Uso de modelos animales (ratas y ratones) en la educación con fines investigación

El mundo actual demanda profesionales formados en ética, bienestar animal y uso responsable de biomodelos, capaces de responder a las necesidades sociales mediante una formación académica sólida desde el pregrado. Este conocimiento debe transferirse posteriormente a la industria, centros de investig...

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Autores:
Rios Diaz, Adrian Samir
Cardenas Contreras, Zaida Liliana
Tipo de recurso:
https://purl.org/coar/resource_type/c_7a1f
Fecha de publicación:
2025
Institución:
Universidad El Bosque
Repositorio:
Repositorio U. El Bosque
Idioma:
spa
OAI Identifier:
oai:repositorio.unbosque.edu.co:20.500.12495/14649
Acceso en línea:
https://hdl.handle.net/20.500.12495/14649
Palabra clave:
Investigación experimental
Fisiología conductual y cognitiva
Roedores
Medicina veterinaria
Modelos animales
Educación bioética
Enriquecimiento ambiental y cognitivo
Medicina medioambiental y veterinaria
Bienestar animal
Experimentación con animales
378.12
Experimental research
Behavioral and cognitive physiology
Rodents
Veterinary Medicine
Animal models
Bioethical Education
Environmental enrichment and cognitive
Environmental and veterinary medicine
Animal welfare
Animal experimentation
Rights
License
Attribution-NonCommercial-NoDerivatives 4.0 International
id UNBOSQUE2_013c2d94015ec34b0f7e79c3477f119a
oai_identifier_str oai:repositorio.unbosque.edu.co:20.500.12495/14649
network_acronym_str UNBOSQUE2
network_name_str Repositorio U. El Bosque
repository_id_str
dc.title.none.fl_str_mv Uso de modelos animales (ratas y ratones) en la educación con fines investigación
dc.title.translated.none.fl_str_mv Use of animal models (rats and mice) in education for research purposes
title Uso de modelos animales (ratas y ratones) en la educación con fines investigación
spellingShingle Uso de modelos animales (ratas y ratones) en la educación con fines investigación
Investigación experimental
Fisiología conductual y cognitiva
Roedores
Medicina veterinaria
Modelos animales
Educación bioética
Enriquecimiento ambiental y cognitivo
Medicina medioambiental y veterinaria
Bienestar animal
Experimentación con animales
378.12
Experimental research
Behavioral and cognitive physiology
Rodents
Veterinary Medicine
Animal models
Bioethical Education
Environmental enrichment and cognitive
Environmental and veterinary medicine
Animal welfare
Animal experimentation
title_short Uso de modelos animales (ratas y ratones) en la educación con fines investigación
title_full Uso de modelos animales (ratas y ratones) en la educación con fines investigación
title_fullStr Uso de modelos animales (ratas y ratones) en la educación con fines investigación
title_full_unstemmed Uso de modelos animales (ratas y ratones) en la educación con fines investigación
title_sort Uso de modelos animales (ratas y ratones) en la educación con fines investigación
dc.creator.fl_str_mv Rios Diaz, Adrian Samir
Cardenas Contreras, Zaida Liliana
dc.contributor.advisor.none.fl_str_mv Sánchez Gómez, Juan Sebastián
dc.contributor.author.none.fl_str_mv Rios Diaz, Adrian Samir
Cardenas Contreras, Zaida Liliana
dc.subject.none.fl_str_mv Investigación experimental
Fisiología conductual y cognitiva
Roedores
Medicina veterinaria
Modelos animales
Educación bioética
Enriquecimiento ambiental y cognitivo
Medicina medioambiental y veterinaria
Bienestar animal
Experimentación con animales
topic Investigación experimental
Fisiología conductual y cognitiva
Roedores
Medicina veterinaria
Modelos animales
Educación bioética
Enriquecimiento ambiental y cognitivo
Medicina medioambiental y veterinaria
Bienestar animal
Experimentación con animales
378.12
Experimental research
Behavioral and cognitive physiology
Rodents
Veterinary Medicine
Animal models
Bioethical Education
Environmental enrichment and cognitive
Environmental and veterinary medicine
Animal welfare
Animal experimentation
dc.subject.ddc.none.fl_str_mv 378.12
dc.subject.keywords.none.fl_str_mv Experimental research
Behavioral and cognitive physiology
Rodents
Veterinary Medicine
Animal models
Bioethical Education
Environmental enrichment and cognitive
Environmental and veterinary medicine
Animal welfare
Animal experimentation
description El mundo actual demanda profesionales formados en ética, bienestar animal y uso responsable de biomodelos, capaces de responder a las necesidades sociales mediante una formación académica sólida desde el pregrado. Este conocimiento debe transferirse posteriormente a la industria, centros de investigación, universidades y demás instituciones relacionadas. El desarrollo de biotecnología requiere personal calificado y entrenado, lo que no solo ofrece soluciones a problemas de salud, sino que también genera empleo y contribuye al crecimiento económico del país. La investigación biomédica utiliza animales para desarrollar actividades que permitan comprender fenómenos fisiológicos a través de diseños experimentales. Los modelos animales se utilizan en diversas áreas, como la simulación de infecciones humanas, tratamientos y procesos inmunológicos. El principal hallazgo de esta revisión fue la implementación de modelos animales en procesos de formación académica, investigación y ciencia, bajo lineamientos obligatorios que ya están regulados para asegurar el bienestar animal y minimizar su sufrimiento. El avance del conocimiento en investigación aplicada y control de enfermedades requiere el uso de modelos animales, empleando prácticas adecuadas que consideren la ética y el cuidado de los animales, con el objetivo de obtener resultados científicamente válidos que contribuyan al tratamiento de enfermedades y a la mejora de las condiciones de vida humana. La metodología PRISMA en esta revisión proporcionó una guía práctica para realizar búsquedas de literatura científica de manera rigurosa y reproducible, asegurando la obtención de evidencia confiable. En la modernidad actual, existen herramientas tecnológicas que permiten facilitar el aprendizaje, sin embargo, esto no aplica para todos los contextos, a modo de ejemplo la realidad virtual facilita la enseñanza de algunos temas como es la geografía, sin embargo, no reemplaza la práctica educativa del que hacer con el manejo de los animales para el caso de la ciencia de la salud como la medicina veterinaria.
