Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá

ilustraciones

Autores:
Lasso Benavides, Jairo Fernando
Tipo de recurso:
Fecha de publicación:
2023
Institución:
Universidad Nacional de Colombia
Repositorio:
Universidad Nacional de Colombia
Idioma:
spa
OAI Identifier:
oai:repositorio.unal.edu.co:unal/83246
Acceso en línea:
https://repositorio.unal.edu.co/handle/unal/83246
https://repositorio.unal.edu.co/
Palabra clave:
610 - Medicina y salud::616 - Enfermedades
Diagnosis
Diagnóstico
Amiloidosis
Amyloidosis
Polineuropatía amiloidótica hereditaria por transtiretina
Prueba cuantitativa sensitiva
Fibra pequeña
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional
id UNACIONAL2_f334e2a6341d169f6961f7dbe0733ad1
oai_identifier_str oai:repositorio.unal.edu.co:unal/83246
network_acronym_str UNACIONAL2
network_name_str Universidad Nacional de Colombia
repository_id_str
dc.title.spa.fl_str_mv Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
dc.title.translated.none.fl_str_mv Characterization of Patients with Hereditary Transthyretin Amyloid Polyneuropathy Using Quantitative Sensory Testing at an Electrophysiological Research Center in Bogotá
title Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
spellingShingle Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
610 - Medicina y salud::616 - Enfermedades
Diagnosis
Diagnóstico
Amiloidosis
Amyloidosis
Polineuropatía amiloidótica hereditaria por transtiretina
Prueba cuantitativa sensitiva
Fibra pequeña
title_short Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
title_full Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
title_fullStr Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
title_full_unstemmed Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
title_sort Caracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de Bogotá
dc.creator.fl_str_mv Lasso Benavides, Jairo Fernando
dc.contributor.advisor.none.fl_str_mv Ruiz Ospina, Edicson
dc.contributor.author.none.fl_str_mv Lasso Benavides, Jairo Fernando
dc.contributor.researchgroup.spa.fl_str_mv CIFEL (Centro de Investigación en Fisiatría y Electrodiagnóstico)
dc.subject.ddc.spa.fl_str_mv 610 - Medicina y salud::616 - Enfermedades
topic 610 - Medicina y salud::616 - Enfermedades
Diagnosis
Diagnóstico
Amiloidosis
Amyloidosis
Polineuropatía amiloidótica hereditaria por transtiretina
Prueba cuantitativa sensitiva
Fibra pequeña
dc.subject.decs.spa.fl_str_mv Diagnosis
Diagnóstico
Amiloidosis
dc.subject.lemb.eng.fl_str_mv Amyloidosis
dc.subject.proposal.spa.fl_str_mv Polineuropatía amiloidótica hereditaria por transtiretina
Prueba cuantitativa sensitiva
Fibra pequeña
description ilustraciones
publishDate 2023
dc.date.accessioned.none.fl_str_mv 2023-02-02T16:33:41Z
dc.date.available.none.fl_str_mv 2023-02-02T16:33:41Z
dc.date.issued.none.fl_str_mv 2023-02-01
dc.type.spa.fl_str_mv Trabajo de grado - Especialidad Médica
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/masterThesis
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/acceptedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/TM
status_str acceptedVersion
dc.identifier.uri.none.fl_str_mv https://repositorio.unal.edu.co/handle/unal/83246
dc.identifier.instname.spa.fl_str_mv Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv https://repositorio.unal.edu.co/
url https://repositorio.unal.edu.co/handle/unal/83246
https://repositorio.unal.edu.co/
identifier_str_mv Universidad Nacional de Colombia
Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Adams, D. (2013). Recent advances in the treatment of familial amyloid polyneuropathy. Ther Adv Neurol Disord, 6(2), 129-139. https://doi.org/10.1177/1756285612470192
Adams, D., Algalarrondo, V., Polydefkis, M., Sarswat, N., Slama, M. S., & Nativi-Nicolau, J. (2021). Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression. Orphanet J Rare Dis, 16(1), 411. https://doi.org/10.1186/s13023-021-01960-9
Adams, D., Coelho, T., Obici, L., Merlini, G., Mincheva, Z., Suanprasert, N., . . . Dyck, P. J. (2015). Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology, 85(8), 675-682. https://doi.org/10.1212/wnl.0000000000001870
Adams, D., Gonzalez-Duarte, A., O'Riordan, W. D., Yang, C. C., Ueda, M., Kristen, A. V., . . . Suhr, O. B. (2018). Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis. N Engl J Med, 379(1), 11-21. https://doi.org/10.1056/NEJMoa1716153
Adams, D., Koike, H., Slama, M., & Coelho, T. (2019). Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease. Nat Rev Neurol, 15(7), 387-404. https://doi.org/10.1038/s41582-019-0210-4
Adams, D., Samuel, D., Goulon-Goeau, C., Nakazato, M., Costa, P. M., Feray, C., . . . Said, G. (2000). The course and prognostic factors of familial amyloid polyneuropathy after liver transplantation. Brain, 123 ( Pt 7), 1495-1504. https://doi.org/10.1093/brain/123.7.1495
Adams, D., Suhr, O. B., Dyck, P. J., Litchy, W. J., Leahy, R. G., Chen, J., . . . Coelho, T. (2017). Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy. BMC Neurol, 17(1), 181. https://doi.org/10.1186/s12883-017-0948-5
Adams, D., Suhr, O. B., Hund, E., Obici, L., Tournev, I., Campistol, J. M., . . . Coelho, T. (2016). First European consensus for diagnosis, management, and treatment of transthyretin familial amyloid polyneuropathy. Curr Opin Neurol, 29 Suppl 1(Suppl 1), S14-26. https://doi.org/10.1097/wco.0000000000000289
Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., . . . Maier, M. A. (2010). Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol Ther, 18(7), 1357-1364. https://doi.org/10.1038/mt.2010.85
Andersson, R. (1976). Familial amyloidosis with polyneuropathy. A clinical study based on patients living in northern Sweden. Acta Med Scand Suppl, 590, 1-64.
Ando, Y., Coelho, T., Berk, J. L., Cruz, M. W., Ericzon, B. G., Ikeda, S., . . . Salvi, F. (2013). Guideline of transthyretin-related hereditary amyloidosis for clinicians. Orphanet J Rare Dis, 8, 31. https://doi.org/10.1186/1750-1172-8-31
Andrade, C. (1952). A peculiar form of peripheral neuropathy; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves. Brain, 75(3), 408-427. https://doi.org/10.1093/brain/75.3.408
Araki, S., Mawatari, S., Ohta, M., Nakajima, A., & Kuroiwa, Y. (1968). Polyneuritic amyloidosis in a Japanese family. Arch Neurol, 18(6), 593-602. https://doi.org/10.1001/archneur.1968.00470360015001
Arda, O., Göksügür, N., & Tüzün, Y. (2014). Basic histological structure and functions of facial skin. Clin Dermatol, 32(1), 3-13. https://doi.org/10.1016/j.clindermatol.2013.05.021
Bakkers, M., Faber, C. G., Hoeijmakers, J. G. J., Lauria, G., & Merkies, I. S. J. (2014). Small fibers, large impact: Quality of life in small-fiber neuropathy. Muscle & Nerve, 49(3), 329-336. https://doi.org/https://doi.org/10.1002/mus.23910
Baron, R., Maier, C., Attal, N., Binder, A., Bouhassira, D., Cruccu, G., . . . Treede, R. D. (2017). Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain, 158(2), 261-272. https://doi.org/10.1097/j.pain.0000000000000753
Beirão, J. M., Malheiro, J., Lemos, C., Beirão, I., Costa, P., & Torres, P. (2015). Ophthalmological manifestations in hereditary transthyretin (ATTR V30M) carriers: a review of 513 cases. Amyloid, 22(2), 117-122. https://doi.org/10.3109/13506129.2015.1015678
Benson, M. D., & Kincaid, J. C. (2007). The molecular biology and clinical features of amyloid neuropathy. Muscle Nerve, 36(4), 411-423. https://doi.org/10.1002/mus.20821
Benson, M. D., Waddington-Cruz, M., Berk, J. L., Polydefkis, M., Dyck, P. J., Wang, A. K., . . . Coelho, T. (2018). Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis. N Engl J Med, 379(1), 22-31. https://doi.org/10.1056/NEJMoa1716793
Berk, J. L., Suhr, O. B., Obici, L., Sekijima, Y., Zeldenrust, S. R., Yamashita, T., . . . Dyck, P. J. (2013). Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial. Jama, 310(24), 2658-2667. https://doi.org/10.1001/jama.2013.283815
Bitzi, L. M., Lehnick, D., & Wilder-Smith, E. P. (2021). Small fiber neuropathy: Swiss cohort characterization. Muscle Nerve, 64(3), 293-300. https://doi.org/10.1002/mus.27340
Bonaïti, B., Alarcon, F., Bonaïti-Pellié, C., & Planté-Bordeneuve, V. (2009). Parent-of-origin effect in transthyretin related amyloid polyneuropathy. Amyloid, 16(3), 149-150. https://doi.org/10.1080/13506120903093944
Bouhassira, D., Attal, N., Alchaar, H., Boureau, F., Brochet, B., Bruxelle, J., . . . Vicaut, E. (2005). Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain, 114(1), 29-36. https://doi.org/https://doi.org/10.1016/j.pain.2004.12.010
