Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico

tablas

Autores:: Rodriguez Cortes, Alba del Pilar

Tipo de recurso:

Fecha de publicación:: 2020

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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dc.title.spa.fl_str_mv	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico
dc.title.translated.eng.fl_str_mv	Oxygen Therapy with High Flow Nasal Cannula for Patients with Acute Respiratory Insufficiency due to COVID – 19 at the National University Hospital (HUN)
title	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico
spellingShingle	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico 610 - Medicina y salud Cánula Hipoxia Intubación Mascara nasal Insuficiencia respiratoria Nasal mask Covid 19 Cannula Hypoxia Intubation Respiratory insufficiency
title_short	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico
title_full	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico
title_fullStr	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico
title_full_unstemmed	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico
title_sort	Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico
dc.creator.fl_str_mv	Rodriguez Cortes, Alba del Pilar
dc.contributor.advisor.none.fl_str_mv	Cortes Luna, Jorge Alberto
dc.contributor.author.none.fl_str_mv	Rodriguez Cortes, Alba del Pilar
dc.subject.ddc.spa.fl_str_mv	610 - Medicina y salud
topic	610 - Medicina y salud Cánula Hipoxia Intubación Mascara nasal Insuficiencia respiratoria Nasal mask Covid 19 Cannula Hypoxia Intubation Respiratory insufficiency
dc.subject.proposal.spa.fl_str_mv	Cánula Hipoxia Intubación Mascara nasal Insuficiencia respiratoria Nasal mask Covid 19
dc.subject.proposal.eng.fl_str_mv	Cannula Hypoxia Intubation Respiratory insufficiency
description	tablas
publishDate	2020
dc.date.issued.none.fl_str_mv	2020-11
dc.date.accessioned.none.fl_str_mv	2021-08-27T22:26:11Z
dc.date.available.none.fl_str_mv	2021-08-27T22:26:11Z
dc.type.spa.fl_str_mv	Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/updatedVersion
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dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TM
status_str	updatedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80047
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80047 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
dc.relation.references.spa.fl_str_mv	1. Price AM, Plowright C, Makowski A, Misztal B. Using a high-flow respiratory system (Vapotherm) within a high dependency setting. Nurs Crit Care 2008;13(6): 298-304.doi: 10.1111/j.1478-5153.2008.00299.x. 2. Tiruvoipati R, Lewis D, Haji K, Botha J. High flow nasal oxygen vs high flow face mask: a random crossover trial in extubated patients. J Crit Care 2010;25(3):463-68.doi: 10.1016/j.jcrc.2009.06.050. 3. Roca O, Riera J, Torres F, Masclans JR. High flow oxygen therapy in acute respiratory failure. Respir Care 2010;55(4):408-13. https://doi.org/10.52379/mcs.v3i2.87 4. Parke RL, McGuinness SP, Eccleston M. A preliminary randomized controlled trial to assess effectiveness of nasal high flow oxygen in intenive care patients. Respir Care 2011;56(3):265- 70. doi: 10.4187 / respcare.00801. Epub 2011 21 de enero. 5. Sztrymf B, Messika J, Bertrand F, Hurel D, Leon R, Dreyfuss D, Ricard JD. Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Int Care Med 2011;37(11):1780-6. doi: 10.1007 / s00134-011-2354-6. Epub 2011 27 de septiembre. 