Modelling the dynamics of antibody production in birds

This paper presents a dynamical model of avian immune response, for antibody production purposes. Antibodies are fundamental tools for research, diagnosis, and the treatment of several diseases. It has been recognized for some time that antibodies obtained from poultry are an efficient alternative for applications in medicine and biology. Therefore, a dynamical model for this process might be very useful. The model being proposed consists of seven non-linear ordinary differential equations with constant coefficients that represent the main cellular and molecular populations in avian immune response. Values for the parameters were obtained from avian and mammalian literature. In silico-generated responses in terms of antibody concentrations are presented and compared to reported kinetics.

• Autores: Olarte Dussan, Fredy Andres; Clavijo Ramirez, Carlos Arturo; Díaz Morales, Hernando
• Tipo de recurso: Article of journal
• Fecha de publicación: 2011
• Institución: Universidad Nacional de Colombia
• Repositorio: Universidad Nacional de Colombia
• Idioma: spa
• OAI Identifier: oai:repositorio.unal.edu.co:unal/37751
• Acceso en línea: https://repositorio.unal.edu.co/handle/unal/37751; http://bdigital.unal.edu.co/27835/
• Palabra clave: Avian immunology; antibodies; dynamical models.
• Rights: openAccess
• License: Atribución-NoComercial 4.0 Internacional