publishDate 2025
dc.date.accessioned.none.fl_str_mv 2025-06-13T17:11:30Z
dc.date.available.none.fl_str_mv 2025-06-13T17:11:30Z
dc.date.issued.none.fl_str_mv 2025-06
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.local.spa.fl_str_mv Tesis/Trabajo de grado - Monografía - Especialización
dc.type.coar.none.fl_str_mv https://purl.org/coar/resource_type/c_7a1f
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/bachelorThesis
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dc.identifier.instname.spa.fl_str_mv instname:Universidad El Bosque
dc.identifier.reponame.spa.fl_str_mv reponame:Repositorio Institucional Universidad El Bosque
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dc.relation.references.none.fl_str_mv Abdimanapov, Bakhadurkhan, Sanat Kumarbekuly, and Ilgizar Gaisin. 2024. “Technology for Achieving Learning Objectives Through a System-Activity Approach and the Development of Critical Thinking in Geography Studies.” Journal of Ecohumanism 3(8): 3032–46. doi:10.62754/joe. v3i8.5797.
Augustsson, H, L Lindberg, A U Hö, and & K Dahlborn. Human-Animal Interactions and Animal Welfare in Conventionally and Pen-Housed Rats.
Bahramsoltani, Mahtab, Sonja Bröer, Susann Langforth, Corinna Eule, Alina Prior, Lena Vogt, Ting Ting Li, et al. 2023. “Outcome of Communication Training in Veterinary Studies: Influence on the Perception of the Relevance of Veterinary Competencies and Self-Assessment of Communication Skills.” Animals 13(9). doi:10.3390/ani13091516.
Baumans, Vera. Environmental Enrichment for Laboratory Rodents and Rabbits: Requirements of Rodents, Rabbits, and Research. https://academic.oup.com/ilarjournal/article/46/2/162/910262.
Bonilla-Aldana, D. Katterine, Jorge Luis Bonilla-Aldana, Juan R. Ulloque-Badaracco, Ali Al-kassab-Córdova, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Vicente A. Benites-Zapata, et al. 2024. “Mpox Infection in Animals: A Systematic Review and Meta-Analysis.” Journal of Infection and Public Health 17(7). doi: 10.1016/j.jiph.2024.04.015.
Buckmaster, Cindy. 2012. “Shifting the Culture of Lab Animal Care.” Lab animal 41(7): 205. doi:10.1038/laban0712-205.
Cai, Yiming, Ruofan Zhao, Yuxuan Huang, Huiping Yang, Ye Liu, Rui Yang, Xiangyu Zhang, et al. 2024. “Environmental Enrichment Attenuates Maternal Separation-Induced Excessive Hoarding Behavior in Adult Female Mice.” Pharmacology Biochemistry and Behavior 245. doi: 10.1016/j.pbb.2024.173913.
Cait, Jessica, Charlotte B. Winder, and Georgia J. Mason. 2024. “How Much ‘enrichment’ Is Enough for Laboratory Rodents? A Systematic Review and Meta-Analysis Re-Assessing the Impact of Well-Resourced Cages on Morbidity and Mortality.” Applied Animal Behaviour Science 278. doi: 10.1016/j.applanim.2024.106361.
Chaplinski, Nick. 2016. “Animal Biosafety.” In Ensuring National Biosecurity: Institutional Biosafety Committees, Elsevier Inc., 137–50. doi:10.1016/B978-0-12-801885-9.00008-1.
Díez-Solinska, Alina, Zurine De Miguel, Garikoitz Azkona, and Oscar Vegas. 2024. “Behavioral Coping with Chronic Defeat Stress in Mice: A Systematic Review of Current Protocols.” Neurobiology of Stress 33. doi: 10.1016/j.ynstr.2024.100689.
Eltayeb, Galal Eldin Abbas. 2025. “Harnessing Artificial Intelligence Tools to Enhance Smart Learning.” International Journal of Learning, Teaching and Educational Research 24(2): 503–24. doi:10.26803/ijlter.24.2.25.
Fiege, Jessica K., Katharine E. Block, Mark J. Pierson, Hezkiel Nanda, Frances K. Shepherd, Clayton K. Mickelson, J. Michael Stolley, et al. 2021. “Mice with Diverse Microbial Exposure Histories as a Model for Preclinical Vaccine Testing.” Cell Host and Microbe 29(12): 1815-1827.e6. doi: 10.1016/j.chom.2021.10.001.
Gargiulo, Sara, Sandra Albanese, Rosario Megna, Matteo Gramanzini, Gerardo Marsella, and Lidovina Vecchiarelli. 2025a. “Veterinary Medical Care in Rodent Models of Stroke: Pitfalls and Refinements to Balance Quality of Science and Animal Welfare.” Neuroscience. doi: 10.1016/j.neuroscience.2025.01.044.
Gargiulo, Sara, Sandra Albanese, Rosario Megna, Matteo Gramanzini, Gerardo Marsella, and Lidovina Vecchiarelli. 2025b. “Veterinary Medical Care in Rodent Models of Stroke: Pitfalls and Refinements to Balance Quality of Science and Animal Welfare.” Neuroscience. doi: 10.1016/j.neuroscience.2025.01.044.
Gaskill, B. N., H. Davis, R. P. Gosselin, J. P. Garner, J. S. Radcliffe, L. A. Robbins, and K. R. Pritchett-Corning. 2025. “Behavioral or Nutritional Drive: Which Motivation Affects Rates of Food Grinding in CD1 Mice?” Applied Animal Behaviour Science 284. doi: 10.1016/j.applanim.2025.106533.
