Association mapping, a method to detect quantitative trait loci: statistical bases
Traditionally, QTL mapping has been used as methodology to understand the genetic control of polygenic traits and has been useful for identifying QTL in different species, however QTL mapping presents limitations, such as the difficulty to build segregating populations in some species, the presence...
- Autores:
-
Gómez, Gustavo Ernesto
Álvarez Vargas, María Fernanda
Mosquera, Teresa
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2011
- Institución:
- Universidad Nacional de Colombia
- Repositorio:
- Universidad Nacional de Colombia
- Idioma:
- spa
- OAI Identifier:
- oai:repositorio.unal.edu.co:unal/39673
- Acceso en línea:
- https://repositorio.unal.edu.co/handle/unal/39673
http://bdigital.unal.edu.co/29770/
- Palabra clave:
- 63 Agricultura y tecnologías relacionadas / Agriculture
association genetics
linkage disequilibrium
population structure
genetic mapping
complex traits.
- Rights
- openAccess
- License
- Atribución-NoComercial 4.0 Internacional
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Association mapping, a method to detect quantitative trait loci: statistical bases |
| title |
Association mapping, a method to detect quantitative trait loci: statistical bases |
| spellingShingle |
Association mapping, a method to detect quantitative trait loci: statistical bases 63 Agricultura y tecnologías relacionadas / Agriculture association genetics linkage disequilibrium population structure genetic mapping complex traits. |
| title_short |
Association mapping, a method to detect quantitative trait loci: statistical bases |
| title_full |
Association mapping, a method to detect quantitative trait loci: statistical bases |
| title_fullStr |
Association mapping, a method to detect quantitative trait loci: statistical bases |
| title_full_unstemmed |
Association mapping, a method to detect quantitative trait loci: statistical bases |
| title_sort |
Association mapping, a method to detect quantitative trait loci: statistical bases |
| dc.creator.fl_str_mv |
Gómez, Gustavo Ernesto Álvarez Vargas, María Fernanda Mosquera, Teresa |
| dc.contributor.author.spa.fl_str_mv |
Gómez, Gustavo Ernesto Álvarez Vargas, María Fernanda Mosquera, Teresa |
| dc.subject.ddc.spa.fl_str_mv |
63 Agricultura y tecnologías relacionadas / Agriculture |
| topic |
63 Agricultura y tecnologías relacionadas / Agriculture association genetics linkage disequilibrium population structure genetic mapping complex traits. |
| dc.subject.proposal.spa.fl_str_mv |
association genetics linkage disequilibrium population structure genetic mapping complex traits. |
| description |
Traditionally, QTL mapping has been used as methodology to understand the genetic control of polygenic traits and has been useful for identifying QTL in different species, however QTL mapping presents limitations, such as the difficulty to build segregating populations in some species, the presence of only one meiotic generation and the reduced genetically diversity derived of just two parental. Recently, association genetics studies are becoming an important methodology to identify quantitative trait loci and to find diagnostic molecular markers associated with complex traits. This methodology overcomes some barriers of QTL mapping and it is an alternative to apply in plant breeding in direct way. However, it is necessary to considerer important aspects in this methodology to avoid false associations between trait-markers. Association genetics employs as parameter linkage disequilibrium to find these associations. Here we present methods to analyze and establish population structure, factors that affect linkage disequilibrium and how to measure it and methods to perform association mapping. |
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2011 |
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2011-09-01 |
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2019-06-28T04:15:29Z |
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2019-06-28T04:15:29Z |
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Artículo de revista |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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publishedVersion |
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ISSN: 2357-3732 |
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https://repositorio.unal.edu.co/handle/unal/39673 |
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http://bdigital.unal.edu.co/29770/ |
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ISSN: 2357-3732 |
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https://repositorio.unal.edu.co/handle/unal/39673 http://bdigital.unal.edu.co/29770/ |
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spa |
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spa |
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http://revistas.unal.edu.co/index.php/agrocol/article/view/28419 |
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Universidad Nacional de Colombia Revistas electrónicas UN Agronomía Colombiana Agronomía Colombiana |