Bouhassira, D., Lantéri-Minet, M., Attal, N., Laurent, B., & Touboul, C. (2008). Prevalence of chronic pain with neuropathic characteristics in the general population. PAIN, 136(3), 380-387. https://doi.org/https://doi.org/10.1016/j.pain.2007.08.013
Brannagan, T. H., 3rd. (2012). Current issues in peripheral neuropathy. J Peripher Nerv Syst, 17 Suppl 2, 1-3. https://doi.org/10.1111/j.1529-8027.2012.00387.x
Bril, V. (1999). NIS-LL: the primary measurement scale for clinical trial endpoints in diabetic peripheral neuropathy. Eur Neurol, 41 Suppl 1, 8-13. https://doi.org/10.1159/000052074
Buxbaum, J. N., & Ruberg, F. L. (2017). Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans. Genet Med, 19(7), 733-742. https://doi.org/10.1038/gim.2016.200
Cappellari, M., Cavallaro, T., Ferrarini, M., Cabrini, I., Taioli, F., Ferrari, S., . . . Fabrizi, G. M. (2011). Variable presentations of TTR-related familial amyloid polyneuropathy in seventeen patients. J Peripher Nerv Syst, 16(2), 119-129. https://doi.org/10.1111/j.1529-8027.2011.00331.x
Casellini, C. M., Parson, H. K., Richardson, M. S., Nevoret, M. L., & Vinik, A. I. (2013). Sudoscan, a noninvasive tool for detecting diabetic small fiber neuropathy and autonomic dysfunction. Diabetes Technol Ther, 15(11), 948-953. https://doi.org/10.1089/dia.2013.0129
Castro, J., Miranda, B., Castro, I., de Carvalho, M., & Conceição, I. (2016). The diagnostic accuracy of Sudoscan in transthyretin familial amyloid polyneuropathy. Clin Neurophysiol, 127(5), 2222-2227. https://doi.org/10.1016/j.clinph.2016.02.013
Chong, P. S. T., & Cros, D. P. (2004). Technology literature review: Quantitative sensory testing. Muscle & Nerve, 29(5), 734-747. https://doi.org/https://doi.org/10.1002/mus.20053
Coelho, T., Maia, L. F., Martins da Silva, A., Waddington Cruz, M., Planté-Bordeneuve, V., Lozeron, P., . . . Grogan, D. R. (2012). Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial. Neurology, 79(8), 785-792. https://doi.org/10.1212/WNL.0b013e3182661eb1
Coelho, T., Vinik, A., Vinik, E. J., Tripp, T., Packman, J., & Grogan, D. R. (2017). Clinical measures in transthyretin familial amyloid polyneuropathy. Muscle & Nerve, 55(3), 323-332. https://doi.org/https://doi.org/10.1002/mus.25257
Contijoch Roqueta, C., Izquierdo, M. F., & Arrabal Solano, L. (2020). Neuropatía de fibras pequeñas: una revisión. Medicina de Familia. SEMERGEN, 46(4), 277-282. https://doi.org/https://doi.org/10.1016/j.semerg.2019.11.003
Debanne, D., Campanac, E., Bialowas, A., Carlier, E., & Alcaraz, G. (2011). Axon physiology. Physiol Rev, 91(2), 555-602. https://doi.org/10.1152/physrev.00048.2009
Derry, S., Bell, R. F., Straube, S., Wiffen, P. J., Aldington, D., & Moore, R. A. (2019). Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev, 1(1), Cd007076. https://doi.org/10.1002/14651858.CD007076.pub3
Devigili, G., Rinaldo, S., Lombardi, R., Cazzato, D., Marchi, M., Salvi, E., . . . Lauria, G. (2019). Diagnostic criteria for small fibre neuropathy in clinical practice and research. Brain, 142(12), 3728-3736. https://doi.org/10.1093/brain/awz333
Devigili, G., Tugnoli, V., Penza, P., Camozzi, F., Lombardi, R., Melli, G., . . . Lauria, G. (2008). The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain, 131(Pt 7), 1912-1925. https://doi.org/10.1093/brain/awn093
Dohrn, M. F., Röcken, C., De Bleecker, J. L., Martin, J. J., Vorgerd, M., Van den Bergh, P. Y., . . . Claeys, K. G. (2013). Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy. J Neurol, 260(12), 3093-3108. https://doi.org/10.1007/s00415-013-7124-7
Dyck, P. J., Davies, J. L., Litchy, W. J., & O'Brien, P. C. (1997). Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort. Neurology, 49(1), 229-239. https://doi.org/10.1212/wnl.49.1.229
Dyck, P. J., Kratz, K. M., Lehman, K. A., Karnes, J. L., Melton, L. J., 3rd, O'Brien, P. C., . . . et al. (1991). The Rochester Diabetic Neuropathy Study: design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests. Neurology, 41(6), 799-807. https://doi.org/10.1212/wnl.41.6.799
Dyck, P. J., Zimmerman, I. R., Johnson, D. M., Gillen, D., Hokanson, J. L., Karnes, J. L., . . . O'Brien, P. C. (1996). A standard test of heat-pain responses using CASE IV. J Neurol Sci, 136(1-2), 54-63. https://doi.org/10.1016/0022-510x(95)00277-9
Dyck, P. J. B., González-Duarte, A., Obici, L., Polydefkis, M., Wiesman, J. F., Antonino, I., . . . Dyck, P. J. (2019). Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7. Journal of the Neurological Sciences, 405. https://doi.org/10.1016/j.jns.2019.116424
Dyck, P. J. B., González-Duarte, A., Obici, L., Polydefkis, M., Wiesman, J. F., Antonino, I., . . . Dyck, P. J. (2019). Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7. J Neurol Sci, 405, 116424. https://doi.org/10.1016/j.jns.2019.116424
Ericzon, B. G., Wilczek, H. E., Larsson, M., Wijayatunga, P., Stangou, A., Pena, J. R., . . . Suhr, O. (2015). Liver Transplantation for Hereditary Transthyretin Amyloidosis: After 20 Years Still the Best Therapeutic Alternative? Transplantation, 99(9), 1847-1854. https://doi.org/10.1097/tp.0000000000000574
Fabry, V., Gerdelat, A., Acket, B., Cintas, P., Rousseau, V., Uro-Coste, E., . . . Pavy-Le Traon, A. (2020). Which Method for Diagnosing Small Fiber Neuropathy? [Original Research]. Frontiers in Neurology, 11. https://doi.org/10.3389/fneur.2020.00342
Fernández Fuertes, J., Rodríguez Vicente, Ó., Sánchez Herráez, S., & Ramos Pascua, L. R. (2017). Early diagnosis of systemic amyloidosis by means of a transverse carpal ligament biopsy carried out during carpal tunnel syndrome surgery. Med Clin (Barc), 148(5), 211-214. https://doi.org/10.1016/j.medcli.2016.10.046
Gonzalez-Duarte, A. (2019). Autonomic involvement in hereditary transthyretin amyloidosis (hATTR amyloidosis). Clinical Autonomic Research, 29(2), 245-251. https://doi.org/10.1007/s10286-018-0514-2
González-López, E., López-Sainz, Á., & Garcia-Pavia, P. (2017). Diagnóstico y tratamiento de la amiloidosis cardiaca por transtiretina. Progreso y esperanza [10.1016/j.recesp.2017.05.018]. Revista Española de Cardiología, 70(11), 991-1004. https://doi.org/10.1016/j.recesp.2017.05.018
Gorson, K. C., Herrmann, D. N., Thiagarajan, R., Brannagan, T. H., Chin, R. L., Kinsella, L. J., & Ropper, A. H. (2008). Non-length dependent small fibre neuropathy/ganglionopathy. J Neurol Neurosurg Psychiatry, 79(2), 163-169. https://doi.org/10.1136/jnnp.2007.128801
Hawkins, P. N., Ando, Y., Dispenzeri, A., Gonzalez-Duarte, A., Adams, D., & Suhr, O. B. (2015). Evolving landscape in the management of transthyretin amyloidosis. Ann Med, 47(8), 625-638. https://doi.org/10.3109/07853890.2015.1068949
Hellman, U., Alarcon, F., Lundgren, H. E., Suhr, O. B., Bonaiti-Pellié, C., & Planté-Bordeneuve, V. (2008). Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population. Amyloid, 15(3), 181-186. https://doi.org/10.1080/13506120802193720
Hoitsma, E., Reulen, J. P. H., de Baets, M., Drent, M., Spaans, F., & Faber, C. G. (2004). Small fiber neuropathy: a common and important clinical disorder. Journal of the Neurological Sciences, 227(1), 119-130. https://doi.org/https://doi.org/10.1016/j.jns.2004.08.012
Holmgren, G., Steen, L., Ekstedt, J., Groth, C. G., Ericzon, B. G., Eriksson, S., . . . et al. (1991). Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP-met30). Clin Genet, 40(3), 242-246. https://doi.org/10.1111/j.1399-0004.1991.tb03085.x
Kaku, M., & Berk, J. L. (2019). Neuropathy Associated with Systemic Amyloidosis. Semin Neurol, 39(5), 578-588. https://doi.org/10.1055/s-0039-1688994
Kim, D. H., Zeldenrust, S. R., Low, P. A., & Dyck, P. J. (2009). Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy. Muscle Nerve, 40(3), 363-370. https://doi.org/10.1002/mus.21332
Klein-Weigel, P. F., Volz, T. S., & Richter, J. G. (2018). Erythromelalgia. Vasa, 47(2), 91-97. https://doi.org/10.1024/0301-1526/a000675
Koike, H., & Katsuno, M. (2020). Transthyretin Amyloidosis: Update on the Clinical Spectrum, Pathogenesis, and Disease-Modifying Therapies. Neurol Ther, 9(2), 317-333. https://doi.org/10.1007/s40120-020-00210-7
Koike, H., Kawagashira, Y., Iijima, M., Yamamoto, M., Hattori, N., Tanaka, F., . . . Sobue, G. (2008). Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci. J Neurol, 255(10), 1526-1533. https://doi.org/10.1007/s00415-008-0962-z
Kucera, P., Goldenberg, Z., & Kurca, E. (2004). Sympathetic skin response: review of the method and its clinical use. Bratisl Lek Listy, 105(3), 108-116.