Gelizon, Mary Joy B. 2024. “Play to Learn: Exploring the Impact of Fun English Classes on the Literacy Skills of Elementary Learners.” Environment and Social Psychology 9(10). doi:10.59429/esp. v9i10.3164.
Haque, Rosa, Aysenur Deniz Song, Jongsun Lee, Seung Jae V. Lee, and Jae Myoung Suh. 2025. “Essential Resources and Best Practices for Laboratory Mouse Research.” Molecules and Cells 48(2). doi: 10.1016/j.mocell.2025.100178.
Hawkins, Penny, and Huw D.R. Golledge. 2018. “The 9-to-5 Rodent − Time for Change? Scientific and Animal Welfare Implications of Circadian and Light Effects on Laboratory Mice and Rats.” Journal of Neuroscience Methods 300: 20–25. doi: 10.1016/j.jneumeth.2017.05.014.
Iancu, Mariana. 2014. “Bioethical Education in Teaching Biology.” Procedia - Social and Behavioral Sciences 127: 73–77. doi: 10.1016/j.sbspro.2014.03.215.
Iliff, Susan A. An Additional “R”: Remembering the Animals. https://academic.oup.com/ilarjournal/article/43/1/38/846351.
Kerimbayev, Nurassyl, Zhanat Umirzakova, Rustam Shadiev, and Vladimir Jotsov. 2023. “A Student-Centered Approach Using Modern Technologies in Distance Learning: A Systematic Review of the Literature.” Smart Learning Environments 10(1). doi:10.1186/s40561-023-00280-8.
Klein, H J, and K a Bayne. Establishing a Culture of Care, Conscience, and Responsibility: Addressing the Improvement of Scientific Discovery and Animal Welfare Through Science-Based Performance Standards. www.phrma.org/publications.
Knight, Andrew. 2022. “SCIENTIFIC AND EDUCATIONAL ANIMAL USE.” In Routledge Handbook of Animal Welfare, Taylor and Francis, 161–75. doi:10.4324/9781003182351-16.
Komba, Erick V.G., Maulilio J. Kipanyula, Amandus P. Muhairwa, Rudovick R. Kazwala, Jahashi Nzalawahe, Modesta J. Makungu, Tesfaalem T. Sebhatu, et al. 2020. “Evaluation of the Bachelor of Veterinary Medicine (BVM) Curriculum at Sokoine University of Agriculture in Tanzania: Mapping to OIE Veterinary Graduate ‘Day 1 Competencies.’” Journal of Veterinary Medical Education 47: 20–29. doi:10.3138/JVME-2019-0120.
Lange, Sigrun, and Jameel M. Inal. 2024. “Animal Models of Human Disease 2.0.” International Journal of Molecular Sciences 25(24): 13743. doi:10.3390/ijms252413743.
Li, Xiao Yan, Kang Ning Xue, Jin Sheng Jiang, and Xuan Cheng Lu. 2016. “The Main Biological Hazards in Animal Biosafety Level 2 Facilities and Strategies for Control.” Biomedical and Environmental Sciences 29(4): 300–304. doi:10.3967/bes2016.039.
Lidster, Katie, John G. Jefferys, Ingmar Blümcke, Vincenzo Crunelli, Paul Flecknell, Bruno G. Frenguelli, William P. Gray, et al. 2016. “Opportunities for Improving Animal Welfare in Rodent Models of Epilepsy and Seizures.” Journal of Neuroscience Methods 260: 2–25. doi: 10.1016/j.jneumeth.2015.09.007.
Losansky, Vera A., Stefan Arnhold, Jörg R. Aschenbach, Thomas Göbel, Kerstin Fey, Christin Kleinsorgen, Christoph Mülling, et al. 2022. “Survey on the Relevance of Subjects in the Current and Future Veterinary Curriculum among Veterinarians and Veterinary Students in Germany.” Berliner und Munchener Tierarztliche Wochenschrift 135. doi:10.2376/1439-0299-2021-13.
Love, Chloe J., Carolina Gubert, Thibault Renoir, and Anthony J. Hannan. 2022. “Environmental Enrichment and Exercise Housing Protocols for Mice.” STAR Protocols 3(4). doi: 10.1016/j.xpro.2022.101689.
Ma, Cunling, Leyi Yu, Shensi Chen, Xin Wu, Yuanyuan Yang, Haibo Xie, Xiaojiang Chen, et al. 2025. “Investigating the Self-Healing Potential of Polycystic Ovary Syndrome in a Mouse Model: Implications for Offspring Health.” Biochemical and Biophysical Research Communications 747. doi: 10.1016/j.bbrc.2024.151266.
Marhaeni, Nafida Hetty, Mónica Arnal-Palacián, and Muhammad Irfan. 2025. “Interactive Math Comics: An Analysis of Indonesian and Spanish Students’ Responses.” Infinity Journal 14(1): 143–62. doi:10.22460/infinity. v14i1.p143-162.
Martin-Alguacil, Nieves, Luis Avedillo, Ruben Mota-Blanco, and Miguel Gallego-Agundez. 2024. “Student-Centered Learning: Some Issues and Recommendations for Its Implementation in a Traditional Curriculum Setting in Health Sciences.” Education Sciences 14(11). doi:10.3390/educsci14111179.
Medina, Leticia V. “Building a Culture of Animal Welfare: Past, Present and Future.” http://arbs.biblioteca.unesp.br.
Miziara, Ivan Dieb, Ana Tereza De Matos Magalhães, Maruska D´aparecida Santos, Érika Ferreira Gomes, and Reinaldo Ayer De Oliveira. 78 Publishing Management System-Brazilian Journal of Otorhinolaryngology) on December Research Ethics in Animal Models Abstract. http://www.bjorl.org/.