6. Rello J, Perez M, Roca O, Poulako G, Souto J, Laborda C, Balcells J, Serra J, Masclans JR. High flow nasal therapy in adults with severe acute respiratory infection. A cohort study in patients with 2009 influenza A/H1N1v. J Crit Care 2012;27: 434-9.doi: 10.1016 / j.jcrc.2012.04.006. Epub 2012 2 de julio. 7. Lenglet H, Sztrymf B, Leroy C, Brun P, Dreyfus D, Ricard JD. Humidified high flow nasal oxygen during respiratory failure in the emergency department: a feasibility and efficacy study. Respir Care 2012;57(11):1873-8. doi: 10.4187 / respcare.01575. Publicación electrónica 13 de marzo de 2012. 8. Lucangelo U, Vassallo FG, Marras E, Ferluga M, Beziza E, Comuzzi L, Berlot G, Zin WA. High flow nasal interface improves oxygenation in patients undergoing bronchoscopy. Crit Care Res pract 2012;2012:506382.). doi: 10.1155 / 2012/506382. Epub 2012 20 de mayo. 9. Meduri, G.U., Rochwerg, B., Annane, D. et al. Reference. Crit Care. 2018 May 24;22(1):135. doi: 10.1186/s13054-018-2007-z 10. Chatila W, Nugent T, Vance G, Gaughan J, Criner GJ. The effects of high flow vs low-flow oxygen in advanced obstructive airways disease. Chest 2004;126(4):1108-15. doi: 10.1378 / cofre.126.4.1108. 11. Sebastián Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt, Bart N Lambrecht. Respir Res. 2020 Jul 28;21(1):198. doi:10.1186/s12931-020-01462-5. 12. High-flow nasal cannula oxygen therapy to treat patients with hypoxemic acute respiratory failure consequent to SARS-CoV-2 infection. Andrea Vianello , Giovanna Arcaro, Beatrice Molena, Cristian Turato, Andi Sukthi,2 Gabriella Guarnieri, Francesca Lugato, Gianenrico Senna, Paolo Navalesi Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy. Doi:10.1136/thoraxjnl-2020-214993. 13. Prediction of outcome of nasal high fow use during COVID-19-related acute hypoxemic respiratory failure. Noémie Zucman, Jimmy Mullaert, Damien Roux, Oriol Roca, Jean‑Damien Ricard,©️ 2020 Springer-Verlag GmbH Germany, part of Springer Nature. Intensive Care Med. Doi.org/10.1007/s00134-020-06177-1. 14. Use of Prone Positioning in Nonintubated Patients With COVID-19 and Hypoxemic Acute Respiratory Failure. Xavier Elharrar, Youssef Trigui, Anne-Marie Dols, François Touchon, Stéphanie Martinez, Eloi Prud’homme, and Laurent Papazian. JAMA 2020 Jun 9; 323(22): 2336–2338. Doi: 10.1001/jama.2020.8255. 15. ROX Index Predicts Intubation in Patients with COVID-19 Pneumonia and Moderate to Severe Hypoxemic Respiratory Failure Receiving High Flow Nasal Therapy. Maulin Patel, Junad Chowdhury, Nicole Mills, Robert Marron, Andrew Gangemi, Zachariah Dorey-Stein, Ibraheem Yousef, Matthew Zheng, Lauren Tragesser, Julie Giurintano, Rohit Gupta, Parth Rali, Gilbert D’Alonzo, Huaqing Zhao, P hd2 , Nicole Patlakh BSc2 , Nathaniel Marchetti MD1 , Gerard J. Criner MD1 and Matthew Gordon for the Temple University COVID-19. Department of Thoracic Medicine and Surgery, Temple University Hospital. Doi:. org/10.1101/2020.06.30.20143867. 16. High Flow Nasal Canula in Critically Ill Severe COVID-19 Patients. Alexandre Demoule, Antoine Vieillard Baron, Michael Darmon, Alexandra Beurton, Guillaume Géri, Guillaume Voiriot, Thibault Dupont, Lara Zafrani, Lola Girodias, Vincent Labbé, Martin Dres, Muriel Fartoukh,Elie Azoulay.This article is open access and distributed under the terms of the Creative Commons Attribution. 17. Papazian L ACBLea. Formal guidelines: management of acute respiratory distress symdrome. Ann Intensive Care. 2919 Octubre. https://doi.org/10.1186/s13613-019-0540-9. 