NLRP3 inflammasome: A therapeutic option for kidney disease?

Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others (hypertension, diabetes, gout, atherosclerosis, amyloido...

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Autores:: Buelvas Jiménez, Neudo
Suárez Useche, Raibel Janis
Vielma Guevara, José Ramón

Tipo de recurso:: Article of journal

Fecha de publicación:: 2017

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	NLRP3 inflammasome: A therapeutic option for kidney disease?
title	NLRP3 inflammasome: A therapeutic option for kidney disease?
spellingShingle	NLRP3 inflammasome: A therapeutic option for kidney disease? 36 Problemas y servicios sociales, asociaciones / Social problems and social services 61 Ciencias médicas; Medicina / Medicine and health Inflammation inflammasomes chronic renal diseases hypertension interleukins Inflamación inflamasomas insuficiencia renal crónica interleucinas hipertensión
title_short	NLRP3 inflammasome: A therapeutic option for kidney disease?
title_full	NLRP3 inflammasome: A therapeutic option for kidney disease?
title_fullStr	NLRP3 inflammasome: A therapeutic option for kidney disease?
title_full_unstemmed	NLRP3 inflammasome: A therapeutic option for kidney disease?
title_sort	NLRP3 inflammasome: A therapeutic option for kidney disease?
dc.creator.fl_str_mv	Buelvas Jiménez, Neudo Suárez Useche, Raibel Janis Vielma Guevara, José Ramón
dc.contributor.author.spa.fl_str_mv	Buelvas Jiménez, Neudo Suárez Useche, Raibel Janis Vielma Guevara, José Ramón
dc.subject.ddc.spa.fl_str_mv	36 Problemas y servicios sociales, asociaciones / Social problems and social services 61 Ciencias médicas; Medicina / Medicine and health
topic	36 Problemas y servicios sociales, asociaciones / Social problems and social services 61 Ciencias médicas; Medicina / Medicine and health Inflammation inflammasomes chronic renal diseases hypertension interleukins Inflamación inflamasomas insuficiencia renal crónica interleucinas hipertensión
dc.subject.proposal.spa.fl_str_mv	Inflammation inflammasomes chronic renal diseases hypertension interleukins Inflamación inflamasomas insuficiencia renal crónica interleucinas hipertensión
description	Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others (hypertension, diabetes, gout, atherosclerosis, amyloidosis, Alzheimer's disease); the systematic review was made searching in the databases PubMed and SciELO for the following terms: "The NLRP3 inflammasome therapeutic for kidney disease", "NLRP3 nflammasome in kidney disease" in PubMed, and "Inflammasome" for Scielo.Results 146 documents were found, althoughonly 34 matched the working hypothesis concerning the NLRP3 inflammasome as a central component of various diseases in humans, with potential therapeutic use. The NLRP3 inflammasome is responsible for the maturation of inflammatory pro-interleukin IL-1 β and IL-18, which can be triggered by aggregated or crystalline materials (particles), and by various microorganisms and toxins derived from these; however, the way how activation mechanisms work is not completely clear.Conclusions Research on new therapies that focus on removing or inhibiting inflammasome components, both individually and together, is proposed.
publishDate	2017
dc.date.issued.spa.fl_str_mv	2017-01-01
dc.date.accessioned.spa.fl_str_mv	2019-07-03T00:32:54Z
dc.date.available.spa.fl_str_mv	2019-07-03T00:32:54Z
dc.type.spa.fl_str_mv	Artículo de revista
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dc.identifier.issn.spa.fl_str_mv	ISSN: 2539-3596
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/65553
dc.identifier.eprints.spa.fl_str_mv	http://bdigital.unal.edu.co/66576/
identifier_str_mv	ISSN: 2539-3596
url	https://repositorio.unal.edu.co/handle/unal/65553 http://bdigital.unal.edu.co/66576/
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dc.relation.spa.fl_str_mv	https://revistas.unal.edu.co/index.php/revsaludpublica/article/view/54415
dc.relation.ispartof.spa.fl_str_mv	Universidad Nacional de Colombia Revistas electrónicas UN Revista de Salud Pública Revista de Salud Pública
dc.relation.references.spa.fl_str_mv	Buelvas Jiménez, Neudo and Suárez Useche, Raibel Janis and Vielma Guevara, José Ramón (2017) NLRP3 inflammasome: A therapeutic option for kidney disease? Revista de Salud Pública, 19 (1). pp. 118-122. ISSN 2539-3596
dc.rights.spa.fl_str_mv	Derechos reservados - Universidad Nacional de Colombia
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial 4.0 Internacional
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dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.mimetype.spa.fl_str_mv	application/pdf
dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Salud Pública
institution	Universidad Nacional de Colombia