Nambisan, Padma. 2017. “Laboratory Biosafety and Good Laboratory Practices.” In An Introduction to Ethical, Safety and Intellectual Property Rights Issues in Biotechnology, Elsevier, 253–71. doi:10.1016/b978-0-12-809231-6.00011-9.
Page, Matthew J., Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, Larissa Shamseer, et al. 2021. “The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews.” The BMJ 372. doi:10.1136/bmj. n71.
Pozzebon, Mattia. 2024. “Animal Welfare Issues in Space Settlement Expeditions.” Futures 163. doi: 10.1016/j.futures.2024.103443.
Qafa, Adriana, Zenel Sina, and Llambi Prendi. 2024. “The Impact of Teachers’ Attitudes on the Effectiveness of Teaching with the Student in the Center.” Journal of Educational and Social Research 14(6): 88–103. doi:10.36941/jesr-2024-0158.
Ray, Heather, and Michael Klymkowsky. 2025. “Approaching Ethical Issues in the Developmental Biology Classroom.” Developmental Biology 518: 48–52. doi: 10.1016/j.ydbio.2024.11.008.
Reinhard, Addie R., Kristina D. Hains, Bryan J. Hains, and Elizabeth B. Strand. 2021. “Are They Ready? Trials, Tribulations, and Professional Skills Vital for New Veterinary Graduate Success.” Frontiers in Veterinary Science 8. doi:10.3389/fvets.2021.785844.
Robinson, N. Bryce, Katherine Krieger, Faiza Khan, William Huffman, Michelle Chang, Ajita Naik, Ruan Yongle, et al. 2019. “The Current State of Animal Models in Research: A Review.” International Journal of Surgery 72: 9–13. doi: 10.1016/j.ijsu.2019.10.015.
Rollin, Bernard E. 2003. “Toxicology and New Social Ethics for Animals.” Toxicologic Pathology 31(1_suppl): 128–31. doi:10.1080/01926230390175011.
Schipper, Lidewij, Steffen van Heijningen, Giorgio Karapetsas, Jocelien D.A. Olivier, and Gertjan van Dijk. 2025. “Social Housing Conditions, Hierarchical Status and Testing Order Affect Behavioral Test Outcomes of Male C57BL6/J Mice.” Physiology and Behavior 293. doi: 10.1016/j.physbeh.2025.114859.
Schneidewind, Stephanie, Raffaela Lesch, Veronika Heizmann, and Ines Windschnurer. 2024. “Exploring Pet Rat Care: A Comprehensive Survey of Husbandry, Health, Behavior, and the Associations between Caretaker Attitudes, Attachment, and Husbandry Practices.” Journal of Veterinary Behavior 75: 1–19. doi: 10.1016/j.jveb.2024.06.009.
Shahzad, Muhammad Farrukh, Shuo Xu, Weng Marc Lim, Xingbing Yang, and Qasim Raza Khan. 2024. “Artificial Intelligence and Social Media on Academic Performance and Mental Well-Being: Student Perceptions of Positive Impact in the Age of Smart Learning.” Heliyon 10(8). doi: 10.1016/j.heliyon. 2024.e29523.
Souza, Thiago Moreno L., and Carlos Medicis Morel. 2021. “The COVID-19 Pandemics and the Relevance of Biosafety Facilities for Metagenomics Surveillance, Structured Disease Prevention and Control.” Biosafety and Health 3(1): 1–3. doi: 10.1016/j.bsheal.2020.11.007.
Stuart, Sarah A., and Emma S.J. Robinson. 2015. “Reducing the Stress of Drug Administration: Implications for the 3Rs.” Scientific Reports 5. doi:10.1038/srep14288.
Suksutdhi, Thanasit. 2024. “INNOVATION MODEL OF HUMAN RESOURCES TRAINING AND DEVELOPMENT FOR THE HOTEL INDUSTRY FROM THE ASEAN STANDARD FRAMEWORK: A CASE IN NAKHON RATCHASIMA PROVINCE, THAILAND.” Geojournal of Tourism and Geosites 52(1): 267–75. doi:10.30892/gtg.52126-1203.
Taylor, Katy, and Laura Rego Alvarez. 2019. “An Estimate of the Number of Animals Used for Scientific Purposes Worldwide in 2015.” ATLA Alternatives to Laboratory Animals 47(5–6): 196–213. doi:10.1177/0261192919899853.
Tigma, Maxmillian Younyi, Sophie Etomes, and Roland Ndille. 2024. “Pedagogic and Programmes Change and the Enhancement of Relevance of State Higher Education System in Cameroon.” Perspectives in Education 42(4): 70–100. doi:10.38140/pie. v42i4.7891.
Von der Beck, Birte, Andreas Wissmann, Rene H. Tolba, Philip Dammann, and Gero Hilken. 2024. “What Can Laboratory Animal Facility Managers Do to Improve the Welfare of Laboratory Animals and Laboratory Animal Facility Staff? A German Perspective.” Animals 14(7). doi:10.3390/ani14071136.
West-Eberhard, Mary Jane. 2024. “Animal Behaviour and the New Natural History.” Animal Behaviour. doi: 10.1016/j.anbehav.2023.12.009.
Wu, Zhenxing, Jianbo Jiang, Fritz W. Lischka, and Kai Zhao. 2024. “Is the Mouse Nose a Miniature Version of a Rat Nose? A Computational Comparative Study.” Computer Methods and Programs in Biomedicine 254. doi: 10.1016/j.cmpb.2024.108282.
Zahra, Ismat, Mai Neo, and Soon Hin Hew. 2025. “Level-Up Learning with CIGLE Framework: Enhancing Learning Through Interactive, Game-Based Collaboration for Effective Problem Solving.” International Journal of Technology 16(1): 187–206. doi:10.14716/ijtech. v16i1.7143.