Kuritzky, L., Espay, A. J., Gelblum, J., Payne, R., & Dietrich, E. (2015). Diagnosing and treating neurogenic orthostatic hypotension in primary care. Postgrad Med, 127(7), 702-715. https://doi.org/10.1080/00325481.2015.1050340
Langford, J. S., Tokita, E., Martindale, C., Millsap, L., Hemp, J., Pace, L. A., & Cortez, M. M. (2022). Quantitative gastrointestinal function and corresponding symptom profiles in autonomic neuropathy. Front Neurol, 13, 1027348. https://doi.org/10.3389/fneur.2022.1027348
Lauria, G., Bakkers, M., Schmitz, C., Lombardi, R., Penza, P., Devigili, G., . . . Merkies, I. S. (2010). Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst, 15(3), 202-207. https://doi.org/10.1111/j.1529-8027.2010.00271.x
Lefaucheur, J. P. (2014). Neuropathies douloureuses et atteinte des petites fibres. Revue Neurologique, 170(12), 825-836. https://doi.org/https://doi.org/10.1016/j.neurol.2014.10.008
Lefaucheur, J. P., Wahab, A., Planté-Bordeneuve, V., Sène, D., Ménard-Lefaucheur, I., Rouie, D., . . . Ng Wing Tin, S. (2015). Diagnosis of small fiber neuropathy: A comparative study of five neurophysiological tests. Neurophysiologie Clinique/Clinical Neurophysiology, 45(6), 445-455. https://doi.org/https://doi.org/10.1016/j.neucli.2015.09.012
Lehrke, S., Steen, H., Kristen, A. V., Merten, C., Lossnitzer, D., Dengler, T. J., . . . Giannitsis, E. (2009). Serum levels of NT-proBNP as surrogate for cardiac amyloid burden: new evidence from gadolinium-enhanced cardiac magnetic resonance imaging in patients with amyloidosis. Amyloid, 16(4), 187-195. https://doi.org/10.3109/13506120903421538
Liampas, A., Rekatsina, M., Vadalouca, A., Paladini, A., Varrassi, G., & Zis, P. (2021). Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review. Pain Ther, 10(1), 55-68. https://doi.org/10.1007/s40122-020-00210-3
Loavenbruck, A. J., Singer, W., Mauermann, M. L., Sandroni, P., PJ, B. D., Gertz, M., . . . Low, P. A. (2016). Transthyretin amyloid neuropathy has earlier neural involvement but better prognosis than primary amyloid counterpart: an answer to the paradox? Ann Neurol, 80(3), 401-411. https://doi.org/10.1002/ana.24725
Lobato, L., & Rocha, A. (2012). Transthyretin amyloidosis and the kidney. Clin J Am Soc Nephrol, 7(8), 1337-1346. https://doi.org/10.2215/cjn.08720811
Luigetti, M., Romano, A., Di Paolantonio, A., Bisogni, G., & Sabatelli, M. (2020). Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR) Polyneuropathy: Current Perspectives on Improving Patient Care. Ther Clin Risk Manag, 16, 109-123. https://doi.org/10.2147/tcrm.s219979
Mahfouz, M., Maruyama, R., & Yokota, T. (2020). Inotersen for the Treatment of Hereditary Transthyretin Amyloidosis. Methods Mol Biol, 2176, 87-98. https://doi.org/10.1007/978-1-0716-0771-8_6
Mariani, L. L., Lozeron, P., Théaudin, M., Mincheva, Z., Signate, A., Ducot, B., . . . Adams, D. (2015). Genotype-phenotype correlation and course of transthyretin familial amyloid polyneuropathies in France. Ann Neurol, 78(6), 901-916. https://doi.org/10.1002/ana.24519
Martins, A. C., Rosa, A. M., Costa, E., Tavares, C., Quadrado, M. J., & Murta, J. N. (2015). Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review. Biomed Res Int, 2015, 282405. https://doi.org/10.1155/2015/282405
Mathias, C. J., & Bannister, S. R. (2013). Autonomic FailureA Textbook of Clinical Disorders of the Autonomic Nervous System: A Textbook of Clinical Disorders of the Autonomic Nervous System. Oxford University Press. https://doi.org/10.1093/med/9780198566342.001.0001
Matsunaga, N., Anan, I., Forsgren, S., Nagai, R., Rosenberg, P., Horiuchi, S., . . . Suhr, O. B. (2002). Advanced glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce NF-kappaB activation. Acta Neuropathol, 104(5), 441-447. https://doi.org/10.1007/s00401-002-0574-0
Maurer, M. S., Hanna, M., Grogan, M., Dispenzieri, A., Witteles, R., Drachman, B., . . . Rapezzi, C. (2016). Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol, 68(2), 161-172. https://doi.org/10.1016/j.jacc.2016.03.596
Menorca, R. M., Fussell, T. S., & Elfar, J. C. (2013). Nerve physiology: mechanisms of injury and recovery. Hand Clin, 29(3), 317-330. https://doi.org/10.1016/j.hcl.2013.04.002
Munsat, T. L. (1989). Quantification of neurologic deficit 1ª Edición (Butterworths, Ed.).
O'Brien, P. C., & Dyck, P. J. (1995). Procedures for setting normal values. Neurology, 45(1), 17-23. https://doi.org/10.1212/wnl.45.1.17
Obayashi, K., Ando, Y., Nakamura, M., Yamashita, T., Ueda, M., Haraoka, K., . . . Uchino, M. (2004). Near-infrared spectrophotoscopy of finger venules in assessment of autonomic dysfunction. Neurology, 63(1), 164-166. https://doi.org/10.1212/01.wnl.0000133135.10172.f3
Park, J. W., Okamoto, L. E., Shibao, C. A., & Biaggioni, I. (2020). Pharmacologic treatment of orthostatic hypotension. Auton Neurosci, 229, 102721. https://doi.org/10.1016/j.autneu.2020.102721
Petropoulos, I. N., Ponirakis, G., Ferdousi, M., Azmi, S., Kalteniece, A., Khan, A., . . . Malik, R. A. (2021). Corneal Confocal Microscopy: A Biomarker for Diabetic Peripheral Neuropathy. Clin Ther, 43(9), 1457-1475. https://doi.org/10.1016/j.clinthera.2021.04.003
Picken, M. M., Herrera, G. A., & Dogan, A. (2015). Amyloid and related disorders: surgical pathology and clinical correlations. Humana Press.
Planté-Bordeneuve, V., Ferreira, A., Lalu, T., Zaros, C., Lacroix, C., Adams, D., & Said, G. (2007). Diagnostic pitfalls in sporadic transthyretin familial amyloid polyneuropathy (TTR-FAP). Neurology, 69(7), 693-698. https://doi.org/10.1212/01.wnl.0000267338.45673.f4
Planté-Bordeneuve, V., & Said, G. (2011). Familial amyloid polyneuropathy. Lancet Neurol, 10(12), 1086-1097. https://doi.org/10.1016/s1474-4422(11)70246-0
Pérez Zauner, A. M. (2016). Caracterización sociodemográfica de las enfermedades huérfanas en Colombia Universidad del Rosario].
Rapezzi, C., Quarta, C. C., Obici, L., Perfetto, F., Longhi, S., Salvi, F., . . . Perlini, S. (2013). Disease profile and differential diagnosis of hereditary transthyretin-related amyloidosis with exclusively cardiac phenotype: an Italian perspective. Eur Heart J, 34(7), 520-528. https://doi.org/10.1093/eurheartj/ehs123
Richardson, S. J. (2007). Cell and molecular biology of transthyretin and thyroid hormones. Int Rev Cytol, 258, 137-193. https://doi.org/10.1016/s0074-7696(07)58003-4
Ruberg, F. L., & Berk, J. L. (2012). Transthyretin (TTR) cardiac amyloidosis. Circulation, 126(10), 1286-1300. https://doi.org/10.1161/circulationaha.111.078915
Rubinow, A., & Cohen, A. S. (1986). Scalloped pupils in familial amyloid polyneuropathy. Arthritis Rheum, 29(3), 445-447. https://doi.org/10.1002/art.1780290323
Said, G., Grippon, S., & Kirkpatrick, P. (2012). Tafamidis. In Nat Rev Drug Discov (Vol. 11, pp. 185-186). https://doi.org/10.1038/nrd3675
Saraiva, M. J., Magalhaes, J., Ferreira, N., & Almeida, M. R. (2012). Transthyretin deposition in familial amyloidotic polyneuropathy. Curr Med Chem, 19(15), 2304-2311. https://doi.org/10.2174/092986712800269236
Sattianayagam, P. T., Hahn, A. F., Whelan, C. J., Gibbs, S. D., Pinney, J. H., Stangou, A. J., . . . Gillmore, J. D. (2012). Cardiac phenotype and clinical outcome of familial amyloid polyneuropathy associated with transthyretin alanine 60 variant. Eur Heart J, 33(9), 1120-1127. https://doi.org/10.1093/eurheartj/ehr383
Schmidt, H. H., Waddington-Cruz, M., Botteman, M. F., Carter, J. A., Chopra, A. S., Hopps, M., . . . Amass, L. (2018). Estimating the global prevalence of transthyretin familial amyloid polyneuropathy. Muscle Nerve, 57(5), 829-837. https://doi.org/10.1002/mus.26034
Sekijima, Y., Tojo, K., Morita, H., Koyama, J., & Ikeda, S. (2015). Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis. Amyloid, 22(2), 79-83. https://doi.org/10.3109/13506129.2014.997872
Sekijima, Y., Ueda, M., Koike, H., Misawa, S., Ishii, T., & Ando, Y. (2018). Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm. Orphanet J Rare Dis, 13(1), 6. https://doi.org/10.1186/s13023-017-0726-x
Sekijima, Y., Yazaki, M., Oguchi, K., Ezawa, N., Yoshinaga, T., Yamada, M., . . . Ikeda, S. (2016). Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis. Neurology, 87(8), 773-781. https://doi.org/10.1212/wnl.0000000000003001
Sletten, D. M., Suarez, G. A., Low, P. A., Mandrekar, J., & Singer, W. (2012). COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin Proc, 87(12), 1196-1201. https://doi.org/10.1016/j.mayocp.2012.10.013
Smith, S. C., Lamping, D. L., & Maclaine, G. D. H. (2012). Measuring health-related quality of life in diabetic peripheral neuropathy: A systematic review. Diabetes Research and Clinical Practice, 96(3), 261-270. https://doi.org/10.1016/j.diabres.2011.11.013
Snell, R. S. (2007). Neuroanatomía clínica. Ed. Médica Panamericana.