18. Norbert Schwabbauer, Björn Berg, Gunnar Blumenstock, Michael Haap, Jürgen Hetzel, Reimer Riessen. Nasal high–flow oxygen therapy in patients with hypoxic respiratory failure: effect on functional and subjective respiratory parameters compared to conventional oxygen therapy and non-invasive ventilation (NIV). BMC Anesthesiology. 2014 Agosto. doi: 10.1186 / 1471-2253-14-66. eCollection 2014. 19. Cheng-Chieh Huang HMLCJLTHLWLCWYL. Use High-Flow Nasal Cannula for Acute Respiratory Failure Patients in the Emergency Department: A Meta-Analysis Study. Hindawi. 2019 Agosto; 14(2019). https://doi.org/10.1155/2019/2130935. 20. Ding L MW. Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study. Crit Care. 2020 January. doi: 10.1186 / s13054-020-2738-5. 21. Papazian L ACBLea. Formal guidelines: management of acute respiratory distress symdrome. Ann Intensive Care. 2919 Octubre. https://doi.org/10.1186/s13613-019-0540-9. 22. Riera J. Effect of high-flow nasal cannula and body position on end-respiratory lung volume: a cohort study using electrical impedance tomography. Respir Care. 2013. doi: 10.4187 / respcare.02086. 23. Cochi. Mortality trends of acute respiratory distress syndrome in the United States from 1999 to 2013. Ann Am Thorac. 2016 Oct; 1742-51(13). doi: 10.1513 / AnnalsATS.201512-841OC. 24. Massimo A. Prone positioning during high flow oxygen therapy in acute hypoxemic respiratory failure. Clinical Trialsgov. 2020 Febrero. NCT 03095300. 25. Piehl MA BR. Use of extreme position changes in acute respiratory failure. Crit Care Med. 1976; 13(4). doi: 10.1097 / 00003246-197601000-00003. 26. Munshi L Dea. Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis. Ann Am Thorac Soc. 2017; S280-s8(14). https://doi.org/10.1513/AnnalsATS.201704-343OT PubMed: 29068269. 27. Eddy Fan , Lorenzo del Sorbo , Ewan C Goligher , Carol L. Hodgsonicial American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017; 1253-63(195). doi: 10.1164 / rccm.201703-0548ST. 28. Gattinoni L. What has computed tomography taught us about the acute respiratory distress syndrome? Am J Respir Crit Care Med. 2001; 1701-11(164(9)).doi: 10.1164 / ajrccm.164.9.2103121. 29 .Krayer S RKVJDERE. Position and motion of the human diaphragm during anesthesia-paralysis. Anesthesiology. 1989; 891-8(70(6)). doi: 10.1097 / 00000542-198906000-00002. 30. RK. Albert 1, RD. Hubmayr. The prone position eliminates compression of the lungs by the heart. Am J Respir Crit Care Med. 2000; 1660-5(161(5)). doi: 10.1164 / ajrccm.161.5.9901037. 31. K Rehder , TJ Knopp , AD Sessler. Regional intrapulmonary gas distribution in awake and anesthetized-paralyzed prone man. J Appl Physiol Respir Environ Exerc Physiol. 1978; 45(4)(528-35). doi: 10.1152 / jappl.1978.45.4.528. 32.Lamm WJ SINBPNGRHM. Hypoxic pulmonary vasoconstriction is heterogeneously distributed in the prone dog. Respir Physiol Neurobiol. 2004; 144(2-3)(281-94). 33.Yasutaka Koga, Kotaro Kaneda, Nao Fujii , Ryo Tanaka , Takashi Miyauchi , Motoki Fujita , Kouko Hidaka , Yasutaka Oda , Ryosuke Tsuruta. Comparison of high-flow nasal cannula oxygen therapy and non-invasive ventilation as first-line therapy in respiratory failure: a multicenter retrospective study Scaravilli V. Prone positioning improves oxygenation in spontaneously breathing nonintubated patients with hypoxemic acute respiratory failure: A retrospective study. J Crit Care. 2015; 30(6)(1390-4). doi: 10.1002 / ams2.461. eCollection enero-diciembre de 2020. 