bitstream.url.fl_str_mv	https://repositorio.unal.edu.co/bitstream/unal/65553/1/54415-342575-1-PB.pdf https://repositorio.unal.edu.co/bitstream/unal/65553/2/54415-342575-1-PB.pdf.jpg
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spelling	Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Buelvas Jiménez, Neudo95c8f836-5c6e-4b09-a870-38f64f68ee2c300Suárez Useche, Raibel Janis47e7b0d9-0a73-4f13-b2d9-1dafec0839d9300Vielma Guevara, José Ramónb689b679-be41-4194-9dbc-7e5fdba03db53002019-07-03T00:32:54Z2019-07-03T00:32:54Z2017-01-01ISSN: 2539-3596https://repositorio.unal.edu.co/handle/unal/65553http://bdigital.unal.edu.co/66576/Objective To determine if considering inflammasome NLRP3 as a treatment option for kidney disease is possible.Methods Literature review related to NLRP3 inflammasome structure, biological function and relationship with renal disease and others (hypertension, diabetes, gout, atherosclerosis, amyloidosis, Alzheimer's disease); the systematic review was made searching in the databases PubMed and SciELO for the following terms: "The NLRP3 inflammasome therapeutic for kidney disease", "NLRP3 nflammasome in kidney disease" in PubMed, and "Inflammasome" for Scielo.Results 146 documents were found, althoughonly 34 matched the working hypothesis concerning the NLRP3 inflammasome as a central component of various diseases in humans, with potential therapeutic use. The NLRP3 inflammasome is responsible for the maturation of inflammatory pro-interleukin IL-1 β and IL-18, which can be triggered by aggregated or crystalline materials (particles), and by various microorganisms and toxins derived from these; however, the way how activation mechanisms work is not completely clear.Conclusions Research on new therapies that focus on removing or inhibiting inflammasome components, both individually and together, is proposed.Objetivo Determinar si el inflamasoma NLRP3 puede considerarse como opción de tratamiento para la enfermedad renal.Métodos Con el fin de encontrar bibliografía relacionada con la estructura del inflamasoma NLRP3, su función biológica y su relación con la enfermedad renal y otras (hipertensión, diabetes, gota, aterosclerosis, amiloidosis, enfermedad de Alzheimer), se realizó una revisión sistemática en dos bases de datos (PubMed y SciELO) con los términos: "NLRP3 inflammasome therapeutic for kidney disease" y "NLRP3 inflammasome in kidney disease" en PubMed, e "Iinflammasome" en SciELO.Resultados Se encontró un total de 146 documentos, de los cuales solo 34 concuerdan con la hipótesis de trabajo desarrollada con relación al inflamasoma NLRP3 como componente central de diversas enfermedades en seres humanos y con potencial uso terapéutico. El inflamasoma NLRP3 es responsable de la maduración de la interleucina inflamatoria pro-IL-1 β y IL-18, l cual puede darse por causa de materiales agregados o cristalinos (partículas), y por diversos microorganismos y toxinas derivadas de los mismos; sin embargo, los mecanismos de activación de este proceso siguen sin ser claros en la actualidad.Conclusiones Se propone estudiar nuevas terapias que se centren en la eliminación o inhibición de los componentes inflamasoma, de manera individual y conjunta.application/pdfspaUniversidad Nacional de Colombia - Sede Bogotá - Facultad de Medicina - Instituto de Salud Públicahttps://revistas.unal.edu.co/index.php/revsaludpublica/article/view/54415Universidad Nacional de Colombia Revistas electrónicas UN Revista de Salud PúblicaRevista de Salud PúblicaBuelvas Jiménez, Neudo and Suárez Useche, Raibel Janis and Vielma Guevara, José Ramón (2017) NLRP3 inflammasome: A therapeutic option for kidney disease? Revista de Salud Pública, 19 (1). pp. 118-122. ISSN 2539-359636 Problemas y servicios sociales, asociaciones / Social problems and social services61 Ciencias médicas; Medicina / Medicine and healthInflammationinflammasomeschronic renal diseaseshypertensioninterleukinsInflamacióninflamasomasinsuficiencia renal crónicainterleucinashipertensiónNLRP3 inflammasome: A therapeutic option for kidney disease?Artículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL54415-342575-1-PB.pdfapplication/pdf236463https://repositorio.unal.edu.co/bitstream/unal/65553/1/54415-342575-1-PB.pdffef6e913a1fe1f02cdbd9635a90461adMD51THUMBNAIL54415-342575-1-PB.pdf.jpg54415-342575-1-PB.pdf.jpgGenerated Thumbnailimage/jpeg8069https://repositorio.unal.edu.co/bitstream/unal/65553/2/54415-342575-1-PB.pdf.jpg065996ff1ebb455cf9cbd5794a8deb41MD52unal/65553oai:repositorio.unal.edu.co:unal/655532023-05-19 23:47:53.707Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co

NLRP3 inflammasome: A therapeutic option for kidney disease?

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