Stewart, J. D., Low, P. A., & Fealey, R. D. (1992). Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascular reflexes. Muscle Nerve, 15(6), 661-665. https://doi.org/10.1002/mus.880150605
Suanprasert, N., Berk, J. L., Benson, M. D., Dyck, P. J., Klein, C. J., Gollob, J. A., . . . Karsten, V. (2014). Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials. J Neurol Sci, 344(1-2), 121-128. https://doi.org/10.1016/j.jns.2014.06.041
Suhr, O. B., Larsson, M., Ericzon, B. G., & Wilczek, H. E. (2016). Survival After Transplantation in Patients With Mutations Other Than Val30Met: Extracts From the FAP World Transplant Registry. Transplantation, 100(2), 373-381. https://doi.org/10.1097/tp.0000000000001021
Sène, D. (2018). Small fiber neuropathy: Diagnosis, causes, and treatment. Joint Bone Spine, 85(5), 553-559. https://doi.org/10.1016/j.jbspin.2017.11.002
Terkelsen, A. J., Karlsson, P., Lauria, G., Freeman, R., Finnerup, N. B., & Jensen, T. S. (2017). The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol, 16(11), 934-944. https://doi.org/10.1016/s1474-4422(17)30329-0
Tesfaye, S., Boulton, A. J., Dyck, P. J., Freeman, R., Horowitz, M., Kempler, P., . . . Valensi, P. (2010). Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care, 33(10), 2285-2293. https://doi.org/10.2337/dc10-1303
Thaisetthawatkul, P., Fernandes Filho, J. A., & Herrmann, D. N. (2013). Contribution of QSART to the diagnosis of small fiber neuropathy. Muscle Nerve, 48(6), 883-888. https://doi.org/10.1002/mus.23891
Themistocleous, A. C., Ramirez, J. D., Serra, J., & Bennett, D. L. (2014). The clinical approach to small fibre neuropathy and painful channelopathy. Pract Neurol, 14(6), 368-379. https://doi.org/10.1136/practneurol-2013-000758
Treede, R. D., Lorenz, J., & Baumgärtner, U. (2003). Clinical usefulness of laser-evoked potentials. Neurophysiol Clin, 33(6), 303-314. https://doi.org/10.1016/j.neucli.2003.10.009
Treister, R., O'Neil, K., Downs, H. M., & Oaklander, A. L. (2015). Validation of the composite autonomic symptom scale 31 (COMPASS-31) in patients with and without small fiber polyneuropathy. Eur J Neurol, 22(7), 1124-1130. https://doi.org/10.1111/ene.12717
Tsuzuki, T., Mita, S., Maeda, S., Araki, S., & Shimada, K. (1985). Structure of the human prealbumin gene. J Biol Chem, 260(22), 12224-12227.
Vetrugno, R., Liguori, R., Cortelli, P., & Montagna, P. (2003). Sympathetic skin response: basic mechanisms and clinical applications. Clin Auton Res, 13(4), 256-270. https://doi.org/10.1007/s10286-003-0107-5
Vieira, M., & Saraiva, M. J. (2014). Transthyretin: a multifaceted protein. Biomol Concepts, 5(1), 45-54. https://doi.org/10.1515/bmc-2013-0038
Vinik, E. J., Hayes, R. P., Oglesby, A., Bastyr, E., Barlow, P., Ford-Molvik, S. L., & Vinik, A. I. (2005). The development and validation of the Norfolk QOL-DN, a new measure of patients' perception of the effects of diabetes and diabetic neuropathy. Diabetes Technol Ther, 7(3), 497-508. https://doi.org/10.1089/dia.2005.7.497
Vinik, E. J., Vinik, A. I., Paulson, J. F., Merkies, I. S., Packman, J., Grogan, D. R., & Coelho, T. (2014). Norfolk QOL-DN: validation of a patient reported outcome measure in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst, 19(2), 104-114. https://doi.org/10.1111/jns5.12059
Walk, D., Sehgal, N., Moeller-Bertram, T., Edwards, R. R., Wasan, A., Wallace, M., . . . Backonja, M. M. (2009). Quantitative sensory testing and mapping: a review of nonautomated quantitative methods for examination of the patient with neuropathic pain. Clin J Pain, 25(7), 632-640. https://doi.org/10.1097/AJP.0b013e3181a68c64
Wang, Q., Liu, C., & Zhang, Z. (2016). Transthyretin and Normal Human Pregnancy: Mini Review. Crit Rev Eukaryot Gene Expr, 26(3), 273-277. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2016017323
Waxman, S. G., Arias Rebatet, G., & Medina Soriano, C. A. (2004). Neuroanatomía clínica.
Wieczorek, E., & Ożyhar, A. (2021). Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases. Cells, 10(7). https://doi.org/10.3390/cells10071768
Wilczek, H. E., Larsson, M., & Ericzon, B. G. (2011). Long-term data from the Familial Amyloidotic Polyneuropathy World Transplant Registry (FAPWTR). Amyloid, 18 Suppl 1, 193-195. https://doi.org/10.3109/13506129.2011.574354072
Wixner, J., Mundayat, R., Karayal, O. N., Anan, I., Karling, P., & Suhr, O. B. (2014). THAOS: gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease. Orphanet J Rare Dis, 9, 61. https://doi.org/10.1186/1750-1172-9-61
Wixner, J., Suhr, O. B., & Anan, I. (2018). Management of gastrointestinal complications in hereditary transthyretin amyloidosis: a single-center experience over 40 years. Expert Rev Gastroenterol Hepatol, 12(1), 73-81. https://doi.org/10.1080/17474124.2018.1397511
Yamashita, T., Ando, Y., Okamoto, S., Misumi, Y., Hirahara, T., Ueda, M., . . . Uchino, M. (2012). Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy. Neurology, 78(9), 637-643. https://doi.org/10.1212/WNL.0b013e318248df18
Yee, A. W., Aldeghi, M., Blakeley, M. P., Ostermann, A., Mas, P. J., Moulin, M., . . . Forsyth, V. T. (2019). A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10(1), 925. https://doi.org/10.1038/s41467-019-08609-z
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dc.publisher.branch.spa.fl_str_mv Universidad Nacional de Colombia - Sede Bogotá
institution Universidad Nacional de Colombia
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spelling Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Ruiz Ospina, Edicsoneb7bf951410bc589e96d5348ac2e98e5Lasso Benavides, Jairo Fernandof4f9656e9ebf966e7c18d621c4dbe857CIFEL (Centro de Investigación en Fisiatría y Electrodiagnóstico)2023-02-02T16:33:41Z2023-02-02T16:33:41Z2023-02-01https://repositorio.unal.edu.co/handle/unal/83246Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustracionesCaracterización de Pacientes con Polineuropatía Amiloidótica Hereditaria por Transtiretina, Usando la Prueba Cuantitativa Sensitiva en un Centro de Investigación Electrofisiológica en la Ciudad de Bogotá Introducción: La amiloidosis hereditaria por transtiretina (hATTR) es una condición genética rara caracterizada por la polineuropatía de fibra pequeña, que causa síntomas como dolor neuropático y disautonomías. Metodología: Investigación retrospectiva de casos que examina la correlación entre la variante genética de la hATTR, los umbrales de la prueba cuantitativa sensitiva, los puntajes de las escalas Norfolk QOL y COMPASS 31. Se recolectaron datos de pacientes en el centro de investigación en fisiatría y electrodiagnóstico (CIFEL) en la ciudad de Bogotá y se realizó un análisis estadístico no paramétrico de Spearman. Resultados: 11 pacientes con polineuropatía amiloidótica hereditaria por transtiretina (hATTR-PN) en Colombia mostraron que la variante genética más frecuente fue ATTRVal142Ile, se encontraron alteraciones del QST en 5 pacientes, síntomas disautonómicos en el 90,6% y compromiso cardiaco en el 72,9%. Se encontraron correlaciones significativas entre las escalas de valoración y los umbrales del QST. Discusión: El perfil clínico en el país coincide con la literatura mundial. Altos puntajes en la escalas de valoración asocian alteraciones en el QST. Conclusión: Existe un incremento en la prevalencia de ATTR en Colombia, con la evidencia de correlaciones estadísticamente significativas entre las escalas Norfolk y COMPASS 31 y los umbrales del QST. La prueba cuantitativa sensitiva se ha demostrado como un método útil para el diagnóstico, seguimiento y monitoreo de esta neuropatía. Palabras clave: Polineuropatía amiloidótica hereditaria por transtiretina, Prueba cuantitativa sensitiva, Fibra pequeña (Texto tomado de la fuente)Characterization of Patients with Hereditary Transthyretin Amyloid Polyneuropathy Using Quantitative Sensory Testing at an Electrophysiological Research