34. Scaravilli V GGCLZAISLAea. Prone positioning improves oxygenation in spontaneously breathing nonintubated patients with hypoxemic acute respiratory failure: A retrospective study. J Crit Care. 2015; 30(6)(1390-4). 35. Orlando R Pérez-Nieto , Manuel A Guerrero-Gutiérrez , Ernesto Deloya-Tomas , Silvio A Ñamendys-Silva. Prone positioning combined with high-flow nasal cannula in severe noninfectious ARDS. Crit Care. 2020; 24(1)(114). doi: 10.1186 / s13054-020-2821-y. 36. Matt Arentz, Eric Yim, Lindy Klaff, et al. Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State. JAMA. 2020. doi: 10.1001 / jama.2020.4326. 37. Chun Pan, Lu Chen, Cong Lu, Wei Zhang, Jia-An Xia, Michael C Sklar , Bin Du , Laurent Brochard, Haibo Qiu. Lung Recruitability in SARS-CoV-2 Associated Acute Respiratory Distress Syndrome: A Single-center, Observational Study. Am J Respir Crit Care Med. 2020. doi: 10.1164 / rccm.202003-0527LE. 38. Sun, Q., Qiu, H., Huang, M. et al. Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province. Ann Intensive Care. 2020; 10(1)(33). https://doi.org/10.1186/s13613-020-00650-2. 39. Domenico Luca Grieco, Luca S Menga, Valeria Raggi, Filippo Bongiovanni, Gian Marco Anzellotti, Eloisa S Tanzarella, Maria Grazia Bocci, Giovanna Mercurio, Antonio M Dell'Anna, Davide Eleuteri, Giuseppe Bello, Riccardo Maviglia, Giorgio Conti, Salvatore Maurizio Maggiore, Massimo Antonelli. 2019 Noviembre. doi: 10.1164 / rccm.201904-0841OC. 40. Protocolo para manejo médico de pacientes hospitalizados con diagnóstico de caso sospechoso/confirmado de neumonía por virus SARS-COV-2.(hun/unal). https://www.iets.org.co/Archivos/853-2765-1-PB.pdf. 41. R. Artacho Ruiz A, B. R. Artacho Raizaba, B. Artacho Jurado C., F. Caballero Güetoa,b, A. Cano Yusted, I. Durbán García, F. García Delgado, J.A. Guzmán Pérez, M. López Obispo, I. Quero del Ríof, F. Rivera Espinara, E. del Campo Molina. Servicio de Cuidados Críticos y Urgencias, Hospital de Montilla, Montilla, Córdoba, España, doi: 10.1016/j.medin.2019.07.012 Open Accessspana. 42. Lili Guan, Luqian Zhou, Jinnong Zhang, Wei Peng, Rongchang Chen. More awareness is needed for severe acute respiratory syndrome coronavirus 2019 transmission through exhaled air during non-invasive respiratory support: experience from China. Cross Mark. 2020 Feb. doi: 10.1183 / 13993003.00352-2020. Imprimir 2020 Mar. 43. Thalía Monro-Somerville 1, Malcolm Sim , James Ruddy , Mark Vilas , Michael A Gillies. The Effect of High-Flow Nasal Cannula Oxygen Therapy on Mortality and Intubation Rate in Acute Respiratory Failure: A Systematic Review and Meta-Analysis. Crit Care Med. 2017; 45(449). doi: 10.1097 / CCM.0000000000002091. 44. Tommaso Mauri, Cecilia Turrini, Nilde Eronia, Giacomo Grasselli, Carlo Alberto Volta, Giacomo Bellani, Antonio Pesenti. Physiologic Effects of High-Flow Nasal Cannula in Acute Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2017; 195(1207). doi: 10.1164 / rccm.201605-0916OC. 45. Xiaofeng Ou, Yusi Hua, Jin Liu, Cansheng Gong, Wenling Zhao. Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure: a meta-analysis of randomized controlled trials. CMAJ. 2017; 189(E260). doi: 10.1503 / cmaj.160570. 46. Jean-Pierre Frat, Arnaud W. Thille, Alain Mercat, Christophe Girault, Stéphanie Ragot, Sébastien Perbet, Gwénael, Prat Thierry Boulain, Elise Morawiec, Alice Cottereau, Jérôme Devaquet, Saad Nseir. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 May; 372(2185}). doi: 10.1056 / NEJMoa1503326. 47. Amanda Corley, Claire M Rickard, Leanne M Aitken, Amy Johnston, Adrian Barnett, John F Fraser, Sharon R. Lewis, Andrew F Smith. High-flow nasal cannulae for respiratory support in adult intensive. Cochrane Database Syst Rev. 2017; 5.doi: 10.1002 / 14651858.CD010172.pub2. 48. Chun Pan, Lu Chen, Cong Lu, Wei Zhang, Jia-An Xia, Michael C Sklar , Bin Du , Laurent Brochard, Haibo Qiu. Lung Recruitability in SARS-CoV-2 Associated Acute Respiratory Distress Syndrome: A Single-center, Observational Study. Am J Respir Crit Care Med. 2020. doi: 10.1164 / rccm.202003-0527LE. 49. Ke Wang, Wei Zhao, Ji Li, Weiwei Shu, Jun Duan . Ann. Intensive Care (2020) 10:37. The experience of high-fow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China. Ke Wang1†, Wei Zhao2†, Ji Li3. https://doi.org/10.1186/s13613-020-00653-z. 50. Yasutaka Koga, Kotaro Kaneda, Nao Fujii, Ryo Tanaka, Takashi Miyauchi, Motoki Fujita, Kouko Hidaka, Yasutaka Oda, Ryosuke Tsuruta. Comparison of high-flow nasal cannula oxygen therapy and non-invasive ventilation as first-line therapy in respiratory failure: a multicenter retrospective study. doi: 10.1002 / ams2.461. eCollection enero-diciembre de 2020. 51. R. Artacho Ruiz. R. Artacho Ruiz A, B. Artacho Jurado C, F. Caballero Güetoa,b, A. Cano Yuste D,I. Durbán García, F. García Delgado A, J.A. Guzmán Pérez a, M. López Obispo A,I. Quero del Río F. Predictores de éxito del tratamiento con cánula nasal de alto flujo en el fallo respiratorio agudo hipoxémico. ELSEIVER. 2019 Julio. doi: 10.1016/j.medin.2019.07.012. 52.Fowler RA, Guest CB, Lapinsky SE, Sibbald WJ, Louie M, Tang P, Simor AE, Stewart TE, (2004) Transmission of severe acute respiratory syndrome during intubation and mechanical ventilation. Am J Respir Crit Care Med 169: 1198–1202. doi: 10.1164 / rccm.200305-715OC. Publicación electrónica 27 de febrero de 2004. 53.Leung CCH, Joynt GM, Gomersall CD, Wong WT, Lee A, Ling L, Chan PKS, Lui PCW, Tsoi PCY, Ling CM, Hui M, (2019) Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial. J Hosp Infect 101: 84–87.doi: 10.1016 / j.jhin.2018.10.007. Epub 2018 15 de octubre. 54.Tran K, Cimon K, Severn M, Pessoa-Silva CL, Conly J, (2012) Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PLoS One 7: e35797. https://doi.org/10.1371/journal.pone.003579. 55. Rebecca F. D'Cruz, Nicholas Hart, Georgios Kaltsakas High-flow therapy: physiological effects and clinical applications. Breathe 2020; 16: 200224. doi: 10.1183/20734735.0224-2020. 56. Cheng-Chieh Huang HMLCJLTHLWLCWYL. Use High-Flow Nasal Cannula for Acute Respiratory Failure Patients in the Emergency Department: A Meta-Analysis Study. Hindawi. 2019 Agosto; 14(2019). https://doi.org/10.1155/2019/2130935. 57. Tran K, Cimon K, Severn M, Pessoa-Silva CL, Conly J, (2012) Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review. PLoS One 7: e35797. https://doi.org/10.1371/journal.pone.003579. 58. Raboud J, Shigayeva A, McGeer A, Bontovics E, Chapman M, Gravel D, Henry B, Lapinsky S, Loeb M, McDonald LC, Ofner M, Paton S, Reynolds D, Scales D, Shen S, Simor A, Stewart T, Vearncombe M, Zoutman D, Green K, (2010) Risk factors for SARS transmission from patients requiring intubation: a multicentre investigation in Toronto, Canada. PLoS One 5: e10717. doi: 10.1371 / journal. pone.0010717.