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spelling Sánchez Gómez, Juan SebastiánRios Diaz, Adrian SamirCardenas Contreras, Zaida Liliana2025-06-13T17:11:30Z2025-06-13T17:11:30Z2025-06https://hdl.handle.net/20.500.12495/14649instname:Universidad El Bosquereponame:Repositorio Institucional Universidad El Bosquerepourl:https://repositorio.unbosque.edu.coEl mundo actual demanda profesionales formados en ética, bienestar animal y uso responsable de biomodelos, capaces de responder a las necesidades sociales mediante una formación académica sólida desde el pregrado. Este conocimiento debe transferirse posteriormente a la industria, centros de investigación, universidades y demás instituciones relacionadas. El desarrollo de biotecnología requiere personal calificado y entrenado, lo que no solo ofrece soluciones a problemas de salud, sino que también genera empleo y contribuye al crecimiento económico del país. La investigación biomédica utiliza animales para desarrollar actividades que permitan comprender fenómenos fisiológicos a través de diseños experimentales. Los modelos animales se utilizan en diversas áreas, como la simulación de infecciones humanas, tratamientos y procesos inmunológicos. El principal hallazgo de esta revisión fue la implementación de modelos animales en procesos de formación académica, investigación y ciencia, bajo lineamientos obligatorios que ya están regulados para asegurar el bienestar animal y minimizar su sufrimiento. El avance del conocimiento en investigación aplicada y control de enfermedades requiere el uso de modelos animales, empleando prácticas adecuadas que consideren la ética y el cuidado de los animales, con el objetivo de obtener resultados científicamente válidos que contribuyan al tratamiento de enfermedades y a la mejora de las condiciones de vida humana. La metodología PRISMA en esta revisión proporcionó una guía práctica para realizar búsquedas de literatura científica de manera rigurosa y reproducible, asegurando la obtención de evidencia confiable. En la modernidad actual, existen herramientas tecnológicas que permiten facilitar el aprendizaje, sin embargo, esto no aplica para todos los contextos, a modo de ejemplo la realidad virtual facilita la enseñanza de algunos temas como es la geografía, sin embargo, no reemplaza la práctica educativa del que hacer con el manejo de los animales para el caso de la ciencia de la salud como la medicina veterinaria.Especialista en Docencia UniversitariaEspecializaciónThe modern world demands professionals trained in ethics, animal welfare, and the responsible use of biomodels, capable of responding to social needs through a solid academic foundation starting at the undergraduate level. This knowledge must then be transferred to industry, research centers, universities, and other related institutions. The development of biotechnology requires qualified and trained personnel, which not only provides solutions to health problems but also creates employment and contributes to the country’s economic growth. Biomedical research uses animals to carry out activities aimed at understanding physiological phenomena through experimental designs. Animal models are used in various fields, such as the simulation of human infections, treatments, and immunological processes. The main finding of this review was the implementation of animal models in academic training, research, and science processes, under mandatory guidelines that are already regulated to ensure animal welfare and minimize their suffering. The advancement of knowledge in applied research and disease control requires the use of animal models, employing appropriate practices that consider ethics and animal care, with the goal of obtaining scientifically valid results that contribute to disease treatment and the improvement of human living conditions. The PRISMA methodology in this review provided a practical guide for conducting rigorous and reproducible searches of scientific literature, ensuring the acquisition of reliable evidence. In today's modern world, there are technological tools that facilitate learning; however, these are not applicable in all contexts. For example, virtual reality can enhance the teaching of certain subjects, such as geography, but it does not replace the hands-on educational practice involved in working with animals in health sciences, such as veterinary medicine.application/pdfAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Acceso abiertohttps://purl.org/coar/access_right/c_abf2http://purl.org/coar/access_right/c_abf2Investigación experimentalFisiología conductual y cognitivaRoedoresMedicina veterinariaModelos animalesEducación bioéticaEnriquecimiento ambiental y cognitivoMedicina medioambiental y veterinariaBienestar animalExperimentación con animales378.12Experimental researchBehavioral and cognitive physiologyRodentsVeterinary MedicineAnimal modelsBioethical EducationEnvironmental enrichment and cognitiveEnvironmental and veterinary medicineAnimal welfareAnimal experimentationUso de modelos animales (ratas y ratones) en la educación con fines investigaciónUse of animal models (rats and mice) in education for research purposesEspecialización en Docencia UniversitariaUniversidad El BosqueFacultad de EducaciónTesis/Trabajo de grado - Monografía - Especializaciónhttps://purl.org/coar/resource_type/c_7a1fhttp://purl.org/coar/resource_type/c_7a1finfo:eu-repo/semantics/bachelorThesishttps://purl.org/coar/version/c_ab4af688f83e57aaAbdimanapov, Bakhadurkhan, Sanat Kumarbekuly, and Ilgizar Gaisin. 