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Gómez, Gustavo Ernesto and Álvarez Vargas, María Fernanda and Mosquera, Teresa (2011) Association mapping, a method to detect quantitative trait loci: statistical bases. Agronomía Colombiana, 29 (3). pp. 367-376. ISSN 2357-3732 |
| dc.rights.spa.fl_str_mv |
Derechos reservados - Universidad Nacional de Colombia |
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http://purl.org/coar/access_right/c_abf2 |
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Atribución-NoComercial 4.0 Internacional |
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http://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial 4.0 Internacional Derechos reservados - Universidad Nacional de Colombia http://creativecommons.org/licenses/by-nc/4.0/ http://purl.org/coar/access_right/c_abf2 |
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Universidad Nacional de Colombia, Facultad de Agronomía, Centro Editorial |
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Atribución-NoComercial 4.0 InternacionalDerechos reservados - Universidad Nacional de Colombiahttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Gómez, Gustavo Ernesto2eaba8f2-a149-4577-81db-1f0e413333a0300Álvarez Vargas, María Fernandabd21753c-eb7d-4dce-a730-5606255dd48a300Mosquera, Teresa2656d1b0-0e22-48d7-b5b4-74185c2d2fa83002019-06-28T04:15:29Z2019-06-28T04:15:29Z2011-09-01ISSN: 2357-3732https://repositorio.unal.edu.co/handle/unal/39673http://bdigital.unal.edu.co/29770/Traditionally, QTL mapping has been used as methodology to understand the genetic control of polygenic traits and has been useful for identifying QTL in different species, however QTL mapping presents limitations, such as the difficulty to build segregating populations in some species, the presence of only one meiotic generation and the reduced genetically diversity derived of just two parental. Recently, association genetics studies are becoming an important methodology to identify quantitative trait loci and to find diagnostic molecular markers associated with complex traits. This methodology overcomes some barriers of QTL mapping and it is an alternative to apply in plant breeding in direct way. However, it is necessary to considerer important aspects in this methodology to avoid false associations between trait-markers. Association genetics employs as parameter linkage disequilibrium to find these associations. Here we present methods to analyze and establish population structure, factors that affect linkage disequilibrium and how to measure it and methods to perform association mapping.Tradicionalmente, el Mapeo de QTL ha sido usado como metodología para aproximarse a la comprensión del control genético de rasgos poli génicos y ha sido útil en la identificación de QTL en diferentes especies, sin embargo presenta limitaciones como la dificultad de construir poblaciones segregantes en algunas especies, contar son solamente una generación meiótica. y visualizar únicamente la diversidad genética derivada de dos parentales. Recientemente, los estudios de Asociación Genética se han posicionado como una metodología importante para la identificación y localización de loci de rasgos cuantitativos y para encontrar marcadores moleculares diagnóstico asociados con rasgos complejos. Esta metodología resuelve algunas barreras del Mapeo de QTL y es una alternativa para aplicar en mejoramiento de plantas de manera directa. Sin embargo es necesario considerar aspectos importantes para evitar falsas asociaciones entre rasgo y marcador. En este artículo presentamos métodos para analizar y establecer la estructura poblacional, factores que afectan el desequilibrio en el ligamiento y cómo medirlo y métodos para realizar el mapeo por asociaciónapplication/pdfspaUniversidad Nacional de Colombia, Facultad de Agronomía, Centro Editorialhttp://revistas.unal.edu.co/index.php/agrocol/article/view/28419Universidad Nacional de Colombia Revistas electrónicas UN Agronomía ColombianaAgronomía ColombianaGómez, Gustavo Ernesto and Álvarez Vargas, María Fernanda and Mosquera, Teresa (2011) Association mapping, a method to detect quantitative trait loci: statistical bases. Agronomía Colombiana, 29 (3). pp. 367-376. ISSN 2357-373263 Agricultura y tecnologías relacionadas / Agricultureassociation geneticslinkage disequilibriumpopulation structuregenetic mappingcomplex traits.Association mapping, a method to detect quantitative trait loci: statistical basesArtículo de revistainfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Texthttp://purl.org/redcol/resource_type/ARTORIGINAL28419-115256-2-PB.pdfapplication/pdf2299256https://repositorio.unal.edu.co/bitstream/unal/39673/1/28419-115256-2-PB.pdf5da6a2d337faa46ed398f4f6444d7f9aMD51THUMBNAIL28419-115256-2-PB.pdf.jpg28419-115256-2-PB.pdf.jpgGenerated Thumbnailimage/jpeg8819https://repositorio.unal.edu.co/bitstream/unal/39673/2/28419-115256-2-PB.pdf.jpg9c8b0daa751f0d5539b531f6b982d957MD52unal/39673oai:repositorio.unal.edu.co:unal/396732024-01-21 23:06:02.823Repositorio Institucional Universidad Nacional de Colombiarepositorio_nal@unal.edu.co |