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dc.rights.license.spa.fl_str_mv	Atribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.uri.spa.fl_str_mv	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv	info:eu-repo/semantics/openAccess
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dc.format.extent.spa.fl_str_mv	73 página
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Medicina - Especialidad en Medicina Interna
dc.publisher.department.spa.fl_str_mv	Departamento de Medicina Interna
dc.publisher.faculty.spa.fl_str_mv	Facultad de Medicina
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
institution	Universidad Nacional de Colombia
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spelling	Atribución-NoComercial-SinDerivadas 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Cortes Luna, Jorge Alberto610921aec64f15b2f1a63be37e6f3c88600Rodriguez Cortes, Alba del Pilar7995c92dd273359d80f682683c11a3f46002021-08-27T22:26:11Z2021-08-27T22:26:11Z2020-11https://repositorio.unal.edu.co/handle/unal/80047Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/tablasIntroducción La infección por SARS CoV-2 se asocia con una mayor mortalidad en pacientes con neumonía grave y los que progresan a falla ventilatoria. Existe controversia sobre el beneficio de diferentes formas de manejo ventilatorio, en este tipo de pacientes. Objetivo Determinar el efecto del uso de la cánula nasal de alto flujo (CNAF) en pacientes adultos con infección por SARS-CoV 2 que desarrollaron falla respiratoria hipoxémica sobre la estancia hospitalaria y la mortalidad. Metodología: Estudio de cohorte retrospectiva entre marzo 2020 y febrero 2021, en el que se identificaron pacientes adultos con neumonía grave confirmada por SARS CoV-2, con falla ventilatoria definida por PaO2 < a 60 mmHg. Se evaluó el efecto de la CNAF y se comparó con pacientes en ventilación mecánica convencional, apareados con una relación 1:3 en relación a la fecha del ingreso al hospital. Se utilizó un puntaje de propensión basado en covariables y posibles confusores sobre la estancia y la mortalidad, con pesos estabilizados por la probabilidad inversa del tratamiento. Se evaluó el efecto del uso de CNAF sobre la estancia hospitalaria y la mortalidad a 30 días, con un modelo Poisson. Se evaluaron otros desenlaces con modelos de regresión logística. Resultados: Se identificaron 40 pacientes con CNAF que se aparearon con 120 pacientes con IOT. La mayoría, 107(66.9%), fueron hombres, con una edad promedio de 63 años. En total 81 (50.6%) pacientes fallecieron a los 30 días. Después de ajustar por los confusores se encontró una asociación entre la CNAF y un menor tiempo a egreso (razón de tasa de incidencia ajustada -IRRa-: 0.71, IC95%: 0.55-0.91), aunque no se identificó una asociación con la mortalidad (IRRa 1.13, IC 95%: 0.93 - 1.37). Se observó una disminución en la frecuencia de IOT (45.1% de los pacientes después del ajuste). Se observaron menores frecuencias de neumonía asociada a la ventilación mecánica (OR: 0.32 , IC95%: 0.06 - 1.55), infección del torrente sanguíneo (OR: 0.36, IC95% 0.10-1.26), y falla renal aguda (OR: 0.36, IC95%: 0.14-0.91). Conclusión: El abordaje con CNAF en pacientes con falla ventilatoria por SARS CoV-2 podría asociarse con una menor estancia hospitalaria, menor frecuencia de ventilación mecánica invasiva y menor falla renal aguda. En este estudio no se identificó una asociación entre el uso de CNAF y la mortalidad.Especialidades MédicasMedico Internista73 páginaapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Medicina InternaDepartamento de Medicina InternaFacultad de MedicinaBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y saludCánulaHipoxiaIntubaciónMascara nasalInsuficiencia respiratoriaNasal maskCovid 19CannulaHypoxiaIntubationRespiratory insufficiencyTerapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémicoOxygen Therapy with High Flow Nasal Cannula for Patients with Acute Respiratory Insufficiency due to COVID – 19 at the National University Hospital (HUN)Trabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/updatedVersionhttp://purl.org/coar/version/c_dc82b40f9837b551Texthttp://purl.org/redcol/resource_type/TM1. 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PLoS One 5: e10717. doi: 10.1371 / journal. pone.0010717.LICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/80047/1/license.txtcccfe52f796b7c63423298c2d3365fc6MD51ORIGINAL1032391959.2021.pdf1032391959.2021.pdfTESIS CANULA NASAL ALTO FLUJO EN COVID. 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Terapia de oxigenación con cánula de alto flujo en pacientes con insuficiencia respiratoria aguda por COVID-19 atendidos en el Hospital Universitario Nacional de Colombia durante el periodo pandémico

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