistance gene detection and pulsed-field gel electrophoresis (PFGE) typing. Additionally, the presence of genes associated with an acquired pathogenicity island of E. faecalis and a hyl-like gene of E. faecium was assessed by hybridisation assays. Eleven cases of VREG were identified between May through June 2004. VREG was isolated from blood (N=4), surgical secretions (N=4), paranasal sinus secretion (N=1), lung abscess (N=1) and urine (N=1). Infections with VREG were associated with mucositis, hospitalisation in the haematology ward and surgical unit, length of hospital stay prior to culture and invasive procedures within 30 days prior to the culture. Logistic regression found that female sex and hospitalisation in the surgical unit were independent factors for VREG infection. All isolates were identified as E. gallinarum, harboured the vanC1 gene and exhibited indistinguishable restriction patterns by PFGE. Virulence-associated genes were not detected. This is the first documented hospital-wide outbreak of VREG and highlights the fact that uncommon species of enterococci are capable of nosocomial dissemination.
publishDate 2008
dc.date.issued.none.fl_str_mv 2008
dc.date.accessioned.none.fl_str_mv 2021-02-15T14:05:47Z
dc.date.available.none.fl_str_mv 2021-02-15T14:05:47Z
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dc.type.local.none.fl_str_mv Artículo de revista
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dc.identifier.issn.none.fl_str_mv 1532-2939
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/20.500.12495/5321
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.jhin.2008.07.012
dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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url http://hdl.handle.net/20.500.12495/5321
https://doi.org/10.1016/j.jhin.2008.07.012
https://repositorio.unbosque.edu.co
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartofseries.spa.fl_str_mv Journal of Hospital Infection, 1532-2939, Vol. 70, Nro. 4, 2008 p. 346-352
dc.relation.uri.none.fl_str_mv https://www.journalofhospitalinfection.com/article/S0195-6701(08)00312-5/fulltext
dc.rights.local.spa.fl_str_mv Acceso abierto
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rights_invalid_str_mv Acceso abierto
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dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.journal.spa.fl_str_mv Journal of Hospital Infection
institution Universidad El Bosque
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spelling Contreras, G. A.DiazGranados, C. A.Cortes, L.Reyes, JVanegas, S.Panesso, DianaRincón, S.Díaz, L.Prada, G.Murray, B. E.Arias, C. A.Panesso, Diana [0000-0002-4049-9702]2021-02-15T14:05:47Z2021-02-15T14:05:47Z20081532-2939http://hdl.handle.net/20.500.12495/5321https://doi.org/10.1016/j.jhin.2008.07.012instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquehttps://repositorio.unbosque.edu.coapplication/pdfengElsevierJournal of Hospital InfectionJournal of Hospital Infection, 1532-2939, Vol. 70, Nro. 4, 2008 p. 346-352https://www.journalofhospitalinfection.com/article/S0195-6701(08)00312-5/fulltextNosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococciNosocomial outbreak of Enteroccocus gallinarum: untaming of rare species of enterococciArtículo de revistahttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a85Enterococcus gallinarumInfection controlNosocomial infectionOutbreakVancomycinAn unusual increase in infections caused by vancomycin-resistant Enterococcus gallinarum (VREG) was identified in May 2004, in a Colombian tertiary care teaching hospital. A case-control study was subsequently designed to identify risk factors associated with the development of infections due to these organisms. All VREG isolates were subjected to antimicrobial susceptibility testing, vancomycin resistance gene detection and pulsed-field gel electrophoresis (PFGE) typing. Additionally, the presence of genes associated with an acquired pathogenicity island of E. faecalis and a hyl-like gene of E. faecium was assessed by hybridisation assays. Eleven cases of VREG were identified between May through June 2004. VREG was isolated from blood (N=4), surgical secretions (N=4), paranasal sinus secretion (N=1), lung abscess (N=1) and urine (N=1). Infections with VREG were associated with mucositis, hospitalisation in the haematology ward and surgical unit, length of hospital stay prior to culture and invasive procedures within 30 days prior to the culture. Logistic regression found that female sex and hospitalisation in the surgical unit were independent factors for VREG infection. All isolates were identified as E. gallinarum, harboured the vanC1 gene and exhibited indistinguishable restriction patterns by PFGE. Virulence-associated genes were not detected. This is the first documented hospital-wide outbreak of VREG and highlights the fact that uncommon species of enterococci are capable of nosocomial dissemination.Acceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessAcceso abierto2008ORIGINALContreras_G_A_2008.pdfContreras_G_A_2008.pdfapplication/pdf566247https://repositorio.unbosque.edu.co/bitstreams/e05d0ab0-abd9-4946-87c6-ba26c045d3ea/downloadea56e255cac55298e3eeedb5a57b87a8MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.unbosque.edu.co/bitstreams/a3c66ab6-30b8-4871-8493-6685ee0faee6/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILContreras_G_A_2008.pdf.jpgContreras_G_A_2008.pdf.jpgimage/jpeg5775https://repositorio.unbosque.edu.co/bitstreams/924e5857-b700-4da7-ba79-2f2dd75ef4d7/download7210a811635d1799e7c05fee5d259be7MD53TEXTContreras_G_A_2008.pdf.txtContreras_G_A_2008.pdf.txtExtracted texttext/plain29738https://repositorio.unbosque.edu.co/bitstreams/1197fc7e-4100-4002-b282-86ffb139b796/downloadce33e79e082d9b167f390a1d6dc72226MD5420.500.12495/5321oai:repositorio.unbosque.edu.co:20.500.12495/53212024-02-07 10:08:29.781restrictedhttps://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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