2024. “Technology for Achieving Learning Objectives Through a System-Activity Approach and the Development of Critical Thinking in Geography Studies.” Journal of Ecohumanism 3(8): 3032–46. doi:10.62754/joe. v3i8.5797.Augustsson, H, L Lindberg, A U Hö, and & K Dahlborn. Human-Animal Interactions and Animal Welfare in Conventionally and Pen-Housed Rats.Bahramsoltani, Mahtab, Sonja Bröer, Susann Langforth, Corinna Eule, Alina Prior, Lena Vogt, Ting Ting Li, et al. 2023. “Outcome of Communication Training in Veterinary Studies: Influence on the Perception of the Relevance of Veterinary Competencies and Self-Assessment of Communication Skills.” Animals 13(9). doi:10.3390/ani13091516.Baumans, Vera. Environmental Enrichment for Laboratory Rodents and Rabbits: Requirements of Rodents, Rabbits, and Research. https://academic.oup.com/ilarjournal/article/46/2/162/910262.Bonilla-Aldana, D. Katterine, Jorge Luis Bonilla-Aldana, Juan R. Ulloque-Badaracco, Ali Al-kassab-Córdova, Enrique A. Hernandez-Bustamante, Esteban A. Alarcon-Braga, Vicente A. Benites-Zapata, et al. 2024. “Mpox Infection in Animals: A Systematic Review and Meta-Analysis.” Journal of Infection and Public Health 17(7). doi: 10.1016/j.jiph.2024.04.015.Buckmaster, Cindy. 2012. “Shifting the Culture of Lab Animal Care.” Lab animal 41(7): 205. doi:10.1038/laban0712-205.Cai, Yiming, Ruofan Zhao, Yuxuan Huang, Huiping Yang, Ye Liu, Rui Yang, Xiangyu Zhang, et al. 2024. “Environmental Enrichment Attenuates Maternal Separation-Induced Excessive Hoarding Behavior in Adult Female Mice.” Pharmacology Biochemistry and Behavior 245. doi: 10.1016/j.pbb.2024.173913.Cait, Jessica, Charlotte B. Winder, and Georgia J. Mason. 2024. “How Much ‘enrichment’ Is Enough for Laboratory Rodents? A Systematic Review and Meta-Analysis Re-Assessing the Impact of Well-Resourced Cages on Morbidity and Mortality.” Applied Animal Behaviour Science 278. doi: 10.1016/j.applanim.2024.106361.Chaplinski, Nick. 2016. “Animal Biosafety.” In Ensuring National Biosecurity: Institutional Biosafety Committees, Elsevier Inc., 137–50. doi:10.1016/B978-0-12-801885-9.00008-1.Díez-Solinska, Alina, Zurine De Miguel, Garikoitz Azkona, and Oscar Vegas. 2024. “Behavioral Coping with Chronic Defeat Stress in Mice: A Systematic Review of Current Protocols.” Neurobiology of Stress 33. doi: 10.1016/j.ynstr.2024.100689.Eltayeb, Galal Eldin Abbas. 2025. “Harnessing Artificial Intelligence Tools to Enhance Smart Learning.” International Journal of Learning, Teaching and Educational Research 24(2): 503–24. doi:10.26803/ijlter.24.2.25.Fiege, Jessica K., Katharine E. Block, Mark J. Pierson, Hezkiel Nanda, Frances K. Shepherd, Clayton K. Mickelson, J. Michael Stolley, et al. 2021. “Mice with Diverse Microbial Exposure Histories as a Model for Preclinical Vaccine Testing.” Cell Host and Microbe 29(12): 1815-1827.e6. doi: 10.1016/j.chom.2021.10.001.Gargiulo, Sara, Sandra Albanese, Rosario Megna, Matteo Gramanzini, Gerardo Marsella, and Lidovina Vecchiarelli. 2025a. “Veterinary Medical Care in Rodent Models of Stroke: Pitfalls and Refinements to Balance Quality of Science and Animal Welfare.” Neuroscience. doi: 10.1016/j.neuroscience.2025.01.044.Gargiulo, Sara, Sandra Albanese, Rosario Megna, Matteo Gramanzini, Gerardo Marsella, and Lidovina Vecchiarelli. 2025b. “Veterinary Medical Care in Rodent Models of Stroke: Pitfalls and Refinements to Balance Quality of Science and Animal Welfare.” Neuroscience. doi: 10.1016/j.neuroscience.2025.01.044.Gaskill, B. N., H. Davis, R. P. Gosselin, J. P. Garner, J. S. Radcliffe, L. A. Robbins, and K. R. Pritchett-Corning. 2025. “Behavioral or Nutritional Drive: Which Motivation Affects Rates of Food Grinding in CD1 Mice?” Applied Animal Behaviour Science 284. doi: 10.1016/j.applanim.2025.106533.Gelizon, Mary Joy B. 2024. “Play to Learn: Exploring the Impact of Fun English Classes on the Literacy Skills of Elementary Learners.” Environment and Social Psychology 9(10). doi:10.59429/esp. v9i10.3164.Haque, Rosa, Aysenur Deniz Song, Jongsun Lee, Seung Jae V. Lee, and Jae Myoung Suh. 2025. “Essential Resources and Best Practices for Laboratory Mouse Research.” Molecules and Cells 48(2). doi: 10.1016/j.mocell.2025.100178.Hawkins, Penny, and Huw D.R. Golledge. 2018. “The 9-to-5 Rodent − Time for Change? Scientific and Animal Welfare Implications of Circadian and Light Effects on Laboratory Mice and Rats.” Journal of Neuroscience Methods 300: 20–25. doi: 10.1016/j.jneumeth.2017.05.014.Iancu, Mariana. 