Center in Bogotá Introduction: Hereditary transthyretin amyloidosis (hATTR) is a rare genetic condition characterized by small-fiber polyneuropathy, causing symptoms such as neuropathic pain and dysautonomias. Methodology: Retrospective case study examining the correlation between hATTR genetic variant, quantitative sensory testing thresholds, Norfolk QOL scale scores and COMPASS 31 scores. Data was collected from patients at the Center for Research in Physical Medicine and Electrodiagnosis (CIFEL) in the city of Bogota and a non-parametric Spearman statistical analysis was performed. Results: 11 patients with hereditary amyloidotic polyneuropathy due to transthyretin (hATTR-PN) in Colombia showed that the most frequent genetic variant was ATTRVal142Ile, QST alterations were found in 5 patients, autonomic symptoms in 90.6% and cardiac involvement in 72.9%. Significant correlations were found between the assessment scales and the QST thresholds. Discussion: The clinical profile in the country coincides with the world literature. High scores on the assessment scales associate with changes in the QST. Conclusion: There is an increase in the prevalence of ATTR in Colombia, with evidence of statistically significant correlations between the Norfolk and COMPASS 31 scales and the QST thresholds. Quantitative sensory testing has been shown to be a useful method for the diagnosis, monitoring, and monitoring of this neuropathy. Keywords: Hereditary transthyretin amyloid polyneuropathy, Quantitative Sensory Testing, Small Fiber  Especialidades MédicasEspecialista en Medicina Física y RehabilitaciónEstudio electrofisiológico de fibra pequeñaxv, 98 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Medicina - Especialidad en Medicina Física y RehabilitaciónFacultad de MedicinaBogotá - ColombiaUniversidad Nacional de Colombia - Sede Bogotá610 - Medicina y salud::616 - EnfermedadesDiagnosisDiagnósticoAmiloidosisAmyloidosisPolineuropatía amiloidótica hereditaria por transtiretinaPrueba cuantitativa sensitivaFibra pequeñaCaracterización de pacientes con polineuropatía amiloidótica hereditaria por transtiretina, usando la prueba cuantitativa sensitiva en un centro de investigación electrofisiológica en la ciudad de BogotáCharacterization of Patients with Hereditary Transthyretin Amyloid Polyneuropathy Using Quantitative Sensory Testing at an Electrophysiological Research Center in BogotáTrabajo de grado - Especialidad Médicainfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/acceptedVersionTexthttp://purl.org/redcol/resource_type/TMBogotá - ColombiaAdams, D. (2013). Recent advances in the treatment of familial amyloid polyneuropathy. Ther Adv Neurol Disord, 6(2), 129-139. https://doi.org/10.1177/1756285612470192Adams, D., Algalarrondo, V., Polydefkis, M., Sarswat, N., Slama, M. S., & Nativi-Nicolau, J. (2021). Expert opinion on monitoring symptomatic hereditary transthyretin-mediated amyloidosis and assessment of disease progression. Orphanet J Rare Dis, 16(1), 411. https://doi.org/10.1186/s13023-021-01960-9Adams, D., Coelho, T., Obici, L., Merlini, G., Mincheva, Z., Suanprasert, N., . . . Dyck, P. J. (2015). Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study. Neurology, 85(8), 675-682. https://doi.org/10.1212/wnl.0000000000001870Adams, D., Gonzalez-Duarte, A., O'Riordan, W. D., Yang, C. C., Ueda, M., Kristen, A. V., . . . Suhr, O. B. (2018). Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis. N Engl J Med, 379(1), 11-21. https://doi.org/10.1056/NEJMoa1716153Adams, D., Koike, H., Slama, M., & Coelho, T. (2019). Hereditary transthyretin amyloidosis: a model of medical progress for a fatal disease. Nat Rev Neurol, 15(7), 387-404. https://doi.org/10.1038/s41582-019-0210-4Adams, D., Samuel, D., Goulon-Goeau, C., Nakazato, M., Costa, P. M., Feray, C., . . . Said, G. (2000). The course and prognostic factors of familial amyloid polyneuropathy after liver transplantation. Brain, 123 ( Pt 7), 1495-1504. https://doi.org/10.1093/brain/123.7.1495Adams, D., Suhr, O. B., Dyck, P. J., Litchy, W. J., Leahy, R. G., Chen, J., . . . Coelho, T. (2017). Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy. BMC Neurol, 17(1), 181. https://doi.org/10.1186/s12883-017-0948-5Adams, D., Suhr, O. B., Hund, E., Obici, L., Tournev, I., Campistol, J. M., . . . Coelho, T. (2016). First European consensus for diagnosis, management, and treatment of transthyretin familial amyloid polyneuropathy. Curr Opin Neurol, 29 Suppl 1(Suppl 1), S14-26. https://doi.org/10.1097/wco.0000000000000289Akinc, A., Querbes, W., De, S., Qin, J., Frank-Kamenetsky, M., Jayaprakash, K. N., . . . Maier, M. A. (2010). Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol Ther, 18(7), 1357-1364. https://doi.org/10.1038/mt.2010.85Andersson, R. (1976). Familial amyloidosis with polyneuropathy. A clinical study based on patients living in northern Sweden. Acta Med Scand Suppl, 590, 1-64.Ando, Y., Coelho, T., Berk, J. L., Cruz, M. W., Ericzon, B. G., Ikeda, S., . . . Salvi, F. (2013). Guideline of transthyretin-related hereditary amyloidosis for clinicians. Orphanet J Rare Dis, 8, 31. https://doi.org/10.1186/1750-1172-8-31Andrade, C. (1952). A peculiar form of peripheral neuropathy; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves. Brain, 75(3), 408-427. https://doi.org/10.1093/brain/75.3.408Araki, S., Mawatari, S., Ohta, M., Nakajima, A., & Kuroiwa, Y. (1968). Polyneuritic amyloidosis in a Japanese family. Arch Neurol, 18(6), 593-602. https://doi.org/10.1001/archneur.1968.00470360015001Arda, O., Göksügür, N., & Tüzün, Y. (2014). Basic histological structure and functions of facial skin. Clin Dermatol, 32(1), 3-13. https://doi.org/10.1016/j.clindermatol.2013.05.021Bakkers, M., Faber, C. G., Hoeijmakers, J. G. J., Lauria, G., & Merkies, I. S. J. (2014). Small fibers, large impact: Quality of life in small-fiber neuropathy. Muscle & Nerve, 49(3), 329-336. https://doi.org/https://doi.org/10.1002/mus.23910Baron, R., Maier, C., Attal, N., Binder, A., Bouhassira, D., Cruccu, G., . . . Treede, R. D. (2017). Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles. Pain, 158(2), 261-272. https://doi.org/10.1097/j.pain.0000000000000753Beirão, J. M., Malheiro, J., Lemos, C., Beirão, I., Costa, P., & Torres, P. (2015). Ophthalmological manifestations in hereditary transthyretin (ATTR V30M) carriers: a review of 513 cases. Amyloid, 22(2), 117-122. https://doi.org/10.3109/13506129.2015.1015678Benson, M. D., & Kincaid, J. C. (2007). The molecular biology and clinical features of amyloid neuropathy. Muscle Nerve, 36(4), 411-423. https://doi.org/10.1002/mus.20821Benson, M. D., Waddington-Cruz, M., Berk, J. L., Polydefkis, M., Dyck, P. J., Wang, A. K., . . . Coelho, T. (2018). Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis. N Engl J Med, 379(1), 22-31. https://doi.org/10.1056/NEJMoa1716793Berk, J. L., Suhr, O. B., Obici, L., Sekijima, Y., Zeldenrust, S. R., Yamashita, T., . . . Dyck, P. J. (2013). Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial. Jama, 310(24), 2658-2667. https://doi.org/10.1001/jama.2013.283815Bitzi, L. M., Lehnick, D., & Wilder-Smith, E. P. (2021). Small fiber neuropathy: Swiss cohort characterization. Muscle Nerve, 64(3), 293-300. https://doi.org/10.1002/mus.27340Bonaïti, B., Alarcon, F., Bonaïti-Pellié, C., & Planté-Bordeneuve, V. (2009). Parent-of-origin effect in transthyretin related amyloid polyneuropathy. Amyloid, 16(3), 149-150. https://doi.org/10.1080/13506120903093944Bouhassira, D., Attal, N., Alchaar, H., Boureau, F., Brochet, B., Bruxelle, J., . . . Vicaut, E. (2005). Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4). Pain, 114(1), 29-36. https://doi.org/https://doi.org/10.1016/j.pain.2004.12.010Bouhassira, D., Lantéri-Minet, M., Attal, N., Laurent, B., & Touboul, C. (2008). Prevalence of chronic pain with neuropathic characteristics in the general population. PAIN, 136(3), 380-387. https://doi.org/https://doi.org/10.1016/j.pain.2007.08.013Brannagan, T. H., 3rd. (2012). Current issues in peripheral neuropathy. J Peripher Nerv Syst, 17 Suppl 2, 1-3. https://doi.org/10.1111/j.1529-8027.2012.00387.xBril, V. (1999). NIS-LL: the primary measurement scale for clinical trial endpoints in diabetic peripheral neuropathy. Eur Neurol, 41 Suppl 1, 8-13. https://doi.org/10.1159/000052074Buxbaum, J. N., & Ruberg, F. L. (2017). Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans. Genet Med, 19(7), 733-742. https://doi.org/10.1038/gim.2016.200Cappellari, M., Cavallaro, T., Ferrarini, M., Cabrini, I., Taioli, F., Ferrari, S., . . . Fabrizi, G. M. (2011). Variable presentations of TTR-related familial amyloid polyneuropathy in seventeen patients. J Peripher Nerv Syst, 16(2), 119-129. https://doi.org/10.1111/j.1529-8027.2011.00331.xCasellini, C. M., Parson, H. K., Richardson, M. S., Nevoret, M. L., & Vinik, A. I. (2013). Sudoscan, a noninvasive tool for detecting diabetic small fiber neuropathy and autonomic dysfunction. Diabetes Technol Ther, 15(11), 948-953. https://doi.org/10.1089/dia.2013.0129Castro, J., Miranda, B., Castro, I., de Carvalho, M., & Conceição, I. (2016). The diagnostic accuracy of Sudoscan in transthyretin familial amyloid polyneuropathy. Clin Neurophysiol, 127(5), 2222-2227. https://doi.org/10.1016/j.clinph.2016.02.013Chong, P. S. T., & Cros, D. P. (2004). Technology literature review: Quantitative sensory testing. Muscle & Nerve, 29(5), 734-747. https://doi.org/https://doi.org/10.1002/mus.20053Coelho, T., Maia, L. F., Martins da Silva, A., Waddington Cruz, M., Planté-Bordeneuve, V., Lozeron, P., . . . Grogan, D. R. (2012). Tafamidis for transthyretin familial amyloid polyneuropathy: a randomized, controlled trial. Neurology, 79(8), 785-792. https://doi.org/10.1212/WNL.0b013e3182661eb1Coelho, T., Vinik, A., Vinik, E. J., Tripp, T., Packman, J., & Grogan, D. R. (2017). Clinical measures in transthyretin familial amyloid polyneuropathy. Muscle & Nerve, 55(3), 323-332. https://doi.org/https://doi.org/10.1002/mus.25257Contijoch Roqueta, C., Izquierdo, M. F., & Arrabal Solano, L. (2020). Neuropatía de fibras pequeñas: una revisión. Medicina de Familia. SEMERGEN, 46(4), 277-282. https://doi.org/https://doi.org/10.1016/j.semerg.2019.11.003Debanne, D., Campanac, E., Bialowas, A., Carlier, E., & Alcaraz, G. (2011). Axon physiology. Physiol Rev, 91(2), 555-602. https://doi.org/10.1152/physrev.00048.2009Derry, S., Bell, R. F., Straube, S., Wiffen, P. J., Aldington, D., & Moore, R. A. (2019). Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev, 1(1), Cd007076. https://doi.org/10.1002/14651858.CD007076.pub3Devigili, G., Rinaldo, S., Lombardi, R., Cazzato, D., Marchi, M., Salvi, E., . . . Lauria, G. (2019). Diagnostic criteria for small fibre neuropathy in clinical practice and research. Brain, 142(12), 3728-3736. https://doi.org/10.1093/brain/awz333Devigili, G., Tugnoli, V., Penza, P., Camozzi, F., Lombardi, R., Melli, G., . . . Lauria, G. (2008). The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain, 131(Pt 7), 1912-1925. https://doi.org/10.1093/brain/awn093Dohrn, M. F., Röcken, C., De Bleecker, J. L., Martin, J. J., Vorgerd, M., Van den Bergh, P. Y., . . . Claeys, K. G. (2013). Diagnostic hallmarks and pitfalls in late-onset progressive transthyretin-related amyloid-neuropathy. J Neurol, 260(12), 3093-3108. https://doi.org/10.1007/s00415-013-7124-7Dyck, P. J., Davies, J. L., Litchy, W. J., & O'Brien, P. C. (1997). Longitudinal assessment of diabetic polyneuropathy using a composite score in the Rochester Diabetic Neuropathy Study cohort. Neurology, 49(1), 229-239. https://doi.org/10.1212/wnl.49.1.229Dyck, P. J., Kratz, K. M., Lehman, K. A., Karnes, J. L., Melton, L. J., 3rd, O'Brien, P. C., . . . et al. (1991). The Rochester Diabetic Neuropathy Study: design, criteria for types of neuropathy, selection bias, and reproducibility of neuropathic tests. Neurology, 41(6), 799-807. https://doi.org/10.1212/wnl.41.6.799Dyck, P. J., Zimmerman, I. R., Johnson, D. M., Gillen, D., Hokanson, J. L., Karnes, J. L., . . . O'Brien, P. C. (1996). A standard test of heat-pain responses using CASE IV. J Neurol Sci, 136(1-2), 54-63. https://doi.org/10.1016/0022-510x(95)00277-9Dyck, P. J. B., González-Duarte, A., Obici, L., Polydefkis, M., Wiesman, J. F., Antonino, I., . . . Dyck, P. J. (2019). Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7. Journal of the Neurological Sciences, 405. https://doi.org/10.1016/j.jns.2019.116424Dyck, P. J. B., González-Duarte, A., Obici, L., Polydefkis, M., Wiesman, J. F., Antonino, I., . . . Dyck, P. J. (2019). Development of measures of polyneuropathy impairment in hATTR amyloidosis: From NIS to mNIS + 7. J Neurol Sci, 405, 116424. https://doi.org/10.1016/j.jns.2019.116424Ericzon, B. G., Wilczek, H. E., Larsson, M., Wijayatunga, P., Stangou, A., Pena, J. R., . . . Suhr, O. (2015). Liver Transplantation for Hereditary Transthyretin Amyloidosis: After 20 Years Still the Best Therapeutic Alternative? Transplantation, 99(9), 1847-1854. https://doi.org/10.1097/tp.0000000000000574Fabry, V., Gerdelat, A., Acket, B., Cintas, P., Rousseau, V., Uro-Coste, E., . . . Pavy-Le Traon, A. (2020). Which Method for Diagnosing Small Fiber Neuropathy? [Original Research]. Frontiers in Neurology, 11. https://doi.org/10.3389/fneur.2020.00342Fernández Fuertes, J., Rodríguez Vicente, Ó., Sánchez Herráez, S., & Ramos Pascua, L. R. (2017). Early diagnosis of systemic amyloidosis by means of a transverse carpal ligament biopsy carried out during carpal tunnel syndrome surgery. Med Clin (Barc), 148(5), 211-214. https://doi.org/10.1016/j.medcli.2016.10.046Gonzalez-Duarte, A. (2019). Autonomic involvement in hereditary transthyretin amyloidosis (hATTR amyloidosis). Clinical Autonomic Research, 29(2), 245-251. https://doi.org/10.1007/s10286-018-0514-2González-López, E., López-Sainz, Á., & Garcia-Pavia, P. (2017). Diagnóstico y tratamiento de la amiloidosis cardiaca por transtiretina. Progreso y esperanza [10.1016/j.recesp.2017.05.018]. Revista Española de Cardiología, 70(11), 991-1004. https://doi.org/10.1016/j.recesp.2017.05.018Gorson, K. C., Herrmann, D. N., Thiagarajan, R., Brannagan, T. H., Chin, R. L., Kinsella, L. J., & Ropper, A. H. (2008). Non-length dependent small fibre neuropathy/ganglionopathy. J Neurol Neurosurg Psychiatry, 79(2), 163-169. https://doi.org/10.1136/jnnp.2007.128801Hawkins, P. N., Ando, Y., Dispenzeri, A., Gonzalez-Duarte, A., Adams, D., & Suhr, O. B. (2015). Evolving landscape in the management of transthyretin amyloidosis. Ann Med, 47(8), 625-638. https://doi.org/10.3109/07853890.2015.1068949Hellman, U., Alarcon, F., Lundgren, H. E., Suhr, O. B., Bonaiti-Pellié, C., & Planté-Bordeneuve, V. (2008). Heterogeneity of penetrance in familial amyloid polyneuropathy, ATTR Val30Met, in the Swedish population. Amyloid, 15(3), 181-186. https://doi.org/10.1080/13506120802193720Hoitsma, E., Reulen, J. P. H., de Baets, M., Drent, M., Spaans, F., & Faber, C. G. (2004). Small fiber neuropathy: a common and important clinical disorder. Journal of the Neurological Sciences, 227(1), 119-130. https://doi.org/https://doi.org/10.1016/j.jns.2004.08.012Holmgren, G., Steen, L., Ekstedt, J., Groth, C. G., Ericzon, B. G., Eriksson, S., . . . et al. (1991). Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP-met30). Clin Genet, 40(3), 242-246. https://doi.org/10.1111/j.1399-0004.1991.tb03085.xKaku, M., & Berk, J. L. (2019). Neuropathy Associated with Systemic Amyloidosis. Semin Neurol, 39(5), 578-588. https://doi.org/10.1055/s-0039-1688994Kim, D. H., Zeldenrust, S. R., Low, P. A., & Dyck, P. J. (2009). Quantitative sensation and autonomic test abnormalities in transthyretin amyloidosis polyneuropathy. Muscle Nerve, 40(3), 363-370. https://doi.org/10.1002/mus.21332Klein-Weigel, P. F., Volz, T. S., & Richter, J. G. (2018). Erythromelalgia. Vasa, 47(2), 91-97. https://doi.org/10.1024/0301-1526/a000675Koike, H., & Katsuno, M. (2020). Transthyretin Amyloidosis: Update on the Clinical Spectrum, Pathogenesis, and Disease-Modifying Therapies. Neurol Ther, 9(2), 317-333. https://doi.org/10.1007/s40120-020-00210-7Koike, H., Kawagashira, Y., Iijima, M., Yamamoto, M., Hattori, N., Tanaka, F., . . . Sobue, G. (2008). Electrophysiological features of late-onset transthyretin Met30 familial amyloid polyneuropathy unrelated to endemic foci. J Neurol, 255(10), 1526-1533. https://doi.org/10.1007/s00415-008-0962-zKucera, P., Goldenberg, Z., & Kurca, E. (2004). Sympathetic skin response: review of the method and its clinical use. Bratisl Lek Listy, 105(3), 108-116.Kuritzky, L., Espay, A. J., Gelblum, J., Payne, R., & Dietrich, E. (2015). Diagnosing and treating neurogenic orthostatic hypotension in primary care. Postgrad Med, 127(7), 702-715. https://doi.org/10.1080/00325481.2015.1050340Langford, J. S., Tokita, E., Martindale, C., Millsap, L., Hemp, J., Pace, L. A., & Cortez, M. M. (2022). Quantitative gastrointestinal function and corresponding symptom profiles in autonomic neuropathy. Front Neurol, 13, 1027348. https://doi.org/10.3389/fneur.2022.1027348Lauria, G., Bakkers, M., Schmitz, C., Lombardi, R., Penza, P., Devigili, G., . . . Merkies, I. S. (2010). Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst, 15(3), 202-207. https://doi.org/10.1111/j.1529-8027.2010.00271.xLefaucheur, J. P. (2014). Neuropathies douloureuses et atteinte des petites fibres. Revue Neurologique, 170(12), 825-836. https://doi.org/https://doi.org/10.1016/j.neurol.2014.10.008Lefaucheur, J. P., Wahab, A., Planté-Bordeneuve, V., Sène, D., Ménard-Lefaucheur, I., Rouie, D., . . . Ng Wing Tin, S. (2015). Diagnosis of small fiber neuropathy: A comparative study of five neurophysiological tests. Neurophysiologie Clinique/Clinical Neurophysiology, 45(6), 445-455. https://doi.org/https://doi.org/10.1016/j.neucli.2015.09.012Lehrke, S., Steen, H., Kristen, A. V., Merten, C., Lossnitzer, D., Dengler, T. J., . . . Giannitsis, E. (2009). Serum levels of NT-proBNP as surrogate for cardiac amyloid burden: new evidence from gadolinium-enhanced cardiac magnetic resonance imaging in patients with amyloidosis. Amyloid, 16(4), 187-195. https://doi.org/10.3109/13506120903421538Liampas, A., Rekatsina, M., Vadalouca, A., Paladini, A., Varrassi, G., & Zis, P. (2021). Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review. Pain Ther, 10(1), 55-68. https://doi.org/10.1007/s40122-020-00210-3Loavenbruck, A. J., Singer, W., Mauermann, M. L., Sandroni, P., PJ, B. D., Gertz, M., . . . Low, P. A. (2016). Transthyretin amyloid neuropathy has earlier neural involvement but better prognosis than primary amyloid counterpart: an answer to the paradox? Ann Neurol, 80(3), 401-411. https://doi.org/10.1002/ana.24725Lobato, L., & Rocha, A. (2012). Transthyretin amyloidosis and the kidney. Clin J Am Soc Nephrol, 7(8), 1337-1346. https://doi.org/10.2215/cjn.08720811Luigetti, M., Romano, A., Di Paolantonio, A., Bisogni, G., & Sabatelli, M. (2020). Diagnosis and Treatment of Hereditary Transthyretin Amyloidosis (hATTR) Polyneuropathy: Current Perspectives on Improving Patient Care. Ther Clin Risk Manag, 16, 109-123. https://doi.org/10.2147/tcrm.s219979Mahfouz, M., Maruyama, R., & Yokota, T. (2020). Inotersen for the Treatment of Hereditary Transthyretin Amyloidosis. Methods Mol Biol, 2176, 87-98. https://doi.org/10.1007/978-1-0716-0771-8_6Mariani, L. L., Lozeron, P., Théaudin, M., Mincheva, Z., Signate, A., Ducot, B., . . . Adams, D. (2015). Genotype-phenotype correlation and course of transthyretin familial amyloid polyneuropathies in France. Ann Neurol, 78(6), 901-916. https://doi.org/10.1002/ana.24519Martins, A. C., Rosa, A. M., Costa, E., Tavares, C., Quadrado, M. J., & Murta, J. N. (2015). Ocular Manifestations and Therapeutic Options in Patients with Familial Amyloid Polyneuropathy: A Systematic Review. Biomed Res Int, 2015, 282405. https://doi.org/10.1155/2015/282405Mathias, C. J., & Bannister, S. R. (2013). Autonomic FailureA Textbook of Clinical Disorders of the Autonomic Nervous System: A Textbook of Clinical Disorders of the Autonomic Nervous System. Oxford University Press. https://doi.org/10.1093/med/9780198566342.001.0001Matsunaga, N., Anan, I., Forsgren, S., Nagai, R., Rosenberg, P., Horiuchi, S., . . . Suhr, O. B. (2002). Advanced glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce NF-kappaB activation. Acta Neuropathol, 104(5), 441-447. https://doi.org/10.1007/s00401-002-0574-0Maurer, M. S., Hanna, M., Grogan, M., Dispenzieri, A., Witteles, R., Drachman, B., . . . Rapezzi, C. (2016). Genotype and Phenotype of Transthyretin Cardiac Amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey). J Am Coll Cardiol, 68(2), 161-172. https://doi.org/10.1016/j.jacc.2016.03.596Menorca, R. M., Fussell, T. S., & Elfar, J. C. (2013). Nerve physiology: mechanisms of injury and recovery. Hand Clin, 29(3), 317-330. https://doi.org/10.1016/j.hcl.2013.04.002Munsat, T. L. (1989). Quantification of neurologic deficit 1ª Edición (Butterworths, Ed.).O'Brien, P. C., & Dyck, P. J. (1995). Procedures for setting normal values. Neurology, 45(1), 17-23. https://doi.org/10.1212/wnl.45.1.17Obayashi, K., Ando, Y., Nakamura, M., Yamashita, T., Ueda, M., Haraoka, K., . . . Uchino, M. (2004). Near-infrared spectrophotoscopy of finger venules in assessment of autonomic dysfunction. Neurology, 63(1), 164-166. https://doi.org/10.1212/01.wnl.0000133135.10172.f3Park, J. W., Okamoto, L. E., Shibao, C. A., & Biaggioni, I. (2020). Pharmacologic treatment of orthostatic hypotension. Auton Neurosci, 229, 102721. https://doi.org/10.1016/j.autneu.2020.102721Petropoulos, I. N., Ponirakis, G., Ferdousi, M., Azmi, S., Kalteniece, A., Khan, A., . . . Malik, R. A. (2021). Corneal Confocal Microscopy: A Biomarker for Diabetic Peripheral Neuropathy. Clin Ther, 43(9), 1457-1475. https://doi.org/10.1016/j.clinthera.2021.04.003Picken, M. M., Herrera, G. A., & Dogan, A. (2015). Amyloid and related disorders: surgical pathology and clinical correlations. Humana Press.Planté-Bordeneuve, V., Ferreira, A., Lalu, T., Zaros, C., Lacroix, C., Adams, D., & Said, G. (2007). Diagnostic pitfalls in sporadic transthyretin familial amyloid polyneuropathy (TTR-FAP). Neurology, 69(7), 693-698. https://doi.org/10.1212/01.wnl.0000267338.45673.f4Planté-Bordeneuve, V., & Said, G. (2011). Familial amyloid polyneuropathy. Lancet Neurol, 10(12), 1086-1097. https://doi.org/10.1016/s1474-4422(11)70246-0Pérez Zauner, A. M. (2016). Caracterización sociodemográfica de las enfermedades huérfanas en Colombia Universidad del Rosario].Rapezzi, C., Quarta, C. C., Obici, L., Perfetto, F., Longhi, S., Salvi, F., . . . Perlini, S. (2013). Disease profile and differential diagnosis of hereditary transthyretin-related amyloidosis with exclusively cardiac phenotype: an Italian perspective. Eur Heart J, 34(7), 520-528. https://doi.org/10.1093/eurheartj/ehs123Richardson, S. J. (2007). Cell and molecular biology of transthyretin and thyroid hormones. Int Rev Cytol, 258, 137-193. https://doi.org/10.1016/s0074-7696(07)58003-4Ruberg, F. L., & Berk, J. L. (2012). Transthyretin (TTR) cardiac amyloidosis. Circulation, 126(10), 1286-1300. https://doi.org/10.1161/circulationaha.111.078915Rubinow, A., & Cohen, A. S. (1986). Scalloped pupils in familial amyloid polyneuropathy. Arthritis Rheum, 29(3), 445-447. https://doi.org/10.1002/art.1780290323Said, G., Grippon, S., & Kirkpatrick, P. (2012). Tafamidis. In Nat Rev Drug Discov (Vol. 11, pp. 185-186). https://doi.org/10.1038/nrd3675Saraiva, M. J., Magalhaes, J., Ferreira, N., & Almeida, M. R. (2012). Transthyretin deposition in familial amyloidotic polyneuropathy. Curr Med Chem, 19(15), 2304-2311. https://doi.org/10.2174/092986712800269236Sattianayagam, P. T., Hahn, A. F., Whelan, C. J., Gibbs, S. D., Pinney, J. H., Stangou, A. J., . . . Gillmore, J. D. (2012). Cardiac phenotype and clinical outcome of familial amyloid polyneuropathy associated with transthyretin alanine 60 variant. Eur Heart J, 33(9), 1120-1127. https://doi.org/10.1093/eurheartj/ehr383Schmidt, H. H., Waddington-Cruz, M., Botteman, M. F., Carter, J. A., Chopra, A. S., Hopps, M., . . . Amass, L. (2018). Estimating the global prevalence of transthyretin familial amyloid polyneuropathy. Muscle Nerve, 57(5), 829-837. https://doi.org/10.1002/mus.26034Sekijima, Y., Tojo, K., Morita, H., Koyama, J., & Ikeda, S. (2015). Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis. Amyloid, 22(2), 79-83. https://doi.org/10.3109/13506129.2014.997872Sekijima, Y., Ueda, M., Koike, H., Misawa, S., Ishii, T., & Ando, Y. (2018). Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm. Orphanet J Rare Dis, 13(1), 6. https://doi.org/10.1186/s13023-017-0726-xSekijima, Y., Yazaki, M., Oguchi, K., Ezawa, N., Yoshinaga, T., Yamada, M., . . . Ikeda, S. (2016). Cerebral amyloid angiopathy in posttransplant patients with hereditary ATTR amyloidosis. Neurology, 87(8), 773-781. https://doi.org/10.1212/wnl.0000000000003001Sletten, D. M., Suarez, G. A., Low, P. A., Mandrekar, J., & Singer, W. (2012). COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin Proc, 87(12), 1196-1201. https://doi.org/10.1016/j.mayocp.2012.10.013Smith, S. C., Lamping, D. L., & Maclaine, G. D. H. (2012). Measuring health-related quality of life in diabetic peripheral neuropathy: A systematic review. Diabetes Research and Clinical Practice, 96(3), 261-270. https://doi.org/10.1016/j.diabres.2011.11.013Snell, R. S. (2007). Neuroanatomía clínica. Ed. Médica Panamericana.Stewart, J. D., Low, P. A., & Fealey, R. D. (1992). Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascular reflexes. Muscle Nerve, 15(6), 661-665. https://doi.org/10.1002/mus.880150605Suanprasert, N., Berk, J. L., Benson, M. D., Dyck, P. J., Klein, C. J., Gollob, J. A., . . . Karsten, V. (2014). Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials. J Neurol Sci, 344(1-2), 121-128. https://doi.org/10.1016/j.jns.2014.06.041Suhr, O. B., Larsson, M., Ericzon, B. G., & Wilczek, H. E. (2016). Survival After Transplantation in Patients With Mutations Other Than Val30Met: Extracts From the FAP World Transplant Registry. Transplantation, 100(2), 373-381. https://doi.org/10.1097/tp.0000000000001021Sène, D. (2018). Small fiber neuropathy: Diagnosis, causes, and treatment. Joint Bone Spine, 85(5), 553-559. https://doi.org/10.1016/j.jbspin.2017.11.002Terkelsen, A. J., Karlsson, P., Lauria, G., Freeman, R., Finnerup, N. B., & Jensen, T. S. (2017). The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes. Lancet Neurol, 16(11), 934-944. https://doi.org/10.1016/s1474-4422(17)30329-0Tesfaye, S., Boulton, A. J., Dyck, P. J., Freeman, R., Horowitz, M., Kempler, P., . . . Valensi, P. (2010). Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care, 33(10), 2285-2293. https://doi.org/10.2337/dc10-1303Thaisetthawatkul, P., Fernandes Filho, J. A., & Herrmann, D. N. (2013). Contribution of QSART to the diagnosis of small fiber neuropathy. Muscle Nerve, 48(6), 883-888. https://doi.org/10.1002/mus.23891Themistocleous, A. C., Ramirez, J. D., Serra, J., & Bennett, D. L. (2014). The clinical approach to small fibre neuropathy and painful channelopathy. Pract Neurol, 14(6), 368-379. https://doi.org/10.1136/practneurol-2013-000758Treede, R. D., Lorenz, J., & Baumgärtner, U. (2003). Clinical usefulness of laser-evoked potentials. Neurophysiol Clin, 33(6), 303-314. https://doi.org/10.1016/j.neucli.2003.10.009Treister, R., O'Neil, K., Downs, H. M., & Oaklander, A. L. (2015). Validation of the composite autonomic symptom scale 31 (COMPASS-31) in patients with and without small fiber polyneuropathy. Eur J Neurol, 22(7), 1124-1130. https://doi.org/10.1111/ene.12717Tsuzuki, T., Mita, S., Maeda, S., Araki, S., & Shimada, K. (1985). Structure of the human prealbumin gene. J Biol Chem, 260(22), 12224-12227.Vetrugno, R., Liguori, R., Cortelli, P., & Montagna, P. (2003). Sympathetic skin response: basic mechanisms and clinical applications. Clin Auton Res, 13(4), 256-270. https://doi.org/10.1007/s10286-003-0107-5Vieira, M., & Saraiva, M. J. (2014). Transthyretin: a multifaceted protein. Biomol Concepts, 5(1), 45-54. https://doi.org/10.1515/bmc-2013-0038Vinik, E. J., Hayes, R. P., Oglesby, A., Bastyr, E., Barlow, P., Ford-Molvik, S. L., & Vinik, A. I. (2005). The development and validation of the Norfolk QOL-DN, a new measure of patients' perception of the effects of diabetes and diabetic neuropathy. Diabetes Technol Ther, 7(3), 497-508. https://doi.org/10.1089/dia.2005.7.497Vinik, E. J., Vinik, A. I., Paulson, J. F., Merkies, I. S., Packman, J., Grogan, D. R., & Coelho, T. (2014). Norfolk QOL-DN: validation of a patient reported outcome measure in transthyretin familial amyloid polyneuropathy. J Peripher Nerv Syst, 19(2), 104-114. https://doi.org/10.1111/jns5.12059Walk, D., Sehgal, N., Moeller-Bertram, T., Edwards, R. R., Wasan, A., Wallace, M., . . . Backonja, M. M. (2009). Quantitative sensory testing and mapping: a review of nonautomated quantitative methods for examination of the patient with neuropathic pain. Clin J Pain, 25(7), 632-640. https://doi.org/10.1097/AJP.0b013e3181a68c64Wang, Q., Liu, C., & Zhang, Z. (2016). Transthyretin and Normal Human Pregnancy: Mini Review. Crit Rev Eukaryot Gene Expr, 26(3), 273-277. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2016017323Waxman, S. G., Arias Rebatet, G., & Medina Soriano, C. A. (2004). Neuroanatomía clínica.Wieczorek, E., & Ożyhar, A. (2021). Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases. Cells, 10(7). https://doi.org/10.3390/cells10071768Wilczek, H. E., Larsson, M., & Ericzon, B. G. (2011). Long-term data from the Familial Amyloidotic Polyneuropathy World Transplant Registry (FAPWTR). Amyloid, 18 Suppl 1, 193-195. https://doi.org/10.3109/13506129.2011.574354072Wixner, J., Mundayat, R., Karayal, O. N., Anan, I., Karling, P., & Suhr, O. B. (2014). THAOS: gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease. Orphanet J Rare Dis, 9, 61. https://doi.org/10.1186/1750-1172-9-61Wixner, J., Suhr, O. B., & Anan, I. (2018). Management of gastrointestinal complications in hereditary transthyretin amyloidosis: a single-center experience over 40 years. Expert Rev Gastroenterol Hepatol, 12(1), 73-81. https://doi.org/10.1080/17474124.2018.1397511Yamashita, T., Ando, Y., Okamoto, S., Misumi, Y., Hirahara, T., Ueda, M., . . . Uchino, M. (2012). Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy. Neurology, 78(9), 637-643. https://doi.org/10.1212/WNL.0b013e318248df18Yee, A. W., Aldeghi, M., Blakeley, M. P., Ostermann, A., Mas, P. J., Moulin, M., . . . Forsyth, V. T. (2019). A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10(1), 925. https://doi.org/10.1038/s41467-019-08609-zPúblico generalLICENSElicense.txtlicense.txttext/plain; charset=utf-85879https://repositorio.unal.edu.co/bitstream/unal/83246/1/license.txteb34b1cf90b7e1103fc9dfd26be24b4aMD51ORIGINAL79953271.2022.pdf79953271.2022.pdfTrabajo de grado - Especialidad Médica en Medicina Física y Rehabilitaciónapplication/pdf2846513https://repositorio.unal.edu.co/bitstream/unal/83246/3/79953271.2022.pdfa6aa5d1a35017459a8b15c4d52d538deMD53THUMBNAIL79953271.2022.pdf.jpg79953271.2022.pdf.jpgGenerated Thumbnailimage/jpeg5895https://repositorio.unal.edu.co/bitstream/unal/83246/4/79953271.2022.pdf.jpg26de38776d2824d5178104dc727976d5MD54unal/83246oai:repositorio.unal.edu.co:unal/832462024-08-17 00:01:27.512Repositorio Institucional Universidad Nacional de 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