Multivariate characterization of brain dynamics for disorders of consciousness

ilustraciones, gráficas, tablas

Autores:: Rudas Castaño, Jorge Eliécer

Tipo de recurso:: Doctoral thesis

Fecha de publicación:: 2021

Institución:: Universidad Nacional de Colombia

Repositorio:: Universidad Nacional de Colombia

Idioma:: spa

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repository_id_str
dc.title.eng.fl_str_mv	Multivariate characterization of brain dynamics for disorders of consciousness
dc.title.translated.spa.fl_str_mv	Caracterización de los desórdenes de la conciencia
title	Multivariate characterization of brain dynamics for disorders of consciousness
spellingShingle	Multivariate characterization of brain dynamics for disorders of consciousness 000 - Ciencias de la computación, información y obras generales Enfermedades cerebrales Disfunción cerebral crónica Brain - Diseases Brain damage, Chronic Desórdenes de la conciencia Resonancia magnética funcional Cerebro Redes en estado de descanso Conectividad funcional multivariada Multivariate functional connectivity Brain Disorders of consciousness Functional magnetic resonance Resting state networks
title_short	Multivariate characterization of brain dynamics for disorders of consciousness
title_full	Multivariate characterization of brain dynamics for disorders of consciousness
title_fullStr	Multivariate characterization of brain dynamics for disorders of consciousness
title_full_unstemmed	Multivariate characterization of brain dynamics for disorders of consciousness
title_sort	Multivariate characterization of brain dynamics for disorders of consciousness
dc.creator.fl_str_mv	Rudas Castaño, Jorge Eliécer
dc.contributor.advisor.none.fl_str_mv	Gómez Jaramillo, Francisco Castellanos, Gabriel
dc.contributor.author.none.fl_str_mv	Rudas Castaño, Jorge Eliécer
dc.contributor.researchgroup.spa.fl_str_mv	Grupo de Investigación en Modelado Computacional de Sistemas Biológicos (COMBIOS)
dc.subject.ddc.spa.fl_str_mv	000 - Ciencias de la computación, información y obras generales
topic	000 - Ciencias de la computación, información y obras generales Enfermedades cerebrales Disfunción cerebral crónica Brain - Diseases Brain damage, Chronic Desórdenes de la conciencia Resonancia magnética funcional Cerebro Redes en estado de descanso Conectividad funcional multivariada Multivariate functional connectivity Brain Disorders of consciousness Functional magnetic resonance Resting state networks
dc.subject.lemb.spa.fl_str_mv	Enfermedades cerebrales Disfunción cerebral crónica
dc.subject.lemb.emg.fl_str_mv	Brain - Diseases
dc.subject.lemb.eng.fl_str_mv	Brain damage, Chronic
dc.subject.proposal.spa.fl_str_mv	Desórdenes de la conciencia Resonancia magnética funcional Cerebro Redes en estado de descanso Conectividad funcional multivariada
dc.subject.proposal.eng.fl_str_mv	Multivariate functional connectivity Brain Disorders of consciousness Functional magnetic resonance Resting state networks
description	ilustraciones, gráficas, tablas
publishDate	2021
dc.date.accessioned.none.fl_str_mv	2021-09-08T04:23:48Z
dc.date.available.none.fl_str_mv	2021-09-08T04:23:48Z
dc.date.issued.none.fl_str_mv	2021-10
dc.type.spa.fl_str_mv	Trabajo de grado - Doctorado
dc.type.driver.spa.fl_str_mv	info:eu-repo/semantics/doctoralThesis
dc.type.version.spa.fl_str_mv	info:eu-repo/semantics/acceptedVersion
dc.type.coar.spa.fl_str_mv	http://purl.org/coar/resource_type/c_db06
dc.type.content.spa.fl_str_mv	Text
dc.type.redcol.spa.fl_str_mv	http://purl.org/redcol/resource_type/TD
format	http://purl.org/coar/resource_type/c_db06
status_str	acceptedVersion
dc.identifier.uri.none.fl_str_mv	https://repositorio.unal.edu.co/handle/unal/80127
dc.identifier.instname.spa.fl_str_mv	Universidad Nacional de Colombia
dc.identifier.reponame.spa.fl_str_mv	Repositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourl.spa.fl_str_mv	https://repositorio.unal.edu.co/
url	https://repositorio.unal.edu.co/handle/unal/80127 https://repositorio.unal.edu.co/
identifier_str_mv	Universidad Nacional de Colombia Repositorio Institucional Universidad Nacional de Colombia
dc.language.iso.spa.fl_str_mv	spa
language	spa
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dc.publisher.spa.fl_str_mv	Universidad Nacional de Colombia
dc.publisher.program.spa.fl_str_mv	Bogotá - Ciencias - Doctorado en Biotecnología
dc.publisher.department.spa.fl_str_mv	Instituto de Biotecnología (IBUN)
dc.publisher.faculty.spa.fl_str_mv	Facultad de Ciencias
dc.publisher.place.spa.fl_str_mv	Bogotá, Colombia
dc.publisher.branch.spa.fl_str_mv	Universidad Nacional de Colombia - Sede Bogotá
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spelling	Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Gómez Jaramillo, Franciscof0ed776717c063b789127232a75b29c7Castellanos, Gabriel2b7005395a1a5340eb69ec1636910944Rudas Castaño, Jorge Eliécerd61abcad45a12af889d9288d63af5da5Grupo de Investigación en Modelado Computacional de Sistemas Biológicos (COMBIOS)2021-09-08T04:23:48Z2021-09-08T04:23:48Z2021-10https://repositorio.unal.edu.co/handle/unal/80127Universidad Nacional de ColombiaRepositorio Institucional Universidad Nacional de Colombiahttps://repositorio.unal.edu.co/ilustraciones, gráficas, tablasDespués de una lesión cerebral severa algunos pacientes pueden presentar alteraciones graves de la conciencia. Estas lesiones limitan grandemente la calidad de vida de estos pacientes y en consecuencia la de su familia. Las ultimas dos décadas