2014. “Bioethical Education in Teaching Biology.” Procedia - Social and Behavioral Sciences 127: 73–77. doi: 10.1016/j.sbspro.2014.03.215.Iliff, Susan A. An Additional “R”: Remembering the Animals. https://academic.oup.com/ilarjournal/article/43/1/38/846351.Kerimbayev, Nurassyl, Zhanat Umirzakova, Rustam Shadiev, and Vladimir Jotsov. 2023. “A Student-Centered Approach Using Modern Technologies in Distance Learning: A Systematic Review of the Literature.” Smart Learning Environments 10(1). doi:10.1186/s40561-023-00280-8.Klein, H J, and K a Bayne. Establishing a Culture of Care, Conscience, and Responsibility: Addressing the Improvement of Scientific Discovery and Animal Welfare Through Science-Based Performance Standards. www.phrma.org/publications.Knight, Andrew. 2022. “SCIENTIFIC AND EDUCATIONAL ANIMAL USE.” In Routledge Handbook of Animal Welfare, Taylor and Francis, 161–75. doi:10.4324/9781003182351-16.Komba, Erick V.G., Maulilio J. Kipanyula, Amandus P. Muhairwa, Rudovick R. Kazwala, Jahashi Nzalawahe, Modesta J. Makungu, Tesfaalem T. Sebhatu, et al. 2020. “Evaluation of the Bachelor of Veterinary Medicine (BVM) Curriculum at Sokoine University of Agriculture in Tanzania: Mapping to OIE Veterinary Graduate ‘Day 1 Competencies.’” Journal of Veterinary Medical Education 47: 20–29. doi:10.3138/JVME-2019-0120.Lange, Sigrun, and Jameel M. Inal. 2024. “Animal Models of Human Disease 2.0.” International Journal of Molecular Sciences 25(24): 13743. doi:10.3390/ijms252413743.Li, Xiao Yan, Kang Ning Xue, Jin Sheng Jiang, and Xuan Cheng Lu. 2016. “The Main Biological Hazards in Animal Biosafety Level 2 Facilities and Strategies for Control.” Biomedical and Environmental Sciences 29(4): 300–304. doi:10.3967/bes2016.039.Lidster, Katie, John G. Jefferys, Ingmar Blümcke, Vincenzo Crunelli, Paul Flecknell, Bruno G. Frenguelli, William P. Gray, et al. 2016. “Opportunities for Improving Animal Welfare in Rodent Models of Epilepsy and Seizures.” Journal of Neuroscience Methods 260: 2–25. doi: 10.1016/j.jneumeth.2015.09.007.Losansky, Vera A., Stefan Arnhold, Jörg R. Aschenbach, Thomas Göbel, Kerstin Fey, Christin Kleinsorgen, Christoph Mülling, et al. 2022. “Survey on the Relevance of Subjects in the Current and Future Veterinary Curriculum among Veterinarians and Veterinary Students in Germany.” Berliner und Munchener Tierarztliche Wochenschrift 135. doi:10.2376/1439-0299-2021-13.Love, Chloe J., Carolina Gubert, Thibault Renoir, and Anthony J. Hannan. 2022. “Environmental Enrichment and Exercise Housing Protocols for Mice.” STAR Protocols 3(4). doi: 10.1016/j.xpro.2022.101689.Ma, Cunling, Leyi Yu, Shensi Chen, Xin Wu, Yuanyuan Yang, Haibo Xie, Xiaojiang Chen, et al. 2025. “Investigating the Self-Healing Potential of Polycystic Ovary Syndrome in a Mouse Model: Implications for Offspring Health.” Biochemical and Biophysical Research Communications 747. doi: 10.1016/j.bbrc.2024.151266.Marhaeni, Nafida Hetty, Mónica Arnal-Palacián, and Muhammad Irfan. 2025. “Interactive Math Comics: An Analysis of Indonesian and Spanish Students’ Responses.” Infinity Journal 14(1): 143–62. doi:10.22460/infinity. v14i1.p143-162.Martin-Alguacil, Nieves, Luis Avedillo, Ruben Mota-Blanco, and Miguel Gallego-Agundez. 2024. “Student-Centered Learning: Some Issues and Recommendations for Its Implementation in a Traditional Curriculum Setting in Health Sciences.” Education Sciences 14(11). doi:10.3390/educsci14111179.Medina, Leticia V. “Building a Culture of Animal Welfare: Past, Present and Future.” http://arbs.biblioteca.unesp.br.Miziara, Ivan Dieb, Ana Tereza De Matos Magalhães, Maruska D´aparecida Santos, Érika Ferreira Gomes, and Reinaldo Ayer De Oliveira. 78 Publishing Management System-Brazilian Journal of Otorhinolaryngology) on December Research Ethics in Animal Models Abstract. http://www.bjorl.org/.Nambisan, Padma. 2017. “Laboratory Biosafety and Good Laboratory Practices.” In An Introduction to Ethical, Safety and Intellectual Property Rights Issues in Biotechnology, Elsevier, 253–71. doi:10.1016/b978-0-12-809231-6.00011-9.Page, Matthew J., Joanne E. McKenzie, Patrick M. Bossuyt, Isabelle Boutron, Tammy C. Hoffmann, Cynthia D. Mulrow, Larissa Shamseer, et al. 2021. “The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews.” The BMJ 372. doi:10.1136/bmj. n71.Pozzebon, Mattia. 2024. “Animal Welfare Issues in Space Settlement Expeditions.” Futures 163. doi: 10.1016/j.futures.2024.103443.Qafa, Adriana, Zenel Sina, and Llambi Prendi. 2024. “The Impact of Teachers’ Attitudes on the Effectiveness of Teaching with the Student in the Center.” Journal of Educational and Social Research 14(6): 88–103. doi:10.36941/jesr-2024-0158.Ray, Heather, and Michael Klymkowsky. 2025. “Approaching Ethical Issues in the Developmental Biology Classroom.” Developmental Biology 518: 48–52. doi: 10.1016/j.ydbio.2024.11.008.Reinhard, Addie R., Kristina D. Hains, Bryan J. Hains, and Elizabeth B. Strand. 2021. “Are They Ready? Trials, Tribulations, and Professional Skills Vital for New Veterinary Graduate Success.” Frontiers in Veterinary Science 8. doi:10.3389/fvets.2021.785844.Robinson, N. Bryce, Katherine Krieger, Faiza Khan, William Huffman, Michelle Chang, Ajita Naik, Ruan Yongle, et al. 2019. “The Current State of Animal Models in Research: A Review.” International Journal of Surgery 72: 9–13. doi: 10.1016/j.ijsu.2019.10.015.Rollin, Bernard E. 2003. “Toxicology and New Social Ethics for Animals.” Toxicologic Pathology 31(1_suppl): 128–31. doi:10.1080/01926230390175011.Schipper, Lidewij, Steffen van Heijningen, Giorgio Karapetsas, Jocelien D.A. Olivier, and Gertjan van Dijk. 2025. “Social Housing Conditions, Hierarchical Status and Testing Order Affect Behavioral Test Outcomes of Male C57BL6/J Mice.” Physiology and Behavior 293. doi: 10.1016/j.physbeh.2025.114859.Schneidewind, Stephanie, Raffaela Lesch, Veronika Heizmann, and Ines Windschnurer. 2024. “Exploring Pet Rat Care: A Comprehensive Survey of Husbandry, Health, Behavior, and the Associations between Caretaker Attitudes, Attachment, and Husbandry Practices.” Journal of Veterinary Behavior 75: 1–19. doi: 10.1016/j.jveb.2024.06.009.Shahzad, Muhammad Farrukh, Shuo Xu, Weng Marc Lim, Xingbing Yang, and Qasim Raza Khan. 2024. “Artificial Intelligence and Social Media on Academic Performance and Mental Well-Being: Student Perceptions of Positive Impact in the Age of Smart Learning.” Heliyon 10(8). doi: 10.1016/j.heliyon. 2024.e29523.Souza, Thiago Moreno L., and Carlos Medicis Morel. 2021. “The COVID-19 Pandemics and the Relevance of Biosafety Facilities for Metagenomics Surveillance, Structured Disease Prevention and Control.” Biosafety and Health 3(1): 1–3. doi: 10.1016/j.bsheal.2020.11.007.Stuart, Sarah A., and Emma S.J. Robinson. 2015. “Reducing the Stress of Drug Administration: Implications for the 3Rs.” Scientific Reports 5. doi:10.1038/srep14288.Suksutdhi, Thanasit. 2024. “INNOVATION MODEL OF HUMAN RESOURCES TRAINING AND DEVELOPMENT FOR THE HOTEL INDUSTRY FROM THE ASEAN STANDARD FRAMEWORK: A CASE IN NAKHON RATCHASIMA PROVINCE, THAILAND.” Geojournal of Tourism and Geosites 52(1): 267–75. doi:10.30892/gtg.52126-1203.Taylor, Katy, and Laura Rego Alvarez. 2019. “An Estimate of the Number of Animals Used for Scientific Purposes Worldwide in 2015.” ATLA Alternatives to Laboratory Animals 47(5–6): 196–213. doi:10.1177/0261192919899853.Tigma, Maxmillian Younyi, Sophie Etomes, and Roland Ndille. 2024. “Pedagogic and Programmes Change and the Enhancement of Relevance of State Higher Education System in Cameroon.” Perspectives in Education 42(4): 70–100. doi:10.38140/pie. v42i4.7891.Von der Beck, Birte, Andreas Wissmann, Rene H. Tolba, Philip Dammann, and Gero Hilken. 2024. “What Can Laboratory Animal Facility Managers Do to Improve the Welfare of Laboratory Animals and Laboratory Animal Facility Staff? A German Perspective.” Animals 14(7). doi:10.3390/ani14071136.West-Eberhard, Mary Jane. 2024. “Animal Behaviour and the New Natural History.” Animal Behaviour. doi: 10.1016/j.anbehav.2023.12.009.Wu, Zhenxing, Jianbo Jiang, Fritz W. Lischka, and Kai Zhao. 2024. “Is the Mouse Nose a Miniature Version of a Rat Nose? A Computational Comparative Study.” Computer Methods and Programs in Biomedicine 254. doi: 10.1016/j.cmpb.2024.108282.Zahra, Ismat, Mai Neo, and Soon Hin Hew. 2025. “Level-Up Learning with CIGLE Framework: Enhancing Learning Through Interactive, Game-Based Collaboration for Effective Problem Solving.” International Journal of Technology 16(1): 187–206. doi:10.14716/ijtech. v16i1.7143.spaORIGINALTrabajo de grado.pdfTrabajo de grado.pdfapplication/pdf259531https://repositorio.unbosque.edu.co/bitstreams/01201a4e-218d-4fcf-9c1f-bf706c4801de/download12c1eb0cdf75242eae738a2b1b1ea536MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82000https://repositorio.unbosque.edu.co/bitstreams/0aaf7946-627e-4aa9-a0b2-521e03f30fcb/download17cc15b951e7cc6b3728a574117320f9MD55Carta de autorizacion.pdfapplication/pdf518126https://repositorio.unbosque.edu.co/bitstreams/7895291f-fe0e-4d61-ae6d-a3574e6e2a25/downloadf0b5dc4e61aa9f1684d7da7b4019d3b4MD57Anexo 1 acta de aprobacion.pdfapplication/pdf262794https://repositorio.unbosque.edu.co/bitstreams/952593c7-2c1d-4b39-80b3-1f54ebaad53a/downloadd36085a243c571ccff32bcb60941b3c2MD58CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8899https://repositorio.unbosque.edu.co/bitstreams/75a8b8a5-9564-4b57-a244-c46c276ea34f/download3b6ce8e9e36c89875e8cf39962fe8920MD56TEXTTrabajo de grado.pdf.txtTrabajo de grado.pdf.txtExtracted texttext/plain46106https://repositorio.unbosque.edu.co/bitstreams/3d62fd14-e09a-4d34-8623-78a5c86fb47d/download4a8438da1a7d969eb4384b648c4f77bdMD59THUMBNAILTrabajo de grado.pdf.jpgTrabajo de grado.pdf.jpgGenerated Thumbnailimage/jpeg3775https://repositorio.unbosque.edu.co/bitstreams/0de9046c-cdee-4452-aa62-9d024bf46ae8/downloadd1c0c3bdd8bb64a9b33ff68275286bdaMD51020.500.12495/14649oai:repositorio.unbosque.edu.co:20.500.12495/146492025-06-14 05:00:27.286http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalembargo2027-06-12https://repositorio.unbosque.edu.coRepositorio Institucional Universidad El Bosquebibliotecas@biteca.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