han suscitado especial interés el entendimiento, descripción y caracterización de forma objetiva de la dinámica cerebral en este grupo de pacientes. La consecuencia inmediata de este entendimiento es la construcción de herramientas que permitan mejorar la toma de decisiones para los médicos que asisten o intervienen a estos pacientes. Múltiples estrategias han sido exploradas para ello, desde la construcción de rigurosas pruebas comportamentales hasta el uso de novedosas técnicas de neuroimágenes. Estas ultimas han mostrado un futuro prometedor para el contexto de estudio, alcanzando transcendentales hallazgos en relación al entendimiento de la emergencia de la conciencia, su alteración en estados comatosos y hasta han derivado en potenciales herramientas diagnosticas. Sin embargo y muy a pesar de estos importantes logros, aún existen múltiples retos por resolver en él área. Uno de esos retos fundamentales es la definición de un marco experimental adecuado para modelar la dinámica cerebral dada su abrumadora complejidad. Diversas estrategias han sido propuestas, sin embargo, aún permanece la imposibilidad de unificar en una única representación los agentes más relevantes para la emergencia de la conciencia. Es así como, en esta tesis doctoral se explora una aproximación en la representación de la dinámica cerebral que generaliza la noción de conectividad funcional entre unidades cerebrales. Los resultados aquí descritos se discuten en el marco de la caracterización de la dinámica cerebral de pacientes con desordenes de la conciencia, y su potencial uso como biomarcadores se resaltan en los resultados de esta tesis doctoral. (texto tomado de la fuente)After a brain injury some patients may have severe disturbances in consciousness. These injuries greatly limit the quality of life of these patients and their families. The last two decades have raised special interest in the understanding, description and objective charac terization of brain dynamics in this group of patients. The immediate consequence of this understanding is the construction of tools that allow better decision-making for the phy sicians who assist or intervene these patients. Multiple strategies have been explored for this, from the construction of rigorous behavioral tests to the use of novel neuroimaging techniques. Neuroimaging approach have shown a promising future in this context, reaching transcendental findings in relation to the understanding of the emergence of consciousness, its alteration in comatose states and have even led to potential diagnostic tools. However, there are still many important challenges to overcome. One of these fundamental challenges is the definition of a suitable experimental framework to model brain dynamics, because the overwhelming complexity of this phenomena. Various strategies have been proposed, ho wever, the impossibility of unifying in a single representation the most relevant agents for the emergence of consciousness still remains as an open problem. Thus, this doctoral thesis explores an approach in the representation of brain dynamics that generalizes the notion of functional connectivity between brain units. The results described here are discussed within the framework of the characterization of the brain dynamics of patients with disorders of consciousness, and their potential use as biomarkers is highlighted in the results of this doc toral thesis.DoctoradoDoctor en BiotecnologíaBioinformáticaxvi, 104 páginasapplication/pdfspaUniversidad Nacional de ColombiaBogotá - Ciencias - Doctorado en BiotecnologíaInstituto de Biotecnología (IBUN)Facultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá000 - Ciencias de la computación, información y obras generalesEnfermedades cerebralesDisfunción cerebral crónicaBrain - DiseasesBrain damage, ChronicDesórdenes de la concienciaResonancia magnética funcionalCerebroRedes en estado de descansoConectividad funcional multivariadaMultivariate functional connectivityBrainDisorders of consciousnessFunctional magnetic resonanceResting state networksMultivariate characterization of brain dynamics for disorders of consciousnessCaracterización de los desórdenes de la concienciaTrabajo de grado - Doctoradoinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_db06Texthttp://purl.org/redcol/resource_type/TDS Laureys, M Boly, G Moonen, and P Maquet. 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Structural and functional connectivity of ascending reticular activatingsystem in a patient with impaired consciousness after a cardiac arrest: A case report.Medicine (Baltimore), 98(19):e15620, May 2019LICENSElicense.txtlicense.txttext/plain; charset=utf-83964https://repositorio.unal.edu.co/bitstream/unal/80127/3/license.txtcccfe52f796b7c63423298c2d3365fc6MD53ORIGINALMultivariate characterization of brain.2021.pdfMultivariate characterization of brain.2021.pdfTesis de Doctorado en Biotecnologíaapplication/pdf3103956https://repositorio.unal.edu.co/bitstream/unal/80127/6/Multivariate%20characterization%20of%20brain.2021.pdf45f886d3941b95d4bd411dc93ab5ddc0MD56THUMBNAILMultivariate characterization of brain.2021.pdf.jpgMultivariate characterization of brain.2021.pdf.jpgGenerated 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Colombiarepositorio_nal@unal.edu.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

Multivariate characterization of brain dynamics for disorders of consciousness

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